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Select item 53475711.

Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET

Tomoya Kubota, Thomas Durek, Bobo Dang, Rocio K. Finol-Urdaneta, David J. Craik, Stephen B. H. Kent, Robert J. French, Francisco Bezanilla, Ana M. Correa

Proc Natl Acad Sci U S A. 2017 Mar 7; 114(10): E1857–E1865. Published online 2017 Feb 15. doi: 10.1073/pnas.1700453114

PMCID:: PMC5347571

Article PDF–1.8M

Select item 41368382.

Molecular Dynamics Study of Binding of µ-Conotoxin GIIIA to the Voltage-Gated Sodium Channel Na_v1.4

Somayeh Mahdavi, Serdar Kuyucak

PLoS One. 2014; 9(8): e105300. Published online 2014 Aug 18. doi: 10.1371/journal.pone.0105300

PMCID:: PMC4136838

Article PDF–4.4M

Select item 35624583.

Multiple pore conformations driven by asynchronous movements of voltage sensors in a eukaryotic sodium channel

Marcel P. Goldschen-Ohm, Deborah L. Capes, Kevin M. Oelstrom, Baron Chanda

Nat Commun. 2013 Jan 15; 4: 1350. Published online 2013 Jan 15. doi: 10.1038/ncomms2356

PMCID:: PMC3562458

Article PDF–2.0M

Select item 29981344.

A Molecular Switch between the Outer and the Inner Vestibules of the Voltage-gated Na⁺ Channel

Touran Zarrabi, Rene Cervenka, Walter Sandtner, Peter Lukacs, Xaver Koenig, Karlheinz Hilber, Markus Mille, Gregory M. Lipkind, Harry A. Fozzard, Hannes Todt

J Biol Chem. 2010 Dec 10; 285(50): 39458–39470. Published online 2010 Oct 6. doi: 10.1074/jbc.M110.132886

PMCID:: PMC2998134

Article PDF–2.9M

Select item 29120695.

Ion permeation and block of the gating pore in the voltage sensor of Na_V1.4 channels with hypokalemic periodic paralysis mutations

Stanislav Sokolov, Todd Scheuer, William A. Catterall

J Gen Physiol. 2010 Aug; 136(2): 225–236. doi: 10.1085/jgp.201010414

PMCID:: PMC2912069

Article PDF–1.5M

Select item 26049776.

Depolarization-activated gating pore current conducted by mutant sodium channels in potassium-sensitive normokalemic periodic paralysis

Stanislav Sokolov, Todd Scheuer, William A. Catterall

Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50): 19980–19985. Published online 2008 Dec 3. doi: 10.1073/pnas.0810562105

PMCID:: PMC2604977

Article PDF–809K

Select item 25533917.

Gating Pore Currents in DIIS4 Mutations of NaV1.4 Associated with Periodic Paralysis: Saturation of Ion Flux and Implications for Disease Pathogenesis

Arie F. Struyk, Vladislav S. Markin, David Francis, Stephen C. Cannon

J Gen Physiol. 2008 Oct; 132(4): 447–464. doi: 10.1085/jgp.200809967

PMCID:: PMC2553391

Article PDF–2.4M

Select item 21543648.

A Na⁺ Channel Mutation Linked to Hypokalemic Periodic Paralysis Exposes a Proton-selective Gating Pore

Arie F. Struyk, Stephen C. Cannon

J Gen Physiol. 2007 Jul; 130(1): 11–20. doi: 10.1085/jgp.200709755

PMCID:: PMC2154364

Article PDF–836K

Select item 21516469.

β-Scorpion Toxin Modifies Gating Transitions in All Four Voltage Sensors of the Sodium Channel

Fabiana V. Campos, Baron Chanda, Paulo S.L. Beirão, Francisco Bezanilla

J Gen Physiol. 2007 Sep; 130(3): 257–268. doi: 10.1085/jgp.200609719

PMCID:: PMC2151646

Article PDF–4.0M

Select item 173867210.

Severe infantile hyperkalaemic periodic paralysis and paramyotonia congenita: broadening the clinical spectrum associated with the T704M mutation in SCN4A

F Brancati, E Valente, N Davies, A Sarkozy, M Sweeney, M LoMonaco, A Pizzuti, M Hanna, B Dallapiccola

J Neurol Neurosurg Psychiatry. 2003 Sep; 74(9): 1339–1341. doi: 10.1136/jnnp.74.9.1339

PMCID:: PMC1738672

Summary PDF–86K

Select item 467582011.

Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels

Michael F. Sheets, Harry A. Fozzard, Dorothy A. Hanck

Biophys J. 2015 Dec 1; 109(11): 2277–2286. Published online 2015 Dec 1. doi: 10.1016/j.bpj.2015.10.012

PMCID:: PMC4675820

Article PDF–1.0M

Select item 342766012.

Effect of SkM1 Sodium Channels Delivered Via a Cell Platform on Cardiac Conduction and Arrhythmia Induction

Gerard J.J. Boink, Jia Lu, Helen E. Driessen, Lian Duan, Eugene A. Sosunov, Evgeny P. Anyukhovsky, Iryna N. Shlapakova, David H. Lau, Tove S. Rosen, Peter Danilo, Zhiheng Jia, Nazira Ozgen, Yevgeniy Bobkov, Yuanjian Guo, Peter R. Brink, Yelena Kryukova, Richard B. Robinson, Emilia Entcheva, Ira S. Cohen, Michael R. Rosen

Circ Arrhythm Electrophysiol. Author manuscript; available in PMC 2013 Aug 1.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2012 Aug 1; 5(4): 831–840. Published online 2012 Jun 21. doi: 10.1161/CIRCEP.111.969907

PMCID:: PMC3427660

Article PDF–2.1M

Select item 341040813.

SkM1 and Cx32 improve conduction in canine myocardial infarcts yet only SkM1 is antiarrhythmic

Gerard J.J. Boink, David H. Lau, Iryna N. Shlapakova, Eugene A. Sosunov, Evgeny P. Anyukhovsky, Helen E. Driessen, Wen Dun, Ming Chen, Peter Danilo, Jr, Tove S. Rosen, Nazira Őzgen, Heather S. Duffy, Yelena Kryukova, Penelope A Boyden, Richard B. Robinson, Peter R. Brink, Ira S. Cohen, Michael R. Rosen

Cardiovasc Res. 2012 Jun 1; 94(3): 450–459. Published online 2012 Feb 27. doi: 10.1093/cvr/cvs107

PMCID:: PMC3410408

Article PDF–576K

Select item 319547014.

A sodium channel knockin mutant (Na_V1.4-R669H) mouse model of hypokalemic periodic paralysis

Fenfen Wu, Wentao Mi, Dennis K. Burns, Yu Fu, Hillery F. Gray, Arie F. Struyk, Stephen C. Cannon

J Clin Invest. 2011 Oct 3; 121(10): 4082–4094. Published online 2011 Sep 1. doi: 10.1172/JCI57398

PMCID:: PMC3195470

Article PDF–2.7M

Select item 290710515.

µ-Conotoxin KIIIA Derivatives with Divergent Affinities versus Efficacies in Blocking Voltage-gated Sodium Channels

Min-Min Zhang, Tiffany S. Han, Baldomero M. Olivera, Grzegorz Bulaj, Doju Yoshikami

Biochemistry. Author manuscript; available in PMC 2011 Jun 15.

Published in final edited form as: Biochemistry. 2010 Jun 15; 49(23): 4804–4812. doi: 10.1021/bi100207k

PMCID:: PMC2907105

Article PDF–675K

Select item 263913116.

Expression of skeletal but not cardiac Na⁺ channel isoform preserves normal conduction in a depolarized cardiac syncytium

Lev Protas, Wen Dun, Zhiheng Jia, Jia Lu, Annalisa Bucchi, Sindhu Kumari, Ming Chen, Ira S. Cohen, Michael R. Rosen, Emilia Entcheva, Richard B. Robinson

Cardiovasc Res. 2009 Feb 15; 81(3): 528–535. Published online 2008 Oct 31. doi: 10.1093/cvr/cvn290