Volume 15(4); 2024 Apr 24
Articles from this journal are generally available in PMC after a 12-month delay (embargo); however, the delay may vary at the discretion of the publisher.
Chemistry
AiZynth impact on medicinal chemistry practice at AstraZeneca
Jason D. Shields, Rachel Howells, Gillian Lamont, Yin Leilei, Andrew Madin, Christopher E. Reimann, Hadi Rezaei, Tristan Reuillon, Bryony Smith, Clare Thomson, Yuting Zheng, Robert E. Ziegler
RSC Med Chem. 2024 Apr 24; 15(4): 1085–1095. Published online 2024 Feb 16. doi: 10.1039/d3md00651d
- PMCID:
- PMC11042116
Currently embargoed: Free in PMC on Feb 16, 2025
Beyond inhibition against the PD-1/PD-L1 pathway: development of PD-L1 inhibitors targeting internalization and degradation of PD-L1
Jiazheng Guo, Fengyi Yu, Kuojun Zhang, Sheng Jiang, Xiangyu Zhang, Tianyu Wang
RSC Med Chem. 2024 Apr 24; 15(4): 1096–1108. Published online 2023 Dec 21. doi: 10.1039/d3md00636k
- PMCID:
- PMC11042118
Currently embargoed: Free in PMC on Dec 21, 2024
Small molecules modulating RNA splicing: a review of targets and future perspectives
Léa Bouton, Agathe Ecoutin, Florian Malard, Sébastien Campagne
RSC Med Chem. 2024 Apr 24; 15(4): 1109–1126. Published online 2024 Jan 11. doi: 10.1039/d3md00685a
- PMCID:
- PMC11042171
Currently embargoed: Free in PMC on Jan 11, 2025
Recent advances of tryptanthrin and its derivatives as potential anticancer agents
Xiaofeng Zhou
RSC Med Chem. 2024 Apr 24; 15(4): 1127–1147. Published online 2024 Jan 4. doi: 10.1039/d3md00698k
- PMCID:
- PMC11042161
Currently embargoed: Free in PMC on Jan 4, 2025
Emerging potential approaches in alkaline phosphatase (ALP) activatable cancer theranostics
Kartikay Tyagi, V. Venkatesh
RSC Med Chem. 2024 Apr 24; 15(4): 1148–1160. Published online 2024 Jan 10. doi: 10.1039/d3md00565h
- PMCID:
- PMC11042160
Currently embargoed: Free in PMC on Jan 10, 2025
Progress in small-molecule inhibitors targeting PD-L1
Jindan Xu, Yuanfang Kong, Pengbo Zhu, Mingyan Du, Xuan Liang, Yan Tong, Xiaofei Li, Chunhong Dong
RSC Med Chem. 2024 Apr 24; 15(4): 1161–1175. Published online 2024 Mar 4. doi: 10.1039/d3md00655g
- PMCID:
- PMC11042164
Currently embargoed: Free in PMC on Mar 4, 2025
Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland, Sridhar Sreeramulu, Franziska Kinnen, Christian Richter, Charis Georgiou, Vladyslav Yadrykhinsky, Edgar Specker, Kristaps Jaudzems, Tanja Miletić, Robert Harmel, Phil Gribbon, Harald Schwalbe, Ruth Brenk, Aigars Jirgensons, Andrea Zaliani, Jordi Mestres
RSC Med Chem. 2024 Apr 24; 15(4): 1176–1188. Published online 2024 Feb 12. doi: 10.1039/d3md00724c
- PMCID:
- PMC11042166
Insa Klemt, Viktor Reshetnikov, Subrata Dutta, Galyna Bila, Rostyslav Bilyy, Itziar Cossío Cuartero, Andrés Hidalgo, Adrian Wünsche, Maximilian Böhm, Marit Wondrak, Leoni A. Kunz-Schughart, Rainer Tietze, Frank Beierlein, Petra Imhof, Sabrina Gensberger-Reigl, Monika Pischetsrieder, Marlies Körber, Tina Jost, Andriy Mokhir
RSC Med Chem. 2024 Apr 24; 15(4): 1189–1197. Published online 2024 Jan 31. doi: 10.1039/d3md00609c
- PMCID:
- PMC11042170
Design, synthesis, and evaluation of novel ferrostatin derivatives for the prevention of HG-induced VEC ferroptosis
Xin-Xin Wang, Run-Jie Wang, Hua-Long Ji, Xiao-Yu Liu, Nai-Yu Zhang, Kai-Ming Wang, Kai Chen, Ping-Ping Liu, Ning Meng, Cheng-Shi Jiang
RSC Med Chem. 2024 Apr 24; 15(4): 1198–1209. Published online 2024 Feb 28. doi: 10.1039/d4md00038b
- PMCID:
- PMC11042167
Currently embargoed: Free in PMC on Feb 28, 2025
Robin van der Straat, Rosalie Draijer, Ewa Surmiak, Roberto Butera, Lennart Land, Katarzyna Magiera-Mularz, Bogdan Musielak, Jacek Plewka, Tad A. Holak, Alexander Dömling
RSC Med Chem. 2024 Apr 24; 15(4): 1210–1215. Published online 2024 Feb 21. doi: 10.1039/d3md00746d
- PMCID:
- PMC11042242
A novel BODIPY-based theranostic agent for in vivo fluorescence imaging of cerebral Aβ and ameliorating Aβ-associated disorders in Alzheimer's disease transgenic mice
Jingjing Zhang, Wenming Ren, Xiaohui Liu, Jingjing Chen, Yuteng Zeng, Huaijiang Xiang, Youhong Hu, Haiyan Zhang
RSC Med Chem. 2024 Apr 24; 15(4): 1216–1224. Published online 2024 Mar 15. doi: 10.1039/d3md00744h
- PMCID:
- PMC11042169
Currently embargoed: Free in PMC on Mar 15, 2025
Screening of efficient salicylaldoxime reactivators for DFP and paraoxon-inhibited acetylcholinesterase
Zhao Wei, Dongxu Zhang, Xueying Liu, Huifang Nie, Qin Ouyang, Xinlei Zhang, Zhibing Zheng
RSC Med Chem. 2024 Apr 24; 15(4): 1225–1235. Published online 2024 Jan 30. doi: 10.1039/d3md00628j
- PMCID:
- PMC11042241
Currently embargoed: Free in PMC on Jan 30, 2025
New azole derivatives linked to indole/indoline moieties combined with FLC against drug-resistant Candida albicans
Yunhong Shen, Min Pan, Hui Gao, Yi Zhang, Ruirui Wang, Jun Li, Zewei Mao
RSC Med Chem. 2024 Apr 24; 15(4): 1236–1246. Published online 2024 Feb 28. doi: 10.1039/d4md00021h
- PMCID:
- PMC11042159
Currently embargoed: Free in PMC on Feb 28, 2025
Letizia Crocetti, Francesca Catarzi, Maria Paola Giovannoni, Claudia Vergelli, Gianluca Bartolucci, Marco Pallecchi, Paola Paoli, Patrizia Rossi, Martina Lippi, Igor A. Schepetkin, Mark T. Quinn, Gabriella Guerrini
RSC Med Chem. 2024 Apr 24; 15(4): 1247–1257. Published online 2024 Mar 19. doi: 10.1039/d3md00736g
- PMCID:
- PMC11042244
Recognition of arylmethylidene derivatives of imidazothiazolotriazinones as novel tubulin polymerization inhibitors
Alexei N. Izmest'ev, Elena V. Svirshchevskaya, Sergey B. Akopov, Angelina N. Kravchenko, Galina A. Gazieva
RSC Med Chem. 2024 Apr 24; 15(4): 1258–1273. Published online 2024 Feb 28. doi: 10.1039/d4md00027g
- PMCID:
- PMC11042243
Currently embargoed: Free in PMC on Feb 28, 2025
Enhanced inhibitory activity of compounds containing purine scaffolds compared to protein kinase CK2α considering crystalline water
Keiji Nishiwaki, Shiori Nakatani, Shinya Nakamura, Kenji Yoshioka, Eri Nakagawa, Masato Tsuyuguchi, Takayoshi Kinoshita, Isao Nakanishi
RSC Med Chem. 2024 Apr 24; 15(4): 1274–1282. Published online 2024 Mar 12. doi: 10.1039/d3md00755c
- PMCID:
- PMC11042117
Currently embargoed: Free in PMC on Mar 12, 2025
Design, synthesis, and cytotoxicity of ibuprofen-appended benzoxazole analogues against human breast adenocarcinoma
Vishnu Thumma, Veerabhadraiah Mallikanti, Raghavender Matta, Ravinder Dharavath, Pochampally Jalapathi
RSC Med Chem. 2024 Apr 24; 15(4): 1283–1294. Published online 2024 Jan 2. doi: 10.1039/d3md00479a
- PMCID:
- PMC11042172
Currently embargoed: Free in PMC on Jan 2, 2025
Trifluoroacetic acid-mediated synthesis of xanthene constructs and their extensive anti-tuberculosis evaluation
Bisma Teli, Mohamad Mosa Mubarak, Zahoor Ahmad, Bilal A. Bhat
RSC Med Chem. 2024 Apr 24; 15(4): 1295–1306. Published online 2024 Jan 12. doi: 10.1039/d3md00518f
- PMCID:
- PMC11042163
Currently embargoed: Free in PMC on Jan 12, 2025
Discovery of novel positive allosteric modulators targeting GluN1/2A NMDARs as anti-stroke therapeutic agents
Hongyu Zhu, Xin Chen, Lu Zhang, Xuequan Liu, Ji Chen, Han-Ting Zhang, Mingxin Dong
RSC Med Chem. 2024 Apr 24; 15(4): 1307–1319. Published online 2024 Jan 4. doi: 10.1039/d3md00455d
- PMCID:
- PMC11042165
Currently embargoed: Free in PMC on Jan 4, 2025
Identification of novel phenylalanine derivatives bearing a hydroxamic acid moiety as potent quorum sensing inhibitors
Truong Thanh Tung, Nguyen Quoc Thang, Nguyen Cao Huy, Pham Bao Phuong, Dinh Ngoc Minh, Nguyen Hai Nam, John Nielsen
RSC Med Chem. 2024 Apr 24; 15(4): 1320–1328. Published online 2024 Jan 23. doi: 10.1039/d3md00670k
- PMCID:
- PMC11042162
Currently embargoed: Free in PMC on Jan 23, 2025
Design, synthesis, in vitro and in silico evaluation of indole-based tetrazole derivatives as putative anti-breast cancer agents
Kamalpreet Kaur, Harkomal Verma, Prabhakar Gangwar, Monisha Dhiman, Vikas Jaitak
RSC Med Chem. 2024 Apr 24; 15(4): 1329–1347. Published online 2024 Feb 19. doi: 10.1039/d3md00730h
- PMCID:
- PMC11042173
Currently embargoed: Free in PMC on Feb 19, 2025
Joana R. L. Ribeiro, Nikoletta Szemerédi, Bruno M. F. Gonçalves, Gabriella Spengler, Carlos A. M. Afonso, Maria-José U. Ferreira
RSC Med Chem. 2024 Apr 24; 15(4): 1348–1361. Published online 2024 Feb 26. doi: 10.1039/d3md00711a
- PMCID:
- PMC11042158
In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therapeutic agents for triple negative breast cancer
Luísa Carvalho, Fábio Pedroso de Lima, Mónica Cerqueira, Ana Silva, Olívia Pontes, Sofia Oliveira-Pinto, Sara Guerreiro, Marta D. Costa, Sara Granja, Patrícia Maciel, Adhemar Longatto-Filho, Fátima Baltazar, Fernanda Proença, Marta Costa
RSC Med Chem. 2024 Apr 24; 15(4): 1362–1380. Published online 2024 Mar 19. doi: 10.1039/d3md00682d
- PMCID:
- PMC11042168
Currently embargoed: Free in PMC on Mar 19, 2025
Synthesis and biological evaluation of new naphthalimide–thiourea derivatives as potent antimicrobial agents active against multidrug-resistant Staphylococcus aureus and Mycobacterium tuberculosis
Preeti Rana, Ramulu Parupalli, Abdul Akhir, Deepanshi Saxena, Rahul Maitra, Mohmmad Imran, Pradip Malik, Shaik Mahammad Ghouse, Swanand Vinayak Joshi, Danaboina Srikanth, Y. V. Madhavi, Arunava Dasgupta, Sidharth Chopra, Srinivas Nanduri
RSC Med Chem. 2024 Apr 24; 15(4): 1381–1391. Published online 2024 Mar 19. doi: 10.1039/d4md00062e
- PMCID:
- PMC11042119
Currently embargoed: Free in PMC on Mar 19, 2025
Lihui Duo, Yi Chen, Qiupei Liu, Zhangyi Ma, Amin Farjudian, Wan Yong Ho, Sze Shin Low, Jianfeng Ren, Jonathan D. Hirst, Hua Xie, Bencan Tang
RSC Med Chem. 2024 Apr 24; 15(4): 1392–1403. Published online 2024 Mar 15. doi: 10.1039/d4md00063c
- PMCID:
- PMC11042245
Articles from RSC Medicinal Chemistry are provided here courtesy of Royal Society of Chemistry