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Select item 91987201.

A close shave: How SARS-CoV-2 induces the loss of cilia

Barbara F. Fonseca, Lisa A. Chakrabarti

J Cell Biol. 2022 Jul 4; 221(7): e202206023. Published online 2022 Jun 13. doi: 10.1083/jcb.202206023

PMCID:: PMC9198720

Article PDF–858K

Select item 91216542.

Structural insights into ORF10 recognition by ZYG11B

Bing Zhang, Yao Li, Qiqi Feng, Lili Song, Cheng Dong, Xiaojie Yan

Biochem Biophys Res Commun. 2022 Aug 6; 616: 14–18. Published online 2022 May 20. doi: 10.1016/j.bbrc.2022.05.069

PMCID:: PMC9121654

Article PDF–1.2M

Select item 103444393.

LncRNA LINC01871 sponging miR-142-3p to modulate ZYG11B promotes the chemoresistance of colorectal cancer cells by inducing autophagy

Bensong Duan, Haibin Zhang, Zhen Zhu, Xiaohan Yan, Zhonghua Ji, Jingze Li

Anticancer Drugs. 2023 Aug; 34(7): 827–836. Published online 2023 Feb 20. doi: 10.1097/CAD.0000000000001478

PMCID:: PMC10344439

Article PDF–1.2M

Select item 97416524.

CRL2^ZER1/ZYG11B recognizes small N-terminal residues for degradation

Yao Li, Yueling Zhao, Xiaojie Yan, Chen Ye, Sara Weirich, Bing Zhang, Xiaolu Wang, Lili Song, Chenhao Jiang, Albert Jeltsch, Cheng Dong, Wenyi Mi

Nat Commun. 2022; 13: 7636. Published online 2022 Dec 10. doi: 10.1038/s41467-022-35169-6

PMCID:: PMC9741652

Article PDF–1.7M

Select item 91848505.

SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2^ZYG11B activity

Liying Wang, Chao Liu, Bo Yang, Haotian Zhang, Jian Jiao, Ruidan Zhang, Shujun Liu, Sai Xiao, Yinghong Chen, Bo Liu, Yanjie Ma, Xuefeng Duan, Yueshuai Guo, Mengmeng Guo, Bingbing Wu, Xiangdong Wang, Xingxu Huang, Haitao Yang, Yaoting Gui, Min Fang, Luo Zhang, Shuguang Duo, Xuejiang Guo, Wei Li

J Cell Biol. 2022 Jul 4; 221(7): e202108015. Published online 2022 Jun 8. doi: 10.1083/jcb.202108015

PMCID:: PMC9184850

Article PDF–8.1M

Select item 70903756.

A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation

Richard T. Timms, Zhiqian Zhang, David Y. Rhee, J. Wade Harper, Itay Koren, Stephen J. Elledge

Science. Author manuscript; available in PMC 2020 Mar 24.

Published in final edited form as: Science. 2019 Jul 5; 365(6448): eaaw4912. doi: 10.1126/science.aaw4912

PMCID:: PMC7090375

Article PDF–3.1M

Select item 80925987.

ORF10–Cullin-2–ZYG11B complex is not required for SARS-CoV-2 infection

Elijah L. Mena, Callie J. Donahue, Laura Pontano Vaites, Jie Li, Gergely Rona, Colin O’Leary, Luca Lignitto, Bearach Miwatani-Minter, Joao A. Paulo, Avantika Dhabaria, Beatrix Ueberheide, Steven P. Gygi, Michele Pagano, J. Wade Harper, Robert A. Davey, Stephen J. Elledge

Proc Natl Acad Sci U S A. 2021 Apr 27; 118(17): e2023157118. Published online 2021 Apr 7. doi: 10.1073/pnas.2023157118

PMCID:: PMC8092598

Article PDF–1.3M

Select item 50846448.

The ubiquitin ligase CRL2^ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage

Riju S. Balachandran, Cassandra S. Heighington, Natalia G. Starostina, James W. Anderson, David L. Owen, Srividya Vasudevan, Edward T. Kipreos

J Cell Biol. 2016 Oct 24; 215(2): 151–166. doi: 10.1083/jcb.201601083

PMCID:: PMC5084644

Article PDF–2.3M

Select item 75495789.

Functional and genetic analyses of ZYG11B provide evidences for its involvement in OAVS

Angèle Tingaud‐Sequeira, Aurélien Trimouille, Sandrine Marlin, Estelle Lopez, Marie Berenguer, Souad Gherbi, Benoit Arveiler, Didier Lacombe, Caroline Rooryck

Mol Genet Genomic Med. 2020 Oct; 8(10): e1375. Published online 2020 Aug 1. doi: 10.1002/mgg3.1375

PMCID:: PMC7549578

Article PDF–956K

Select item 180803210.

The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components

Srividya Vasudevan, Natalia G Starostina, Edward T Kipreos

EMBO Rep. 2007 Mar; 8(3): 279–286. Published online 2007 Feb 16. doi: 10.1038/sj.embor.7400895

PMCID:: PMC1808032

Article PDF–339K

Select item 509166811.

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

Daniel C. Scott, David Y. Rhee, David M. Duda, Ian R. Kelsall, Jennifer L. Olszewski, Joao A. Paulo, Annemieke de Jong, Huib Ovaa, Arno F. Alpi, J. Wade Harper, Brenda A. Schulman

Cell. Author manuscript; available in PMC 2017 Aug 25.

Published in final edited form as: Cell. 2016 Aug 25; 166(5): 1198–1214.e24. doi: 10.1016/j.cell.2016.07.027

PMCID:: PMC5091668

Article PDF–4.2M

Select item 589826612.

ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest

Aya Noguchi, Shungo Adachi, Naoto Yokota, Tomohisa Hatta, Tohru Natsume, Hiroyuki Kawahara

Biol Open. 2018 Mar 15; 7(3): bio031575. Published online 2018 Feb 15. doi: 10.1242/bio.031575

PMCID:: PMC5898266

Article PDF–3.4M

Select item 743103013.

A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing

David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O’Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Huettenhain, Robyn M. Kaake, Alicia L. Richards, Beril Tutuncuoglu, Helene Foussard, Jyoti Batra, Kelsey Haas, Maya Modak, Minkyu Kim, Paige Haas, Benjamin J. Polacco, Hannes Braberg, Jacqueline M. Fabius, Manon Eckhardt, Margaret Soucheray, Melanie J. Bennett, Merve Cakir, Michael J. McGregor, Qiongyu Li, Bjoern Meyer, Ferdinand Roesch, Thomas Vallet, Alice Mac Kain, Lisa Miorin, Elena Moreno, Zun Zar Chi Naing, Yuan Zhou, Shiming Peng, Ying Shi, Ziyang Zhang, Wenqi Shen, Ilsa T. Kirby, James E. Melnyk, John S. Chorba, Kevin Lou, Shizhong A. Dai, Inigo Barrio-Hernandez, Danish Memon, Claudia Hernandez-Armenta, Jiankun Lyu, Christopher J.P. Mathy, Tina Perica, Kala B. Pilla, Sai J. Ganesan, Daniel J. Saltzberg, Ramachandran Rakesh, Xi Liu, Sara B. Rosenthal, Lorenzo Calviello, Srivats Venkataramanan, Jose Liboy-Lugo, Yizhu Lin, Xi-Ping Huang, YongFeng Liu, Stephanie A. Wankowicz, Markus Bohn, Maliheh Safari, Fatima S. Ugur, Cassandra Koh, Nastaran Sadat Savar, Quang Dinh Tran, Djoshkun Shengjuler, Sabrina J Fletcher, Michael C. O’Neal, Yiming Cai, Jason C.J.Chang, David J. Broadhurst, Saker Klippsten, Phillip P. Sharp, Nicole A. Wenzell, Duygu Kuzuoglu, Hao-Yuan Wang, Raphael Trenker, Janet M. Young, Devin A. Cavero, Joseph Hiatt, Theodore L. Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, Robert M. Stroud, Alan D. Frankel, Oren S. Rosenberg, Kliment A Verba, David A. Agard, Melanie Ott, Michael Emerman, Natalia Jura, Mark von Zastrow, Eric Verdin, Alan Ashworth, Olivier Schwartz, Christophe d’Enfert, Shaeri Mukherjee, Matt Jacobson, Harmit S. Malik, Danica G. Fujimori, Trey Ideker, Charles S. Craik, Stephen N. Floor, James S. Fraser, John D. Gross, Andrej Sali, Bryan L. Roth, Davide Ruggero, Jack Taunton, Tanja Kortemme, Pedro Beltrao, Marco Vignuzzi, Adolfo García-Sastre, Kevan M. Shokat, Brian K. Shoichet, Nevan J. Krogan

Nature. Author manuscript; available in PMC 2020 Oct 30.

Published in final edited form as: Nature. 2020 Jul; 583(7816): 459–468. Published online 2020 Apr 30. doi: 10.1038/s41586-020-2286-9

PMCID:: PMC7431030

Article PDF–7.7M

Select item 715369514.

ARIH2 is a Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection

Ruth Hüttenhain, Jiewei Xu, Lily A. Burton, David E. Gordon, Judd F. Hultquist, Jeffrey R. Johnson, Laura Satkamp, Joseph Hiatt, David Y. Rhee, Kheewoong Baek, David C. Crosby, Alan D. Frankel, Alexander Marson, J. Wade Harper, Arno F. Alpi, Brenda A. Schulman, John D. Gross, Nevan J. Krogan

Cell Host Microbe. Author manuscript; available in PMC 2020 Jul 10.

Published in final edited form as: Cell Host Microbe. 2019 Jul 10; 26(1): 86–99.e7. Published online 2019 Jun 25. doi: 10.1016/j.chom.2019.05.008

PMCID:: PMC7153695

Article PDF–2.6M

Select item 476376915.

CHK2–BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly

Norman Ertych, Ailine Stolz, Oliver Valerius, Gerhard H. Braus, Holger Bastians

Proc Natl Acad Sci U S A. 2016 Feb 16; 113(7): 1817–1822. Published online 2016 Feb 1. doi: 10.1073/pnas.1525129113

PMCID:: PMC4763769

Article PDF–1.3M

Select item 557737616.

Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase

Daniel C. Scott, Jared T. Hammill, Jaeki Min, David Y. Rhee, Michele Connelly, Vladislav O. Sviderskiy, Deepak Bhasin, Yizhe Chen, Su-Sien Ong, Sergio C. Chai, Asli N. Goktug, Guochang Huang, Julie K. Monda, Jonathan Low, Ho Shin Kim, Joao A. Paulo, Joe R. Cannon, Anang A. Shelat, Taosheng Chen, Ian R. Kelsall, Arno F. Alpi, Vishwajeeth Pagala, Xusheng Wang, Junmin Peng, Bhuvanesh Singh, J. Wade Harper, Brenda A. Schulman, R. Kip Guy

Nat Chem Biol. Author manuscript; available in PMC 2017 Dec 5.

Published in final edited form as: Nat Chem Biol. 2017 Aug; 13(8): 850–857. Published online 2017 Jun 5. doi: 10.1038/nchembio.2386

PMCID:: PMC5577376

Article PDF–1.2M

Select item 482661417.

?F508 CFTR interactome remodeling promotes rescue of Cystic Fibrosis

Sandra Pankow, Casimir Bamberger, Diego Calzolari, Salvador Martínez-Bartolomé, Mathieu Lavallée-Adam, William E. Balch, John R. Yates, III

Nature. Author manuscript; available in PMC 2016 May 30.

Published in final edited form as: Nature. 2015 Dec 24; 528(7583): 510–516. Published online 2015 Nov 30. doi: 10.1038/nature15729

PMCID:: PMC4826614

Article PDF–5.7M

Select item 780840818.

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

David E. Gordon, Joseph Hiatt, Mehdi Bouhaddou, Veronica V. Rezelj, Svenja Ulferts, Hannes Braberg, Alexander S. Jureka, Kirsten Obernier, Jeffrey Z. Guo, Jyoti Batra, Robyn M. Kaake, Andrew R. Weckstein, Tristan W. Owens, Meghna Gupta, Sergei Pourmal, Erron W. Titus, Merve Cakir, Margaret Soucheray, Michael McGregor, Zeynep Cakir, Gwendolyn Jang, Matthew J. O’Meara, Tia A. Tummino, Ziyang Zhang, Helene Foussard, Ajda Rojc, Yuan Zhou, Dmitry Kuchenov, Ruth Hüttenhain, Jiewei Xu, Manon Eckhardt, Danielle L. Swaney, Jacqueline M. Fabius, Manisha Ummadi, Beril Tutuncuoglu, Ujjwal Rathore, Maya Modak, Paige Haas, Kelsey M. Haas, Zun Zar Chi Naing, Ernst H. Pulido, Ying Shi, Inigo Barrio-Hernandez, Danish Memon, Eirini Petsalaki, Alistair Dunham, Miguel Correa Marrero, David Burke, Cassandra Koh, Thomas Vallet, Jesus A. Silvas, Caleigh M. Azumaya, Christian Billesbølle, Axel F. Brilot, Melody G. Campbell, Amy Diallo, Miles Sasha Dickinson, Devan Diwanji, Nadia Herrera, Nick Hoppe, Huong T. Kratochvil, Yanxin Liu, Gregory E. Merz, Michelle Moritz, Henry C. Nguyen, Carlos Nowotny, Cristina Puchades, Alexandrea N. Rizo, Ursula Schulze-Gahmen, Amber M. Smith, Ming Sun, Iris D. Young, Jianhua Zhao, Daniel Asarnow, Justin Biel, Alisa Bowen, Julian R. Braxton, Jen Chen, Cynthia M. Chio, Un Seng Chio, Ishan Deshpande, Loan Doan, Bryan Faust, Sebastian Flores, Mingliang Jin, Kate Kim, Victor L. Lam, Fei Li, Junrui Li, Yen-Li Li, Yang Li, Xi Liu, Megan Lo, Kyle E. Lopez, Arthur A. Melo, Frank R. Moss, III, Phuong Nguyen, Joana Paulino, Komal Ishwar Pawar, Jessica K. Peters, Thomas H. Pospiech, Jr., Maliheh Safari, Smriti Sangwan, Kaitlin Schaefer, Paul V. Thomas, Aye C. Thwin, Raphael Trenker, Eric Tse, Tsz Kin Martin Tsui, Feng Wang, Natalie Whitis, Zanlin Yu, Kaihua Zhang, Yang Zhang, Fengbo Zhou, Daniel Saltzberg, QCRG Structural Biology Consortium, Anthony J. Hodder, Amber S. Shun-Shion, Daniel M. Williams, Kris M. White, Romel Rosales, Thomas Kehrer, Lisa Miorin, Elena Moreno, Arvind H. Patel, Suzannah Rihn, Mir M. Khalid, Albert Vallejo-Gracia, Parinaz Fozouni, Camille R. Simoneau, Theodore L. Roth, David Wu, Mohd Anisul Karim, Maya Ghoussaini, Ian Dunham, Francesco Berardi, Sebastian Weigang, Maxime Chazal, Jisoo Park, James Logue, Marisa McGrath, Stuart Weston, Robert Haupt, C. James Hastie, Matthew Elliott, Fiona Brown, Kerry A. Burness, Elaine Reid, Mark Dorward, Clare Johnson, Stuart G. Wilkinson, Anna Geyer, Daniel M. Giesel, Carla Baillie, Samantha Raggett, Hannah Leech, Rachel Toth, Nicola Goodman, Kathleen C. Keough, Abigail L. Lind, Zoonomia Consortium, Reyna J. Klesh, Kafi R. Hemphill, Jared Carlson-Stevermer, Jennifer Oki, Kevin Holden, Travis Maures, Katherine S. Pollard, Andrej Sali, David A. Agard, Yifan Cheng, James S. Fraser, Adam Frost, Natalia Jura, Tanja Kortemme, Aashish Manglik, Daniel R. Southworth, Robert M. Stroud, Dario R. Alessi, Paul Davies, Matthew B. Frieman, Trey Ideker, Carmen Abate, Nolwenn Jouvenet, Georg Kochs, Brian Shoichet, Melanie Ott, Massimo Palmarini, Kevan M. Shokat, Adolfo García-Sastre, Jeremy A. Rassen, Robert Grosse, Oren S. Rosenberg, Kliment A. Verba, Christopher F. Basler, Marco Vignuzzi, Andrew A. Peden, Pedro Beltrao, Nevan J. Krogan

Science. 2020 Dec 4; 370(6521): eabe9403. Published online 2020 Oct 15. doi: 10.1126/science.abe9403

PMCID:: PMC7808408

Article PDF–4.2M

Select item 271642219.

Defining the Human Deubiquitinating Enzyme Interaction Landscape

Mathew E. Sowa, Eric J. Bennett, Steven P. Gygi, J. Wade Harper

Cell. Author manuscript; available in PMC 2010 Jul 23.

Published in final edited form as: Cell. 2009 Jul 23; 138(2): 389–403. Published online 2009 Jul 16. doi: 10.1016/j.cell.2009.04.042

PMCID:: PMC2716422

Article PDF–6.1M

Select item 486917020.

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, Konstantinos Koutroumpas, Thanh-Minh T. Nguyen, Yves Texier, Sylvia E. C. van Beersum, Nicola Horn, Jason R. Willer, Dorus A. Mans, Gerard Dougherty, Ideke J. C. Lamers, Karlien L. M. Coene, Heleen H. Arts, Matthew J. Betts, Tina Beyer, Emine Bolat, Christian Johannes Gloeckner, Khatera Haidari, Lisette Hetterschijt, Daniela Iaconis, Dagan Jenkins, Franziska Klose, Barbara Knapp, Brooke Latour, Stef J. F. Letteboer, Carlo L. Marcelis, Dragana Mitic, Manuela Morleo, Machteld M. Oud, Moniek Riemersma, Susan Rix, Paulien A. Terhal, Grischa Toedt, Teunis J. P. van Dam, Erik de Vrieze, Yasmin Wissinger, Ka Man Wu, Gordana Apic, Philip L. Beales, Oliver E. Blacque, Toby J. Gibson, Martijn A. Huynen, Nicholas Katsanis, Hannie Kremer, Heymut Omran, Erwin van Wijk, Uwe Wolfrum, François Kepes, Erica E. Davis, Brunella Franco, Rachel H. Giles, Marius Ueffing, Robert B. Russell, Ronald Roepman, UK10K Rare Diseases Group

Nat Commun. 2016; 7: 11491. Published online 2016 May 13. doi: 10.1038/ncomms11491

PMCID:: PMC4869170

Article PDF–2.0M

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