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Select item 107666171.

15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling T_reg cell function through IFN-β

A. Zamora, M. Nougué, L. Verdu, E. Balzan, T. Draia-Nicolau, E. Benuzzi, F. Pujol, V. Baillif, E. Lacazette, F. Morfoisse, J. Galitzky, A. Bouloumié, M. Dubourdeau, B. Chaput, N. Fazilleau, J. Malloizel-Delaunay, A. Bura-Rivière, A. C. Prats, B. Garmy-Susini

Nat Commun. 2024; 15: 221. Published online 2024 Jan 4. doi: 10.1038/s41467-023-43554-y

PMCID:: PMC10766617

Article PDF–6.9M

Select item 106856872.

Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system

Florian Reisch, Dagmar Heydeck, Marjann Schäfer, Michael Rothe, Jiaxing Yang, Sabine Stehling, Gerhard P. Püschel, Hartmut Kuhn

Cell Mol Biol Lett. 2023; 28: 97. Published online 2023 Nov 29. doi: 10.1186/s11658-023-00511-3

PMCID:: PMC10685687

Article PDF–4.3M

Select item 103933463.

Hematopoietic 12/15-lipoxygenase activity negatively contributes to fungal-associated allergic asthma

Mgayya Makullah, Diandra A. Ellis, MaryJane Jones, Chad Steele

Am J Physiol Lung Cell Mol Physiol. 2023 Aug 1; 325(2): L104–L113. Published online 2023 May 30. doi: 10.1152/ajplung.00090.2023

PMCID:: PMC10393346

Article

Select item 101515774.

12/15-lipoxygenase activity promotes efficient inflammation resolution in a murine model of Lyme arthritis

Christa D. Jackson, Kinsey A. Hilliard, Charles R. Brown

Front Immunol. 2023; 14: 1144172. Published online 2023 Apr 18. doi: 10.3389/fimmu.2023.1144172

PMCID:: PMC10151577

Article PDF–4.5M

Select item 92977115.

Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes

Annie R. Piñeros, Abhishek Kulkarni, Hongyu Gao, Kara S. Orr, Lindsey Glenn, Fei Huang, Yunlong Liu, Maureen Gannon, Farooq Syed, Wenting Wu, Cara M. Anderson, Carmella Evans-Molina, Marcia McDuffie, Jerry L. Nadler, Margaret A. Morris, Raghavendra G. Mirmira, Sarah A. Tersey

Cell Rep. Author manuscript; available in PMC 2022 Jul 20.

Published in final edited form as: Cell Rep. 2022 Jun 28; 39(13): 111011. doi: 10.1016/j.celrep.2022.111011

PMCID:: PMC9297711

Article PDF–2.9M

Select item 88764806.

P. aeruginosa augments irradiation injury via 15-lipoxygenase–catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis

Haider H. Dar, Michael W. Epperly, Vladimir A. Tyurin, Andrew A. Amoscato, Tamil S. Anthonymuthu, Austin B. Souryavong, Alexander A. Kapralov, Galina V. Shurin, Svetlana N. Samovich, Claudette M. St. Croix, Simon C. Watkins, Sally E. Wenzel, Rama K. Mallampalli, Joel S. Greenberger, Hülya Bayır, Valerian E. Kagan, Yulia Y. Tyurina

JCI Insight. 2022 Feb 22; 7(4): e156013. Published online 2022 Feb 22. doi: 10.1172/jci.insight.156013

PMCID:: PMC8876480

Article PDF–3.7M

Select item 87427247.

15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction

John R. Montford, Colin Bauer, Jeremy Rahkola, Julie A. Reisz, Deanna Floyd, Katharina Hopp, Danielle E. Soranno, Jelena Klawitter, Mary C. M. Weiser-Evans, Raphael Nemenoff, Sarah Faubel, Seth B. Furgeson

Am J Physiol Renal Physiol. 2022 Jan 1; 322(1): F105–F119. Published online 2021 Dec 6. doi: 10.1152/ajprenal.00214.2021

PMCID:: PMC8742724

Article

Select item 87285858.

12/15–Lipoxygenase debilitates mitochondrial health in intermittent hypobaric hypoxia induced neuronal damage: An in vivo study

Richa Choudhary, Mukesh Kumar, Anju Katyal

Redox Biol. 2022 Feb; 49: 102228. Published online 2021 Dec 30. doi: 10.1016/j.redox.2021.102228

PMCID:: PMC8728585

Article PDF–14M

Select item 80389979.

Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD₂ in the kidney

Naohiro Takahashi, Hiroaki Kikuchi, Ayaka Usui, Taisuke Furusho, Takuya Fujimaru, Tamami Fujiki, Tomoki Yanagi, Yoshiaki Matsuura, Kenichi Asano, Kouhei Yamamoto, Fumiaki Ando, Koichiro Susa, Shintaro Mandai, Takayasu Mori, Tatemitsu Rai, Shinichi Uchida, Makoto Arita, Eisei Sohara

Clin Exp Nephrol. 2021; 25(5): 445–455. Published online 2021 Feb 17. doi: 10.1007/s10157-021-02021-y

PMCID:: PMC8038997

Article PDF–2.3M

Select item 780648410.

Activation of EP4 receptor limits transition of acute to chronic heart failure in lipoxygenase deficient mice

Vasundhara Kain, Kevin A. Ingle, Namakkal S. Rajasekaran, Ganesh V. Halade

Theranostics. 2021; 11(6): 2742–2754. Published online 2021 Jan 1. doi: 10.7150/thno.51183

PMCID:: PMC7806484

Article PDF–2.2M

Select item 675098911.

A DUAL ROLE OF 12/15-LIPOXYGENASE IN LPS-INDUCED ACUTE RENAL INFLAMMATION AND INJURY

Ahmed A. Elmarakby, Ahmed S. Ibrahim, Mohamed A. Katary, Nehal M. Elsherbini, Mohamed El-Shafey, Ahmed M. Abd-Elrazik, Rafik A. Abdelsayed, Krishna Rao Maddipati, Mohamed Al-Shabrawey

Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2020 Nov 1.

Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Nov; 1864(11): 1669–1680. Published online 2019 Jul 23. doi: 10.1016/j.bbalip.2019.07.009

PMCID:: PMC6750989

Article PDF–2.5M

Select item 674052912.

12-Lipoxygenase Metabolites of Arachidonic Acid Mediate Metabotropic Glutamate Receptor-Dependent Long-Term Depression at Hippocampal CA3-CA1 Synapses

Steven J. Feinmark, Roxana Begum, Evgeny Tsvetkov, Ivan Goussakov, Colin D. Funk, Steven A. Siegelbaum, Vadim Y. Bolshakov

J Neurosci. 2003 Dec 10; 23(36): 11427–11435. doi: 10.1523/JNEUROSCI.23-36-11427.2003

PMCID:: PMC6740529

Article PDF–710K

Select item 634948413.

Impact of 12/15-lipoxygenase on brain injury after subarachnoid hemorrhage

Thomas Gaberel, Clement Gakuba, Yi Zheng, Matthieu Lépine, Eng H Lo, Klaus van Leyen

Stroke. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: Stroke. 2019 Feb; 50(2): 520–523. doi: 10.1161/STROKEAHA.118.022325

PMCID:: PMC6349484

Article PDF–1021K

Select item 610317614.

Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis

Thomas W. Carion, Matthew Greenwood, Abdul Shukkur Ebrahim, Andrew Jerome, Susmit Suvas, Karsten Gronert, Elizabeth A. Berger

FASEB J. 2018 Sep; 32(9): 5026–5038. Published online 2018 Apr 13. doi: 10.1096/fj.201701502R

PMCID:: PMC6103176

Article

Select item 609366115.

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase

Andrew Hinman, Charles R. Holst, Joey C. Latham, Joel J. Bruegger, Gözde Ulas, Kevin P. McCusker, Akiko Amagata, Dana Davis, Kevin G. Hoff, Amanda H. Kahn-Kirby, Virna Kim, Yuko Kosaka, Edgar Lee, Stephanie A. Malone, Janet J. Mei, Steve James Richards, Veronica Rivera, Guy Miller, Jeffrey K. Trimmer, William D. Shrader

PLoS One. 2018; 13(8): e0201369. Published online 2018 Aug 15. doi: 10.1371/journal.pone.0201369

PMCID:: PMC6093661

Article PDF–2.4M

Select item 594055216.

Genetic Deletion of 12/15 Lipoxygenase Promotes Effective Resolution of Inflammation Following Myocardial Infarction

Vasundhara Kain, Kevin A. Ingle, Janusz Kabarowski, Stephen Barnes, Nita A. Limdi, Sumanth D. Prabhu, Ganesh V. Halade

J Mol Cell Cardiol. Author manuscript; available in PMC 2018 May 9.

Published in final edited form as: J Mol Cell Cardiol. 2018 May; 118: 70–80. Published online 2018 Mar 8. doi: 10.1016/j.yjmcc.2018.03.004

PMCID:: PMC5940552

Article PDF–1014K

Select item 580813617.

Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice

Dennis R. Warner, Huilin Liu, Matthew E. Miller, Christopher E. Ramsden, Bin Gao, Ariel E. Feldstein, Susanne Schuster, Craig J. McClain, Irina A. Kirpich

Am J Pathol. 2017 Oct; 187(10): 2232–2245. doi: 10.1016/j.ajpath.2017.06.008

PMCID:: PMC5808136

Article

Select item 565260118.

Inhibition of 12/15-Lipoxygenase Protects Against β-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes

Marimar Hernandez-Perez, Gaurav Chopra, Jonathan Fine, Abass M. Conteh, Ryan M. Anderson, Amelia K. Linnemann, Chanelle Benjamin, Jennifer B. Nelson, Kara S. Benninger, Jerry L. Nadler, David J. Maloney, Sarah A. Tersey, Raghavendra G. Mirmira

Diabetes. 2017 Nov; 66(11): 2875–2887. Published online 2017 Aug 25. doi: 10.2337/db17-0215

PMCID:: PMC5652601

Article PDF–2.9M

Select item 556719619.

Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice

Wenliang Zhang, Wei Zhong, Qian Sun, Xinguo Sun, Zhanxiang Zhou

Sci Rep. 2017; 7: 8976. Published online 2017 Aug 21. doi: 10.1038/s41598-017-02759-0

PMCID:: PMC5567196

Article PDF–2.5M

Select item 553886320.

Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healing

Ganesh V. Halade, Vasundhara Kain, Kevin A. Ingle, Sumanth D. Prabhu

Am J Physiol Heart Circ Physiol. 2017 Jul 1; 313(1): H89–H102. Published online 2017 Apr 14. doi: 10.1152/ajpheart.00040.2017

PMCID:: PMC5538863

Article

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