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Items: 1 to 20 of 52

1.
Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by Involving an Integrin-αVβ6/TGF-β Signaling Cascade
Camilla Schinner, Lifen Xu, Henriette Franz, Aude Zimmermann, Marie-Therès Wanuske, Maitreyi Rathod, Pauline Hanns, Florian Geier, Pawel Pelczar, Yan Liang, Vera Lorenz, Chiara Stüdle, Piotr I. Maly, Silke Kauferstein, Britt M. Beckmann, Farah Sheikh, Gabriela M. Kuster, Volker Spindler
Circulation. 2022 Nov 22; 146(21): 1610–1626. Published online 2022 Oct 21. doi: 10.1161/CIRCULATIONAHA.121.057329
PMCID:
PMC9674449
ArticlePDF–5.1M
2.
A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis
Lisa K. McLellan, Michael R. McAllaster, Arthur S. Kim, Ľubomíra Tóthová, Patrick D. Olson, Jerome S. Pinkner, Allyssa L. Daugherty, Teri N. Hreha, James W. Janetka, Daved H. Fremont, Scott J. Hultgren, Herbert W. Virgin, David A. Hunstad
PLoS Pathog. 2021 Jan; 17(1): e1009314. Published online 2021 Jan 29. doi: 10.1371/journal.ppat.1009314
PMCID:
PMC7875428
ArticlePDF–1.9M
3.
Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy
Nadine Lubos, Svenja van der Gaag, Muhammed Gerçek, Sebastian Kant, Rudolf E. Leube, Claudia A. Krusche
Basic Res Cardiol. 2020; 115(4): 42. Published online 2020 Jun 12. doi: 10.1007/s00395-020-0803-5
PMCID:
PMC7289786
ArticlePDF–21M
4.
Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy
Stephen P. Chelko, Angeliki Asimaki, Justin Lowenthal, Carlos Bueno-Beti, Djahida Bedja, Arianna Scalco, Nuria Amat-Alarcon, Peter Andersen, Daniel P. Judge, Leslie Tung, Jeffrey E. Saffitz
Circulation. Author manuscript; available in PMC 2020 Oct 29.
Published in final edited form as: Circulation. 2019 Oct 29; 140(18): 1491–1505. Published online 2019 Sep 19. doi: 10.1161/CIRCULATIONAHA.119.040676
PMCID:
PMC6817418
Article
5.
Enhancement of cutaneous wound healing by Dsg2 augmentation of uPAR secretion
Felicia Cooper, Andrew M Overmiller, Anthony Loder, Donna M Brennan-Crispi, Kathleen P McGuinn, Molly R Marous, Theresa A Freeman, Natalia A Riobo-Del Galdo, Linda D Siracusa, James K Wahl, III, Mỹ G Mahoney
J Invest Dermatol. Author manuscript; available in PMC 2019 Nov 1.
Published in final edited form as: J Invest Dermatol. 2018 Nov; 138(11): 2470–2479. Published online 2018 May 9. doi: 10.1016/j.jid.2018.04.024
PMCID:
PMC6200597
ArticlePDF–963K
6.
Co-administration of epithelial junction opener JO-1 improves the efficacy and safety of chemotherapeutic drugs
Ines Beyer, Hua Cao, Jonas Persson, Hui Song, Maximilian Richter, Qinghua Feng, Roma Yumul, Ruan van Rensburg, Zongyi Li, Ronald Berenson, Darrick Carter, Steve Roffler, Charles Drescher, André Lieber
Clin Cancer Res. Author manuscript; available in PMC 2013 Jan 17.
Published in final edited form as: Clin Cancer Res. 2012 Jun 15; 18(12): 3340–3351. Published online 2012 Apr 24. doi: 10.1158/1078-0432.CCR-11-3213
PMCID:
PMC3547677
ArticlePDF–3.5M
7.
A New Human DSG2-Transgenic Mouse Model for Studying the Tropism and Pathology of Human Adenoviruses
Hongjie Wang, Ines Beyer, Jonas Persson, Hui Song, ZongYi Li, Maximilian Richter, Hua Cao, Ruan van Rensburg, Xiaoying Yao, Kelly Hudkins, Roma Yumul, Xiao-Bing Zhang, Mujun Yu, Pascal Fender, Akseli Hemminki, André Lieber
J Virol. 2012 Jun; 86(11): 6286–6302. doi: 10.1128/JVI.00205-12
PMCID:
PMC3372198
ArticlePDF–5.1M
8.
Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy
Kalliopi Pilichou, Carol Ann Remme, Cristina Basso, Maria E. Campian, Stefania Rizzo, Phil Barnett, Brendon P. Scicluna, Barbara Bauce, Maurice J.B. van den Hoff, Jacques M.T. de Bakker, Hanno L. Tan, Marialuisa Valente, Andrea Nava, Arthur A.M. Wilde, Antoon F.M. Moorman, Gaetano Thiene, Connie R. Bezzina
J Exp Med. 2009 Aug 3; 206(8): 1787–1802. doi: 10.1084/jem.20090641
PMCID:
PMC2722163
ArticlePDF–6.9M
9.
Desmoglein-2 is important for islet function and β-cell survival
Kay K. Myo Min, Darling Rojas-Canales, Daniella Penko, Mark DeNichilo, Michaelia P. Cockshell, Charlie B. Ffrench, Emma J. Thompson, Olof Asplund, Christopher J. Drogemuller, Rashmi B. Prasad, Leif Groop, Shane T. Grey, Helen E. Thomas, Thomas Loudovaris, Thomas W. Kay, My G. Mahoney, Claire F. Jessup, P. Toby Coates, Claudine S. Bonder
Cell Death Dis. 2022 Oct; 13(10): 911. Published online 2022 Oct 29. doi: 10.1038/s41419-022-05326-2
PMCID:
PMC9617887
ArticlePDF–6.7M
10.
Activation of PPARα Ameliorates Cardiac Fibrosis in Dsg2-Deficient Arrhythmogenic Cardiomyopathy
Zirui Qiu, Yawen Zhao, Tian Tao, Wenying Guo, Ruonan Liu, Jingmin Huang, Geyang Xu
Cells. 2022 Oct; 11(20): 3184. Published online 2022 Oct 11. doi: 10.3390/cells11203184
PMCID:
PMC9601208
ArticlePDF–2.4M
11.
A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis
Lisa M. Ebert, Lih Y. Tan, M. Zahied Johan, Kay Khine Myo Min, Michaelia P. Cockshell, Kate A. Parham, Kelly L. Betterman, Paceman Szeto, Samantha Boyle, Lokugan Silva, Angela Peng, YouFang Zhang, Andrew Ruszkiewicz, Andrew C. W. Zannettino, Stan Gronthos, Simon Koblar, Natasha L. Harvey, Angel F. Lopez, Mark Shackleton, Claudine S. Bonder
Angiogenesis. 2016; 19(4): 463–486. Published online 2016 Jun 23. doi: 10.1007/s10456-016-9520-y
PMCID:
PMC5026727
ArticlePDF–5.9M
12.
Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy
Stephen P. Chelko, Angeliki Asimaki, Peter Andersen, Djahida Bedja, Nuria Amat-Alarcon, Deeptankar DeMazumder, Ravirasmi Jasti, Calum A. MacRae, Remo Leber, Andre G. Kleber, Jeffrey E. Saffitz, Daniel P. Judge
JCI Insight. 2016 Apr 21; 1(5): e85923. Published online 2016 Apr 21. doi: 10.1172/jci.insight.85923
PMCID:
PMC4861310
ArticlePDF–8.0M
13.
Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis
Donna M. Brennan-Crispi, Claudia Hossain, Joya Sahu, Mary Brady, Natalia A. Riobo, Mỹ G. Mahoney
Oncotarget. 2015 Apr 20; 6(11): 8593–8605. Published online 2015 Mar 24. doi: 10.18632/oncotarget.3309
PMCID:
PMC4496169
ArticlePDF–2.8M
14.
Desmoglein 2 Compensates for Desmoglein 3 but Does Not Control Cell Adhesion via Regulation of p38 Mitogen-activated Protein Kinase in Keratinocytes
Eva Hartlieb, Vera Rötzer, Mariya Radeva, Volker Spindler, Jens Waschke
J Biol Chem. 2014 Jun 13; 289(24): 17043–17053. Published online 2014 Apr 29. doi: 10.1074/jbc.M113.489336
PMCID:
PMC4059146
ArticlePDF–2.5M
15.
Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy
Stephen P. Chelko, Gizem Keceli, Andrea Carpi, Nunzianna Doti, Jacopo Agrimi, Angeliki Asimaki, Carlos Bueno Beti, Matthew Miyamoto, Nuria Amat-Codina, Djahida Bedja, An-Chi Wei, Brittney Murray, Crystal Tichnell, Chulan Kwon, Hugh Calkins, Cynthia A. James, Brian O’Rourke, Marc K. Halushka, Edon Melloni, Jeffrey E. Saffitz, Daniel P. Judge, Menotti Ruvo, Richard N. Kitsis, Peter Andersen, Fabio Di Lisa, Nazareno Paolocci
Sci Transl Med. Author manuscript; available in PMC 2022 Mar 21.
Published in final edited form as: Sci Transl Med. 2021 Feb 17; 13(581): eabf0891. doi: 10.1126/scitranslmed.abf0891
PMCID:
PMC8936193
ArticlePDF–3.6M
16.
Human Desmoglein-2 and Human CD46 Mediate Human Adenovirus Type 55 Infection, but Human Desmoglein-2 Plays the Major Roles
Ying Feng, Changhua Yi, Xinglong Liu, Linbing Qu, Wan Su, Tao Shu, Xuehua Zheng, Xianmiao Ye, Jia Luo, Mingli Hao, Xikui Sun, Liang Li, Xiaolin Liu, Chenchen Yang, Suhua Guan, Ling Chen, Liqiang Feng
J Virol. 2020 Sep; 94(17): e00747-20. Prepublished online 2020 Jun 24. Published online 2020 Aug 17. doi: 10.1128/JVI.00747-20
PMCID:
PMC7431812
ArticlePDF–3.4M
17.
Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy
Camilla Schinner, Bernd Markus Erber, Sunil Yeruva, Angela Schlipp, Vera Rötzer, Ellen Kempf, Sebastian Kant, Rudolf E. Leube, Thomas D. Mueller, Jens Waschke
JCI Insight. 2020 May 7; 5(9): e130141. Published online 2020 May 7. doi: 10.1172/jci.insight.130141
PMCID:
PMC7253015
ArticlePDF–25M
18.
Overexpression of Desmoglein 2 in a mouse model of Gorlin syndrome enhances spontaneous basal cell carcinoma formation through STAT3-mediated Gli1 expression
Donna M. Brennan-Crispi, Andrew M. Overmiller, Lukas Tamayo-Orrego, Molly R. Marous, Joya Sahu, Kathleen P. McGuinn, Felicia Cooper, Ioanna Ch. Georgiou, Maxwell Frankfurter, Julio C. Salas-Alanis, Frédéric Charron, Sarah E. Millar, Mỹ G. Mahoney, Natalia A. Riobo-Del Galdo
J Invest Dermatol. Author manuscript; available in PMC 2020 Feb 1.
Published in final edited form as: J Invest Dermatol. 2019 Feb; 139(2): 300–307. Published online 2018 Oct 3. doi: 10.1016/j.jid.2018.09.009
PMCID:
PMC6342634
ArticlePDF–822K
19.
Desmoglein 2 mutant mice develop cardiac fibrosis and dilation
Claudia A. Krusche, Bastian Holthöfer, Valérie Hofe, Annette M. van de Sandt, Leonid Eshkind, Ernesto Bockamp, Marc W. Merx, Sebastian Kant, Reinhard Windoffer, Rudolf E. Leube
Basic Res Cardiol. 2011 Jul; 106(4): 617–633. Published online 2011 Apr 1. doi: 10.1007/s00395-011-0175-y
PMCID:
PMC3105238
ArticlePDF–2.0M
20.
Desmoglein 2 Functions As A Receptor for Fatty Acid Binding Protein 4 in Breast Cancer Epithelial Cells
Dongmei Chen, Keith M. Wirth, Scott Kizy, Joseph M. Muretta, Todd W Markowski, Peter Yong, Adam Sheka, Hisham Abdelwahab, Ann V. Hertzel, Sayeed Ikramuddin, Masato Yamamoto, David A Bernlohr
Mol Cancer Res. Author manuscript; available in PMC 2024 Feb 1.
Published in final edited form as: Mol Cancer Res. 2023 Aug 1; 21(8): 836–848. doi: 10.1158/1541-7786.MCR-22-0763
PMCID:
PMC10524127
ArticlePDF–2.1M

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