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Select item 86141571.

ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice

Takahiro Nakajima, Toshio Kanno, Satoru Yokoyama, Shigemi Sasamoto, Hikari K. Asou, Damon J. Tumes, Osamu Ohara, Toshinori Nakayama, Yusuke Endo

J Exp Med. 2021 Dec 6; 218(12): e20210639. Published online 2021 Nov 23. doi: 10.1084/jem.20210639

PMCID:: PMC8614157

Article PDF–8.6M

Select item 62907312.

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

James Cantley, Aimee Davenport, Laurène Vetterli, Nandor J. Nemes, P. Tess Whitworth, Ebru Boslem, Le May Thai, Natalie Mellett, Peter J. Meikle, Kyle L. Hoehn, David E. James, Trevor J. Biden

Diabetologia. 2019; 62(1): 99–111. Published online 2018 Oct 17. doi: 10.1007/s00125-018-4743-7

PMCID:: PMC6290731

Article PDF–1.2M

Select item 39656313.

Regulator of fatty acid metabolism, acetyl CoA carboxylase 1 (ACC1), controls T cell immunity

JangEun Lee, Matthew C. Walsh, Kyle L. Hoehn, David E. James, E. John Wherry, Yongwon Choi

J Immunol. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: J Immunol. 2014 Apr 1; 192(7): 3190–3199. Published online 2014 Feb 24. doi: 10.4049/jimmunol.1302985

PMCID:: PMC3965631

Article PDF–2.0M

Select item 27626774.

aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues

Jianqiang Mao, Tao Yang, Ziwei Gu, William C. Heird, Milton J. Finegold, Brendan Lee, Salih J. Wakil

Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41): 17576–17581. Published online 2009 Sep 24. doi: 10.1073/pnas.0909055106

PMCID:: PMC2762677

Article PDF–639K

Select item 11893515.

Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal

Lutfi Abu-Elheiga, Martin M. Matzuk, Parichher Kordari, WonKeun Oh, Tattym Shaikenov, Ziwei Gu, Salih J. Wakil

Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34): 12011–12016. Published online 2005 Aug 15. doi: 10.1073/pnas.0505714102

PMCID:: PMC1189351

Article PDF–445K

Select item 102058626.

Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts

Yung-Chi Huang, Ming-Feng Hou, Ying-Ming Tsai, Yi-Chung Pan, Pei-Hsun Tsai, Yi-Shiuan Lin, Chao-Yuan Chang, Eing-Mei Tsai, Ya-Ling Hsu

Cell Oncol (Dordr) 2023; 46(3): 643–660. Published online 2023 Jan 6. doi: 10.1007/s13402-022-00767-5

PMCID:: PMC10205862

Article PDF–11M

Select item 89334127.

Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion

Anna Veprik, Geoffrey Denwood, Dong Liu, Rula Bany Bakar, Valentin Morfin, Kara McHugh, Nchimunya N. Tebeka, Laurène Vetterli, Ekaterina Yonova-Doing, Fiona Gribble, Frank Reimann, Kyle L. Hoehn, Piers A. Hemsley, Jonas Ahnfelt-Rønne, Patrik Rorsman, Quan Zhang, Heidi de Wet, James Cantley

Commun Biol. 2022; 5: 238. Published online 2022 Mar 18. doi: 10.1038/s42003-022-03170-w

PMCID:: PMC8933412

Article PDF–2.2M

Select item 66432978.

Inhibition of acetyl-CoA carboxylase (ACC) by phosphorylation or by the liver-specific inhibitor, ND-654, suppresses lipogenesis and hepatocellular carcinoma

James S.V. Lally, Sarani Ghoshal, Danielle K. DePeralta, Omeed Moaven, Lan Wei, Ricard Masia, Derek J. Erstad, Naoto Fujiwara, Vivian Leong, Vanessa P. Houde, Alexander E. Anagnostopoulos, Alice Wang, Lindsay A. Broadfield, Rebecca J. Ford, Robert A. Foster, Jamie Bates, Hailing Sun, Ting Wang, Henry Liu, Adrian S. Ray, Asish K. Saha, Jeremy Greenwood, Sathesh Bhat, Geraldine Harriman, Wenyan Miao, Jennifer L. Rocnik, William F. Westlin, Paola Muti, Theodoros Tsakiridis, H. James Harwood, Jr, Rosana Kapeller, Yujin Hoshida, Kenneth K. Tanabe, Gregory R. Steinberg, Bryan C. Fuchs

Cell Metab. Author manuscript; available in PMC 2020 Jan 8.

Published in final edited form as: Cell Metab. 2019 Jan 8; 29(1): 174–182.e5. Published online 2018 Sep 20. doi: 10.1016/j.cmet.2018.08.020

PMCID:: PMC6643297

Article PDF–1.1M

Select item 66206719.

Acetyl-CoA carboxylase inhibition regulates microtubule dynamics and intracellular transport in cystic fibrosis epithelial cells

Sharon M. Rymut, Binyu Lu, Aura Perez, Deborah A. Corey, Kata Lamb, Calvin U. Cotton, Thomas J. Kelley

Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1; 316(6): L1081–L1093. Published online 2019 Mar 20. doi: 10.1152/ajplung.00369.2018

PMCID:: PMC6620671

Article

Select item 611565410.

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin

Mardiana Lee, Marina Katerelos, Kurt Gleich, Sandra Galic, Bruce E. Kemp, Peter F. Mount, David A. Power

J Am Soc Nephrol. 2018 Sep; 29(9): 2326–2336. Published online 2018 Jul 5. doi: 10.1681/ASN.2018010050

PMCID:: PMC6115654

Article

Select item 581121111.

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

Sandra Galic, Kim Loh, Lisa Murray-Segal, Gregory R Steinberg, Zane B Andrews, Bruce E Kemp

eLife. 2018; 7: e32656. Published online 2018 Feb 13. doi: 10.7554/eLife.32656

PMCID:: PMC5811211

Article PDF–2.9M

Select item 538654512.

Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway

Xiaotian Xu, Yuhui Wang, Zhifeng Wei, Wenhui Wei, Peng Zhao, Bei Tong, Yufeng Xia, Yue Dai

Cell Death Dis. 2017 Mar; 8(3): e2723. Published online 2017 Mar 30. doi: 10.1038/cddis.2017.150

PMCID:: PMC5386545

Article PDF–6.8M

Select item 406028513.

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation

Jenny D.Y. Chow, Robert T. Lawrence, Marin E. Healy, John E. Dominy, Jason A. Liao, David S. Breen, Frances L. Byrne, Brandon M. Kenwood, Carolin Lackner, Saeko Okutsu, Valeria R. Mas, Stephen H. Caldwell, Jose L. Tomsig, Gregory J. Cooney, Pere B. Puigserver, Nigel Turner, David E. James, Judit Villén, Kyle L. Hoehn

Mol Metab. 2014 Jul; 3(4): 419–431. Published online 2014 Mar 12. doi: 10.1016/j.molmet.2014.02.004

PMCID:: PMC4060285

Article PDF–3.6M

Select item 392002214.

Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2

Kapil Kampe, Jonas Sieber, Jana Marina Orellana, Peter Mundel, Andreas Werner Jehle

Am J Physiol Renal Physiol. 2014 Feb 15; 306(4): F401–F409. Published online 2013 Dec 11. doi: 10.1152/ajprenal.00454.2013

PMCID:: PMC3920022

Article

Select item 157010615.

Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis

Jianqiang Mao, Francesco J. DeMayo, Huiguang Li, Lutfi Abu-Elheiga, Ziwei Gu, Tattym E. Shaikenov, Parichher Kordari, Subrahmanyam S. Chirala, William C. Heird, Salih J. Wakil

Proc Natl Acad Sci U S A. 2006 May 30; 103(22): 8552–8557. Published online 2006 May 22. doi: 10.1073/pnas.0603115103

PMCID:: PMC1570106

Article PDF–868K

Select item 1088541116.

ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis

Jian Dong, Muzi Li, Runsheng Peng, Yuchuan Zhang, Zilin Qiao, Na Sun

J Transl Med. 2024; 22: 196. Published online 2024 Feb 23. doi: 10.1186/s12967-024-04942-0

PMCID:: PMC10885411

Article PDF–3.2M

Select item 968371217.

Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism

Scott Yeudall, Clint M. Upchurch, Philip V. Seegren, Caitlin M. Pavelec, Jan Greulich, Michael C. Lemke, Thurl E. Harris, Bimal N. Desai, Kyle L. Hoehn, Norbert Leitinger

Sci Adv. 2022 Nov; 8(47): eabq1984. Published online 2022 Nov 23. doi: 10.1126/sciadv.abq1984

PMCID:: PMC9683712

Article PDF–2.7M

Select item 698673018.

Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis

Mitsuharu Matsumoto, Hiroaki Yashiro, Hitomi Ogino, Kazunobu Aoyama, Tadahiro Nambu, Sayuri Nakamura, Mayumi Nishida, Xiaolun Wang, Derek M. Erion, Manami Kaneko

PLoS One. 2020; 15(1): e0228212. Published online 2020 Jan 28. doi: 10.1371/journal.pone.0228212

PMCID:: PMC6986730

Article PDF–2.7M

Select item 623815419.

AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation

Sophie Lepropre, Shakeel Kautbally, Marie Octave, Audrey Ginion, Marie-Blanche Onselaer, Gregory R. Steinberg, Bruce E. Kemp, Alexandre Hego, Odile Wéra, Sanne Brouns, Frauke Swieringa, Martin Giera, Victor M. Darley-Usmar, Jérôme Ambroise, Bruno Guigas, Johan Heemskerk, Luc Bertrand, Cécile Oury, Christophe Beauloye, Sandrine Horman

Blood. 2018 Sep 13; 132(11): 1180–1192. Prepublished online 2018 Jul 17. doi: 10.1182/blood-2018-02-831503

PMCID:: PMC6238154

Article

Select item 568938020.

The Na⁺/glucose co-transporter inhibitor canagliflozin activates AMP-activated protein kinase by inhibiting mitochondrial function and increasing cellular AMP levels

Simon A. Hawley, Rebecca J. Ford, Brennan K. Smith, Graeme J. Gowans, Sarah J. Mancini, Ryan D. Pitt, Emily A. Day, Ian P. Salt, Gregory R. Steinberg, D. Grahame Hardie

Diabetes. Author manuscript; available in PMC 2017 Nov 16.

Published in final edited form as: Diabetes. 2016 Sep; 65(9): 2784–2794. Published online 2016 Jul 5. doi: 10.2337/db16-0058

PMCID:: PMC5689380

Article PDF–2.6M

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