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Select item 109115991.

Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets

Anastasiia Stratiievska, Olga Filippova, Tahsin Özpolat, Daire Byrne, S. Lawrence Bailey, Aastha Chauhan, Molly Y. Mollica, Jeff Harris, Kali Esancy, Junmei Chen, Ajay K. Dhaka, Nathan J. Sniadecki, José A. López, Moritz Stolla

PLoS One. 2024; 19(3): e0289395. Published online 2024 Mar 4. doi: 10.1371/journal.pone.0289395

PMCID:: PMC10911599

Article PDF–2.2M

Select item 105872372.

Structure of human TRPM8 channel

Sergii Palchevskyi, Mariusz Czarnocki-Cieciura, Giulio Vistoli, Silvia Gervasoni, Elżbieta Nowak, Andrea R. Beccari, Marcin Nowotny, Carmine Talarico

Commun Biol. 2023; 6: 1065. Published online 2023 Oct 19. doi: 10.1038/s42003-023-05425-6

PMCID:: PMC10587237

Article PDF–4.1M

Select item 100926583.

TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β‐catenin signalling

Ester Pagano, Barbara Romano, Donatella Cicia, Fabio A. Iannotti, Tommaso Venneri, Giuseppe Lucariello, Maria Francesca Nanì, Fabio Cattaneo, Paola De Cicco, Maria D'Armiento, Marcello De Luca, Ruggiero Lionetti, Stefania Lama, Paola Stiuso, Pietro Zoppoli, Geppino Falco, Silvia Marchianò, Stefano Fiorucci, Raffaele Capasso, Vincenzo Di Marzo, Francesca Borrelli, Angelo A. Izzo

Br J Pharmacol. 2023 Jan; 180(2): 235–251. Published online 2022 Oct 17. doi: 10.1111/bph.15960

PMCID:: PMC10092658

Article PDF–2.8M

Select item 95439074.

The cation channel TRPM8 influences the differentiation and function of human monocytes

Eve Hornsby, Hamish W. King, Madusha Peiris, Roberto Buccafusca, Wing‐Yiu Jason Lee, Elinor S. Wing, L. Ashley Blackshaw, James O. Lindsay, Andrew J. Stagg

J Leukoc Biol. 2022 Sep; 112(3): 365–381. Published online 2022 Mar 1. doi: 10.1002/JLB.1HI0421-181R

PMCID:: PMC9543907

Article PDF–5.3M

Select item 95406145.

Cold sensor, hot topic: TRPM8 plays a role in monocyte function and differentiation

Brie Trusiano, Juselyn D. Tupik, Irving C. Allen

J Leukoc Biol. 2022 Sep; 112(3): 361–363. Published online 2022 May 15. doi: 10.1002/JLB.3CE0222-099R

PMCID:: PMC9540614

Article PDF–391K

Select item 92849476.

Current view of ligand and lipid recognition by the menthol receptor TRPM8

Ying Yin, Seok-Yong Lee

Trends Biochem Sci. Author manuscript; available in PMC 2022 Jul 15.

Published in final edited form as: Trends Biochem Sci. 2020 Sep; 45(9): 806–819. Published online 2020 Jun 9. doi: 10.1016/j.tibs.2020.05.008

PMCID:: PMC9284947

Article PDF–3.4M

Select item 92244637.

TRPM8 as an Anti–Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination

Guillaume P. Grolez, Giorgia Chinigò, Alexandre Barras, Mehdi Hammadi, Lucile Noyer, Kateryna Kondratska, Etmar Bulk, Thibauld Oullier, Séverine Marionneau-Lambot, Marilyne Le Mée, Stéphanie Rétif, Stéphanie Lerondel, Antonino Bongiovanni, Tullio Genova, Sébastien Roger, Rabah Boukherroub, Albrecht Schwab, Alessandra Fiorio Pla, Dimitra Gkika

Int J Mol Sci. 2022 Jun; 23(12): 6672. Published online 2022 Jun 15. doi: 10.3390/ijms23126672

PMCID:: PMC9224463

Article PDF–3.7M

Select item 89612908.

The TRPM8 channel as a potential therapeutic target for bladder hypersensitive disorders

Naoki Aizawa, Tomoe Fujita

J Smooth Muscle Res. 2022; 58: 11–21. Published online 2022 Mar 30. doi: 10.1540/jsmr.58.11

PMCID:: PMC8961290

Article PDF–530K

Select item 83951669.

TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation

Carolina Izquierdo, Mercedes Martín-Martínez, Isabel Gómez-Monterrey, Rosario González-Muñiz

Int J Mol Sci. 2021 Aug; 22(16): 8502. Published online 2021 Aug 7. doi: 10.3390/ijms22168502

PMCID:: PMC8395166

Article PDF–7.9M

Select item 829227910.

Linalool inhibits the angiogenic activity of endothelial cells by downregulating intracellular ATP levels and activating TRPM8

Vivien Becker, Xin Hui, Lisa Nalbach, Emmanuel Ampofo, Peter Lipp, Michael D. Menger, Matthias W. Laschke, Yuan Gu

Angiogenesis. 2021; 24(3): 613–630. Published online 2021 Mar 2. doi: 10.1007/s10456-021-09772-y

PMCID:: PMC8292279

Article PDF–2.9M

Select item 816739811.

TRPM8 protein expression in hormone naïve local and lymph node metastatic prostate cancer

Andrea Lunardi, Mattia Barbareschi, Francesco Giuseppe Carbone, Luca Morelli, Matteo Brunelli, Nicolò Fortuna, Sacha Genovesi, Alessandro Alaimo

Pathologica. 2021 Apr; 113(2): 95–101. Published online 2021 Mar 18. doi: 10.32074/1591-951X-262

PMCID:: PMC8167398

Article PDF–1.5M

Select item 765758312.

The cool things to know about TRPM8!

Mircea Iftinca, Christophe Altier

Channels (Austin) 2020; 14(1): 413–420. Published online 2020 Nov 4. doi: 10.1080/19336950.2020.1841419

PMCID:: PMC7657583

Article PDF–727K

Select item 744391413.

A folding reaction at the C-terminal domain drives temperature sensing in TRPM8 channels

Ignacio Díaz-Franulic, Natalia Raddatz, Karen Castillo, Fernando D. González-Nilo, Ramon Latorre

Proc Natl Acad Sci U S A. 2020 Aug 18; 117(33): 20298–20304. Published online 2020 Aug 3. doi: 10.1073/pnas.2004303117

PMCID:: PMC7443914

Article PDF–3.6M

Select item 743208114.

TRPM8 Channel Activation Reduces the Spontaneous Contractions in Human Distal Colon

Antonella Amato, Simona Terzo, Laura Lentini, Pierenrico Marchesa, Flavia Mulè

Int J Mol Sci. 2020 Aug; 21(15): 5403. Published online 2020 Jul 29. doi: 10.3390/ijms21155403

PMCID:: PMC7432081

Article PDF–4.1M

Select item 727705815.

Genome‐Wide Association Study of Pain in Parkinson's Disease Implicates TRPM8 as a Risk Factor

Nigel M. Williams, Leon Hubbard, Cynthia Sandor, Caleb Webber, Hannah Hendry, Michael Lawton, Camille Carroll, K. Ray Chaudhuri, Huw Morris, Michele T. Hu, Donald G. Grosset, Christopher Kobylecki, Monty Silverdale, the UK Parkinson's Pain Study

Mov Disord. 2020 Apr; 35(4): 705–707. Published online 2020 Feb 20. doi: 10.1002/mds.28001

PMCID:: PMC7277058

Article PDF–279K

Select item 692796316.

Reduced TRPM8 expression underpins reduced migraine risk and attenuated cold pain sensation in humans

Narender R. Gavva, Robert Sandrock, Gregory E. Arnold, Michael Davis, Edwin Lamas, Chris Lindvay, Chi-Ming Li, Brian Smith, Miroslav Backonja, Kristin Gabriel, Gabriel Vargas

Sci Rep. 2019; 9: 19655. Published online 2019 Dec 23. doi: 10.1038/s41598-019-56295-0