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Select item 107661981.

SETD2 loss in renal epithelial cells drives epithelial‐to‐mesenchymal transition in a TGF‐β‐independent manner

Tianchu Wang, Ryan T. Wagner, Ryan A. Hlady, Xiaoyu Pan, Xia Zhao, Sungho Kim, Liguo Wang, Jeong‐Heon Lee, Huijun Luo, Erik P. Castle, Douglas F. Lake, Thai H. Ho, Keith D. Robertson

Mol Oncol. 2024 Jan; 18(1): 44–61. Published online 2023 Jul 17. doi: 10.1002/1878-0261.13487

PMCID:: PMC10766198

Article PDF–2.7M

Select item 105236802.

SETD2 safeguards the genome against isochromosome formation

Frank M. Mason, Emily S. Kounlavong, Anteneh T. Tebeje, Rashmi Dahiya, Tiffany Guess, Abid Khan, Logan Vlach, Stephen R. Norris, Courtney A. Lovejoy, Ruhee Dere, Brian D. Strahl, Ryoma Ohi, Peter Ly, Cheryl Lyn Walker, W. Kimryn Rathmell

Proc Natl Acad Sci U S A. 2023 Sep 26; 120(39): e2303752120. Published online 2023 Sep 18. doi: 10.1073/pnas.2303752120

PMCID:: PMC10523680

Article PDF–3.5M

Select item 103602703.

SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy

Xiaobin Zheng, Jing Lin, Jiani Xiong, Yanfang Guan, Bin Lan, Yi Li, Xuan Gao, Zhaodong Fei, Lisha Chen, Lizhu Chen, Ling Chen, Gang Chen, Zengqing Guo, Xin Yi, Weiguo Cao, Xinghao Ai, Chengzhi Zhou, Xiaofeng Li, Jun Zhao, Xiangtao Yan, Qitao Yu, Lu Si, Yu Chen, Chuanben Chen

BMC Cancer. 2023; 23: 686. Published online 2023 Jul 21. doi: 10.1186/s12885-023-10920-4

PMCID:: PMC10360270

Article PDF–1.9M

Select item 102978324.

Clinical Heterogeneity and Different Phenotypes in Patients with SETD2 Variants: 18 New Patients and Review of the Literature

Alejandro Parra, Rachel Rabin, John Pappas, Patricia Pascual, Mario Cazalla, Pedro Arias, Natalia Gallego-Zazo, Alfredo Santana, Ignacio Arroyo, Mercè Artigas, Harry Pachajoa, Yasemin Alanay, Ozlem Akgun-Dogan, Lyse Ruaud, Nathalie Couque, Jonathan Levy, Gloria Liliana Porras-Hurtado, Fernando Santos-Simarro, Maria Juliana Ballesta-Martinez, Encarna Guillén-Navarro, Hugo Muñoz-Hernández, Julián Nevado, Spanish OverGrowth Registry Initiative, Jair Tenorio-Castano, Pablo Lapunzina

Genes (Basel) 2023 Jun; 14(6): 1179. Published online 2023 May 29. doi: 10.3390/genes14061179

PMCID:: PMC10297832

Article PDF–1.8M

Select item 102311775.

The SETD2 Methyltransferase Supports Productive HPV31 Replication through the LEDGF/CtIP/Rad51 Pathway

Michelle Mac, Brianna M. DeVico, Sophia M. Raspanti, Cary A. Moody

J Virol. 2023 May; 97(5): e00201-23. Published online 2023 May 8. doi: 10.1128/jvi.00201-23

PMCID:: PMC10231177

Article PDF–4.2M

Select item 98755566.

Clinical and Histopathologic Characterization of SETD2-Mutated Colorectal Cancer

Omar Bushara, James Wester, Danielle Jacobsen, Leyu Sun, Samuel Weinberg, Juehua Gao, Lawrence J Jennings, Lu Wang, Shannon M. Lauberth, Feng Yue, Jie Liao, Guang-Yu Yang

Hum Pathol. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: Hum Pathol. 2023 Jan; 131: 9–16. Published online 2022 Dec 9. doi: 10.1016/j.humpath.2022.12.001

PMCID:: PMC9875556

Article PDF–1.1M

Select item 98398457.

Tumor Cell‐Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis

Ningning Niu, Xuqing Shen, Li Zhang, Yueyue Chen, Ping Lu, Wenjuan Yang, Mingzhu Liu, Juanjuan Shi, Dapeng Xu, Yingying Tang, Xiaotong Yang, Yawen Weng, Xinxin Zhao, Lian‐Ming Wu, Yongwei Sun, Jing Xue

Adv Sci (Weinh) 2023 Jan; 10(2): 2202937. Published online 2022 Dec 1. doi: 10.1002/advs.202202937

PMCID:: PMC9839845

Article PDF–5.6M

Select item 92410348.

Interplay between H3K36me3, methyltransferase SETD2, and mismatch recognition protein MutSα facilitates processing of oxidative DNA damage in human cells

Sida Guo, Jun Fang, Weizhi Xu, Janice Ortega, Chang-Yi Liu, Liya Gu, Zhijie Chang, Guo-Min Li

J Biol Chem. 2022 Jul; 298(7): 102102. Published online 2022 Jun 3. doi: 10.1016/j.jbc.2022.102102

PMCID:: PMC9241034

Article PDF–2.5M

Select item 89902949.

Methyltransferase SETD2 inhibits tumor growth and metastasis via STAT1–IL‐8 signaling‐mediated epithelial–mesenchymal transition in lung adenocarcinoma

Xin Yang, Rui Chen, Yan Chen, You Zhou, Chen Wu, Qing Li, Jun Wu, Wen‐wei Hu, Wei‐qing Zhao, Wei Wei, Jun‐tao Shi, Mei Ji

Cancer Sci. 2022 Apr; 113(4): 1195–1207. Published online 2022 Feb 22. doi: 10.1111/cas.15299

PMCID:: PMC8990294

Article PDF–3.1M

Select item 888584610.

SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes

Yuchen Xie, Merve Sahin, Sonali Sinha, Yufeng Wang, Amrita M. Nargund, Yang Lyu, Song Han, Yiyu Dong, James J. Hsieh, Christina S. Leslie, Emily H. Cheng

Nat Cancer. Author manuscript; available in PMC 2022 Aug 3.

Published in final edited form as: Nat Cancer. 2022 Feb; 3(2): 188–202. Published online 2022 Feb 3. doi: 10.1038/s43018-021-00316-3

PMCID:: PMC8885846

Article PDF–7.2M

Select item 840593411.

The disordered regions of the methyltransferase SETD2 govern its function by regulating its proteolysis and phase separation

Saikat Bhattacharya, Jeffrey J. Lange, Michaella Levy, Laurence Florens, Michael P. Washburn, Jerry L. Workman

J Biol Chem. 2021 Sep; 297(3): 101075. Published online 2021 Aug 13. doi: 10.1016/j.jbc.2021.101075

PMCID:: PMC8405934

Article PDF–3.8M

Select item 829458212.

Molecular determinants for α-tubulin methylation by SETD2

Sarah Kearns, Frank M. Mason, W. Kimryn Rathmell, In Young Park, Cheryl Walker, Kristen J. Verhey, Michael A. Cianfrocco

J Biol Chem. 2021 Jul; 297(1): 100898. Published online 2021 Jun 19. doi: 10.1016/j.jbc.2021.100898

PMCID:: PMC8294582

Article PDF–2.1M

Select item 793333413.

The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain

Saikat Bhattacharya, Michaella J. Levy, Ning Zhang, Hua Li, Laurence Florens, Michael P. Washburn, Jerry L. Workman

Nat Commun. 2021; 12: 1443. Published online 2021 Mar 4. doi: 10.1038/s41467-021-21663-w

PMCID:: PMC7933334

Article PDF–4.3M

Select item 754210514.

Regulation of SETD2 stability is important for the fidelity of H3K36me3 deposition

Saikat Bhattacharya, Jerry L. Workman

Epigenetics Chromatin. 2020; 13: 40. Published online 2020 Oct 6. doi: 10.1186/s13072-020-00362-8

PMCID:: PMC7542105

Article PDF–2.1M

Select item 749548115.

Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate

Maren Kirstin Schuhmacher, Serap Beldar, Mina S. Khella, Alexander Bröhm, Jan Ludwig, Wolfram Tempel, Sara Weirich, Jinrong Min, Albert Jeltsch

Commun Biol. 2020; 3: 511. Published online 2020 Sep 16. doi: 10.1038/s42003-020-01223-6

Correction in:: Commun Biol. 2020; 3: 600.

PMCID:: PMC7495481

Article PDF–2.4M

Select item 698526216.

SETD2 mutation in renal clear cell carcinoma suppress autophagy via regulation of ATG12

Patricia González-Rodríguez, Pinelopi Engskog-Vlachos, Hanzhao Zhang, Adriana-Natalia Murgoci, Ioannis Zerdes, Bertrand Joseph

Cell Death Dis. 2020 Jan; 11(1): 69. Published online 2020 Jan 27. doi: 10.1038/s41419-020-2266-x

PMCID:: PMC6985262

Article PDF–2.8M

Select item 666898217.

Downregulation of the histone methyltransferase SETD2 promotes imatinib resistance in chronic myeloid leukaemia cells

Yaru Sheng, Zhongzhong Ji, Huifang Zhao, Jinming Wang, Chaping Cheng, Weimin Xu, Xue Wang, Yuman He, Kaiyuan Liu, Li Li, Thibault Voeltzel, Veronique Maguer‐Satta, Wei‐Qiang Gao, Helen He Zhu

Cell Prolif. 2019 Jul; 52(4): e12611. Published online 2019 May 3. doi: 10.1111/cpr.12611

PMCID:: PMC6668982

Article PDF–2.2M

Select item 643796718.

Genetic polymorphisms of histone methyltransferase SETD2 predicts prognosis and chemotherapy response in Chinese acute myeloid leukemia patients

Suwei Wang, Xiaoqing Yuan, Yazhen Liu, Kewei Zhu, Peng Chen, Han Yan, Daoyu Zhang, Xi Li, Hui Zeng, Xielan Zhao, Xiaoping Chen, Gan Zhou, Shan Cao

J Transl Med. 2019; 17: 101. Published online 2019 Mar 28. doi: 10.1186/s12967-019-1848-9

PMCID:: PMC6437967

Article PDF–827K

Select item 639821019.

Integrated Genomic and Proteomic Analyses Reveal Novel Mechanisms of the Methyltransferase SETD2 in Renal Cell Carcinoma Development

Lin Li, Weili Miao, Ming Huang, Preston Williams, Yinsheng Wang

Mol Cell Proteomics. 2019 Mar; 18(3): 437–447. Published online 2018 Nov 28. doi: 10.1074/mcp.RA118.000957

PMCID:: PMC6398210

Article PDF–2.5M

Select item 623127320.

SETD2 mutations in primary central nervous system tumors

Angela N. Viaene, Mariarita Santi, Jason Rosenbaum, Marilyn M. Li, Lea F. Surrey, MacLean P. Nasrallah

Acta Neuropathol Commun. 2018; 6: 123. Published online 2018 Nov 12. doi: 10.1186/s40478-018-0623-0

PMCID:: PMC6231273

Article PDF–4.5M

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