PMC Links for Gene (Select 7155) - PMC

Mushtaq M. Khazeem, John W. Casement, George Schlossmacher, Niall S. Kenneth, Nielda K. Sumbung, Janice Yuen Tung Chan, Jade F. McGow, Ian G. Cowell, Caroline A. Austin

Mol Neurobiol. 2022; 59(10): 5987–6008. Published online 2022 Jul 13. doi: 10.1007/s12035-022-02949-6

PMCID:: PMC9463316

Article PDF–9.2M

Select item 78851025.

Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication

Paul Kaminski, Shiyuan Hong, Takeyuki Kono, Paul Hoover, Laimonis Laimins

mBio. 2021 Jan-Feb; 12(1): e00005-21. Published online 2021 Feb 9. doi: 10.1128/mBio.00005-21

PMCID:: PMC7885102

Article PDF–1.5M

Select item 76122326.

Topoisomerase 2β mutation impairs early B cell development

Olivier Papapietro, Anita Chandra, Davide Eletto, Sarah Inglott, Vincent Plagnol, James Curtis, Mailis Maes, Ali Alisaac, Adriana S. Albuquerque, Eugenie Basseres, Olivier Hermine, Capucine Picard, Alain Fischer, Anne Durandy, Sven Kracker, Siobhan O. Burns, Delphine Cuchet-Lourenco, Klaus Okkenhaug, Sergey Nejentsev

Blood. Author manuscript; available in PMC 2022 Jan 17.

Published in final edited form as: Blood. 2020 Apr 23; 135(17): 1497–1501. doi: 10.1182/blood.2019003299

PMCID:: PMC7612232

Article PDF–1008K

Select item 55603557.

The function of DNA topoisomerase IIβ in neuronal development

Xin Heng, Wei-Dong Le

Neurosci Bull. 2010 Oct; 26(5): 411–416. Published online 2010 Oct 8. doi: 10.1007/s12264-010-0625-9

PMCID:: PMC5560355

Article PDF–774K

Select item 40336268.

Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ

Nicholas A. Smith, Jo Ann W. Byl, Susan L. Mercer, Joseph E. Deweese, Neil Osheroff

Biochemistry. 2014 May 20; 53(19): 3229–3236. Published online 2014 Apr 28. doi: 10.1021/bi500421q

PMCID:: PMC4033626

Article PDF–1015K

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Tyrosine 656 in topoisomerase IIβ is important for the catalytic activity of the enzyme: Identification based on artifactual +80-Da modification at this site

Adrian G. Grozav, Belinda B. Willard, Toshiyuki Kozuki, Kenichi Chikamori, Marius A. Micluta, Andrei-Jose Petrescu, Michael Kinter, Ram Ganapathi, Mahrukh K. Ganapathi

Proteomics. Author manuscript; available in PMC 2013 Mar 26.

Published in final edited form as: Proteomics. 2011 Mar; 11(5): 829–842. Published online 2011 Jan 31. doi: 10.1002/pmic.201000194

PMCID:: PMC3608106

Article PDF–1.9M

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Characterization of the human topoisomerase IIbeta (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites.

Chun-Nam Lok, Alexander J Lang, Shelagh E L Mirski, Susan P C Cole

Biochem J. 2002 Dec 15; 368(Pt 3): 741–751. doi: 10.1042/BJ20020791

PMCID:: PMC1223026

Summary PDF–341K

Select item 33439011.

Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24.

J R Jenkins, P Ayton, T Jones, S L Davies, D L Simmons, A L Harris, D Sheer, I D Hickson

Nucleic Acids Res. 1992 Nov 11; 20(21): 5587–5592. doi: 10.1093/nar/20.21.5587

PMCID:: PMC334390

Summary Page Browse PDF–1.4M

Select item 30987412.

Human cells express two differentially spliced forms of topoisomerase II beta mRNA.

S L Davies, J R Jenkins, I D Hickson

Nucleic Acids Res. 1993 Aug 11; 21(16): 3719–3723. doi: 10.1093/nar/21.16.3719

PMCID:: PMC309874

Summary Page Browse PDF–990K

Select item 1080618813.

MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner

Jianfeng Shu, Jinni Jiang, Xiaofang Wang, Xuejie Yang, Guofang Zhao, Ting Cai

Cell Death Dis. 2024 Jan; 15(1): 83. Published online 2024 Jan 23. doi: 10.1038/s41419-024-06474-3

PMCID:: PMC10806188

Article PDF–7.4M

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Taspase1 Facilitates Topoisomerase IIβ-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription

Lisa Oelschläger, Paul Stahl, Farnusch Kaschani, Roland H. Stauber, Shirley K. Knauer, Astrid Hensel

Cells. 2023 Feb; 12(3): 363. Published online 2023 Jan 18. doi: 10.3390/cells12030363

PMCID:: PMC9913075

Article PDF–5.3M

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Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase IIβ Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide

Jessika Carvajal-Moreno, Victor A. Hernandez, Xinyi Wang, Junan Li, Jack C. Yalowich, Terry S. Elton

J Pharmacol Exp Ther. 2023 Feb; 384(2): 265–276. Published online 2023 Feb. doi: 10.1124/jpet.122.001429

PMCID:: PMC9875313

Article PDF–1.5M

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Association of immunophenotype with expression of topoisomerase II α and β in adult acute myeloid leukemia

Andrew P. Michelson, Shannon McDonough, Cheryl L. Willman, Eric R. Koegle, John E. Godwin, Stephen H. Petersdorf, Alan F. List, Megan Othus, Frederick R. Appelbaum, Jerald P. Radich, Mahrukh K. Ganapathi, Anjali S. Advani, Ram N. Ganapathi

Sci Rep. 2020; 10: 5486. Published online 2020 Mar 26. doi: 10.1038/s41598-020-62345-9

PMCID:: PMC7099013

Article PDF–1.3M

Select item 669241117.

Mutations in topoisomerase IIβ result in a B cell immunodeficiency

Lori Broderick, Shawn Yost, Dong Li, Matthew D. McGeough, Laela M. Booshehri, Marisela Guaderrama, Susannah D. Brydges, Karolina Kucharova, Niraj C. Patel, Margaret Harr, Hakon Hakonarson, Elaine Zackai, Ian G. Cowell, Caroline A. Austin, Boris Hügle, Corinna Gebauer, Jianguo Zhang, Xun Xu, Jian Wang, Ben A. Croker, Kelly A. Frazer, Christopher D. Putnam, Hal M. Hoffman

Nat Commun. 2019; 10: 3644. Published online 2019 Aug 13. doi: 10.1038/s41467-019-11570-6

PMCID:: PMC6692411

Article PDF–2.0M

Select item 658454418.

Doxorubicin‐induced cardiotoxicity is maturation dependent due to the shift from topoisomerase IIα to IIβ in human stem cell derived cardiomyocytes

Ning Cui, Fujian Wu, Wen‐Jing Lu, Rui Bai, Bingbing Ke, Taoyan Liu, Lei Li, Feng Lan, Ming Cui

J Cell Mol Med. 2019 Jul; 23(7): 4627–4639. Published online 2019 May 20. doi: 10.1111/jcmm.14346

PMCID:: PMC6584544

Article PDF–2.0M

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Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2

Anu Hangas, Koit Aasumets, Nina J Kekäläinen, Mika Paloheinä, Jaakko L Pohjoismäki, Joachim M Gerhold, Steffi Goffart

Nucleic Acids Res. 2018 Oct 12; 46(18): 9625–9636. Published online 2018 Aug 31. doi: 10.1093/nar/gky793

PMCID:: PMC6182158

Article PDF–2.8M

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Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint

Toshiyuki Kozuki, Kenichi Chikamori, Marius D. Surleac, Marius A. Micluta, Andrei J. Petrescu, Eric J. Norris, Paul Elson, Gerald A. Hoeltge, Dale R. Grabowski, Andrew C.G. Porter, Ram N. Ganapathi, Mahrukh K. Ganapathi

Nucleic Acids Res. 2017 Jun 2; 45(10): 5995–6010. Published online 2017 May 2. doi: 10.1093/nar/gkx325