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Select item 88198191.

Targeting KDM4C enhances CD8⁺ T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer

Xiaohua Jie, Yunshang Chen, Ye Zhao, Xijie Yang, Yingzhuo Xu, Jian Wang, Rui Meng, Sheng Zhang, Xiaorong Dong, Tao Zhang, Kunyu Yang, Shuangbing Xu, Gang Wu

J Immunother Cancer. 2022; 10(2): e003716. Published online 2022 Feb 4. doi: 10.1136/jitc-2021-003716

PMCID:: PMC8819819

Article PDF–4.8M

Select item 39195002.

Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cells identity

Partha Pratim Das, Zhen Shao, Semir Beyaz, Eftychia Apostolou, Luca Pinello, Alejandro De Los Angeles, Kassandra O’Brien, Jennifer Marino Atsma, Yuko Fujiwara, Minh Nguyen, Damir Ljuboja, Guoji Guo, Andrew Woo, Guo-Cheng Yuan, Tamer Onder, George Daley, Konrad Hochedlinger, Jonghwan Kim, Stuart H. Orkin

Mol Cell. Author manuscript; available in PMC 2015 Jan 9.

Published in final edited form as: Mol Cell. 2014 Jan 9; 53(1): 32–48. Published online 2013 Dec 19. doi: 10.1016/j.molcel.2013.11.011

PMCID:: PMC3919500

Article PDF–3.4M

Select item 94090753.

Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury

Heng-Chih Pan, Yau-Hung Chen, Wei-Ching Fang, Vin-Cent Wu, Chiao-Yin Sun

Int J Mol Sci. 2022 Aug; 23(16): 9318. Published online 2022 Aug 18. doi: 10.3390/ijms23169318

PMCID:: PMC9409075

Article PDF–3.2M

Select item 67767944.

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance

Karl Agger, Koutarou Nishimura, Satoru Miyagi, Jan-Erik Messling, Kasper Dindler Rasmussen, Kristian Helin

Blood. 2019 Oct 3; 134(14): 1154–1158. Prepublished online 2019 Aug 21. doi: 10.1182/blood.2019000855

PMCID:: PMC6776794

Article

Select item 48996635.

Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self‐renewal and early development

Marianne Terndrup Pedersen, Susanne Marije Kooistra, Aliaksandra Radzisheuskaya, Anne Laugesen, Jens Vilstrup Johansen, Daniel Geoffrey Hayward, Jakob Nilsson, Karl Agger, Kristian Helin

EMBO J. 2016 Jul 15; 35(14): 1550–1564. Published online 2016 Jun 6. doi: 10.15252/embj.201593317

PMCID:: PMC4899663

Article PDF–2.1M

Select item 39580416.

The Demethylase JMJD2C Localizes to H3K4me3-Positive Transcription Start Sites and Is Dispensable for Embryonic Development

Marianne Terndrup Pedersen, Karl Agger, Anne Laugesen, Jens V. Johansen, Paul A. C. Cloos, Jesper Christensen, Kristian Helin

Mol Cell Biol. 2014 Mar; 34(6): 1031–1045. doi: 10.1128/MCB.00864-13

PMCID:: PMC3958041

Article PDF–2.5M

Select item 38397297.

Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation

Adam Burton, Cristina Azevedo, Catia Andreassi, Antonella Riccio, Adolfo Saiardi

Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47): 18970–18975. Published online 2013 Nov 4. doi: 10.1073/pnas.1309699110

PMCID:: PMC3839729

Article PDF–963K

Select item 100795418.

The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2^V617F mutated cells

Anne Marie Staehle, Jan Caspar Peeken, Georg Vladimirov, Mirjam Elisabeth Hoeness, Sarolta Bojtine Kovacs, Nikolaos Karantzelis, Albert Gruender, Christoph Koellerer, Jonas Samuel Jutzi, Heike Luise Pahl, Hans Felix Staehle

Leukemia. 2023; 37(4): 919–923. Published online 2023 Jan 28. doi: 10.1038/s41375-023-01826-y

PMCID:: PMC10079541

Article PDF–1.6M

Select item 49119279.

Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells

Karl Agger, Satoru Miyagi, Marianne Terndrup Pedersen, Susanne M. Kooistra, Jens Vilstrup Johansen, Kristian Helin

Genes Dev. 2016 Jun 1; 30(11): 1278–1288. doi: 10.1101/gad.280495.116

PMCID:: PMC4911927

Article PDF–882K

Select item 597799110.

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

Yong Yu, Kolja Schleich, Bin Yue, Sujuan Ji, Philipp Lohneis, Kristel Kemper, Mark R. Silvis, Nouar Qutob, Ellen van Rooijen, Melanie Werner-Klein, Lianjie Li, Dhriti Dhawan, Svenja Meierjohann, Maurice Reimann, Abdel Elkahloun, Steffi Treitschke, Bernd Dörken, Christian Speck, Frédérick A. Mallette, Leonard I. Zon, Sheri L. Holmen, Daniel S. Peeper, Yardena Samuels, Clemens A. Schmitt, Soyoung Lee

Cancer Cell. Author manuscript; available in PMC 2018 May 31.

Published in final edited form as: Cancer Cell. 2018 Feb 12; 33(2): 322–336.e8. doi: 10.1016/j.ccell.2018.01.002

PMCID:: PMC5977991

Article PDF–2.6M

Select item 471202611.

Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia

Ngai Cheung, Tsz Kan Fung, Bernd B. Zeisig, Katie Holmes, Jayant K. Rane, Kerri A. Mowen, Michael G. Finn, Boris Lenhard, Li Chong Chan, Chi Wai Eric So

Cancer Cell. 2016 Jan 11; 29(1): 32–48. doi: 10.1016/j.ccell.2015.12.007

PMCID:: PMC4712026

Article

Select item 148247512.

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells

Barna D. Fodor, Stefan Kubicek, Masato Yonezawa, Roderick J. O’Sullivan, Roopsha Sengupta, Laura Perez-Burgos, Susanne Opravil, Karl Mechtler, Gunnar Schotta, Thomas Jenuwein

Genes Dev. 2006 Jun 15; 20(12): 1557–1562. doi: 10.1101/gad.388206

PMCID:: PMC1482475

Article PDF–406K

Select item 461844213.

Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells

Liangtang Wu, Kishore K. Wary, Sergei Revskoy, Xiaopei Gao, Kitman Tsang, Yulia A. Komarova, Jalees Rehman, Asrar B. Malik

Stem Cell Reports. 2015 Jul 14; 5(1): 10–21. Published online 2015 Jun 25. doi: 10.1016/j.stemcr.2015.05.016

PMCID:: PMC4618442

Article PDF–2.8M

Select item 487245514.

Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse

K Fujiwara, Y Fujita, A Kasai, Y Onaka, H Hashimoto, H Okada, T Yamashita

Transl Psychiatry. 2016 Mar; 6(3): e766. Published online 2016 Mar 29. doi: 10.1038/tp.2016.31

PMCID:: PMC4872455

Article PDF–1.1M

Select item 373399715.

Proteomic and genomic approaches reveal critical functions of H3K9 methylation and Heterochromatin Protein-1? in reprogramming to pluripotency

Rupa Sridharan, Michelle Gonzales-Cope, Constantinos Chronis, Giancarlo Bonora, Robin McKee, Chengyang Huang, Sanjeet Patel, David Lopez, Nilamadhab Mishra, Matteo Pellegrini, Michael Carey, Benjamin A. Garcia, Kathrin Plath

Nat Cell Biol. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: Nat Cell Biol. 2013 Jul; 15(7): 872–882. Published online 2013 Jun 9. doi: 10.1038/ncb2768

PMCID:: PMC3733997

Article PDF–1.6M

Select item 306087416.

Histone Demethylase JMJD2B Functions as a Co-Factor of Estrogen Receptor in Breast Cancer Proliferation and Mammary Gland Development

Masahito Kawazu, Kayoko Saso, Kit I. Tong, Tracy McQuire, Kouichiro Goto, Dong-Ok Son, Andrew Wakeham, Makoto Miyagishi, Tak W. Mak, Hitoshi Okada

PLoS One. 2011; 6(3): e17830. Published online 2011 Mar 18. doi: 10.1371/journal.pone.0017830

PMCID:: PMC3060874

Article PDF–1.8M

Select item 200032017.

Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells

Yuin-Han Loh, Weiwei Zhang, Xi Chen, Joshy George, Huck-Hui Ng

Genes Dev. 2007 Oct 15; 21(20): 2545–2557. doi: 10.1101/gad.1588207

PMCID:: PMC2000320

Article PDF–1.0M

Select item 571618218.

An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers

Cynthia L. Fisher, Hendrik Marks, Lily Ting-yin Cho, Robert Andrews, Sam Wormald, Thomas Carroll, Vivek Iyer, Peri Tate, Barry Rosen, Hendrik G. Stunnenberg, Amanda G. Fisher, William C. Skarnes

Nucleic Acids Res. 2017 Dec 1; 45(21): e174. Published online 2017 Sep 13. doi: 10.1093/nar/gkx811

PMCID:: PMC5716182

Article PDF–3.8M

Select item 562208919.

Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin

Takumi Matsuura, Satsuki Miyazaki, Tatsushi Miyazaki, Fumi Tashiro, Jun-ichi Miyazaki

Sci Rep. 2017; 7: 12462. Published online 2017 Sep 29. doi: 10.1038/s41598-017-12772-y

PMCID:: PMC5622089

Article PDF–8.7M

Select item 449309020.

HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity

Gary T. ZeRuth, Jason G. Williams, Yasemin C. Cole, Anton M. Jetten

PLoS One. 2015; 10(7): e0131303. Published online 2015 Jul 6. doi: 10.1371/journal.pone.0131303

PMCID:: PMC4493090

Article PDF–2.2M

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