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Select item 99544171.

Up-Regulation of Astrocytic Fgfr4 Expression in Adult Mice after Spinal Cord Injury

Claire Mathilde Bringuier, Harun Najib Noristani, Jean-Christophe Perez, Maida Cardoso, Christophe Goze-Bac, Yannick Nicolas Gerber, Florence Evelyne Perrin

Cells. 2023 Feb; 12(4): 528. Published online 2023 Feb 6. doi: 10.3390/cells12040528

PMCID:: PMC9954417

Article PDF–20M

Select item 98717432.

Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis

Francois Moreau, Bruna Brasil Brunao, Xiang-Yu Liu, Frederic Tremblay, Kevin Fitzgerald, Julian Avila-Pacheco, Clary Clish, Ronald C. Kahn, Samir Softic

J Lipid Res. 2023 Feb; 64(2): 100324. Published online 2022 Dec 29. doi: 10.1016/j.jlr.2022.100324

PMCID:: PMC9871743

Article PDF–2.9M

Select item 59801943.

Established gastric cancer cell lines transplantable into C57BL/6 mice show fibroblast growth factor receptor 4 promotion of tumor growth

Masami Yamamoto, Sachiyo Nomura, Akihiro Hosoi, Koji Nagaoka, Tamaki Iino, Tomohiko Yasuda, Tomoko Saito, Hirokazu Matsushita, Eiji Uchida, Yasuyuki Seto, James R. Goldenring, Kazuhiko Kakimi, Masae Tatematsu, Tetsuya Tsukamoto

Cancer Sci. 2018 May; 109(5): 1480–1492. Published online 2018 Apr 15. doi: 10.1111/cas.13569

PMCID:: PMC5980194

Article PDF–12M

Select item 46705834.

Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy

Alexander Grabner, Ansel P. Amaral, Karla Schramm, Saurav Singh, Alexis Sloan, Christopher Yanucil, Jihe Li, Lina A. Shehadeh, Joshua M. Hare, Valentin David, Aline Martin, Alessia Fornoni, Giovana Seno Di Marco, Dominik Kentrup, Stefan Reuter, Anna B. Mayer, Hermann Pavenstädt, Jörg Stypmann, Christian Kuhn, Susanne Hille, Norbert Frey, Maren Leifheit-Nestler, Beatrice Richter, Dieter Haffner, Reimar Abraham, Johannes Bange, Bianca Sperl, Axel Ullrich, Marcus Brand, Myles Wolf, Christian Faul

Cell Metab. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: Cell Metab. 2015 Dec 1; 22(6): 1020–1032. Published online 2015 Oct 1. doi: 10.1016/j.cmet.2015.09.002

PMCID:: PMC4670583

Article PDF–2.4M

Select item 42152295.

Fibroblast Growth Factor Receptor 4 (FGFR4) Deficiency Improves Insulin Resistance and Glucose Metabolism under Diet-induced Obesity Conditions

Hongfei Ge, Jun Zhang, Yan Gong, Jamila Gupte, Jay Ye, Jennifer Weiszmann, Kim Samayoa, Suzanne Coberly, Jonitha Gardner, Huilan Wang, Tim Corbin, Danny Chui, Helene Baribault, Yang Li

J Biol Chem. 2014 Oct 31; 289(44): 30470–30480. Published online 2014 Sep 9. doi: 10.1074/jbc.M114.592022

PMCID:: PMC4215229

Article PDF–2.5M

Select item 33529346.

Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models

Dorothy M. French, Benjamin C. Lin, Manping Wang, Camellia Adams, Theresa Shek, Kathy Hötzel, Brad Bolon, Ronald Ferrando, Craig Blackmore, Kurt Schroeder, Luis A. Rodriguez, Maria Hristopoulos, Rayna Venook, Avi Ashkenazi, Luc R. Desnoyers

PLoS One. 2012; 7(5): e36713. Published online 2012 May 15. doi: 10.1371/journal.pone.0036713

PMCID:: PMC3352934

Article PDF–1.0M

Select item 32760707.

FGFR4 and its novel splice form in myogenic cells: interplay of glycosylation and tyrosine phosphorylation

Boguslaw A. Kwiatkowski, Irina Kirillova, Robert E. Richard, David Israeli, Zipora Yablonka-Reuveni

J Cell Physiol. Author manuscript; available in PMC 2012 Feb 9.

Published in final edited form as: J Cell Physiol. 2008 Jun; 215(3): 803–817. doi: 10.1002/jcp.21365

PMCID:: PMC3276070

Article PDF–5.2M

Select item 27128838.

Resident Hepatocyte Fibroblast Growth Factor Receptor 4 Limits Hepatocarcinogenesis

Xinqiang Huang, Chaofeng Yang, Chengliu Jin, Yongde Luo, Fen Wang, Wallace L McKeehan

Mol Carcinog. Author manuscript; available in PMC 2009 Jul 20.

Published in final edited form as: Mol Carcinog. 2009 Jun; 48(6): 553–562. doi: 10.1002/mc.20494

PMCID:: PMC2712883

Article PDF–2.3M

Select item 18508989.

Increased Carbon Tetrachloride-Induced Liver Injury and Fibrosis in FGFR4-Deficient Mice

Chundong Yu, Fen Wang, Chengliu Jin, Xiaochong Wu, Wai-kin Chan, Wallace L. McKeehan

Am J Pathol. 2002 Dec; 161(6): 2003–2010. doi: 10.1016/S0002-9440(10)64478-1

PMCID:: PMC1850898

Article PDF–520K

Select item 1078730110.

Fibroblast growth factor receptor-4 mediates activation of Nuclear Factor Erythroid 2-Related Factor-2 in gastric tumorigenesis

Mohammed Soutto, Xing Zhang, Nadeem Bhat, Zheng Chen, Shoumin Zhu, Selma Maacha, Melanie Genoula, Omar El-Gazzaz, Dunfa Peng, Heng Lu, Oliver G. McDonald, Xi Steven Chen, Longlong Cao, Zekuan Xu, Wael El-Rifai

Redox Biol. 2024 Feb; 69: 102998. Published online 2023 Dec 19. doi: 10.1016/j.redox.2023.102998

PMCID:: PMC10787301

Article PDF–17M

Select item 907254611.

FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes

Christopher Yanucil, Dominik Kentrup, Xueyi Li, Alexander Grabner, Karla Schramm, Eliana C. Martinez, Jinliang Li, Isaac Campos, Brian Czaya, Kylie Heitman, David Westbrook, Adam R. Wende, Alexis Sloan, Johanna M. Roche, Alessia Fornoni, Michael S. Kapiloff, Christian Faul

Sci Rep. 2022; 12: 7326. Published online 2022 May 5. doi: 10.1038/s41598-022-11033-x

PMCID:: PMC9072546

Article PDF–6.4M

Select item 896388112.

Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling

Brian Czaya, Kylie Heitman, Isaac Campos, Christopher Yanucil, Dominik Kentrup, David Westbrook, Orlando Gutierrez, Jodie L Babitt, Grace Jung, Isidro B Salusky, Mark Hanudel, Christian Faul

eLife. 2022; 11: e74782. Published online 2022 Mar 18. doi: 10.7554/eLife.74782

PMCID:: PMC8963881

Article PDF–15M

Select item 842454713.

Fibroblast growth factor 23 (FGF23) induces ventricular arrhythmias and prolongs QTc interval in mice in an FGF receptor 4-dependent manner

Jonah M. Graves, Julian A. Vallejo, Chelsea S. Hamill, Derek Wang, Rohan Ahuja, Shaan Patel, Christian Faul, Michael J. Wacker

Am J Physiol Heart Circ Physiol. 2021 Jun 1; 320(6): H2283–H2294. Published online 2021 Apr 30. doi: 10.1152/ajpheart.00798.2020

PMCID:: PMC8424547

Article

Select item 831502814.

Aberrant FGFR4 signaling worsens nonalcoholic steatohepatitis in FGF21KO mice

Youxi Yu, Xiaoju Shi, Qianqian Zheng, Xingtong Wang, Xingkai Liu, Min Tan, Guoyue Lv, Ping Zhang, Robert C. Martin, Yan Li

Int J Biol Sci. 2021; 17(10): 2576–2589. Published online 2021 Jun 22. doi: 10.7150/ijbs.58776

PMCID:: PMC8315028

Article PDF–3.3M

Select item 677388315.

FGFR4 does not contribute to progression of chronic kidney disease

Ashlee Taylor, Christopher Yanucil, John Musgrove, Melody Shi, Shintaro Ide, Tomokazu Souma, Christian Faul, Myles Wolf, Alexander Grabner

Sci Rep. 2019; 9: 14023. Published online 2019 Oct 1. doi: 10.1038/s41598-019-50669-0

PMCID:: PMC6773883

Article PDF–5.9M

Select item 591982716.

STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion

Daniel Kogan, Alexander Grabner, Christopher Yanucil, Christian Faul, Vijay Kumar Ulaganathan

J Clin Invest. 2018 May 1; 128(5): 1867–1872. Published online 2018 Apr 3. doi: 10.1172/JCI96708

PMCID:: PMC5919827

Article PDF–2.8M

Select item 543401817.

FGF23/FGFR4-mediated left ventricular hypertrophy is reversible

Alexander Grabner, Karla Schramm, Neerupma Silswal, Matt Hendrix, Christopher Yanucil, Brian Czaya, Saurav Singh, Myles Wolf, Sven Hermann, Jörg Stypmann, Giovana Seno Di Marco, Marcus Brand, Michael J. Wacker, Christian Faul

Sci Rep. 2017; 7: 1993. Published online 2017 May 16. doi: 10.1038/s41598-017-02068-6