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Items: 1 to 20 of 69

1.
FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion
Zeda Zhao, Juliang Qin, Ying Qian, Chenshen Huang, Xiaohong Liu, Ning Wang, Liqin Li, Yuqing Chao, Binghe Tan, Na Zhang, Min Qian, Dali Li, Mingyao Liu, Bing Du
J Hematol Oncol. 2024; 17: 9. Published online 2024 Feb 24. doi: 10.1186/s13045-024-01529-6
PMCID:
PMC10894476
ArticlePDF–4.3M
2.
Intestinal FFA2 promotes obesity by altering food intake in Western diet-fed mice
Kristen R Lednovich, Sophie Gough, Medha Priyadarshini, Nupur Pandya, Chioma Nnyamah, Kai Xu, Barton Wicksteed, Sidharth Mishra, Shalini Jain, Joseph L Zapater, Jose Cordoba-Chacon, Hariom Yadav, Brian T Layden
J Endocrinol. 2024 Feb 1; 260(2): e230184. Prepublished online 2023 Nov 30. Published online 2024 Jan 11. doi: 10.1530/JOE-23-0184
PMCID:
PMC10831573
ArticlePDF–6.1M
3.
GPR43 Suppresses Intestinal Tumor Growth by Modification of the Mammalian Target of Rapamycin Complex 1 Activity in ApcMin/+ Mice
Lingling Kong, Namiko Hoshi, Yunlong Sui, Yasutaka Yamada, Ryutaro Yoshida, Makoto Ooi, Zibin Tian, Ikuo Kimura, Yuzo Kodama
Med Princ Pract. 2022 Mar; 31(1): 39–46. Published online 2021 Oct 1. doi: 10.1159/000518621
PMCID:
PMC8995667
ArticlePDF–678K
4.
GPR43 activation-mediated lipotoxicity contributes to podocyte injury in diabetic nephropathy by modulating the ERK/EGR1 pathway
Jian Lu, Pei Pei Chen, Jia Xiu Zhang, Xue Qi Li, Gui Hua Wang, Ben Yin Yuan, Si Jia Huang, Xiao Qi Liu, Ting Ting Jiang, Meng Ying Wang, Wen Tao Liu, Xiong Zhong Ruan, Bi Cheng Liu, Kun Ling Ma
Int J Biol Sci. 2022; 18(1): 96–111. Published online 2022 Jan 1. doi: 10.7150/ijbs.64665
PMCID:
PMC8692141
ArticlePDF–3.9M
5.
Acetate sensing by GPR43 alarms neutrophils and protects from severe sepsis
Katja Schlatterer, Christian Beck, Ulrich Schoppmeier, Andreas Peschel, Dorothee Kretschmer
Commun Biol. 2021; 4: 928. Published online 2021 Jul 30. doi: 10.1038/s42003-021-02427-0
PMCID:
PMC8324776
ArticlePDF–1.6M
6.
Internalization-Dependent Free Fatty Acid Receptor 2 Signaling Is Essential for Propionate-Induced Anorectic Gut Hormone Release
Natarin Caengprasath, Noemi Gonzalez-Abuin, Maria Shchepinova, Yue Ma, Asuka Inoue, Edward W. Tate, Gary Frost, Aylin C. Hanyaloglu
iScience. 2020 Sep 25; 23(9): 101449. Published online 2020 Aug 12. doi: 10.1016/j.isci.2020.101449
PMCID:
PMC7452316
ArticlePDF–4.6M
7.
Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions
Junki Miyamoto, Ryuji Ohue-Kitano, Hiromi Mukouyama, Akari Nishida, Keita Watanabe, Miki Igarashi, Junichiro Irie, Gozoh Tsujimoto, Noriko Satoh-Asahara, Hiroshi Itoh, Ikuo Kimura
Proc Natl Acad Sci U S A. 2019 Nov 19; 116(47): 23813–23821. Published online 2019 Nov 4. doi: 10.1073/pnas.1912573116
PMCID:
PMC6876247
ArticlePDF–1.9M
8.
Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response
Krist Helen Antunes, José Luís Fachi, Rosemeire de Paula, Emanuelle Fraga da Silva, Laís Passariello Pral, Adara Áurea dos Santos, Greicy Brisa Malaquias Dias, José Eduardo Vargas, Renato Puga, Fabiana Quoos Mayer, Fábio Maito, Carlos R. Zárate-Bladés, Nadim J. Ajami, Marcella Ramos Sant’Ana, Thamiris Candreva, Hosana Gomes Rodrigues, Marcio Schmiele, Maria Teresa Pedrosa Silva Clerici, José Luiz Proença-Modena, Angélica Thomas Vieira, Charles R. Mackay, Daniel Mansur, Mauricio T. Caballero, Jacqui Marzec, Jianying Li, Xuting Wang, Douglas Bell, Fernando P. Polack, Steven R. Kleeberger, Renato T. Stein, Marco Aurélio Ramirez Vinolo, Ana Paula Duarte de Souza
Nat Commun. 2019; 10: 3273. Published online 2019 Jul 22. doi: 10.1038/s41467-019-11152-6
PMCID:
PMC6646332
ArticlePDF–5.4M
9.
Microbiota metabolite short-chain fatty acids facilitate mucosal adjuvant activity of cholera toxin through GPR43
Wenjing Yang, Yi Xiao, Xiangsheng Huang, Feidi Chen, Mingming Sun, Anthony J Bilotta, Leiqi Xu, Yao Lu, Suxia Yao, Qihong Zhao, Zhanju Liu, Yingzi Cong
J Immunol. Author manuscript; available in PMC 2020 Jul 1.
Published in final edited form as: J Immunol. 2019 Jul 1; 203(1): 282–292. Published online 2019 May 10. doi: 10.4049/jimmunol.1801068
PMCID:
PMC6581581
ArticlePDF–1.2M
10.
GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3
Ye Zhao, Feidi Chen, Wei Wu, Mingming Sun, Anthony J. Bilotta, Suxia Yao, Yi Xiao, Xiangsheng Huang, Tonyia D. Eaves-Pyles, George Golovko, Yuriy Fofanov, Warren D’Souza, Qihong Zhao, Zhanju Liu, Yingzi Cong
Mucosal Immunol. Author manuscript; available in PMC 2018 Aug 7.
Published in final edited form as: Mucosal Immunol. 2018 May; 11(3): 752–762. Published online 2018 Feb 7. doi: 10.1038/mi.2017.118
PMCID:
PMC5976519
ArticlePDF–1.1M
11.
The Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella pneumoniae Infection in the Lung
Izabela Galvão, Luciana P. Tavares, Renan O. Corrêa, José Luís Fachi, Vitor Melo Rocha, Marcela Rungue, Cristiana C. Garcia, Geovanni Cassali, Caroline M. Ferreira, Flaviano S. Martins, Sergio C. Oliveira, Charles R. Mackay, Mauro M. Teixeira, Marco Aurélio R. Vinolo, Angélica T. Vieira
Front Immunol. 2018; 9: 142. Published online 2018 Feb 20. doi: 10.3389/fimmu.2018.00142
PMCID:
PMC5826235
ArticlePDF–1.5M
12.
Ffar2 expression regulates leukaemic cell growth in vivo
Laure B Bindels, Paolo E Porporato, Sarah Ducastel, Martina Sboarina, Audrey M Neyrinck, Evelyne M Dewulf, Olivier Feron, Sophie Lestavel, Patrice D Cani, Bart Staels, Pierre Sonveaux, Nathalie M Delzenne
Br J Cancer. 2017 Oct 24; 117(9): 1336–1340. Published online 2017 Sep 5. doi: 10.1038/bjc.2017.307
PMCID:
PMC5672929
ArticlePDF–831K
13.
Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses
Warren N. D’Souza, Jason Douangpanya, Sharon Mu, Peter Jaeckel, Ming Zhang, Joseph R. Maxwell, James B. Rottman, Katja Labitzke, Angela Willee, Holger Beckmann, Yingcai Wang, Yang Li, Ralf Schwandner, James A. Johnston, Jennifer E. Towne, Hailing Hsu
PLoS One. 2017; 12(7): e0180190. Published online 2017 Jul 20. doi: 10.1371/journal.pone.0180190
PMCID:
PMC5519041
ArticlePDF–2.6M
14.
The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages
Akira Nakajima, Akiho Nakatani, Sae Hasegawa, Junichiro Irie, Kentaro Ozawa, Gozoh Tsujimoto, Takayoshi Suganami, Hiroshi Itoh, Ikuo Kimura
PLoS One. 2017; 12(7): e0179696. Published online 2017 Jul 10. doi: 10.1371/journal.pone.0179696
PMCID:
PMC5503175
ArticlePDF–12M
15.
FFA2 Contribution to Gestational Glucose Tolerance Is Not Disrupted by Antibiotics
Miles Fuller, Xiaoran Li, Robert Fisch, Moneb Bughara, Barton Wicksteed, Petia Kovatcheva-Datchary, Brian T. Layden
PLoS One. 2016; 11(12): e0167837. Published online 2016 Dec 13. doi: 10.1371/journal.pone.0167837
PMCID:
PMC5154512
ArticlePDF–1.8M
16.
G Protein-Coupled Receptor 43 Modulates Neutrophil Recruitment during Acute Inflammation
Marjon E. Kamp, Raymond Shim, Alyce J. Nicholls, Ana Carolina Oliveira, Linda J. Mason, Lauren Binge, Charles R. Mackay, Connie H. Y. Wong
PLoS One. 2016; 11(9): e0163750. Published online 2016 Sep 22. doi: 10.1371/journal.pone.0163750
PMCID:
PMC5033414
ArticlePDF–2.3M
17.
Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival
Stephanie R. Villa, Medha Priyadarshini, Miles H. Fuller, Tanya Bhardwaj, Michael R. Brodsky, Anthony R. Angueira, Rockann E. Mosser, Bethany A. Carboneau, Sarah A. Tersey, Helena Mancebo, Annette Gilchrist, Raghavendra G. Mirmira, Maureen Gannon, Brian T. Layden
Sci Rep. 2016; 6: 28159. Published online 2016 Jun 21. doi: 10.1038/srep28159
PMCID:
PMC4914960
ArticlePDF–759K
18.
The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis
Miles Fuller, Medha Priyadarshini, Sean M. Gibbons, Anthony R. Angueira, Michael Brodsky, M. Geoffrey Hayes, Petia Kovatcheva-Datchary, Fredrik Bäckhed, Jack A. Gilbert, William L. Lowe, Jr., Brian T. Layden
Am J Physiol Endocrinol Metab. 2015 Nov 15; 309(10): E840–E851. Published online 2015 Sep 22. doi: 10.1152/ajpendo.00171.2015
PMCID:
PMC4838121
Article
19.
Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation.
Allison Agus, Jérémy Denizot, Jonathan Thévenot, Margarita Martinez-Medina, Sébastien Massier, Pierre Sauvanet, Annick Bernalier-Donadille, Sylvain Denis, Paul Hofman, Richard Bonnet, Elisabeth Billard, Nicolas Barnich
Sci Rep. 2016; 6: 19032. Published online 2016 Jan 8. doi: 10.1038/srep19032
PMCID:
PMC4705701
ArticlePDF–1.9M
20.
The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
Ikuo Kimura, Kentaro Ozawa, Daisuke Inoue, Takeshi Imamura, Kumi Kimura, Takeshi Maeda, Kazuya Terasawa, Daiji Kashihara, Kanako Hirano, Taeko Tani, Tomoyuki Takahashi, Satoshi Miyauchi, Go Shioi, Hiroshi Inoue, Gozoh Tsujimoto
Nat Commun. 2013 May 7; 4: 1829. Published online 2013 May 7. doi: 10.1038/ncomms2852
PMCID:
PMC3674247
ArticlePDF–2.1M

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