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Volume 13;  2019

Reviews

Combination of rifaximin and lactulose improves clinical efficacy and mortality in patients with hepatic encephalopathy
Zhida Wang, Pei Chu, Wenjin Wang
Drug Des Devel Ther. 2019; 13: 1–11. Published online 2018 Dec 17. doi: 10.2147/DDDT.S172324
PMCID:
PMC6301297
Article PubReader PDF–1.8MCite
Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection
Martina Biggioggero, Chiara Crotti, Andrea Becciolini, Ennio Giulio Favalli
Drug Des Devel Ther. 2019; 13: 57–70. Published online 2018 Dec 19. doi: 10.2147/DDDT.S150580
PMCID:
PMC6304084
Article PubReader PDF–286KCite
Comparative effectiveness and safety of traditional Chinese medicine supporting Qi and enriching blood for cancer related anemia in patients not receiving chemoradiotherapy: a meta-analysis and systematic review
Zhibo Dang, Xiaoli Liu, Xinhui Wang, Mengge Li, Yuyong Jiang, Xianbo Wang, Zhiyun Yang
Drug Des Devel Ther. 2019; 13: 221–230. Published online 2018 Dec 28. doi: 10.2147/DDDT.S181182
PMCID:
PMC6312692
Article PubReader PDF–747KCite
A brief report of toxicity end points of HER2 vaccines for the treatment of patients with HER2+ breast cancer
Ricardo Costa, Saif Zaman, Susan Sharpe, Irene Helenowski, Colleen Shaw, Hyo Han, Hatem Soliman, Brian Czerniecki
Drug Des Devel Ther. 2019; 13: 309–316. Published online 2019 Jan 14. doi: 10.2147/DDDT.S188925
PMCID:
PMC6338114
Article PubReader PDF–586KCite
Recent advances in the treatment of pathogenic infections using antibiotics and nano-drug delivery vehicles
Vo Van Giau, Seong Soo A An, John Hulme
Drug Des Devel Ther. 2019; 13: 327–343. Published online 2019 Jan 18. doi: 10.2147/DDDT.S190577
PMCID:
PMC6342214
Article PubReader PDF–1.8MCite
Targeting the A3 adenosine receptor to treat cytokine release syndrome in cancer immunotherapy
Shira Cohen, Pnina Fishman
Drug Des Devel Ther. 2019; 13: 491–497. Published online 2019 Jan 30. doi: 10.2147/DDDT.S195294
PMCID:
PMC6363488
Article PubReader PDF–208KCite
Brigatinib for ALK-positive metastatic non-small-cell lung cancer: design, development and place in therapy
Robert Ali, Junaid Arshad, Sofia Palacio, Raja Mudad
Drug Des Devel Ther. 2019; 13: 569–580. Published online 2019 Feb 8. doi: 10.2147/DDDT.S147499
PMCID:
PMC6372006
Article PubReader PDF–235KCite
Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives
Sabrina Bimonte, Vittorio Albino, Mauro Piccirillo, Aurelio Nasto, Carlo Molino, Raffaele Palaia, Marco Cascella
Drug Des Devel Ther. 2019; 13: 611–621. Published online 2019 Feb 12. doi: 10.2147/DDDT.S180079
PMCID:
PMC6387605
Article PubReader PDF–3.1MCite
Update in treatment of uveitic macular edema
Spyridon Koronis, Panagiotis Stavrakas, Miltiadis Balidis, Nikolaos Kozeis, Paris G Tranos
Drug Des Devel Ther. 2019; 13: 667–680. Published online 2019 Feb 19. doi: 10.2147/DDDT.S166092
PMCID:
PMC6387597
Article PubReader PDF–1.3MCite
Profile of semaglutide in the management of type 2 diabetes: design, development, and place in therapy
Fernando Gomez-Peralta, Cristina Abreu
Drug Des Devel Ther. 2019; 13: 731–738. Published online 2019 Feb 20. doi: 10.2147/DDDT.S165372
PMCID:
PMC6388990
Article PubReader PDF–676KCite
The journey from gene knockout to clinical medicine: telotristat and sotagliflozin
Marc S Rendell
Drug Des Devel Ther. 2019; 13: 817–824. Published online 2019 Mar 6. doi: 10.2147/DDDT.S144556
PMCID:
PMC6408923
Article PubReader PDF–216KCite
Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities
Sylwia Flis, Tomasz Chojnacki
Drug Des Devel Ther. 2019; 13: 825–843. Published online 2019 Mar 8. doi: 10.2147/DDDT.S191303
PMCID:
PMC6415732
Article PubReader PDF–3.6MCite
Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa
Austin Hoggarth, Andrew Weaver, Qinqin Pu, Ting Huang, Jacob Schettler, Feng Chen, Xiefang Yuan, Min Wu
Drug Des Devel Ther. 2019; 13: 909–924. Published online 2019 Mar 20. doi: 10.2147/DDDT.S189847
PMCID:
PMC6431001
Article PubReader PDF–706KCite
Quizartinib (AC220): a promising option for acute myeloid leukemia
Fang Zhou, Zheng Ge, Baoan Chen
Drug Des Devel Ther. 2019; 13: 1117–1125. Published online 2019 Apr 8. doi: 10.2147/DDDT.S198950
PMCID:
PMC6497874
Article PubReader PDF–342KCite
Caplacizumab as an emerging treatment option for acquired thrombotic thrombocytopenic purpura
Tugrul Elverdi, Ahmet Emre Eskazan
Drug Des Devel Ther. 2019; 13: 1251–1258. Published online 2019 Apr 17. doi: 10.2147/DDDT.S134470
PMCID:
PMC6475094
Article PubReader PDF–565KCite
Nicorandil prior to primary percutaneous coronary intervention improves clinical outcomes in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials
Li Xu, Lefeng Wang, Kuibao Li, Zhiyong Zhang, Hao Sun, Xinchun Yang
Drug Des Devel Ther. 2019; 13: 1389–1400. Published online 2019 Apr 29. doi: 10.2147/DDDT.S195918
PMCID:
PMC6499143
Article PubReader PDF–1.3MCite
Combination of drugs and carriers in drug delivery technology and its development
Ying Du, Baoan Chen
Drug Des Devel Ther. 2019; 13: 1401–1408. Published online 2019 Apr 30. doi: 10.2147/DDDT.S198056
PMCID:
PMC6500434
Article PubReader PDF–426KCite
Safety evaluation and cardiovascular effect of additional use of spironolactone in hemodialysis patients: a meta-analysis
Qing Zeng, XiaoDuo Zhou, Ge Xu
Drug Des Devel Ther. 2019; 13: 1487–1499. Published online 2019 May 3. doi: 10.2147/DDDT.S189454
PMCID:
PMC6504555
Article PubReader PDF–3.6MCite
Inotersen: new promise for the treatment of hereditary transthyretin amyloidosis
Veena Mathew, Annabel K Wang
Drug Des Devel Ther. 2019; 13: 1515–1525. Published online 2019 May 6. doi: 10.2147/DDDT.S162913
PMCID:
PMC6507904
Article PubReader PDF–1.7MCite
Dabigatran must be used carefully: literature review and recommendations for management of adverse events
Shan Lin, Yan Wang, Lei Zhang, Wei Guan
Drug Des Devel Ther. 2019; 13: 1527–1533. Published online 2019 May 6. doi: 10.2147/DDDT.S203112
PMCID:
PMC6511609
Article PubReader PDF–291KCite
Spotlight on anifrolumab and its potential for the treatment of moderate-to-severe systemic lupus erythematosus: evidence to date
Renaud Felten, Florence Scher, Flora Sagez, François Chasset, Laurent Arnaud
Drug Des Devel Ther. 2019; 13: 1535–1543. Published online 2019 May 8. doi: 10.2147/DDDT.S170969
PMCID:
PMC6514126
Article PubReader PDF–598KCite
Effect of pravastatin treatment on circulating adiponectin: a meta-analysis of randomized controlled trials
Xiangrong Shu, Liqun Chi
Drug Des Devel Ther. 2019; 13: 1633–1641. Published online 2019 May 13. doi: 10.2147/DDDT.S186992
PMCID:
PMC6521846
Article PubReader PDF–783KCite
15-Deoxy-Δ12,14-prostaglandin J2 as a potential regulator of bone metabolism via PPARγ-dependent and independent pathways: a review
Zhencheng Xiong, Pan Luo, Jun Zhou, Mingsheng Tan
Drug Des Devel Ther. 2019; 13: 1879–1888. Published online 2019 May 30. doi: 10.2147/DDDT.S206695
PMCID:
PMC6549764
Article PubReader PDF–439KCite
Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis: a meta-analysis
Yao Huang, Hui Wang, Zhe Chen, Yu Wang, Kai Qin, Ying Huang, Xin Ba, Weiji Lin, Shenghao Tu
Drug Des Devel Ther. 2019; 13: 1969–1984. Published online 2019 Jun 17. doi: 10.2147/DDDT.S207226
PMCID:
PMC6588713
Article PubReader PDF–6.4MCite
Evaluating guselkumab: an anti-IL-23 antibody for the treatment of plaque psoriasis
Eric J Yang, Mary Patricia Smith, Karen Ly, Tina Bhutani
Drug Des Devel Ther. 2019; 13: 1993–2000. Published online 2019 Jun 18. doi: 10.2147/DDDT.S137588
PMCID:
PMC6587972
Article PubReader PDF–261KCite
Effect of tumor necrosis factor inhibitors on interstitial lung disease in rheumatoid arthritis: angel or demon?
Ying Huang, Weiji Lin, Zhe Chen, Yu Wang, Yao Huang, Shenghao Tu
Drug Des Devel Ther. 2019; 13: 2111–2125. Published online 2019 Jul 1. doi: 10.2147/DDDT.S204730
PMCID:
PMC6616146
Article PubReader PDF–968KCite
Immune-related adverse events following administration of anti-cytotoxic T-lymphocyte-associated protein-4 drugs: a comprehensive systematic review and meta-analysis
Hang Xu, Ping Tan, Xiaonan Zheng, Yu Huang, Tianhai Lin, Qiang Wei, Jianzhong Ai, Lu Yang
Drug Des Devel Ther. 2019; 13: 2215–2234. Published online 2019 Jul 4. doi: 10.2147/DDDT.S196316
PMCID:
PMC6613615
Article PubReader PDF–5.0MCite
Lumacaftor-ivacaftor in the treatment of cystic fibrosis: design, development and place in therapy
GJ Connett
Drug Des Devel Ther. 2019; 13: 2405–2412. Published online 2019 Jul 19. doi: 10.2147/DDDT.S153719
PMCID:
PMC6650604
Article PubReader PDF–582KCite
Complement system and age-related macular degeneration: drugs and challenges
Jiali Wu, Xiaodong Sun
Drug Des Devel Ther. 2019; 13: 2413–2425. Published online 2019 Jul 19. doi: 10.2147/DDDT.S206355
PMCID:
PMC6650090
Article PubReader PDF–742KCite
Infliximab and biosimilar infliximab in psoriasis: efficacy, loss of efficacy, and adverse events
Smriti Subedi, Yu Gong, Youdong Chen, Yuling Shi
Drug Des Devel Ther. 2019; 13: 2491–2502. Published online 2019 Jul 23. doi: 10.2147/DDDT.S200147
PMCID:
PMC6661374
Article PubReader PDF–332KCite
Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C: design, development, and place in therapy
Thomas G Cotter, Donald M Jensen
Drug Des Devel Ther. 2019; 13: 2565–2577. Published online 2019 Jul 29. doi: 10.2147/DDDT.S172512
PMCID:
PMC6681154
Article PubReader PDF–1.3MCite
Efficacy of chloral hydrate oral solution for sedation in pediatrics: a systematic review and meta-analysis
Zhe Chen, Mao Lin, Zongyao Huang, Linan Zeng, Liang Huang, Dan Yu, Lingli Zhang
Drug Des Devel Ther. 2019; 13: 2643–2653. Published online 2019 Jul 31. doi: 10.2147/DDDT.S201820
Correction in:
Drug Des Devel Ther. 2022; 16: 3491–3492.
PMCID:
PMC6681561
Article PubReader PDF–3.4MCite
Association between the c.415C > T, c.52G > A, and 36_37insGGAGTC polymorphisms of NUDT 15 and thiopurine-induced leukopenia, thiopurine intolerance, and severe hair loss: an updated meta-analysis
Ruili Wang, Baogang Liu, Jiapeng Li, Jiamin Xu, Xiaoling Wang, Zhigang Zhao, Libo Zhao
Drug Des Devel Ther. 2019; 13: 2729–2744. Published online 2019 Aug 5. doi: 10.2147/DDDT.S210512
PMCID:
PMC6689127
Article PubReader PDF–8.4MCite
Minoxidil and its use in hair disorders: a review
Poonkiat Suchonwanit, Sasima Thammarucha, Kanchana Leerunyakul
Drug Des Devel Ther. 2019; 13: 2777–2786. Published online 2019 Aug 9. doi: 10.2147/DDDT.S214907
Correction in:
Drug Des Devel Ther. 2020; 14: 575.
PMCID:
PMC6691938
Article PubReader PDF–489KCite
Denosumab in the treatment of glucocorticoid-induced osteoporosis: a systematic review and meta-analysis
Zeina A Yanbeiy, Karen E Hansen
Drug Des Devel Ther. 2019; 13: 2843–2852. Published online 2019 Aug 14. doi: 10.2147/DDDT.S148654
PMCID:
PMC6698580
Article PubReader PDF–911KCite
Clinical application of obinutuzumab for treating chronic lymphocytic leukemia
Chunyan Luan, Baoan Chen
Drug Des Devel Ther. 2019; 13: 2899–2909. Published online 2019 Aug 19. doi: 10.2147/DDDT.S212500
PMCID:
PMC6707935
Article PubReader PDF–1.1MCite
Attractor – a new turning point in drug discovery
Xucan Hou, Meng Li, Congmin Jia, Xianbao Zhang, Yun Wang
Drug Des Devel Ther. 2019; 13: 2957–2968. Published online 2019 Aug 22. doi: 10.2147/DDDT.S216397
PMCID:
PMC6709805
Article PubReader PDF–921KCite
The development of an oral GLP-1 receptor agonist for the management of type 2 diabetes: evidence to date
Christina Antza, Krishnarajah Nirantharakumar, Ioannis Doundoulakis, Abd A Tahrani, Konstantinos A Toulis
Drug Des Devel Ther. 2019; 13: 2985–2996. Published online 2019 Aug 22. doi: 10.2147/DDDT.S166765
PMCID:
PMC6709822
Article PubReader PDF–446KCite
Ketamine and depression: a narrative review
Alexandrine Corriger, Gisèle Pickering
Drug Des Devel Ther. 2019; 13: 3051–3067. Published online 2019 Aug 27. doi: 10.2147/DDDT.S221437
PMCID:
PMC6717708
Article PubReader PDF–1.8MCite
Clinical evaluation of dacomitinib for the treatment of metastatic non-small cell lung cancer (NSCLC): current perspectives
Daniele Lavacchi, Francesca Mazzoni, Giuseppe Giaccone
Drug Des Devel Ther. 2019; 13: 3187–3198. Published online 2019 Sep 6. doi: 10.2147/DDDT.S194231
PMCID:
PMC6735534
Article PubReader PDF–504KCite
Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications
Mohsen Doostmohammadi, Atefeh Ameri, Reza Mohammadinejad, Negar Dehghannoudeh, Ibrahim M Banat, Mandana Ohadi, Gholamreza Dehghannoudeh
Drug Des Devel Ther. 2019; 13: 3405–3418. Published online 2019 Sep 26. doi: 10.2147/DDDT.S217211
PMCID:
PMC6770672
Article PubReader PDF–864KCite
Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties
Luca Gallelli
Drug Des Devel Ther. 2019; 13: 3425–3437. Published online 2019 Sep 27. doi: 10.2147/DDDT.S207720
PMCID:
PMC6776292
Article PubReader PDF–4.9MCite
The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies
Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana
Drug Des Devel Ther. 2019; 13: 3497–3514. Published online 2019 Oct 7. doi: 10.2147/DDDT.S227738
PMCID:
PMC6789172
Article PubReader PDF–762KCite
In-vitro blood-brain barrier models for drug screening and permeation studies: an overview
Sounak Bagchi, Tanya Chhibber, Behnaz Lahooti, Angela Verma, Vivek Borse, Rahul Dev Jayant
Drug Des Devel Ther. 2019; 13: 3591–3605. Published online 2019 Oct 18. doi: 10.2147/DDDT.S218708
PMCID:
PMC6805046
Article PubReader PDF–4.7MCite
Lanadelumab Injection Treatment For The Prevention Of Hereditary Angioedema (HAE): Design, Development And Place In Therapy
Maria Bova, Anna Valerieva, Maddalena Alessandra Wu, Riccardo Senter, Francesca Perego
Drug Des Devel Ther. 2019; 13: 3635–3646. Published online 2019 Oct 22. doi: 10.2147/DDDT.S192475
PMCID:
PMC6815761
Article PubReader PDF–1.4MCite
Smart Targeting To Improve Cancer Therapeutics
Moraima Morales-Cruz, Yamixa Delgado, Betzaida Castillo, Cindy M Figueroa, Anna M Molina, Anamaris Torres, Melissa Milián, Kai Griebenow
Drug Des Devel Ther. 2019; 13: 3753–3772. Published online 2019 Oct 30. doi: 10.2147/DDDT.S219489
PMCID:
PMC6826196
Article PubReader PDF–3.6MCite
Hesperidin: A Therapeutic Agent For Obesity
Haijun Xiong, Jin Wang, Qian Ran, Guanhua Lou, Chengyi Peng, Qingxia Gan, Ju Hu, Jilin Sun, Renchuan Yao, Qinwan Huang
Drug Des Devel Ther. 2019; 13: 3855–3866. Published online 2019 Nov 12. doi: 10.2147/DDDT.S227499
PMCID:
PMC6859214
Article PubReader PDF–1005KCite
Profile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data
Fumi Varyani, Konstantinos Argyriou, Frank Phillips, Eirini Tsakiridou, Gordon William Moran
Drug Des Devel Ther. 2019; 13: 4091–4105. Published online 2019 Dec 2. doi: 10.2147/DDDT.S182891
PMCID:
PMC6897052
Article PubReader PDF–1.8MCite
The Role of the Reactive Oxygen Species Scavenger Agent, Astaxanthin, in the Protection of Cisplatin-Treated Patients Against Hearing Loss
Benyu Nan, Xi Gu, Xinsheng Huang
Drug Des Devel Ther. 2019; 13: 4291–4303. Published online 2019 Dec 18. doi: 10.2147/DDDT.S212313
PMCID:
PMC6927222
Article PubReader PDF–3.5MCite
Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence
Sachin S Bhagwat, Manohar Nandanwar, Atul Kansagara, Anusuya Patel, Swapna Takalkar, Rajesh Chavan, Hariharan Periasamy, Ravindra Yeole, Prasad K Deshpande, Satish Bhavsar, Ashima Bhatia, Jaishid Ahdal, Rishi Jain, Mahesh Patel
Drug Des Devel Ther. 2019; 13: 4351–4365. Published online 2019 Dec 24. doi: 10.2147/DDDT.S229882
PMCID:
PMC6935279
Article PubReader PDF–1.0MCite

Original Research

Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study
Emine Turkmen Samdanci, Mustafa Huz, Onural Ozhan, Kevser Tanbek, Esra Pamukcu, Ayse Nur Akatli, Hakan Parlakpinar
Drug Des Devel Ther. 2019; 13: 13–21. Published online 2018 Dec 20. doi: 10.2147/DDDT.S181550
PMCID:
PMC6304250
Article PubReader PDF–1.7MCite
Multimetal organic frameworks as drug carriers: aceclofenac as a drug candidate
Muder Al Haydar, Hussein Rasool Abid, Bruce Sunderland, Shaobin Wang
Drug Des Devel Ther. 2019; 13: 23–35. Published online 2018 Dec 18. doi: 10.2147/DDDT.S182983
PMCID:
PMC6305134
Article PubReader PDF–2.3MCite
Osteogenic effect of bone marrow mesenchymal stem cell-derived exosomes on steroid-induced osteonecrosis of the femoral head
Shanhong Fang, Yongfeng Li, Peng Chen
Drug Des Devel Ther. 2019; 13: 45–55. Published online 2018 Dec 18. doi: 10.2147/DDDT.S178698
PMCID:
PMC6305133
Article PubReader PDF–3.2MCite
Protective effects of ethyl gallate and pentagalloylglucose, the active components of Qingwen Baidu Decoction, against lipopolysaccharide-induced acute lung injury in rats
Qi Zhang, Jing Nie, Su-Juan Chen, Qiang Li
Drug Des Devel Ther. 2019; 13: 71–77. Published online 2018 Dec 19. doi: 10.2147/DDDT.S186029
PMCID:
PMC6304083
Article PubReader PDF–1.5MCite
Efficacy of neoadjuvant platinum-based chemotherapy during the second and third trimester of pregnancy in women with cervical cancer: an updated systematic review and meta-analysis
Yizuo Song, Yi Liu, Min Lin, Bo Sheng, Xueqiong Zhu
Drug Des Devel Ther. 2019; 13: 79–102. Published online 2018 Dec 19. doi: 10.2147/DDDT.S186966
PMCID:
PMC6304076
Article PubReader PDF–696KCite
Potential therapeutic effects of Cordyceps cicadae and Paecilomyces cicadae on adenine-induced chronic renal failure in rats and their phytochemical analysis
Ling Li, Tong Zhang, Chunru Li, Lu Xie, Ning Li, Tianling Hou, Yuqin Wang, Bing Wang
Drug Des Devel Ther. 2019; 13: 103–117. Published online 2018 Dec 19. doi: 10.2147/DDDT.S180543
PMCID:
PMC6304081
Article PubReader PDF–5.1MCite
Tetrandrine suppresses cervical cancer growth by inducing apoptosis in vitro and in vivo
Haiyan Zhang, Beibei Xie, Zhen Zhang, Xiugui Sheng, Shiqian Zhang
Drug Des Devel Ther. 2019; 13: 119–127. Published online 2018 Dec 20. doi: 10.2147/DDDT.S187776
PMCID:
PMC6304242
Article PubReader PDF–1.7MCite
Pharmacokinetic interactions and tolerability of berberine chloride with simvastatin and fenofibrate: an open-label, randomized, parallel study in healthy Chinese subjects
Guofei Li, Mingming Zhao, Feng Qiu, Yaxin Sun, Limei Zhao
Drug Des Devel Ther. 2019; 13: 129–139. Published online 2018 Dec 20. doi: 10.2147/DDDT.S185487
PMCID:
PMC6304249
Article PubReader PDF–525KCite
Fenofibrate modified-release pellets with lag phase and high oral bioavailability
Fang Li, Xin Zheng, YongChu Bao, Ting Chen, Jia Zeng, XiaoLi Xu, Chao Yan, LingLin Feng
Drug Des Devel Ther. 2019; 13: 141–151. Published online 2018 Dec 24. doi: 10.2147/DDDT.S179266
PMCID:
PMC6307495
Article PubReader PDF–2.8MCite
Neuroprotective effects of dexmedetomidine against isoflurane-induced neuronal injury via glutamate regulation in neonatal rats
Xue Wang, Yangyang Shan, Zhiyin Tang, Linlin Gao, Hongtao Liu
Drug Des Devel Ther. 2019; 13: 153–160. Published online 2018 Dec 21. doi: 10.2147/DDDT.S163197
PMCID:
PMC6306062
Article PubReader PDF–1.3MCite
Urapidil, compared to nitroglycerin, has better clinical safety in the treatment of hypertensive patients with acute heart failure: a meta-analysis
Jiaxiao Shi, Yulin Li, Cong Xing, Peng Peng, Hongyu Shi, Han Ding, Pengyuan Zheng, Guangzhi Ning, Shiqing Feng
Drug Des Devel Ther. 2019; 13: 161–172. Published online 2018 Dec 27. doi: 10.2147/DDDT.S185972
PMCID:
PMC6312052
Article PubReader PDF–1.2MCite
Xyloketal derivative C53N protects against mild traumatic brain injury in mice
Fengyin Liang, Fengjuan Su, Xiaoxiao Wang, Simei Long, Yinglin Zheng, Xiaofei He, Jiyan Pang, Zhong Pei
Drug Des Devel Ther. 2019; 13: 173–182. Published online 2018 Dec 27. doi: 10.2147/DDDT.S177951
PMCID:
PMC6312055
Article PubReader PDF–3.0MCite
Efficacy and safety of sodium cantharidinate and vitamin B6 injection for the treatment of digestive system neoplasms: a meta-analysis of randomized controlled trials
Meirong Liu, Chunhong Xu, Yingying Sun
Drug Des Devel Ther. 2019; 13: 183–203. Published online 2018 Dec 28. doi: 10.2147/DDDT.S190674
PMCID:
PMC6312696
Article PubReader PDF–3.2MCite
Formulation and clinical investigation of optimized vinpocetine lyoplant-tabs: new strategy in development of buccal solid dosage form
Tarek A Ahmed
Drug Des Devel Ther. 2019; 13: 205–220. Published online 2018 Dec 28. doi: 10.2147/DDDT.S189105
PMCID:
PMC6312694
Article PubReader PDF–1.5MCite
A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model
Yejin Yang, Wooseong Kim, Dayoon Kim, Seongkeun Jeong, Jin-Wook Yoo, Yunjin Jung
Drug Des Devel Ther. 2019; 13: 231–242. Published online 2018 Dec 28. doi: 10.2147/DDDT.S185257
PMCID:
PMC6312693
Article PubReader PDF–1.3MCite
Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway
Yuan Wang, Yali Shao, Yuqing Gao, Guoran Wan, Dong Wan, Huifeng Zhu, Yan Qiu, Xiyue Ye
Drug Des Devel Ther. 2019; 13: 243–253. Published online 2018 Dec 31. doi: 10.2147/DDDT.S188968
PMCID:
PMC6319426
Article PubReader PDF–1.0MCite
Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles
Xiaomei Huang, Suhua Zhang, Yanxia Ma, Heng Yang, Chuan He, Rufang Tian, Han Mei, Lipeng Liu, Bikui Zhang
Drug Des Devel Ther. 2019; 13: 255–264. Published online 2018 Dec 31. doi: 10.2147/DDDT.S182965
PMCID:
PMC6319427
Article PubReader PDF–391KCite
Effect of progesterone administration on the prognosis of patients with severe traumatic brain injury: a meta-analysis of randomized clinical trials
Zhi-Yong Pan, Yu-Hang Zhao, Wen-Hong Huang, Zhi-Ze Xiao, Zhi-Qiang Li
Drug Des Devel Ther. 2019; 13: 265–273. Published online 2019 Jan 11. doi: 10.2147/DDDT.S192633
PMCID:
PMC6333322
Article PubReader PDF–581KCite
Endostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways
Haitao Ren, Yuan Li, Yan Chen, Liang Wang
Drug Des Devel Ther. 2019; 13: 285–290. Published online 2019 Jan 11. doi: 10.2147/DDDT.S191617
Correction in:
Drug Des Devel Ther. 2019; 13: 499–500.
PMCID:
PMC6333321
Article PubReader PDF–1.1MCite
Intravitreal corticosteroid implant vs intravitreal ranibizumab for the treatment of macular edema: a meta-analysis of randomized controlled trials
Qingquan Wei, Rui Chen, Qiyang Lou, Jing Yu
Drug Des Devel Ther. 2019; 13: 301–307. Published online 2019 Jan 11. doi: 10.2147/DDDT.S184520
PMCID:
PMC6333386
Article PubReader PDF–702KCite
YB-1 modulates the drug resistance of glioma cells by activation of MDM2/p53 pathway
Hui Tong, Kai Zhao, Jingyu Zhang, Jinxin Zhu, Jianqi Xiao
Drug Des Devel Ther. 2019; 13: 317–326. Published online 2019 Jan 14. doi: 10.2147/DDDT.S185514
PMCID:
PMC6338113
Article PubReader PDF–2.3MCite
Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation
Denise MS van Marion, Xu Hu, Deli Zhang, Femke Hoogstra-Berends, Jean-Paul G Seerden, Lizette Loen, Andre Heeres, Herman Steen, Robert H Henning, Bianca JJM Brundel
Drug Des Devel Ther. 2019; 13: 345–364. Published online 2019 Jan 18. doi: 10.2147/DDDT.S176924
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Different effects of oxycodone and remifentanil in patients undergoing ultrasound-guided percutaneous radiofrequency ablation of hepatic cancer: a randomized trial
Junbei Wu, Yunhong Lu, Xiaofei Cao
Drug Des Devel Ther. 2019; 13: 365–372. Published online 2019 Jan 18. doi: 10.2147/DDDT.S188728
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Development of dual delivery antituberculotic system containing rifapentine microspheres and adipose stem cells seeded in hydroxyapatite/tricalcium phosphate
Qiuzhen Liang, Xinghua Song, Shengli She, Zhen Wang, Chong Wang, Dawei Jiang
Drug Des Devel Ther. 2019; 13: 373–384. Published online 2019 Jan 18. doi: 10.2147/DDDT.S190696
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Melatonin receptor stimulation by agomelatine prevents Aβ-induced tau phosphorylation and oxidative damage in PC12 cells
Kai Yao, Yong-fei Zhao, Heng-bing Zu
Drug Des Devel Ther. 2019; 13: 387–396. Published online 2019 Jan 21. doi: 10.2147/DDDT.S182684
PMCID:
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A real-life experience of sorafenib treatment for patients with advanced hepatocellular carcinoma: a retrospective analysis at Cathay General Hospital, 2007–2015
Chi-Chun Huang, Hsin-Yi Chen, Ruei-Hsin Chang, Pen-An Liao, Heng-Hui Lien, Chih-Sheng Hung, Sien-Sing Yang, Jui-Ting Hu
Drug Des Devel Ther. 2019; 13: 397–404. Published online 2019 Jan 22. doi: 10.2147/DDDT.S191334
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Statin use and prognosis of lung cancer: a systematic review and meta-analysis of observational studies and randomized controlled trials
Dao-Kui Xia, Zhi-Gang Hu, Yu-Feng Tian, Fan-Jun Zeng
Drug Des Devel Ther. 2019; 13: 405–422. Published online 2019 Jan 23. doi: 10.2147/DDDT.S187690
PMCID:
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Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators
Buthina Abdallah Al-Oudat, Mohammad Ali Alqudah, Suaad Abdallah Audat, Qosay Ali Al-Balas, Tamam El-Elimat, Mohammad Abdelhafeez Hassan, Islam Nawaf Frhat, Marwah Mohammad Azaizeh
Drug Des Devel Ther. 2019; 13: 423–433. Published online 2019 Jan 22. doi: 10.2147/DDDT.S189476
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MicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689
Hui Zeng, Jiaping Zheng, Song Wen, Jun Luo, Guoliang Shao, Yongjun Zhang
Drug Des Devel Ther. 2019; 13: 435–445. Published online 2019 Jan 22. doi: 10.2147/DDDT.S186352
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Structure–activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities
Yuzhang Liu, Qiang Du, Chengbang Ma, Xinping Xi, Lei Wang, Mei Zhou, James F Burrows, Tianbao Chen, Hui Wang
Drug Des Devel Ther. 2019; 13: 447–458. Published online 2019 Jan 23. doi: 10.2147/DDDT.S191072
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Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway
Shiyu Gao, Jianwei Lin, Tianqi Wang, Yan Shen, Yan Li, Wenyu Yang, Kailiang Zhou, Haiyan Hu
Drug Des Devel Ther. 2019; 13: 459–475. Published online 2019 Jan 23. doi: 10.2147/DDDT.S188505
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Model-dependent pharmacokinetic analysis of enalapril administered to healthy adult volunteers using orodispersible minitablets for use in pediatrics
Muhammad Faisal, Willi Cawello, Bjoern B Burckhardt, Stephanie Laer
Drug Des Devel Ther. 2019; 13: 481–490. Published online 2019 Jan 25. doi: 10.2147/DDDT.S188417
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Neuroprotective potential of ketamine prevents developing brain structure impairment and alteration of neurocognitive function induced via isoflurane through the PI3K/AKT/GSK-3β pathway
Ruiwei Wang, Zihao Zhang, Mukesh Kumar, Guangming Xu, Mengyuan Zhang
Drug Des Devel Ther. 2019; 13: 501–512. Published online 2019 Feb 4. doi: 10.2147/DDDT.S188636
PMCID:
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Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling
Yu-jin Tang, Kai Li, Cheng-liang Yang, Ke Huang, Jing Zhou, Yu Shi, Ke-gong Xie, Jia Liu
Drug Des Devel Ther. 2019; 13: 513–521. Published online 2019 Feb 1. doi: 10.2147/DDDT.S187878
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Safety and efficacy of atezolizumab in the treatment of cancers: a systematic review and pooled-analysis
Yan Tie, Hui Yang, Rui Zhao, Heng Zheng, Daoke Yang, Jingyi Zhao, Ming Liu
Drug Des Devel Ther. 2019; 13: 523–538. Published online 2019 Feb 4. doi: 10.2147/DDDT.S188893
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The benefit of taxane-based therapies over fluoropyrimidine plus platinum (FP) in the treatment of esophageal cancer: a meta-analysis of clinical studies
Tao Wang, Jie Yu, Min Liu, Yanliang Chen, Caiyun Zhu, Lin Lu, Mingzhu Wang, Lingfeng Min, Xinxin Liu, Xizhi Zhang, Johannes A Gubat, Yong Chen
Drug Des Devel Ther. 2019; 13: 539–553. Published online 2019 Feb 5. doi: 10.2147/DDDT.S189514
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Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis
Yosuke Kameoka, Fukuko Kishi, Minako Koura, Yoshio Yamakawa, Rora Nagasawa, Fuyu Ito, Junichiro Matsuda, Osamu Suzuki, Toshinori Nakayama, Kazuo Suzuki
Drug Des Devel Ther. 2019; 13: 555–568. Published online 2019 Feb 5. doi: 10.2147/DDDT.S188651
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Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis
Jing Guo, Jie Tu, YingYing Hu, GuoXin Song, ZhiQiang Yin
Drug Des Devel Ther. 2019; 13: 581–588. Published online 2019 Feb 8. doi: 10.2147/DDDT.S194765
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The underlying mechanisms of Jie-Du-Hua-Yu granule for protecting rat liver failure
Hua Qiu, Dewen Mao, Nong Tang, Fuli Long, Rongzhen Zhang, Minggang Wang, Qinglan Shi, Jiahuan Li, Qin Jiang, Yueqiao Chen, Xiufeng Wang
Drug Des Devel Ther. 2019; 13: 589–600. Published online 2019 Feb 11. doi: 10.2147/DDDT.S180969
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Emodin induces apoptosis and autophagy of fibroblasts obtained from patient with ankylosing spondylitis
Cong Ma, Bo Wen, Qin Zhang, Pei-Pei Shao, Wen Gu, Kun Qu, Yang Shi, Bei Wang
Drug Des Devel Ther. 2019; 13: 601–609. Published online 2019 Feb 11. doi: 10.2147/DDDT.S182087
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Amine derivatives of furocoumarin induce melanogenesis by activating Akt/GSK-3β/β-catenin signal pathway
Deng Zang, Chao Niu, Haji Akber Aisa
Drug Des Devel Ther. 2019; 13: 623–632. Published online 2019 Feb 12. doi: 10.2147/DDDT.S180960
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Efficacy of a fixed dose combination of irbesartan and atorvastatin (Rovelito®) in Korean adults with hypertension and hypercholesterolemia
Sang-Hyun Ihm, Jinho Shin, Chang-Gyu Park, Cheol-Ho Kim
Drug Des Devel Ther. 2019; 13: 633–645. Published online 2019 Feb 13. doi: 10.2147/DDDT.S191973
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Ginkgo biloba extract-761 protects myocardium by regulating Akt/Nrf2 signal pathway
Xiao-jie Chen, Shu-min Ren, Jian-zeng Dong, Chun-guang Qiu, Ying-wei Chen, Hai-long Tao
Drug Des Devel Ther. 2019; 13: 647–655. Published online 2019 Feb 13. doi: 10.2147/DDDT.S191537
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Evaluation of pharmacokinetics and pharmaco­dynamics of sinomenine­hyaluronic acid conjugate after intra­articular administration for osteoarthritis treatment
Jie Liu, Huarong Shao, Shaoying Fang, Yanling Cheng, Peixue Ling, Jianying Chen
Drug Des Devel Ther. 2019; 13: 657–665. Published online 2019 Feb 15. doi: 10.2147/DDDT.S186558
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Synthesis of budesonide conjugates and their anti-inflammatory effects: a preliminary study
Yan Yan, Pengchong Wang, Ruiying Li, Ying Sun, Rui Zhang, Chuanchuan Huo, Jianfeng Xing, Yalin Dong
Drug Des Devel Ther. 2019; 13: 681–694. Published online 2019 Feb 19. doi: 10.2147/DDDT.S192348
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Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways
Youbing Tu, Yubing Liang, Yong Xiao, Jing Lv, Ruicong Guan, Fei Xiao, Yubo Xie, Qiang Xiao
Drug Des Devel Ther. 2019; 13: 695–706. Published online 2019 Feb 19. doi: 10.2147/DDDT.S188436
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Monosialoganglioside protects against bupivacaine-induced neurotoxicity caused by endoplasmic reticulum stress in rats
Benquan Liu, Jiemei Ji, Qing Feng, Xi Luo, Xiurong Yan, Yuxia Ni, Yajun He, Zhongxuan Mao, Jingchen Liu
Drug Des Devel Ther. 2019; 13: 707–718. Published online 2019 Feb 19. doi: 10.2147/DDDT.S192225
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Comparisons between ticagrelor and clopidogrel following percutaneous coronary intervention in patients with acute coronary syndrome: a comprehensive meta-analysis
Zhong-Guo Fan, Wen-Ling Zhang, Bing Xu, Jun Ji, Nai-Liang Tian, Sheng-Hu He
Drug Des Devel Ther. 2019; 13: 719–730. Published online 2019 Feb 20. doi: 10.2147/DDDT.S196535
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Maresin 1 mitigates renal ischemia/reperfusion injury in mice via inhibition of the TLR4/MAPK/NF-κB pathways and activation of the Nrf2 pathway
Yun Qiu, Yichen Wu, Hongmei Zhao, Hong Sun, Sumin Gao
Drug Des Devel Ther. 2019; 13: 739–745. Published online 2019 Feb 20. doi: 10.2147/DDDT.S188654
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Resveratrol attenuates hydrogen peroxide-induced aging through upregulation of autophagy in human umbilical vein endothelial cells
Ligen Du, Enping Chen, Ting Wu, Yunjun Ruan, Saizhu Wu
Drug Des Devel Ther. 2019; 13: 747–755. Published online 2019 Feb 22. doi: 10.2147/DDDT.S179894
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siRNA-based breast cancer therapy by suppressing 17β-hydroxysteroid dehydrogenase type 1 in an optimized xenograft cell and molecular biology model in vivo
Fang Li, ZhiHan Zhu, Man Xue, WanHong He, Ting Zhang, LingLin Feng, ShengXiang Lin
Drug Des Devel Ther. 2019; 13: 757–766. Published online 2019 Feb 22. doi: 10.2147/DDDT.S180836
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Ginkgolide B ameliorates myocardial ischemia reperfusion injury in rats via inhibiting endoplasmic reticulum stress
Changlei Guo, Junbiao Zhang, Peiyong Zhang, Aoyang Si, Zhenling Zhang, Liangping Zhao, Fenghua Lv, Guoan Zhao
Drug Des Devel Ther. 2019; 13: 767–774. Published online 2019 Feb 26. doi: 10.2147/DDDT.S179101
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Synthesis, structure elucidation, and antifungal potential of certain new benzodioxole–imidazole molecular hybrids bearing ester functionalities
Reem I Al-Wabli, Alwah R Al-Ghamdi, Hazem A Ghabbour, Mohamed H Al-Agamy, Mohamed I Attia
Drug Des Devel Ther. 2019; 13: 775–789. Published online 2019 Feb 26. doi: 10.2147/DDDT.S199135
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Single-use suvorexant for treating insomnia during overnight polysomnography in patients with suspected obstructive sleep apnea: a single-center experience
Takuma Matsumura, Jiro Terada, Chikara Yoshimura, Ken Koshikawa, Taku Kinoshita, Misuzu Yahaba, Kengo Nagashima, Seiichiro Sakao, Koichiro Tatsumi
Drug Des Devel Ther. 2019; 13: 809–816. Published online 2019 Feb 28. doi: 10.2147/DDDT.S197237
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Clinical efficacy and safety of rituximab in lupus nephritis
Zhiqing Zhong, Hongyan Li, Hongzhen Zhong, Tianbiao Zhou
Drug Des Devel Ther. 2019; 13: 845–856. Published online 2019 Mar 11. doi: 10.2147/DDDT.S195113
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Efficacy and safety of tacrolimus in induction therapy of patients with lupus nephritis
Tianbiao Zhou, Shujun Lin, Shen Yang, Wenshan Lin
Drug Des Devel Ther. 2019; 13: 857–869. Published online 2019 Mar 12. doi: 10.2147/DDDT.S189156
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Intraoperative dexmedetomidine infusion is associated with reduced emergence agitation and improved recovery profiles after lung surgery: a retrospective cohort study
Xianhui Kang, Xiaodong Tang, Yang Yu, Fangping Bao, Shuyuan Gan, Wei Zheng, Jian Zhang, Shengmei Zhu
Drug Des Devel Ther. 2019; 13: 871–879. Published online 2019 Mar 12. doi: 10.2147/DDDT.S195221
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Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis
Hong Huang, Houhe Liu, Hua Zhou, Zhiling Liang, Dandan Song, Yun Zhang, Wanqiu Huang, Xiaotian Zhao, Bo Wu, Guodong Ye, Yugang Huang
Drug Des Devel Ther. 2019; 13: 881–896. Published online 2019 Mar 12. doi: 10.2147/DDDT.S180842
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Hexyl alginate derivative, an amphiphilic innovative buccal film-forming material of promising mechanical and release characteristics for the improvement of repaglinide bioavailability
Ahmed Khames
Drug Des Devel Ther. 2019; 13: 925–940. Published online 2019 Mar 21. doi: 10.2147/DDDT.S196425
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Increased branching and sialylation of N-linked glycans correlate with an improved pharmacokinetic profile for BAY 81–8973 compared with other full-length rFVIII products
John M Teare, David S Kates, Anita Shah, Stephen Garger
Drug Des Devel Ther. 2019; 13: 941–948. Published online 2019 Mar 22. doi: 10.2147/DDDT.S188171
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Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects
Patricia N Sidharta, Meggane Melchior, Martin K Kankam, Jasper Dingemanse
Drug Des Devel Ther. 2019; 13: 949–964. Published online 2019 Mar 22. doi: 10.2147/DDDT.S199051
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Effectiveness and safety of intravenous application of dexmedetomidine for cesarean section under general anesthesia: a meta-analysis of randomized trials
Li Ao, Jinlin Shi, Yaowu Bai, Yujuan Zheng, Jianhui Gan
Drug Des Devel Ther. 2019; 13: 965–974. Published online 2019 Mar 25. doi: 10.2147/DDDT.S197165
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Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes
Bozhi Ye, Xudong Chen, Shanshan Dai, Jibo Han, Xiaohe Liang, Shuang Lin, Xueli Cai, Zhouqing Huang, Weijian Huang
Drug Des Devel Ther. 2019; 13: 975–990. Published online 2019 Mar 25. doi: 10.2147/DDDT.S195412
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Pharmacokinetic comparison of a fixed-dose combination versus concomitant administration of amlodipine, olmesartan, and rosuvastatin in healthy adult subjects
Minkyung Oh, Jae-Gook Shin, Sangzin Ahn, Bo Hoon Kim, Ji Yeon Kim, Hyun Ju Shin, Hyun Ju Shin, Jong-Lyul Ghim
Drug Des Devel Ther. 2019; 13: 991–997. Published online 2019 Apr 3. doi: 10.2147/DDDT.S202730
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Efficacy and safety of paricalcitol in patients undergoing hemodialysis: a meta-analysis
Yang Liu, Ling-Yun Liu, Ye Jia, Mei-Yan Wu, Yan-Yan Sun, Fu-Zhe Ma
Drug Des Devel Ther. 2019; 13: 999–1009. Published online 2019 Mar 28. doi: 10.2147/DDDT.S176257
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A first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson’s disease, in healthy volunteers
Wonsuk Shin, Kyoung Soo Lim, Min-Kyoung Kim, Hyun Sook Kim, Jihwa Hong, Stanford Jhee, Joseph Kim, Sungeun Yoo, Yeon-Tae Chung, Jae Moon Lee, Doo-Yeoun Cho
Drug Des Devel Ther. 2019; 13: 1011–1022. Published online 2019 Mar 29. doi: 10.2147/DDDT.S198753
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Jinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway
Jingren Shi, Wenli Zhang, Lu He, Fanhong Kong, Meichen Pan, Jingjing Guo, Xinmin Xu, Jie Guo, Huizhu Wang, Yajie Wang
Drug Des Devel Ther. 2019; 13: 1023–1032. Published online 2019 Apr 1. doi: 10.2147/DDDT.S195409
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Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system
Nora Freyer, Fanny Knöspel, Georg Damm, Selina Greuel, Christin Schneider, Daniel Seehofer, Thomas Stöhr, Karl-Uwe Petersen, Katrin Zeilinger
Drug Des Devel Ther. 2019; 13: 1033–1047. Published online 2019 Apr 2. doi: 10.2147/DDDT.S186759
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Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers
Mi-Hong Min, Jin-Hyong Park, Jong-Hyun Hur, Ho-Chul Shin, YoungJoo Cho, Dae-Duk Kim
Drug Des Devel Ther. 2019; 13: 1049–1058. Published online 2019 Apr 5. doi: 10.2147/DDDT.S193424
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Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo
Cuiling Zhang, Weigang Ren, Qingxin Liu, Zhikai Tan, Junwei Li, Chunyi Tong
Drug Des Devel Ther. 2019; 13: 1059–1068. Published online 2019 Apr 4. doi: 10.2147/DDDT.S195481
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Systematic elucidation of the mechanism of geraniol via network pharmacology
Yun-Fei Zhang, Yue Huang, Yi-Hua Ni, Zheng-Min Xu
Drug Des Devel Ther. 2019; 13: 1069–1075. Published online 2019 Apr 4. doi: 10.2147/DDDT.S189088
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A novel hybrid compound LLP2A-alendronate accelerates open fracture healing in a rabbit model
Zheng Wang, Yong Zhao, Dong Zhang, Baiwen Qi, Weidong Xiao, Xiang Hu, Aixi Yu
Drug Des Devel Ther. 2019; 13: 1077–1086. Published online 2019 Apr 5. doi: 10.2147/DDDT.S195937
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Lung cancer combination therapy: doxorubicin and β-elemene co-loaded, pH-sensitive nanostructured lipid carriers
Chengsong Cao, Qun Wang, Yong Liu
Drug Des Devel Ther. 2019; 13: 1087–1098. Published online 2019 Apr 5. doi: 10.2147/DDDT.S198003
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Can a cyclooxygenase inhibitor be an option for treatment of ovarian hyperstimulation syndrome?
Hasan Çilgin
Drug Des Devel Ther. 2019; 13: 1099–1105. Published online 2019 Apr 5. doi: 10.2147/DDDT.S188583
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Applications of daunorubicin-loaded PLGA-PLL-PEG-Tf nanoparticles in hematologic malignancies: an in vitro and in vivo evaluation
Wen Bao, Ran Liu, Guohua Xia, Fei Wang, Baoan Chen
Drug Des Devel Ther. 2019; 13: 1107–1115. Published online 2019 Apr 8. doi: 10.2147/DDDT.S195832
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The neuroprotective effects of curcumin are associated with the regulation of the reciprocal function between autophagy and HIF-1α in cerebral ischemia-reperfusion injury
Yang Hou, Jue Wang, Juan Feng
Drug Des Devel Ther. 2019; 13: 1135–1144. Published online 2019 Apr 9. doi: 10.2147/DDDT.S194182
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Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo
Shuifang Chen, Zeying Zhang, Jianli Zhang
Drug Des Devel Ther. 2019; 13: 1145–1153. Published online 2019 Apr 10. doi: 10.2147/DDDT.S196319
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Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation
Wessam M Abdel-Wahab, Farouzia I Moussa
Drug Des Devel Ther. 2019; 13: 1155–1162. Published online 2019 Apr 11. doi: 10.2147/DDDT.S191240
PMCID:
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Effect of umbelliferone on adjuvant-induced arthritis in rats by MAPK/NF-κB pathway
Liu Ouyang, Yang Dan, Zengwu Shao, Shuhua Yang, Cao Yang, Guohui Liu, Wu Zhou, Deyu Duan
Drug Des Devel Ther. 2019; 13: 1163–1170. Published online 2019 Apr 11. doi: 10.2147/DDDT.S190155
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Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds
Abdulsalam AM Alkhaldi, Harry P de Koning, Syed Nasir Abbas Bukhari
Drug Des Devel Ther. 2019; 13: 1179–1185. Published online 2019 Apr 24. doi: 10.2147/DDDT.S204733
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Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage
Shouliang Wang, Bin Xia, Zonglei Qiao, Lian Duan, Gongming Wang, Wenjun Meng, Zhifei Liu, Yu Wang, Mengyuan Zhang
Drug Des Devel Ther. 2019; 13: 1187–1196. Published online 2019 Apr 17. doi: 10.2147/DDDT.S196172
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Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease
Mitra Esfandiarei, Brikena Hoxha, Nicholas A Talley, Miranda R Anderson, Mustafa F Alkhouli, Michaela A Squire, Delrae M Eckman, Jeganathan Ramesh Babu, Gary D Lopaschuk, Tom L Broderick
Drug Des Devel Ther. 2019; 13: 1197–1211. Published online 2019 Apr 17. doi: 10.2147/DDDT.S196119
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Effect of butorphanol on etomidate-induced myoclonus: a systematic review and meta-analysis
Jun Hua, Shuai Miao, Mengzhu Shi, Qing Tu, Xiuli Wang, Su Liu, Guanglei Wang, Jianhui Gan
Drug Des Devel Ther. 2019; 13: 1213–1220. Published online 2019 Apr 16. doi: 10.2147/DDDT.S191982
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The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1
Hong Tao, Tuo Tang, Shengnan Wang, Ziqian Wang, Yunfei Ma, Tianyu Cai, Xiuliang Cheng, Shimei Qi, Yao Zhang, Zhilin Qi
Drug Des Devel Ther. 2019; 13: 1221–1231. Published online 2019 Apr 17. doi: 10.2147/DDDT.S201818
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Effect of loading dose of atorvastatin therapy prior to percutaneous coronary intervention in patients with acute coronary syndrome: a meta-analysis of six randomized controlled trials
Mingfeng Ma, Lixia Bu, Li Shi, Renwei Guo, Bin Yang, Huili Cao, Liangping Luo, Ligong Lu
Drug Des Devel Ther. 2019; 13: 1233–1240. Published online 2019 Apr 16. doi: 10.2147/DDDT.S196588
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In vitro comparative quality assessment of different brands of norfloxacin tablets available in Jimma, Southwest Ethiopia
Solomon Hambisa, Sileshi Belew, Sultan Suleman
Drug Des Devel Ther. 2019; 13: 1241–1249. Published online 2019 Apr 17. doi: 10.2147/DDDT.S189524
PMCID:
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Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates
Scott A Reisman, Sarabjit S Gahir, Chun-Yue I Lee, Joel W Proksch, Mitsumasa Sakamoto, Keith W Ward
Drug Des Devel Ther. 2019; 13: 1259–1270. Published online 2019 Apr 17. doi: 10.2147/DDDT.S193889
PMCID:
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Anti-tumor efficacy of folate modified PLGA-based nanoparticles for the co-delivery of drugs in ovarian cancer
Shu Li, Xiaofeng Li, Jianyi Ding, Lingfei Han, Xiaoqing Guo
Drug Des Devel Ther. 2019; 13: 1271–1280. Published online 2019 Apr 18. doi: 10.2147/DDDT.S195493
PMCID:
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Effects of dezocine for the prevention of postoperative catheter-related bladder discomfort: a prospective randomized trial
Guang-Fen Zhang, Jie Guo, Li-Li Qiu, Shu-Ming Li, Man Zheng, Jiang-Yan Xia, Jian-Jun Yang
Drug Des Devel Ther. 2019; 13: 1281–1288. Published online 2019 Apr 23. doi: 10.2147/DDDT.S199897
PMCID:
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Plumbagin inhibits proliferation and induces apoptosis of hepatocellular carcinoma by downregulating the expression of SIVA
Tingting Li, Mengjiao Lv, Xiaohua Chen, Yongsheng Yu, Guoqing Zang, Zhenghao Tang
Drug Des Devel Ther. 2019; 13: 1289–1300. Published online 2019 Apr 23. doi: 10.2147/DDDT.S200610
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Safety and sedative effect of intranasal dexmedetomidine in mandibular third molar surgery: a systematic review and meta-analysis
Shaopeng Liu, Ye Wang, Yong Zhu, Tingting Yu, Huaqiang Zhao
Drug Des Devel Ther. 2019; 13: 1301–1310. Published online 2019 Apr 23. doi: 10.2147/DDDT.S194894
PMCID:
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Epigallocatechin-3-gallate enhances the osteoblastogenic differentiation of human adipose-derived stem cells
Jing Zhang, Kai Wu, Ting Xu, Jiajun Wu, Pengfei Li, Hong Wang, Huiling Wu, Gang Wu
Drug Des Devel Ther. 2019; 13: 1311–1321. Published online 2019 Apr 23. doi: 10.2147/DDDT.S192683
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Ocular surface squamous neoplasia: angiographic characteristics and response to subconjunctival/perilesional 5-fluorouracil injections
Yuzhao Sun, Rui Hua
Drug Des Devel Ther. 2019; 13: 1323–1334. Published online 2019 Apr 29. doi: 10.2147/DDDT.S191161
PMCID:
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Caffeic acid phenethyl ester suppressed growth and metastasis of nasopharyngeal carcinoma cells by inactivating the NF-κB pathway
Yushan Liang, Guofei Feng, Liang Wu, Suhua Zhong, Xiaoyu Gao, Yan Tong, Wanmeng Cui, Yongying Qin, WenQing Xu, Xue Xiao, Zhe Zhang, Guangwu Huang, Xiaoying Zhou
Drug Des Devel Ther. 2019; 13: 1335–1345. Published online 2019 Apr 26. doi: 10.2147/DDDT.S199182
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Clinical efficacy of 60-mg dexlansoprazole and 40-mg esomeprazole after 24 weeks for the on-demand treatment of gastroesophageal reflux disease grades A and B: a prospective randomized trial
Hung-Hsien Chiang, Deng-Chyang Wu, Pin-I Hsu, Chao-Hung Kuo, Wei-Chen Tai, Shih-Cheng Yang, Keng-Liang Wu, Chih-Chien Yao, Cheng-En Tsai, Chih-Ming Liang, Yao-Kuang Wang, Jiunn-Wei Wang, Chih-Fang Huang, Seng-Kee Chuah, on behalf of the Taiwan Acid-Related Disease Study Group
Drug Des Devel Ther. 2019; 13: 1347–1356. Published online 2019 Apr 26. doi: 10.2147/DDDT.S193559
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Codelivery of GRP78 siRNA and docetaxel via RGD-PEG-DSPE/DOPA/CaP nanoparticles for the treatment of castration-resistant prostate cancer
Xiangyu Zhang, Zelai He, Longquan Xiang, Liang Li, Haiyan Zhang, Fanzhong Lin, Hongying Cao
Drug Des Devel Ther. 2019; 13: 1357–1372. Published online 2019 Apr 29. doi: 10.2147/DDDT.S198400
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The TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP
Qingsheng Huang, Yin Peng, Yuefeng Peng, Dan Wei, Yanjie Wei, Shengzhong Feng
Drug Des Devel Ther. 2019; 13: 1373–1388. Published online 2019 Apr 26. doi: 10.2147/DDDT.S194276
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Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization
Ahmed M Naglah, Moamen S Refat, Mohamed A Al-Omar, Mashooq A Bhat, Hamad M AlKahtani, Asma S Al-Wasidi
Drug Des Devel Ther. 2019; 13: 1409–1420. Published online 2019 Apr 30. doi: 10.2147/DDDT.S190310
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Enhanced immunosuppressive effects of 3,5-bis[4(diethoxymethyl)benzylidene]-1-methyl-piperidin-4-one, an α, β-unsaturated carbonyl-based compound as PLGA-b-PEG nanoparticles
Laiba Arshad, Ibrahim Jantan, Syed Nasir Abbas Bukhari
Drug Des Devel Ther. 2019; 13: 1421–1436. Published online 2019 Apr 30. doi: 10.2147/DDDT.S185191
PMCID:
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Tetramethylpyrazine improved the survival of multiterritory perforator flaps by inducing angiogenesis and suppressing apoptosis via the Akt/Nrf2 pathway
LiMing Qing, PanFeng Wu, ZhengBing Zhou, Fang Yu, JuYu Tang
Drug Des Devel Ther. 2019; 13: 1437–1447. Published online 2019 May 1. doi: 10.2147/DDDT.S195090
PMCID:
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Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells
Yanxi Li, Xiaoxue Qin, Penglei Li, Hao Zhang, Tao Lin, Ziwei Miao, Siping Ma
Drug Des Devel Ther. 2019; 13: 1449–1460. Published online 2019 May 1. doi: 10.2147/DDDT.S192681
PMCID:
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Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress
Jinti Lin, Chang Jia, Yongli Wang, Shanghong Jiang, Zhenyu Jia, Nan Chen, Shimin Sheng, Shihen Li, Liangfu Jiang, Huazi Xu, Kailiang Zhou, Yijie Chen
Drug Des Devel Ther. 2019; 13: 1461–1472. Published online 2019 May 1. doi: 10.2147/DDDT.S195479
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Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro
Hang Zhao, Yunjia Zhang, Linyi Shu, Guangyao Song, Huijuan Ma
Drug Des Devel Ther. 2019; 13: 1473–1485. Published online 2019 May 2. doi: 10.2147/DDDT.S203833
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In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model
Arif Malik, Uzma Jamil, Tariq Tahir Butt, Sulayman Waquar, Siew Hua Gan, Hassan Shafique, Tassadaq Hussain Jafar
Drug Des Devel Ther. 2019; 13: 1501–1513. Published online 2019 May 6. doi: 10.2147/DDDT.S176698
PMCID:
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Glibenclamide alleviates inflammation in oleic acid model of acute lung injury through NLRP3 inflammasome signaling pathway
Hong Chen, Yongjie Ding, Wei Chen, Yun Feng, Guochao Shi
Drug Des Devel Ther. 2019; 13: 1545–1554. Published online 2019 May 7. doi: 10.2147/DDDT.S196040
PMCID:
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Protective effects of five compounds from Livistona chinensis R. Brown leaves against hypoxia/reoxygenation, H2O2, or adriamycin-induced injury in H9c2 cells
Shaoguang Li, Shaohong Luo, Hao Chen, Yanjie Zheng, Liqing Lin, Hong Yao, Xinhua Lin
Drug Des Devel Ther. 2019; 13: 1555–1566. Published online 2019 May 8. doi: 10.2147/DDDT.S201816
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Formulation and evaluation of simvastatin polymeric nanoparticles loaded in hydrogel for optimum wound healing purpose
Usama Farghaly Aly, Heba A Abou-Taleb, Ahmed AH Abdellatif, Nahla Sameh Tolba
Drug Des Devel Ther. 2019; 13: 1567–1580. Published online 2019 May 10. doi: 10.2147/DDDT.S198413
PMCID:
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Extending the application of a magnetic PEG three-part drug release device on a graphene substrate for the removal of Gram-positive and Gram-negative bacteria and cancerous and pathologic cells
M Ramezani Farani, P Khadive Parsi, Gh Riazi, M Shafiee Ardestani, H Saligeh Rad
Drug Des Devel Ther. 2019; 13: 1581–1591. Published online 2019 May 10. doi: 10.2147/DDDT.S181090
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Comparison of the efficacy and safety of remifentanil versus different pharmacological approaches on prevention of etomidate-induced myoclonus: a meta-analysis of randomized controlled trials
Bingchen Lang, Lingli Zhang, Fengshan Li, Yunzhu Lin, Wensheng Zhang, Chunsong Yang
Drug Des Devel Ther. 2019; 13: 1593–1607. Published online 2019 May 9. doi: 10.2147/DDDT.S200200
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6,7-Dihydroxy-2-(4′-hydroxyphenyl)naphthalene induces HCT116 cell apoptosis through activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway
Ching-Feng Chiu, Guan-Ying Lai, Chung-Hwan Chen, Chien-Chao Chiu, Shao-Wen Hung, Chi-Fen Chang
Drug Des Devel Ther. 2019; 13: 1609–1621. Published online 2019 May 9. doi: 10.2147/DDDT.S193914
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Pharmacokinetics of fixed-dose combination of atorvastatin and metformin compared with individual tablets
Jong-Lyul Ghim, Nguyen Thi Thu Phuong, Min Jung Kim, Eun-Ji Kim, Geun Seog Song, Sangzin Ahn, Jae-Gook Shin, Eun-Young Kim
Drug Des Devel Ther. 2019; 13: 1623–1632. Published online 2019 May 13. doi: 10.2147/DDDT.S193254
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Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation
Zaman Ashraf, Tariq Mahmood, Mubashir Hassan, Samina Afzal, Hummera Rafique, Khurram Afzal, Jalifah Latip
Drug Des Devel Ther. 2019; 13: 1643–1657. Published online 2019 May 14. doi: 10.2147/DDDT.S178595
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Andrographolide attenuates bupivacaine-induced cytotoxicity in SH-SY5Y cells through preserving Akt/mTOR activity
Huiyuan Zhang, Weiwei Wang, Qian Du
Drug Des Devel Ther. 2019; 13: 1659–1666. Published online 2019 May 16. doi: 10.2147/DDDT.S201122
PMCID:
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Cardiovascular adverse events during treatment with darunavir-based regimens in an Italian observational study
A Antinori, S Rusconi, N Gianotti, T Bini, D Mancusi, R Termini
Drug Des Devel Ther. 2019; 13: 1667–1685. Published online 2019 May 14. doi: 10.2147/DDDT.S180981
PMCID:
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Sevoflurane post-conditioning alleviates neonatal rat hypoxic-ischemic cerebral injury via Ezh2-regulated autophagy
Hang Xue, Ying Xu, Shuo Wang, Zi-Yi Wu, Xing-Yue Li, Ya-Han Zhang, Jia-Yuan Niu, Qiu-Shi Gao, Ping Zhao
Drug Des Devel Ther. 2019; 13: 1691–1706. Published online 2019 May 15. doi: 10.2147/DDDT.S197325
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Subcutaneous bortezomib might be standard of care for patients with multiple myeloma: a systematic review and meta-analysis
Ziqi Ye, Jie Chen, Zixue Xuan, Wenchao Yang, Jing Chen
Drug Des Devel Ther. 2019; 13: 1707–1716. Published online 2019 May 16. doi: 10.2147/DDDT.S198117
PMCID:
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Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy
Jeong Yee, Woorim Kim, Byung Chul Chang, Jee Eun Chung, Kyung Eun Lee, Hye Sun Gwak
Drug Des Devel Ther. 2019; 13: 1717–1727. Published online 2019 May 17. doi: 10.2147/DDDT.S198018
PMCID:
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The effect of midazolam administration for the prevention of emergence agitation in pediatric patients with extreme fear and non-cooperation undergoing dental treatment under sevoflurane anesthesia, a double-blind, randomized study
Mari Kawai, Shinji Kurata, Takuro Sanuki, Gaku Mishima, Kensuke Kiriishi, Toshihiro Watanabe, Yu Ozaki-Honda, Mizuki Yoshida, Ichiro Okayasu, Terumi Ayuse, Naomi Tanoue, Takao Ayuse
Drug Des Devel Ther. 2019; 13: 1729–1737. Published online 2019 May 17. doi: 10.2147/DDDT.S198123
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Bioequivalence of paclitaxel protein-bound particles in patients with breast cancer: determining total and unbound paclitaxel in plasma by rapid equilibrium dialysis and liquid chromatography–tandem mass spectrometry
Junling Li, Wei Li, Xiaojian Dai, Dafang Zhong, Yaping Ding, Xiaoyan Chen
Drug Des Devel Ther. 2019; 13: 1739–1749. Published online 2019 May 20. doi: 10.2147/DDDT.S200679
PMCID:
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Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6
Joomi Lee, Hee-Doo Yoo, Jung-Woo Bae, Sooyeun Lee, Kwang-Hee Shin
Drug Des Devel Ther. 2019; 13: 1751–1761. Published online 2019 May 23. doi: 10.2147/DDDT.S199574
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SU5416 attenuated lipopolysaccharide-induced acute lung injury in mice by modulating properties of vascular endothelial cells
Xuqing Huang, Junqi Zhu, Yuyue Jiang, Changqing Xu, Qun Lv, Dongwei Yu, Kai Shi, Zhaoyang Ruan, Yan Wang
Drug Des Devel Ther. 2019; 13: 1763–1772. Published online 2019 May 23. doi: 10.2147/DDDT.S188858
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Synthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents
Ahmed A Elhenawy, LM Al-Harbi, Gaber O Moustafa, MA El-Gazzar, Rehab F Abdel-Rahman, Abd Elhamid Salim
Drug Des Devel Ther. 2019; 13: 1773–1790. Published online 2019 May 24. doi: 10.2147/DDDT.S196276
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Low-dose doxycycline inhibits hydrogen peroxide-induced oxidative stress, MMP-2 up-regulation and contractile dysfunction in human saphenous vein grafts
Mazen Saeed, Mehmet Zuhuri Arun, Mehmet Guzeloglu, Ceylan Onursal, Goksel Gokce, Ceren Gonen Korkmaz, Buket Reel
Drug Des Devel Ther. 2019; 13: 1791–1801. Published online 2019 May 23. doi: 10.2147/DDDT.S187842
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Effect of dexmedetomidine on etomidate-induced myoclonus: a randomized, double-blind controlled trial
Shuai Miao, Lan Zou, Guanglei Wang, Xiuli Wang, Su Liu, Mengzhu Shi
Drug Des Devel Ther. 2019; 13: 1803–1808. Published online 2019 May 27. doi: 10.2147/DDDT.S194456
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Frequency, clinical features and differential response to therapy of concurrent ALK/EGFR alterations in Chinese lung cancer patients
Jixian Liu, Zhimin Mu, Li Liu, Kang Li, Richeng Jiang, Peng Chen, Qiang Zhou, Meiling Jin, Yuxiang Ma, Yuancai Xie, Jianxing Xiang, Bing Li, Yafeng Ma, Xinru Mao, Lu Zhang, Tengfei Zhang, Da Wu
Drug Des Devel Ther. 2019; 13: 1809–1817. Published online 2019 May 23. doi: 10.2147/DDDT.S196189
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A novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome
Michiyo Asano, Junko H Ohyashiki, Chiaki Kobayashi-Kawana, Tomohiro Umezu, Satoshi Imanishi, Kenko Azuma, Daigo Akahane, Hiroaki Fujimoto, Yoshikazu Ito, Kazuma Ohyashiki
Drug Des Devel Ther. 2019; 13: 1821–1833. Published online 2019 May 30. doi: 10.2147/DDDT.S195071
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Resveratrol downregulates TNF-α-induced monocyte chemoattractant protein-1 in primary rat pulmonary artery endothelial cells by P38 mitogen-activated protein kinase signaling
Jian-Wei Lin, Le-He Yang, Zhuo-Chao Ren, De-Guang Mu, Ya-Qing Li, Jian-Ping Yan, Liang-Xing Wang, Chun Chen
Drug Des Devel Ther. 2019; 13: 1843–1853. Published online 2019 May 27. doi: 10.2147/DDDT.S184785
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Comparative proteomics reveal negative effects of gonadotropin-releasing hormone agonist and antagonist on human endometrium
Qian Chen, Feng Yu, Yan Li, Ai-Jun Zhang, Xiao-Bin Zhu
Drug Des Devel Ther. 2019; 13: 1855–1863. Published online 2019 May 30. doi: 10.2147/DDDT.S201871
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Efficacy and toxicity of cladribine for the treatment of refractory acute myeloid leukemia: a meta-analysis
Anqi Zhou, Qi Han, Huihui Song, Jie Zi, Jinlong Ma, Zheng Ge
Drug Des Devel Ther. 2019; 13: 1867–1878. Published online 2019 May 29. doi: 10.2147/DDDT.S207425
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Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways
Rong Wang, Fuxing Song, Shengnan Li, Bin Wu, Yanqiu Gu, Yongfang Yuan
Drug Des Devel Ther. 2019; 13: 1889–1900. Published online 2019 May 31. doi: 10.2147/DDDT.S194787
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Effects of Qi Teng Xiao Zhuo granules on circRNA expression profiles in rats with chronic glomerulonephritis
Jia-Rong Gao, Nan-Nan Jiang, Hui Jiang, Liang-Bing Wei, Ya-Chen Gao, Xiu-Juan Qin, Meng-Qing Zhu, Jing Wang
Drug Des Devel Ther. 2019; 13: 1901–1913. Published online 2019 Jun 4. doi: 10.2147/DDDT.S191386
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Decreased sEng plasma levels in hypertensive patients with endothelial dysfunction under chronic treatment with Perindopril
Valentina Buda, Minodora Andor, Dana Emilia Baibata, Ramona Cozlac, Gabriela Radu, Dorina Coricovac, Corina Danciu, Ionut Ledeti, Adelina Cheveresan, Cristian Nica, Paul Tuduce, Mirela Cleopatra Tomescu
Drug Des Devel Ther. 2019; 13: 1915–1925. Published online 2019 Jun 4. doi: 10.2147/DDDT.S186378
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Notopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells
Qinwan Huang, Lin Wang, Qian Ran, Jin Wang, Chengqiang Wang, Hui He, Li Li, Hongyi Qi
Drug Des Devel Ther. 2019; 13: 1927–1940. Published online 2019 Jun 6. doi: 10.2147/DDDT.S189969
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Solutol®HS15+pluronicF127 and Solutol®HS15+pluronicL61 mixed micelle systems for oral delivery of genistein
Pinggang Ding, Yuxuan Chen, Guangshang Cao, Hongxue Shen, Jianming Ju, Weiguang Li
Drug Des Devel Ther. 2019; 13: 1947–1956. Published online 2019 Jun 7. doi: 10.2147/DDDT.S201453
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The neuroprotective effect of bisperoxovandium (pyridin-2-squaramide) in intracerebral hemorrhage
Xin-Yu Liao, Yang Lei, Song-Feng Chen, Jing Cheng, Dan Zhao, Zhi-Feng Zhang, Xin Han, Ya Zhang, Hua-Bao Liao, Yang Zhuang, Juan Chen, Hai-Bing Zhou, Qi Wan, Ying-Ying Zou
Drug Des Devel Ther. 2019; 13: 1957–1967. Published online 2019 Jun 13. doi: 10.2147/DDDT.S204956
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TMF inhibits miR-29a/Wnt/β-catenin signaling through upregulating Foxo3a activity in osteoarthritis chondrocytes
Xianhua Huang, Zhixi Chen, Weimei Shi, Rui Zhang, Linfu Li, Hai Liu, Longhuo Wu
Drug Des Devel Ther. 2019; 13: 2009–2019. Published online 2019 Jun 19. doi: 10.2147/DDDT.S209694
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A novel mutation panel for predicting etoposide resistance in small-cell lung cancer
Zhengang Qiu, Anqi Lin, Kun Li, Weiyin Lin, Qiongyao Wang, Ting Wei, Weiliang Zhu, Peng Luo, Jian Zhang
Drug Des Devel Ther. 2019; 13: 2021–2041. Published online 2019 Jun 21. doi: 10.2147/DDDT.S205633
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In vitro and in vivo effect of hyaluronic acid modified, doxorubicin and gallic acid co-delivered lipid-polymeric hybrid nano-system for leukemia therapy
Yanping Shao, Wenda Luo, Qunyi Guo, Xiaohong Li, Qianqian Zhang, Jing Li
Drug Des Devel Ther. 2019; 13: 2043–2055. Published online 2019 Jun 28. doi: 10.2147/DDDT.S202818
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Ginsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a
Haiyan Liang, Suwei Zhang, Zhiling Li
Drug Des Devel Ther. 2019; 13: 2057–2066. Published online 2019 Jun 24. doi: 10.2147/DDDT.S208328
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Dexmedetomidine protects PC12 cells from lidocaine-induced cytotoxicity via downregulation of Stathmin 1
Yonghong Tan, Xiaobao Bi, Qiong Wang, Yu Li, Na Zhang, Jianxin Lao, Xiaoping Liu
Drug Des Devel Ther. 2019; 13: 2067–2079. Published online 2019 Jul 3. doi: 10.2147/DDDT.S199572
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Phosphocreatine attenuates Gynura segetum-induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway
Dong-Ping Li, Ying-Ling Chen, Hong-Yue Jiang, Yun Chen, Xiao-Qing Zeng, Li-Li Xu, Yang Ye, Chang-Qiang Ke, Ge Lin, Ji-Yao Wang, Hong Gao
Drug Des Devel Ther. 2019; 13: 2081–2096. Published online 2019 Jun 27. doi: 10.2147/DDDT.S203564
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Impact of different emulsifiers on biocompatibility and inflammatory potential of Perfluorohexyloctane (F6H8) emulsions for new intravenous drug delivery systems
Charalambos Tsagogiorgas, Friedrich Anger, Grietje Beck, Annette Breedijk, Benito Yard, Simone Hoeger
Drug Des Devel Ther. 2019; 13: 2097–2110. Published online 2019 Jun 27. doi: 10.2147/DDDT.S195954
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Ginsenoside Rb1 pretreatment reverses hippocampal changes in BDNF/TrkB mRNA and protein in rats subjected to acute immobilization stress
Xianhui Kang, Wandong Hong, Kangjie Xie, Hongli Tang, Jingjing Tang, Shan Luo, Wujun Geng, Danyun Jia
Drug Des Devel Ther. 2019; 13: 2127–2134. Published online 2019 Jul 1. doi: 10.2147/DDDT.S201135
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Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells
Kang Wang, Zhengyang Zhang, Ming Wang, Xiongfeng Cao, Jianchen Qi, Dongqing Wang, Aihua Gong, Haitao Zhu
Drug Des Devel Ther. 2019; 13: 2135–2144. Published online 2019 Jul 2. doi: 10.2147/DDDT.S199459
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Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study
Nguyen Trung Kien, Phillip Geiger, Hoang Van Chuong, Nguyen Manh Cuong, Ngo Van Dinh, Dinh Cong Pho, Vu The Anh, Nguyen Truong Giang
Drug Des Devel Ther. 2019; 13: 2145–2152. Published online 2019 Jul 3. doi: 10.2147/DDDT.S202410
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Novel peptide myristoly-CM4 induces selective cytotoxicity in leukemia K562/MDR and Jurkat cells by necrosis and/or apoptosis pathway
Huidan Zhang, Dongju Han, Tongtong Lv, Kehang Liu, Yunqing Yang, Xixi Xu, Yuqing Chen
Drug Des Devel Ther. 2019; 13: 2153–2167. Published online 2019 Jul 2. doi: 10.2147/DDDT.S207224
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Evaluation of novel pyrimidine derivatives as a new class of mushroom tyrosinase inhibitor
S Shohreh Mirmortazavi, Mahdieh Farvandi, Hossein Ghafouri, Asadollah Mohammadi, Mostafa Shourian
Drug Des Devel Ther. 2019; 13: 2169–2178. Published online 2019 Jul 8. doi: 10.2147/DDDT.S209324
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Efficacy and safety of tacrolimus vs cyclophosphamide in the therapy of patients with idiopathic membranous nephropathy: a meta-analysis
Wenshan Lin, Hong-Yan Li, Shujun Lin, Tianbiao Zhou
Drug Des Devel Ther. 2019; 13: 2179–2186. Published online 2019 Jul 3. doi: 10.2147/DDDT.S209211
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Tablet or capsule form of generic mycophenolate mofetil (My-Rept®) after liver transplantation: a prospective randomized trial
Jong Man Kim, Jong Wook Oh, Sangjin Kim, Jinsoo Rhu, Ji Soo Lee, Kyeong Sik Kim, Gyu-Seong Choi, Jae-Won Joh
Drug Des Devel Ther. 2019; 13: 2187–2193. Published online 2019 Jul 2. doi: 10.2147/DDDT.S204056
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Activation of the P38/CREB/MMP13 axis is associated with osteoarthritis
Bin Ji, Yan Ma, Haimin Wang, Xiangqian Fang, Peihua Shi
Drug Des Devel Ther. 2019; 13: 2195–2204. Published online 2019 Jul 3. doi: 10.2147/DDDT.S209626
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Delivery of folic acid-modified liposomal curcumin for targeted cervical carcinoma therapy
Wen-Yan Wang, Yun-Xia Cao, Xiao Zhou, Bing Wei
Drug Des Devel Ther. 2019; 13: 2205–2213. Published online 2019 Jul 4. doi: 10.2147/DDDT.S205787
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Jatrorrhizine inhibits colorectal carcinoma proliferation and metastasis through Wnt/β-catenin signaling pathway and epithelial–mesenchymal transition
Pan Wang, Xiao-Yan Gao, Si-Qian Yang, Zhi-Xin Sun, Lu-Lu Dian, Muhammad Qasim, Aung Thu Phyo, Zong-Suo Liang, Yan-Fang Sun
Drug Des Devel Ther. 2019; 13: 2235–2247. Published online 2019 Jul 8. doi: 10.2147/DDDT.S207315
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The protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease
Dan-Ying Zhang, Lin Zhu, Hai-Ning Liu, Yu-Jen Tseng, Shu-Qiang Weng, Tao-Tao Liu, Ling Dong, Xi-Zhong Shen
Drug Des Devel Ther. 2019; 13: 2249–2270. Published online 2019 Jul 5. doi: 10.2147/DDDT.S207277
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Durability of INI-containing regimens after switching from PI-containing regimens: a single-centre cohort of drug-experienced HIV-infected subjects
Andrea Giacomelli, Alice Ranzani, Letizia Oreni, Elena Gervasi, Angelica Lupo, Anna Lisa Ridolfo, Massimo Galli, Stefano Rusconi
Drug Des Devel Ther. 2019; 13: 2271–2282. Published online 2019 Jul 9. doi: 10.2147/DDDT.S204415
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Comparative study of β-cyclodextrin, γ-cyclodextrin and 4-tert-butylcalix[8]arene ionophores as electroactive materials for the construction of new sensors for trazodone based on host-guest recognition
Haitham Alrabiah, Haya I Aljohar, Ahmed Hassan Bakheit, Atef MA Homoda, Gamal Abdel-Hafiz Mostafa
Drug Des Devel Ther. 2019; 13: 2283–2293. Published online 2019 Jul 11. doi: 10.2147/DDDT.S201907
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Differences in tolerability of pirfenidone between elderly and younger patients with idiopathic pulmonary fibrosis
Masashi Sakayori, Jiro Terada, Mitsuhiro Abe, Yasutaka Hirasawa, Kenichi Suzuki, Keiichiro Yoshioka, Kenji Tsushima, Koichiro Tatsumi
Drug Des Devel Ther. 2019; 13: 2295–2303. Published online 2019 Jul 11. doi: 10.2147/DDDT.S208733
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Efficacy and safety of cyclosporine A in the treatment of idiopathic membranous nephropathy in an Asian population
Shujun Lin, Hong-Yan Li, Tianbiao Zhou, Wenshan Lin
Drug Des Devel Ther. 2019; 13: 2305–2330. Published online 2019 Jul 11. doi: 10.2147/DDDT.S204974
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Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening
Xuying Li, Pengyu Jia, Zijun Huang, Shuang Liu, Jiaxin Miao, Yuxuan Guo, Nan Wu, Dalin Jia
Drug Des Devel Ther. 2019; 13: 2331–2342. Published online 2019 Jul 11. doi: 10.2147/DDDT.S194753
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Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT
Yanfei Wei, Beibei Lv, Jinling Xie, Yuan Zhang, Yuning Lin, Shengshan Wang, Jing Zhong, Yongxin Chen, Yue Peng, Jing Ma
Drug Des Devel Ther. 2019; 13: 2343–2355. Published online 2019 Jul 15. doi: 10.2147/DDDT.S204787
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Pharmacokinetics of the Yougui pill in experimental autoimmune encephalomyelitis model rats and its pharmacological activity in vitro
Haolong Liu, Feng Qiu, Xinwei Yang, Haiyu Zhao, Baolin Bian, Lei Wang
Drug Des Devel Ther. 2019; 13: 2357–2370. Published online 2019 Jul 16. doi: 10.2147/DDDT.S203874
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MicroRNA-664 suppresses the growth of cervical cancer cells via targeting c-Kit
Mingfen Lv, Rongying Ou, Qianwen Zhang, Fan Lin, Xiangyun Li, Keyu Wang, Yunsheng Xu
Drug Des Devel Ther. 2019; 13: 2371–2379. Published online 2019 Jul 17. doi: 10.2147/DDDT.S203399
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A new approach of ocular nebulization with vitamin B12 versus oxytocin for the treatment of dry eye disease: an in vivo confocal microscopy study
Jiarui Yang, Yushi Liu, Yanhui Xu, Xiaodan Li, Jiayu Fu, Xiaodan Jiang, Yilin Chou, Jiahui Ma, Ran Hao, Rong Zhang, Weiqiang Qiu, Xuemin Li
Drug Des Devel Ther. 2019; 13: 2381–2391. Published online 2019 Jul 18. doi: 10.2147/DDDT.S203464
PMCID:
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A randomized controlled trial evaluating the effects of amlodipine on myocardial iron deposition in pediatric patients with thalassemia major
Arwa Khaled, Hoda A Salem, Dina A Ezzat, Hadeel M Seif, Hoda Rabee
Drug Des Devel Ther. 2019; 13: 2427–2436. Published online 2019 Jul 22. doi: 10.2147/DDDT.S211630
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Novel purine thioglycoside analogs: synthesis, nanoformulation and biological evaluation in in vitro human liver and breast cancer models
Mamdouh A Abu-Zaied, Samah A Loutfy, Ashraf E Hassan, Galal H Elgemeie
Drug Des Devel Ther. 2019; 13: 2437–2457. Published online 2019 Jul 26. doi: 10.2147/DDDT.S201249
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Physicochemical properties and drug-release mechanisms of dual-release bilayer tablet containing mirabegron and fesoterodine fumarate
Hong-Goo Lee, Yun-Sang Park, Jin-Hyuk Jeong, Yong-Bin Kwon, Dae Hwan Shin, Ju-Young Kim, Yun-Seok Rhee, Eun-Seok Park, Dong-Wook Kim, Chun-Woong Park
Drug Des Devel Ther. 2019; 13: 2459–2474. Published online 2019 Jul 23. doi: 10.2147/DDDT.S212520
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Pharmacokinetics of hard micronized progesterone capsules via vaginal or oral route compared with soft micronized capsules in healthy postmenopausal women: a randomized open-label clinical study
Hanbi Wang, Meizhi Liu, Qiang Fu, Chengyan Deng
Drug Des Devel Ther. 2019; 13: 2475–2482. Published online 2019 Jul 23. doi: 10.2147/DDDT.S204624
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Pharmacokinetics and tolerability of IDP-73152 mesylate after a single oral administration under fasted and fed conditions in healthy volunteers
Dongseong Shin, Sang-In Park, Hong-Sub Lee, Kyung-Mi An, Juyoung Jung, MyongJae Lee, Kyung-Sang Yu
Drug Des Devel Ther. 2019; 13: 2483–2490. Published online 2019 Jul 24. doi: 10.2147/DDDT.S209238
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Downregulation of microRNA-23b-3p alleviates IL-1β-induced injury in chondrogenic CHON-001 cells
Qining Yang, Yongwei Zhou, Pengfei Cai, Weicong Fu, Jinhua Wang, Qiang Wei, Xiaofei Li
Drug Des Devel Ther. 2019; 13: 2503–2512. Published online 2019 Jul 23. doi: 10.2147/DDDT.S211051
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Thymol polymeric nanoparticle synthesis and its effects on the toxicity of high glucose on OEC cells: involvement of growth factors and integrin‐linked kinase
Elahe Karimi, Shahryar Abbasi, Naser Abbasi
Drug Des Devel Ther. 2019; 13: 2513–2532. Published online 2019 Jul 25. doi: 10.2147/DDDT.S214454
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Pharmacokinetic interactions between telmisartan/amlodipine and rosuvastatin after multiple oral administrations in healthy Korean male subjects
Seol Ju Moon, Ji-Young Jeon, Kyungho Jang, Kyung-Sang Yu, Yeji Lim, Min-Gul Kim
Drug Des Devel Ther. 2019; 13: 2533–2542. Published online 2019 Jul 25. doi: 10.2147/DDDT.S210364
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Erythropoietin enhances osteogenic differentiation of human periodontal ligament stem cells via Wnt/β-catenin signaling pathway
De-Hua Zheng, Xu-Xia Wang, Dan Ma, Li-Na Zhang, Qing-Fang Qiao, Jun Zhang
Drug Des Devel Ther. 2019; 13: 2543–2552. Published online 2019 Jul 26. doi: 10.2147/DDDT.S214116
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Neonatal outcomes and congenital malformations in children born after dydrogesterone application in progestin-primed ovarian stimulation protocol for IVF: a retrospective cohort study
Jialyu Huang, Qin Xie, Jiaying Lin, Xuefeng Lu, Ningling Wang, Hongyuan Gao, Renfei Cai, Yanping Kuang
Drug Des Devel Ther. 2019; 13: 2553–2563. Published online 2019 Jul 26. doi: 10.2147/DDDT.S210228
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Astragaloside IV protects endothelial progenitor cells from the damage of ox-LDL via the LOX-1/NLRP3 inflammasome pathway
Weibin Qian, Xinrui Cai, Qiuhai Qian, Qianzhu Zhuang, Wenjun Yang, Xinying Zhang, Lijie Zhao
Drug Des Devel Ther. 2019; 13: 2579–2589. Published online 2019 Jul 29. doi: 10.2147/DDDT.S207774
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Nudol, a phenanthrene derivative from Dendrobium nobile, induces cell cycle arrest and apoptosis and inhibits migration in osteosarcoma cells
Yuying Zhang, Qianqian Zhang, Wei Xin, Na Liu, Hua Zhang
Drug Des Devel Ther. 2019; 13: 2591–2601. Published online 2019 Jul 29. doi: 10.2147/DDDT.S180610
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Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model
Andreas Baranowski, Ludwig Schlemmer, Katharina Förster, Ekaterina Slotina, Tim Mickan, Sebastian Truffel, Anja Klein, Stefan G Mattyasovszky, Alexander Hofmann, Ulrike Ritz, Pol M Rommens
Drug Des Devel Ther. 2019; 13: 2603–2618. Published online 2019 Jul 30. doi: 10.2147/DDDT.S204135
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Role of heat shock protein 22 in the protective effect of geranylgeranylacetone in response to oxidized-LDL
Ren Gong, Xi-Yong Li, Huai-Jing Chen, Cong-Cong Xu, Hai-Yang Fang, Jian Xiang, Yan-Qing Wu
Drug Des Devel Ther. 2019; 13: 2619–2632. Published online 2019 Jul 30. doi: 10.2147/DDDT.S209598
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Effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin
Xiaodi Feng, Qianqian Cheng, Qi Meng, Yanhong Yang, Ke Nie
Drug Des Devel Ther. 2019; 13: 2633–2641. Published online 2019 Aug 1. doi: 10.2147/DDDT.S211845
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An investigation of the stability of meropenem in elastomeric infusion devices
Finbarr Foy, Giuseppe Luna, Jorge Martinez, Zach Nizich, Jason Seet, Katie Lie, Bruce Sunderland, Petra Czarniak
Drug Des Devel Ther. 2019; 13: 2655–2665. Published online 2019 Aug 1. doi: 10.2147/DDDT.S212052
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Carvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice
Ying Wu, Zhen Li, Ai-Yuan Xiu, Dong-Xiao Meng, Si-Ning Wang, Chun-Qing Zhang
Drug Des Devel Ther. 2019; 13: 2667–2676. Published online 2019 Aug 1. doi: 10.2147/DDDT.S210797
PMCID:
PMC6681906
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Dextromethorphan and memantine after ketamine analgesia: a randomized control trial
Elodie Martin, Marc Sorel, Véronique Morel, Fabienne Marcaillou, Pascale Picard, Noémie Delage, Florence Tiberghien, Marie-Christine Crosmary, Mitra Najjar, Renato Colamarino, Christelle Créach, Béatrice Lietar, Géraldine Brumauld de Montgazon, Anne Margot-Duclot, Marie-Anne Loriot, Céline Narjoz, Céline Lambert, Bruno Pereira, Gisèle Pickering
Drug Des Devel Ther. 2019; 13: 2677–2688. Published online 2019 Aug 2. doi: 10.2147/DDDT.S207350
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PMC6683947
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Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments
Ye Tao, Miao He, Qinghua Yang, Zhao Ma, Yingxin Qu, Wen Chen, Guanghua Peng, Dengke Teng
Drug Des Devel Ther. 2019; 13: 2689–2702. Published online 2019 Aug 7. doi: 10.2147/DDDT.S194169
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Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway
Xinying Zhou, Zezheng Liu, Bin Huang, Huibo Yan, Changsheng Yang, Qingchu Li, Dadi Jin
Drug Des Devel Ther. 2019; 13: 2703–2713. Published online 2019 Aug 5. doi: 10.2147/DDDT.S208458
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Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach
Lina T Al Kury, Alam Zeb, Zain Ul Abidin, Nadeem Irshad, Imran Malik, Arooj Mohsin Alvi, Atif Ali Khan Khalil, Sareer Ahmad, Muhammad Faheem, Arif-Ullah Khan, Fawad Ali Shah, Shupeng Li
Drug Des Devel Ther. 2019; 13: 2715–2727. Published online 2019 Aug 2. doi: 10.2147/DDDT.S207310
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Liraglutide attenuates cardiac remodeling and improves heart function after abdominal aortic constriction through blocking angiotensin II type 1 receptor in rats
Rong-Hua Zheng, Xiao-Jie Bai, Wei-Wei Zhang, Jing Wang, Feng Bai, Cai-Ping Yan, Erskine A James, Himangshu S Bose, Ning-Ping Wang, Zhi-Qing Zhao
Drug Des Devel Ther. 2019; 13: 2745–2757. Published online 2019 Aug 6. doi: 10.2147/DDDT.S213910
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Cerebral protection of epigallocatechin gallate (EGCG) via preservation of mitochondrial function and ERK inhibition in a rat resuscitation model
Sina Qin, Meng-hua Chen, Wei Fang, Xiao-feng Tan, Lu Xie, Ye-gui Yang, Tao Qin, Nuo Li
Drug Des Devel Ther. 2019; 13: 2759–2768. Published online 2019 Aug 7. doi: 10.2147/DDDT.S215358
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Effects of acarbose and metformin on the inflammatory state in newly diagnosed type 2 diabetes patients: a one-year randomized clinical study
Dan Mo, Songfang Liu, Hong Ma, Haoming Tian, Honglin Yu, Xiangxun Zhang, Nanwei Tong, Jiayu Liao, Yan Ren
Drug Des Devel Ther. 2019; 13: 2769–2776. Published online 2019 Aug 9. doi: 10.2147/DDDT.S208327
PMCID:
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Thapsigargin induces apoptosis in adrenocortical carcinoma by activating endoplasmic reticulum stress and the JNK signaling pathway: an in vitro and in vivo study
Lili Wu, Xuemei Huang, Yaqi Kuang, Zengmiao Xing, Xiujun Deng, Zuojie Luo
Drug Des Devel Ther. 2019; 13: 2787–2798. Published online 2019 Aug 12. doi: 10.2147/DDDT.S209947
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eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats
Linya Guo, Yanbing Li, Ying Tian, Shaoxin Gong, Xi Chen, Tianhong Peng, Aiping Wang, Zhisheng Jiang
Drug Des Devel Ther. 2019; 13: 2799–2809. Published online 2019 Aug 13. doi: 10.2147/DDDT.S213817
PMCID:
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Piceatannol inhibits oxidative stress through modification of Nrf2-signaling pathway in testes and attenuates spermatogenesis and steroidogenesis in rats exposed to cadmium during adulthood
Xiaoxue Shi, Lijie Fu
Drug Des Devel Ther. 2019; 13: 2811–2824. Published online 2019 Aug 13. doi: 10.2147/DDDT.S198444
PMCID:
PMC6698161
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Protective effects of tiopronin against oxidative stress in severely burned patients
Feng-Jun Qin, Xiao-Hua Hu, Zhong Chen, Xu Chen, Yu-Ming Shen
Drug Des Devel Ther. 2019; 13: 2827–2832. Published online 2019 Aug 13. doi: 10.2147/DDDT.S215927
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Overexpression of SOX9 alleviates the progression of human osteoarthritis in vitro and in vivo
Yuanming Ouyang, Wei Wang, Bing Tu, Yi Zhu, Cunyi Fan, Yanfeng Li
Drug Des Devel Ther. 2019; 13: 2833–2842. Published online 2019 Aug 13. doi: 10.2147/DDDT.S203974
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Effects of peri-operative intravenous administration of dexmedetomidine on emergence agitation after general anesthesia in adults: a meta-analysis of randomized controlled trials
Jian Zhang, Yang Yu, Shuai Miao, Lu Liu, Shuyuan Gan, Xianhui Kang, Shengmei Zhu
Drug Des Devel Ther. 2019; 13: 2853–2864. Published online 2019 Aug 15. doi: 10.2147/DDDT.S207016
PMCID:
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Total extract of Xin Jia Xuan Bai Cheng Qi decoction inhibits pulmonary fibrosis via the TGF-β/Smad signaling pathways in vivo and in vitro
Hui Qin, Hao-Tian Wen, Kai-Juan Gu, Xu-Dong Hu, Tao Yang, Xiao-Feng Yan, Ting-Jie Ye, Jin-Lin Huo, Jing Hu
Drug Des Devel Ther. 2019; 13: 2873–2886. Published online 2019 Aug 19. doi: 10.2147/DDDT.S185418
PMCID:
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Bone marrow mesenchymal stem cell-derived exosomes attenuate D-GaIN/LPS-induced hepatocyte apoptosis by activating autophagy in vitro
Shuxian Zhao, Yan Liu, Zenghui Pu
Drug Des Devel Ther. 2019; 13: 2887–2897. Published online 2019 Aug 19. doi: 10.2147/DDDT.S220190
PMCID:
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Impact of postoperative dexmedetomidine infusion on incidence of delirium in elderly patients undergoing major elective noncardiac surgery: a randomized clinical trial
Yuanyuan Sun, Mingming Jiang, Yunjing Ji, Yue Sun, Yao Liu, Wen Shen
Drug Des Devel Ther. 2019; 13: 2911–2922. Published online 2019 Aug 19. doi: 10.2147/DDDT.S208703
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Rutaecarpine may improve neuronal injury, inhibits apoptosis, inflammation and oxidative stress by regulating the expression of ERK1/2 and Nrf2/HO-1 pathway in rats with cerebral ischemia-reperfusion injury
Meiyu Han, Lin Hu, Yang Chen
Drug Des Devel Ther. 2019; 13: 2923–2931. Published online 2019 Aug 20. doi: 10.2147/DDDT.S216156
PMCID:
PMC6708397
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Effect of intrathecal dexmedetomidine on cesarean section during spinal anesthesia: a meta-analysis of randomized trials
Yun-Qi Wang, Xian-Jie Zhang, Ying Wang
Drug Des Devel Ther. 2019; 13: 2933–2939. Published online 2019 Aug 21. doi: 10.2147/DDDT.S207812
PMCID:
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Effect of hepatic and renal impairment on the pharmacokinetics of olanzapine and samidorphan given in combination as a bilayer tablet
Lei Sun, Sergey Yagoda, Yangchun Du, Lisa von Moltke
Drug Des Devel Ther. 2019; 13: 2941–2955. Published online 2019 Aug 22. doi: 10.2147/DDDT.S205000
PMCID:
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Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways
Wei Xie, Xielin Huang, Renpin Chen, Ruru Chen, Tang Li, Wei Wu, Zhiming Huang
Drug Des Devel Ther. 2019; 13: 2969–2984. Published online 2019 Aug 22. doi: 10.2147/DDDT.S193641
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A network pharmacology approach to explore active compounds and pharmacological mechanisms of epimedium for treatment of premature ovarian insufficiency
Huishan Zhao, Yinghua Shan, Zhi Ma, Mingwei Yu, Benjiao Gong
Drug Des Devel Ther. 2019; 13: 2997–3007. Published online 2019 Aug 22. doi: 10.2147/DDDT.S207823
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Network pharmacology study on the active components of Pterocypsela elata and the mechanism of their effect against cerebral ischemia
Bingxuan Niu, Hui Zhang, Chunyan Li, Fulin Yan, Yu Song, Guangfan Hai, Yunjuan Jiao, Yansheng Feng
Drug Des Devel Ther. 2019; 13: 3009–3019. Published online 2019 Sep 5. doi: 10.2147/DDDT.S207955
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Synthesis and antitumor evaluation of neolaxiflorin B inspired compounds
Jing-Ping Liu, Ye-Zhi Xiao, Yu Hu, Xiao-Nian Li, Ming-Jiang Wu, Yong Zhao, Yan Zhao, Ze-Jin Ma, Jing Shen
Drug Des Devel Ther. 2019; 13: 3021–3028. Published online 2019 Aug 23. doi: 10.2147/DDDT.S202345
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Isolation, pharmacological evaluation and molecular docking studies of bioactive compounds from Grewia optiva
Wasim Ul Bari, Mohammad Zahoor, Alam Zeb, Muhammad Umar Khayam Sahibzada, Riaz Ullah, Abdelaaty A Shahat, Hafiz Majid Mahmood, Irfan Khan
Drug Des Devel Ther. 2019; 13: 3029–3036. Published online 2019 Aug 26. doi: 10.2147/DDDT.S220510
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Arsenic sulfide induces miR-4665-3p to inhibit gastric cancer cell invasion and migration
Xiuli Zhang, Zhen Tan, Ting Kang, Chuanying Zhu, Siyu Chen
Drug Des Devel Ther. 2019; 13: 3037–3049. Published online 2019 Aug 26. doi: 10.2147/DDDT.S209219
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Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins
Maha S Almutairi, Eman S Hassan, Adam B Keeton, Gary A Piazza, Ali S Abdelhameed, Mohamed I Attia
Drug Des Devel Ther. 2019; 13: 3069–3078. Published online 2019 Aug 27. doi: 10.2147/DDDT.S208241
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Design, synthesis, and biological study of 4-[(2-nitroimidazole-1H-alkyloxyl)aniline]-quinazolines as EGFR inhibitors exerting cytotoxicities both under normoxia and hypoxia
Weiyan Cheng, Suhua Wang, Zhiheng Yang, Xin Tian, Yongzhou Hu
Drug Des Devel Ther. 2019; 13: 3079–3089. Published online 2019 Aug 28. doi: 10.2147/DDDT.S209481
PMCID:
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Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation
Yong-Liang Yuan, Neng Jiang, Ze-Yun Li, Zhi-Zhen Song, Zhi-Heng Yang, Wen-Hua Xue, Xiao-Jian Zhang, Yue Du
Drug Des Devel Ther. 2019; 13: 3091–3103. Published online 2019 Aug 28. doi: 10.2147/DDDT.S194961
PMCID:
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Therapeutic potential of BLT1 antagonist for COPD: involvement of inducing autophagy and ameliorating inflammation
Li Zhang, Jingwen Huang, Ran Dong, Yun Feng, Min Zhou
Drug Des Devel Ther. 2019; 13: 3105–3116. Published online 2019 Sep 4. doi: 10.2147/DDDT.S215433
PMCID:
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Silibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy
Kun Liu, Shiju Zhou, Jinyan Liu, Yingying Wang, Fengxian Zhu, Man Liu
Drug Des Devel Ther. 2019; 13: 3117–3126. Published online 2019 Aug 29. doi: 10.2147/DDDT.S209981
PMCID:
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Pharmacokinetic and bioequivalence study between two formulations of S-1 in Korean gastric cancer patients
Hae Won Lee, Sook Jin Seong, Woo Youl Kang, Boram Ohk, Mi-Ri Gwon, Bo Kyung Kim, Seungil Cho, Kyunghee Cho, Yong Kyung Sung, Young-Ran Yoon, Jong Gwang Kim
Drug Des Devel Ther. 2019; 13: 3127–3136. Published online 2019 Sep 3. doi: 10.2147/DDDT.S219822
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Dexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulating FKBP12.6/RyR2 signaling
Mei Yuan, Xiao-Wen Meng, Jiao Ma, Hong Liu, Shao-Yong Song, Qing-Cai Chen, Hua-Yue Liu, Juan Zhang, Nan Song, Fu-Hai Ji, Ke Peng
Drug Des Devel Ther. 2019; 13: 3137–3149. Published online 2019 Sep 2. doi: 10.2147/DDDT.S219533
PMCID:
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The safety, pharmacodynamics, and pharmacokinetics of immediate-release formulation containing esomeprazole 20 mg/sodium bicarbonate 800 mg in healthy adult male
Dasohm Kim, Min Soo Park, Byung Won Yoo, Taegon Hong, Shin Jung Park, Choon Ok Kim
Drug Des Devel Ther. 2019; 13: 3151–3159. Published online 2019 Sep 3. doi: 10.2147/DDDT.S212491
PMCID:
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Mifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas
Qi Shen, Shuangwei Zou, Bo Sheng, Menghuang Zhao, Lu-Zhe Sun, Xueqiong Zhu
Drug Des Devel Ther. 2019; 13: 3161–3170. Published online 2019 Sep 3. doi: 10.2147/DDDT.S212157
PMCID:
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Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes
Xiao-yuan Zheng, Shi-ming Yang, Rong Zhang, Su-min Wang, Guo-bing Li, Shi-wen Zhou
Drug Des Devel Ther. 2019; 13: 3171–3180. Published online 2019 Sep 3. doi: 10.2147/DDDT.S204958
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Omalizumab for chronic spontaneous urticaria in “complex” patients: data from real-life clinical practice
Laura Vollono, Arianna Piccolo, Caterina Lanna, Maria Esposito, Mauro Bavetta, Elena Campione, Luca Bianchi, Laura Diluvio
Drug Des Devel Ther. 2019; 13: 3181–3186. Published online 2019 Sep 6. doi: 10.2147/DDDT.S214307
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Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats
Cong Hao, Xuewen Wu, Ruoyu Zhou, Hao Zhang, Yulai Zhou, Xinxing Wang, Yong Feng, Lingyun Mei, Chufeng He, Xinzhang Cai, Lisha Wu
Drug Des Devel Ther. 2019; 13: 3199–3206. Published online 2019 Sep 10. doi: 10.2147/DDDT.S214918
PMCID:
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Palliative chemotherapy with or without anti-EGFR therapy for de novo metastatic nasopharyngeal carcinoma: a propensity score-matching study
Xue-Song Sun, Yu-Jing Liang, Xiao-Yun Li, Sai-Lan Liu, Qiu-Yan Chen, Lin-Quan Tang, Hai-Qiang Mai
Drug Des Devel Ther. 2019; 13: 3207–3216. Published online 2019 Sep 10. doi: 10.2147/DDDT.S215190
PMCID:
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Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway
Yanjun Wang, Bo Pang, Rui Zhang, Yibing Fu, Qi Pang
Drug Des Devel Ther. 2019; 13: 3217–3228. Published online 2019 Sep 12. doi: 10.2147/DDDT.S218371
PMCID:
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Preclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine
Béla Kiss, Zsolt Némethy, Károly Fazekas, Dalma Kurkó, István Gyertyán, Katalin Sághy, István Laszlovszky, Bence Farkas, Norbert Kirschner, Etelka Bolf-Terjéki, Ottilia Balázs, Balázs Lendvai
Drug Des Devel Ther. 2019; 13: 3229–3248. Published online 2019 Sep 16. doi: 10.2147/DDDT.S188760
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Identification of substandard drug products using electronic tongue: cefdinir suspension as a pilot example
Nawaf Abu-Khalaf, Abdel Naser Zaid, Nidal Jaradat, Alaaldin M Alkilany, Samer R Abulateefeh, Rowa Al Ramahi, Mashhour Ghanem
Drug Des Devel Ther. 2019; 13: 3249–3258. Published online 2019 Sep 16. doi: 10.2147/DDDT.S214228
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Carbocisteine inhibits the expression of Muc5b in COPD mouse model
Yan Song, Wei Wang, Yanqing Xie, Bin Xiang, Xuan Huang, Weijie Guan, Jinping Zheng
Drug Des Devel Ther. 2019; 13: 3259–3268. Published online 2019 Sep 16. doi: 10.2147/DDDT.S198874
PMCID:
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A novel curcumin-loaded composite dressing facilitates wound healing due to its natural antioxidant effect
Yong Zhao, Chuanyu Dai, Zheng Wang, Weimin Chen, Jiaguo Liu, Renxi Zhuo, Aixi Yu, Shiwen Huang
Drug Des Devel Ther. 2019; 13: 3269–3280. Published online 2019 Sep 16. doi: 10.2147/DDDT.S219224
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Gemcitabine-loaded RGD modified liposome for ovarian cancer: preparation, characterization and pharmacodynamic studies
Zhongyuan Tang, Weiwei Feng, Yiqing Yang, Qun Wang
Drug Des Devel Ther. 2019; 13: 3281–3290. Published online 2019 Sep 17. doi: 10.2147/DDDT.S211168
PMCID:
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Muscone Promotes The Adipogenic Differentiation Of Human Gingival Mesenchymal Stem Cells By Inhibiting The Wnt/β-Catenin Signaling Pathway
Wen-Xiu Yuan, Xu-Xia Wang, De-Hua Zheng, Dan Ma, Qun Cui, Fan Yang, Jun Zhang
Drug Des Devel Ther. 2019; 13: 3291–3306. Published online 2019 Sep 18. doi: 10.2147/DDDT.S220970
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Topical anesthetic analgesic therapy using the combination of ropivacaine and dexmedetomidine: hyaluronic acid modified long-acting nanostructured lipid carriers containing a skin penetration enhancer
Yongjian Yang, Dahai Qiu, Yajun Liu, Lei Chao
Drug Des Devel Ther. 2019; 13: 3307–3319. Published online 2019 Sep 18. doi: 10.2147/DDDT.S211443
PMCID:
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Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats
Zheen Aorahman Ahmed, Aso Nihad Abtar, Hemn Hassan Othman, Tavga Ahmed Aziz
Drug Des Devel Ther. 2019; 13: 3321–3329. Published online 2019 Sep 20. doi: 10.2147/DDDT.S222127
PMCID:
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Bioequivalence Study Of A Fixed-Dose Combination Tablet Containing Melitracen 10 mg And Flupentixol 0.5 mg In Healthy Chinese Volunteers Under Fasted And Fed Conditions
Lihua Wu, Chang Xu, Guolan Wu, Huili Zhou, Duo Lv, You Zhai, Yujie Huang, Wenling Tang, Fangqiong Li, Jianzhong Shentu
Drug Des Devel Ther. 2019; 13: 3331–3342. Published online 2019 Sep 19. doi: 10.2147/DDDT.S207561
PMCID:
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Effect Of Chinese Herb Danzhi Xiaoyao Pills On Pharmacokinetics Of Venlafaxine In Beagles
Yong-liang Zhu, Shuang-long Li, Ke-li Chen, Kun-peng Ma, De-qian Wu, Xiang-jun Qiu
Drug Des Devel Ther. 2019; 13: 3343–3355. Published online 2019 Sep 20. doi: 10.2147/DDDT.S221927
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Effects of loratadine, a histamine H1 receptor antagonist, on the skeletal system of young male rats
Joanna Folwarczna, Natalia Konarek, Karolina Freier, Dawid Karbowniczek, Piotr Londzin, Aleksandra Janas
Drug Des Devel Ther. 2019; 13: 3357–3367. Published online 2019 Sep 23. doi: 10.2147/DDDT.S215337
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Design, Synthesis, And Evaluation Of Cyanopyridines As Anti-Colorectal Cancer Agents Via Inhibiting STAT3 Pathway
Lingyuan Xu, Lingxi Shi, Sensen Qiu, Siyu Chen, Mengsha Lin, Youqun Xiang, Chengguang Zhao, Jiandong Zhu, Liqun Shen, Zhigui Zuo
Drug Des Devel Ther. 2019; 13: 3369–3381. Published online 2019 Sep 24. doi: 10.2147/DDDT.S217800
PMCID:
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Effect Of Bevacizumab On Growth Of Human Nasal Polyposis In Vitro; An Off-Label Use Of Anti-Angiogenic Agent For Nasal Polyposis Treatment
Shadman Nemati, Faeze Keihanian, Amin Saeidinia, Mahdi Bakhshaei
Drug Des Devel Ther. 2019; 13: 3383–3389. Published online 2019 Sep 24. doi: 10.2147/DDDT.S219724
PMCID:
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Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway
Yu-Ming Wang, Ran Ji, Wei-Wei Chen, Shun-Wei Huang, Yan-Jun Zheng, Zhi-Tao Yang, Hong-Ping Qu, Hao Chen, En-Qiang Mao, Ying Chen, Er-Zhen Chen
Drug Des Devel Ther. 2019; 13: 3391–3404. Published online 2019 Sep 24. doi: 10.2147/DDDT.S222296
PMCID:
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The Efficacy And Safety Of Apatinib Treatment For Patients With Metastatic Or Recurrent Cervical Cancer: A Retrospective Study
Jiangtao Yu, Ziwen Xu, Anyang Li, Jindi Zhang, Yi Wang, Hongqin Zhao, Haiyan Zhu
Drug Des Devel Ther. 2019; 13: 3419–3424. Published online 2019 Sep 26. doi: 10.2147/DDDT.S214743
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Efficacy, Safety And Feasibility Of Antiemetic Prophylaxis With Fosaprepitant, Granisetron And Dexamethasone In Pediatric Patients With Hemato-Oncological Malignancies
Karin Melanie Cabanillas Stanchi, Martin Ebinger, Ulrike Hartmann, Manon Queudeville, Judith Feucht, Michael Ost, Marie-Sarah Koch, Carmen Malaval, Markus Mezger, Sarah Schober, Simone Weber, Sebastian Michaelis, Veit Lange, Peter Lang, Rupert Handgretinger, Michaela Döring
Drug Des Devel Ther. 2019; 13: 3439–3451. Published online 2019 Sep 30. doi: 10.2147/DDDT.S214264
PMCID:
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Efficacy And Safety Of Travoprost Versus Timolol To Treat Early-Onset Ocular Hypertension Secondary To Vitrectomy: A Randomized Trial
Yuan Fang, Hsiangyu Ku, Dekang Gan, Rui Jiang, Xinghuai Sun
Drug Des Devel Ther. 2019; 13: 3453–3463. Published online 2019 Sep 30. doi: 10.2147/DDDT.S222796
PMCID:
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Dexmedetomidine Attenuates Neuroinflammation In LPS-Stimulated BV2 Microglia Cells Through Upregulation Of miR-340
Yang Bao, Yijun Zhu, Guangbao He, Hongwei Ni, Chenxia Liu, Limin Ma, Lifeng Zhang, Dongping Shi
Drug Des Devel Ther. 2019; 13: 3465–3475. Published online 2019 Oct 3. doi: 10.2147/DDDT.S210511
PMCID:
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Evaluation of the effect of long-term use of antidepressants in the SSRI group on bone density with dental volumetric tomography
Kamil Serkan Agacayak, Rıdvan Guler, Bekir Ilyasov
Drug Des Devel Ther. 2019; 13: 3477–3484. Published online 2019 Oct 3. doi: 10.2147/DDDT.S216822
PMCID:
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Enzyme Inhibitory, Antioxidant And Antibacterial Potentials Of Synthetic Symmetrical And Unsymmetrical Thioureas
Sumaira Naz, Muhammad Zahoor, Muhammad Naveed Umar, Barkat Ali, Riaz Ullah, Abdelaaty A Shahat, Hafiz Majid Mahmood, Muhammad Umar Khayam Sahibzada
Drug Des Devel Ther. 2019; 13: 3485–3495. Published online 2019 Oct 7. doi: 10.2147/DDDT.S225311
PMCID:
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Thrombospondin-1 Serum Levels In Hypertensive Patients With Endothelial Dysfunction After One Year Of Treatment With Perindopril
Valentina Buda, Minodora Andor, Carmen Cristescu, Mirela Cleopatra Tomescu, Danina M Muntean, Dana Emilia Bâibâță, Diana Aurora Bordejevic, Corina Danciu, Olivia Dalleur, Dorina Coricovac, Zorin Crainiceanu, Anca Tudor, Ionut Ledeti, Lucian Petrescu
Drug Des Devel Ther. 2019; 13: 3515–3526. Published online 2019 Oct 8. doi: 10.2147/DDDT.S218428
PMCID:
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Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model
Bo-wei Wang, Yi Jiang, Zi-long Yao, Pei-sheng Chen, Bin Yu, Sheng-nan Wang
Drug Des Devel Ther. 2019; 13: 3529–3538. Published online 2019 Oct 9. doi: 10.2147/DDDT.S210220
PMCID:
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Indole-2-Carboxamide Derivative LG25 Inhibits Triple-Negative Breast Cancer Growth By Suppressing Akt/mTOR/NF-κB Signalling Pathway
Xiaohong Xu, Vinothkumar Rajamanickam, Sheng Shu, Zhoudi Liu, Tao Yan, Jinxin He, Zhiguo Liu, Guilong Guo, Guang Liang, Yi Wang
Drug Des Devel Ther. 2019; 13: 3539–3550. Published online 2019 Oct 11. doi: 10.2147/DDDT.S216542
PMCID:
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Clinical And Bacteriological Impact Of Clarithromycin In Streptococcal Pharyngitis: Findings From A Meta-Analysis Of Clinical Trials
Daryl J Hoban, Jos Nauta
Drug Des Devel Ther. 2019; 13: 3551–3558. Published online 2019 Oct 16. doi: 10.2147/DDDT.S205820
PMCID:
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Tanshinone I Inhibits IL-1β-Induced Apoptosis, Inflammation And Extracellular Matrix Degradation In Chondrocytes CHON-001 Cells And Attenuates Murine Osteoarthritis
Xipeng Wang, Jianbo Fan, Xiaomin Ding, Yuyu Sun, Zhiming Cui, Wei Liu
Drug Des Devel Ther. 2019; 13: 3559–3568. Published online 2019 Oct 15. doi: 10.2147/DDDT.S216596
PMCID:
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Formulation, Characterization And Evaluation Of Curcumin- Loaded PLGA- TPGS Nanoparticles For Liver Cancer Treatment
Xiao-ping Chen, Yi Li, Yu Zhang, Gao-wei Li
Drug Des Devel Ther. 2019; 13: 3569–3578. Published online 2019 Oct 16. doi: 10.2147/DDDT.S211748
PMCID:
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Diammonium Glycyrrhizinate Mitigates Liver Injury Via Inhibiting Proliferation Of NKT Cells And Promoting Proliferation Of Tregs
Meixin Gao, Xiulan Li, Lingling He, Junru Yang, Xiaohui Ye, Fan Xiao, Hongshan Wei
Drug Des Devel Ther. 2019; 13: 3579–3589. Published online 2019 Oct 16. doi: 10.2147/DDDT.S220030
PMCID:
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MicroRNA-384-5p/Beclin-1 As Potential Indicators For Epigallocatechin Gallate Against Cardiomyocytes Ischemia Reperfusion Injury By Inhibiting Autophagy Via PI3K/Akt Pathway
Chan Zhang, Ronggan Liang, Xiaowen Gan, Xiufang Yang, LingLin Chen, Jie Jian
Drug Des Devel Ther. 2019; 13: 3607–3623. Published online 2019 Oct 17. doi: 10.2147/DDDT.S219074
PMCID:
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The Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers
Yu Cheng, Bi-Juan Lin, Jin-Hua Guo, Bing-Lin Huang, Lin-Ping Fang, Wan-Cai Que, Mao-Bai Liu, Xin-Feng Chen, Hong-Qiang Qiu
Drug Des Devel Ther. 2019; 13: 3625–3634. Published online 2019 Oct 18. doi: 10.2147/DDDT.S215316
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Coenzyme q10 liquid supplementation in dyslipidemic subjects with statin-related clinical symptoms: a double-blind, randomized, placebo-controlled study
Giuseppe Derosa, Angela D'Angelo, Pamela Maffioli
Drug Des Devel Ther. 2019; 13: 3647–3655. Published online 2019 Oct 21. doi: 10.2147/DDDT.S223153
PMCID:
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Olmesartan Medoxomil, An Angiotensin II-Receptor Blocker, Ameliorates Renal Injury In db/db Mice
Ye Zhu, Ze-Liang Li, Ao Ding, Hui Yang, Wei-Ping Zhu, Tong-Xia Cui, Hui-Tao Zhang, Hua Zhang
Drug Des Devel Ther. 2019; 13: 3657–3667. Published online 2019 Oct 22. doi: 10.2147/DDDT.S217826
PMCID:
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A Novel Octapeptide Derived From G Protein-Coupled Receptor 124 Improves Cognitive Function Via Pro-Angiogenesis In A Rat Model Of Chronic Cerebral Hypoperfusion-Induced Vascular Dementia
Ying Xiao, Hong Shen, Rui Li, Xia Zhou, Hong Xiao, Jun Yan
Drug Des Devel Ther. 2019; 13: 3669–3682. Published online 2019 Oct 23. doi: 10.2147/DDDT.S226473
PMCID:
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Glucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity
Cheng-Ting Zi, Liu Yang, Qing-Hua Kong, Hong-Mei Li, Xing-Zhi Yang, Zhong-Tao Ding, Zi-Hua Jiang, Jiang-Miao Hu, Jun Zhou
Drug Des Devel Ther. 2019; 13: 3683–3692. Published online 2019 Oct 23. doi: 10.2147/DDDT.S215895
PMCID:
PMC6815755
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Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury
Chuanliang Zhao, Xin Zhou, Jie Qiu, Danqing Xin, Tingting Li, Xili Chu, Hongtao Yuan, Haifeng Wang, Zhen Wang, Dachuan Wang
Drug Des Devel Ther. 2019; 13: 3693–3704. Published online 2019 Oct 24. doi: 10.2147/DDDT.S209636
PMCID:
PMC6817353
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Cardio- Renal Outcomes With Long- Term Agalsidase Alfa Enzyme Replacement Therapy: A 10- Year Fabry Outcome Survey (FOS) Analysis
Uma Ramaswami, Michael Beck, Derralynn Hughes, Christoph Kampmann, Jaco Botha, Guillem Pintos-Morell, Michael L West, Dau-Ming Niu, Kathy Nicholls, Roberto Giugliani, On behalf of the FOS Study Group
Drug Des Devel Ther. 2019; 13: 3705–3715. Published online 2019 Oct 25. doi: 10.2147/DDDT.S207856
PMCID:
PMC6819672
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miR- 26a Sensitizes Melanoma Cells To Dabrafenib Via Targeting HMGB1-Dependent Autophagy Pathways
Yan Yu, Niu Xiang, Min Lin, Jin-Wen Huang, Jing Zhang, Bo Cheng, Chao Ji
Drug Des Devel Ther. 2019; 13: 3717–3726. Published online 2019 Oct 29. doi: 10.2147/DDDT.S225671
PMCID:
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Baseline Lymphopenia: A Predictor Of Poor Outcomes In HER2 positive Metastatic Breast Cancer Treated With Trastuzumab
Yi-Qun Che, Yue Zhang, Di Wang, Hui-Ying Liu, Di Shen, Yang Luo
Drug Des Devel Ther. 2019; 13: 3727–3734. Published online 2019 Oct 29. doi: 10.2147/DDDT.S212610
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Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties
Yingying Liu, Xiaohua Xu, Ruisi Xu, Siqi Zhang
Drug Des Devel Ther. 2019; 13: 3735–3751. Published online 2019 Oct 30. doi: 10.2147/DDDT.S213088
PMCID:
PMC6826199
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Protective Effect Of Vasicine Against Myocardial Infarction In Rats Via Modulation Of Oxidative Stress, Inflammation, And The PI3K/Akt Pathway
Tiechao Jiang, Lirong Zhang, Mei Ding, Min Li
Drug Des Devel Ther. 2019; 13: 3773–3784. Published online 2019 Oct 31. doi: 10.2147/DDDT.S220396
PMCID:
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Subarachnoid and epidural dexmedetomidine for the prevention of post-anesthetic shivering: a meta-analysis and systematic review
Yi-Zheng Li, Yi Jiang, Han Lin, Xue-Ping Yang
Drug Des Devel Ther. 2019; 13: 3785–3798. Published online 2019 Nov 1. doi: 10.2147/DDDT.S204411
PMCID:
PMC6831939
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Id-1 Promotes Reendothelialization In The Early Phase After Vascular Injury Through Activation Of NFkB/survivin Signaling Pathway
Wei Li, Dayong Du, Yuntian Li
Drug Des Devel Ther. 2019; 13: 3799–3811. Published online 2019 Oct 31. doi: 10.2147/DDDT.S208707
PMCID:
PMC6827526
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Comparing The Efficacy Of An Anti-Human VEGF-A Neutralizing Antibody Versus Bevacizumab On A Laser-Induced Choroidal Neovascularization (CNV) Rhesus Monkey Model
Oscar Olvera-Montaño, Leopoldo Baiza-Duran, Juan D Quintana-Hau, Mayra G Quiñonez-Alvarado, Wen Zeng, Li Gong, Patricia Muñoz-Villegas
Drug Des Devel Ther. 2019; 13: 3813–3821. Published online 2019 Nov 4. doi: 10.2147/DDDT.S219350
PMCID:
PMC6839577
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Identification Of Natural Compound Derivative For Inhibition Of XLF And Overcoming Chemoresistance In Colorectal Cancer Cells
Zhuo Liu, Miao Yu, Bingyuan Fei, Jing Sun, Dongxin Wang
Drug Des Devel Ther. 2019; 13: 3823–3834. Published online 2019 Nov 6. doi: 10.2147/DDDT.S215967
PMCID:
PMC6847993
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Adenosine Inhibits Ovarian Cancer Growth Through Regulating RhoGDI2 Protein Expression
Bing Xia, Jing Wang
Drug Des Devel Ther. 2019; 13: 3837–3844. Published online 2019 Nov 8. doi: 10.2147/DDDT.S219028
PMCID:
PMC7041303
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Safety, pharmacokinetics and pharmacodynamics of the selective glucocorticoid receptor modulator AZD7594, following inhalation in healthy Japanese volunteers
Susanne Prothon, Ulrika Wählby Hamrén, Ulrika Tehler, Esther Yoon, Henrik Forsman, Cecilia Arfvidsson, Ajay Aggarwal, Yingxue Chen
Drug Des Devel Ther. 2019; 13: 3845–3853. Published online 2019 Nov 12. doi: 10.2147/DDDT.S215170
PMCID:
PMC6858834
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Pregnancy And Neonatal Outcomes Of hMG Stimulation With Or Without Letrozole In Endometrial Preparation For Frozen–Thawed Embryo Transfer In Ovulatory Women: A Large Retrospective Cohort Study
Jiaying Lin, Ningling Wang, Jialv Huang, Renfei Cai, Yong Fan, Yanping Kuang, Yun Wang
Drug Des Devel Ther. 2019; 13: 3867–3877. Published online 2019 Nov 14. doi: 10.2147/DDDT.S212235
PMCID:
PMC6861551
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A Fixed-Dose Combination Of Gemigliptin And Rosuvastatin Exhibits Similar Pharmacokinetics, Pharmacodynamics, And Safety Compared To That Of A Loose Combination In Healthy Subjects
Eunwoo Kim, Kyoung Ryun Park, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee
Drug Des Devel Ther. 2019; 13: 3879–3885. Published online 2019 Nov 13. doi: 10.2147/DDDT.S197054
PMCID:
PMC6859084
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The MAP2K4/JNK/c-Jun Signaling Pathway Plays A Key Role In Dexmedetomidine Protection Against Acetaminophen-Induced Liver Toxicity
An-Hsun Chou, Chia-Chih Liao, Hung-Chen Lee, Jiin-Tarng Liou, Fu-Chao Liu
Drug Des Devel Ther. 2019; 13: 3887–3898. Published online 2019 Nov 14. doi: 10.2147/DDDT.S215473
PMCID:
PMC6861533
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Luteolin Attenuates Atherosclerosis Via Modulating Signal Transducer And Activator Of Transcription 3-Mediated Inflammatory Response
Xiaoji Ding, Lulu Zheng, Bo Yang, Xiaodong Wang, Yin Ying
Drug Des Devel Ther. 2019; 13: 3899–3911. Published online 2019 Nov 18. doi: 10.2147/DDDT.S207185
PMCID:
PMC6874161
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Efficacy And Safety Of Apatinib Treatment In Platinum-Resistant Recurrent Epithelial Ovarian Cancer: A Real World Study
Jindi Zhang, Anyang Li, Qi Jiang, Feiyun Zheng, Haiyan Zhu
Drug Des Devel Ther. 2019; 13: 3913–3918. Published online 2019 Nov 15. doi: 10.2147/DDDT.S220847
PMCID:
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The Effects Of Sevoflurane On The Progression And Cisplatinum Sensitivity Of Cervical Cancer Cells
Fang Xue, Yichi Xu, Yizuo Song, Wenwen Zhang, Ruyi Li, Xueqiong Zhu
Drug Des Devel Ther. 2019; 13: 3919–3928. Published online 2019 Nov 18. doi: 10.2147/DDDT.S219788
PMCID:
PMC6873969
Article PubReader PDF–5.7MCite
Assessment Of Spanlastic Vesicles Of Zolmitriptan For Treating Migraine In Rats
Nagla Ahmed El-Nabarawy, Mahmoud Hassan Teaima, Doaa Ahmed Helal
Drug Des Devel Ther. 2019; 13: 3929–3937. Published online 2019 Nov 21. doi: 10.2147/DDDT.S220473
PMCID:
PMC6877729
Article PubReader PDF–2.0MCite
Alteration of Amino Acid Profiling Influenced by the Active Ingredients of DanHong Injection After Prescription Optimization
Zhili Guo, Yan Zhu, Wenjuan Xu, Kaitao Luo, Hongbin Xiao, Zhong Wang
Drug Des Devel Ther. 2019; 13: 3939–3947. Published online 2019 Nov 21. doi: 10.2147/DDDT.S220314
PMCID:
PMC6876559
Article PubReader PDF–6.0MCite
Icariin Alleviates IL-1β-Induced Matrix Degradation By Activating The Nrf2/ARE Pathway In Human Chondrocytes
Shi Zuo, Wei Zou, Rong-Min Wu, Jing Yang, Jian-Nan Fan, Xue-Ke Zhao, Hai-Yang Li
Drug Des Devel Ther. 2019; 13: 3949–3961. Published online 2019 Nov 21. doi: 10.2147/DDDT.S203094
PMCID:
PMC6876636
Article PubReader PDF–9.4MCite
Effects Of Triptolide On Tooth Movement And Root Resorption In Rats
Fan Yang, Xu Xia Wang, Dan Ma, Qun Cui, De Hua Zheng, Xiao Can Liu, Jun Zhang
Drug Des Devel Ther. 2019; 13: 3963–3975. Published online 2019 Nov 25. doi: 10.2147/DDDT.S217936
PMCID:
PMC6883940
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Postconditioning Protection Against Myocardiocyte Anoxia/Reoxygenation Injury From Penehyclidine Hydrochloride
JY Ren, DM Lin, CB Wang, YL Yang, ZQ Wang, BQ Cui, J Ma
Drug Des Devel Ther. 2019; 13: 3977–3988. Published online 2019 Nov 26. doi: 10.2147/DDDT.S224282
PMCID:
PMC6884978
Article PubReader PDF–8.3MCite
A Network Pharmacology-Based Strategy For Predicting Active Ingredients And Potential Targets Of LiuWei DiHuang Pill In Treating Type 2 Diabetes Mellitus
Dan He, Jian-Hua Huang, Zhe-Yu Zhang, Qing Du, Wei-Jun Peng, Rong Yu, Si-Fang Zhang, Shui-Han Zhang, Yu-Hui Qin
Drug Des Devel Ther. 2019; 13: 3989–4005. Published online 2019 Nov 28. doi: 10.2147/DDDT.S216644
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Drug Des Devel Ther. 2020; 14: 949.
PMCID:
PMC6890936
Article PubReader PDF–8.9MCite
Transformation of Meloxicam Containing Nanosuspension into Surfactant-Free Solid Compositions to Increase the Product Stability and Drug Bioavailability for Rapid Analgesia
Csaba Bartos, Rita Ambrus, Gábor Katona, Tamás Sovány, Róbert Gáspár, Árpád Márki, Eszter Ducza, Anita Ivanov, Ferenc Tömösi, Tamás Janáky, Piroska Szabó-Révész
Drug Des Devel Ther. 2019; 13: 4007–4020. Published online 2019 Nov 28. doi: 10.2147/DDDT.S220876
PMCID:
PMC6886534
Article PubReader PDF–4.7MCite
Delivery Of Curcumin Nanoliposomes Using Surface Modified With CD133 Aptamers For Prostate Cancer
Qi Ma, Wei Qian, Wei Tao, Yanling Zhou, Boxin Xue
Drug Des Devel Ther. 2019; 13: 4021–4033. Published online 2019 Nov 28. doi: 10.2147/DDDT.S210949
PMCID:
PMC6886545
Article PubReader PDF–7.2MCite
An Optimized Surfactant-Based PEG-PLCL In Situ Gel Formulation For Enhanced Activity Of Rosuvastatin In Poloxamer-Induced Hyperlipidemic Rats
Tarek A Ahmed, Mohammed A Mussari, Seham El-Sayed Abdel-Hady, Khalid M El-Say
Drug Des Devel Ther. 2019; 13: 4035–4051. Published online 2019 Dec 3. doi: 10.2147/DDDT.S224442
PMCID:
PMC6904902
Article PubReader PDF–5.9MCite
Neuroprotective Effect of S-trans, Trans-farnesylthiosalicylic Acid via Inhibition of RAS/ERK Pathway for the Treatment of Alzheimer’s Disease
Xiang Wang, Yu Wang, Yiyi Zhu, Luxia Yan, Liandong Zhao
Drug Des Devel Ther. 2019; 13: 4053–4063. Published online 2019 Nov 29. doi: 10.2147/DDDT.S233283
PMCID:
PMC6890185
Article PubReader PDF–7.4MCite
Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways
Ying Luo, Pijian Yang, Zhengming Li, Yunchen Luo, Jing Shen, Ruwen Li, Hua Zheng, Yuzhen Liang, Ning Xia
Drug Des Devel Ther. 2019; 13: 4065–4074. Published online 2019 Dec 2. doi: 10.2147/DDDT.S224688
PMCID:
PMC6896910
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Cinobufagin Suppresses The Characteristics Of Osteosarcoma Cancer Cells By Inhibiting The IL-6-OPN-STAT3 Pathway
Chuan Zhang, Kun Ma, Wu-Yin Li
Drug Des Devel Ther. 2019; 13: 4075–4090. Published online 2019 Dec 4. doi: 10.2147/DDDT.S224312
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Drug Des Devel Ther. 2021; 15: 4445–4446.
PMCID:
PMC6900468
ArticleCite
Efficacy and Safety of Combined Vitrectomy with Intravitreal Dexamethasone Implant for Advanced Stage Epiretinal Membrane
Claudio Iovino, Giuseppe Giannaccare, Marco Pellegrini, Federico Bernabei, Mirco Braghiroli, Tomaso Caporossi, Enrico Peiretti
Drug Des Devel Ther. 2019; 13: 4107–4114. Published online 2019 Dec 3. doi: 10.2147/DDDT.S229031
PMCID:
PMC6899066
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Hongjingtian Injection Inhibits Proliferation and Migration and Promotes Apoptosis in High Glucose-Induced Vascular Smooth Muscle Cells
Zhengyuan Fan, Congcong Guo, Yuhan Zhang, Jinming Yao, Lin Liao, Jianjun Dong
Drug Des Devel Ther. 2019; 13: 4115–4126. Published online 2019 Dec 5. doi: 10.2147/DDDT.S220719
PMCID:
PMC6901383
Article PubReader PDF–11MCite
Radioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation
Seyedeh Atekeh Torabizadeh, Mehdi Rezaeifar, Ali Jomehzadeh, Farzaneh Nabizadeh Haghighi, Mehdi Ansari
Drug Des Devel Ther. 2019; 13: 4127–4134. Published online 2019 Dec 6. doi: 10.2147/DDDT.S218022
PMCID:
PMC6902880
Article PubReader PDF–3.8MCite
Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy in Comparison with Ketamine: A Randomized, Open-Label Clinical Study
Jing Wang, Jie Huang, Shuang Yang, Chang Cui, Ling Ye, Sai-ying Wang, Guo-ping Yang, Qi Pei
Drug Des Devel Ther. 2019; 13: 4135–4144. Published online 2019 Dec 6. doi: 10.2147/DDDT.S224553
PMCID:
PMC6902860
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Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway
Hui-Feng Zhu, Yali Shao, Lei Qin, Jing-Huan Wang, Shan Feng, Yun-Bin Jiang, Dong Wan
Drug Des Devel Ther. 2019; 13: 4145–4157. Published online 2019 Dec 10. doi: 10.2147/DDDT.S223322
PMCID:
PMC6911350
Article PubReader PDF–5.3MCite
Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury
Zhongxiang Xiao, Fengli Xu, Xiaona Zhu, Bin Bai, Lu Guo, Guang Liang, Xiaoou Shan, Yali Zhang, Yunjie Zhao, Bing Zhang
Drug Des Devel Ther. 2019; 13: 4161–4171. Published online 2019 Dec 10. doi: 10.2147/DDDT.S215712
Correction in:
Drug Des Devel Ther. 2022; 16: 249–250.
PMCID:
PMC6911336
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Preparation of a Novel One-Armed Anti-c-Met Antibody with Antitumor Activity Against Hepatocellular Carcinoma
Yanxin Yin, Jia Guo, Fei Teng, Lihua Yu, Yun Jiang, Kun Xie, Ming Jiang, Jianmin Fang
Drug Des Devel Ther. 2019; 13: 4173–4184. Published online 2019 Dec 10. doi: 10.2147/DDDT.S224491
PMCID:
PMC6911325
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Pharmacological Evaluation of Aldehydic-Pyrrolidinedione Against HCT-116, MDA-MB231, NIH/3T3, MCF-7 Cancer Cell Lines, Antioxidant and Enzyme Inhibition Studies
Ashfaq Ahmad, Farhat Ullah, Abdul Sadiq, Muhammad Ayaz, Haroon Rahim, Umer Rashid, Sajjad Ahmad, Muhammad Saeed Jan, Riaz Ullah, Abdelaaty A Shahat, Hafiz Majid Mahmood
Drug Des Devel Ther. 2019; 13: 4185–4194. Published online 2019 Dec 10. doi: 10.2147/DDDT.S226080
PMCID:
PMC6911349
Article PubReader PDF–3.7MCite
In Silico, Cytotoxic and Antioxidant Potential of Novel Ester, 3-hydroxyoctyl -5- trans-docosenoate Isolated from Anchusa arvensis (L.) M.Bieb. Against HepG-2 Cancer Cells
Sajid Hussain, Farhat Ullah, Muhammad Ayaz, Syed Adnan Ali Shah, Azhar-ul-Haq Ali Shah, Syed Majid Shah, Abdul Wadood, Waqar Aman, Riaz Ullah, Abdelaaty A Shahat, Fahd A Nasr
Drug Des Devel Ther. 2019; 13: 4195–4205. Published online 2019 Dec 10. doi: 10.2147/DDDT.S228971
PMCID:
PMC6911335
Article PubReader PDF–7.0MCite
Drug–Drug Interactions Of Amiodarone And Quinidine On The Pharmacokinetics Of Eliglustat In Rats
Qiong Wang, Haiyun Wang, Youyan Zhong, Qiang Zhang
Drug Des Devel Ther. 2019; 13: 4207–4213. Published online 2019 Dec 12. doi: 10.2147/DDDT.S226948
PMCID:
PMC6913762
Article PubReader PDF–3.4MCite
The Effect of Glutamine Supplementation on Oxidative Stress and Matrix Metalloproteinase 2 and 9 After Exhaustive Exercise
Ali Nemati, Reza Alipanah-Moghadam, Leila Molazadeh, Abbas Naghizadeh Baghi
Drug Des Devel Ther. 2019; 13: 4215–4223. Published online 2019 Dec 11. doi: 10.2147/DDDT.S218606
PMCID:
PMC6912001
Article PubReader PDF–440KCite
Molecular Requirements for the Expression of Antiplatelet Effects by Synthetic Structural Optimized Analogues of the Anticancer Drugs Imatinib and Nilotinib
Despoina Pantazi, Nikoleta Ntemou, Alexios Brentas, Dimitrios Alivertis, Konstantinos Skobridis, Alexandros D Tselepis
Drug Des Devel Ther. 2019; 13: 4225–4238. Published online 2019 Dec 12. doi: 10.2147/DDDT.S211907
PMCID:
PMC6913343
Article PubReader PDF–10MCite
Synthesis of Novel Xanthone Analogues and Their Growth Inhibitory Activity Against Human Lung Cancer A549 Cells
Junqi Wu, Jinwei Dai, Yuyang Zhang, Jing Wang, Lei Huang, Hongmei Ding, Tiejun Li, Yuefan Zhang, Junqin Mao, Shichong Yu
Drug Des Devel Ther. 2019; 13: 4239–4246. Published online 2019 Dec 13. doi: 10.2147/DDDT.S217827
PMCID:
PMC6916687
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Small-Molecule Intervention At The Dimerization Interface Of Survivin By Novel Rigidized Scaffolds
Tamer M Ibrahim, Christoph Ernst, Andreas Lange, Susanne Hennig, Frank M Boeckler
Drug Des Devel Ther. 2019; 13: 4247–4263. Published online 2019 Dec 18. doi: 10.2147/DDDT.S224561
PMCID:
PMC6927794
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Valproic Acid Addresses Neuroendocrine Differentiation of LNCaP Cells and Maintains Cell Survival
Francesca Giordano, Giuseppina Daniela Naimo, Alessandra Nigro, Francesco Romeo, Alessandro Paolì, Francesca De Amicis, Adele Vivacqua, Catia Morelli, Loredana Mauro, Maria Luisa Panno
Drug Des Devel Ther. 2019; 13: 4265–4274. Published online 2019 Dec 18. doi: 10.2147/DDDT.S229930
PMCID:
PMC6927225
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The Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation
Feifei Feng, Peng Cheng, Huanan Zhang, Nannan Li, Yuxin Qi, Hui Wang, Yongbin Wang, Wei Wang
Drug Des Devel Ther. 2019; 13: 4275–4290. Published online 2019 Dec 18. doi: 10.2147/DDDT.S230572
PMCID:
PMC6930391
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A Novel Nanomicellar Combination of Fenretinide and Lenalidomide Shows Marked Antitumor Activity in a Neuroblastoma Xenograft Model
Isabella Orienti, Ferro Nguyen, Peng Guan, Venkatadri Kolla, Natalia Calonghi, Giovanna Farruggia, Michael Chorny, Garrett M Brodeur
Drug Des Devel Ther. 2019; 13: 4305–4319. Published online 2019 Dec 19. doi: 10.2147/DDDT.S221909
PMCID:
PMC6930389
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AR-42: A Pan-HDAC Inhibitor with Antitumor and Antiangiogenic Activities in Esophageal Squamous Cell Carcinoma
Yuxuan Zhu, Ting Yuan, Yuan Zhang, Jianyou Shi, Lan Bai, Xingmei Duan, Rongsheng Tong, Lei Zhong
Drug Des Devel Ther. 2019; 13: 4321–4330. Published online 2019 Dec 19. doi: 10.2147/DDDT.S211665
PMCID:
PMC6930838
Article PubReader PDF–9.1MCite
Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cell Therapy for Rheumatoid Arthritis Patients: A Prospective Phase I/II Study
Liming Wang, Shigao Huang, Shimei Li, Ming Li, Jun Shi, Wen Bai, Qianyun Wang, Libo Zheng, Yongjun Liu
Drug Des Devel Ther. 2019; 13: 4331–4340. Published online 2019 Dec 19. doi: 10.2147/DDDT.S225613
PMCID:
PMC6930836
Article PubReader PDF–12MCite
Memory Impairment Induced by Chronic Psychosocial Stress Is Prevented by L-Carnitine
Suzie Y Rababa’h, Karem H Alzoubi, Hana M Hammad, Laiali Alquraan, Khalid El-Salem
Drug Des Devel Ther. 2019; 13: 4341–4350. Published online 2019 Dec 19. doi: 10.2147/DDDT.S225264
PMCID:
PMC6927795
Article PubReader PDF–582KCite
Cytokine and Chemokine Profile Changes in Patients After Intravitreal Conbercept Injection for Diabetic Macular Edema
Qingquan Wei, Zhongqi Wan, Yongcheng Hu, Qing Peng
Drug Des Devel Ther. 2019; 13: 4367–4374. Published online 2019 Dec 24. doi: 10.2147/DDDT.S222004
PMCID:
PMC6935285
Article PubReader PDF–2.1MCite
Inhibition of Disruptor of Telomeric Silencing 1-Like Alleviated Renal Ischemia and Reperfusion Injury-Induced Fibrosis by Blocking PI3K/AKT-Mediated Oxidative Stress
Chuan Yang, Zhiyuan Chen, Hua Yu, Xiuheng Liu
Drug Des Devel Ther. 2019; 13: 4375–4387. Published online 2019 Dec 27. doi: 10.2147/DDDT.S224909
PMCID:
PMC6939406
Article PubReader PDF–13MCite
An Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles
Nagaraja SreeHarsha, Katharigatta N Venugopala, Anroop B Nair, Teeka S Roopashree, Mahesh Attimarad, Jagadeesh G Hiremath, Bandar E Al-Dhubiab, Chandramouli Ramnarayanan, Pottathil Shinu, Mukund Handral, Micheline Haroun, Christophe Tratrat
Drug Des Devel Ther. 2019; 13: 4389–4403. Published online 2019 Dec 27. doi: 10.2147/DDDT.S216660
PMCID:
PMC6938183
Article PubReader PDF–6.2MCite
Developmental Pharmacogenetics of SLCO2B1 on Montelukast Pharmacokinetics in Chinese Children
Qian Li, Kai Wang, Hai-Yan Shi, Yue-E Wu, Yue Zhou, Min Kan, Yi Zheng, Guo-Xiang Hao, Xin-Mei Yang, Yi-Lei Yang, Le-Qun Su, Xiao-Ling Wang, Evelyne Jacqz-Aigrain, Jun Zhou, Wei Zhao
Drug Des Devel Ther. 2019; 13: 4405–4411. Published online 2019 Dec 27. doi: 10.2147/DDDT.S226913
PMCID:
PMC6939174
Article PubReader PDF–437KCite
Development and Evaluation of in-situ Nasal Gel Formulations of Nanosized Transferosomal Sumatriptan: Design, Optimization, in vitro and in vivo Evaluation
Mahmoud M Omar, Nermin E Eleraky, Amani M El Sisi, Omiya Ali Hasan
Drug Des Devel Ther. 2019; 13: 4413–4430. Published online 2019 Dec 27. doi: 10.2147/DDDT.S235004
Retraction in:
Drug Des Devel Ther. 2022; 16: 2291–2292.
PMCID:
PMC6938197
ArticleCite
Generic Tacrolimus (Tacrobell®) Shows Comparable Outcomes to Brand-Name Tacrolimus in the Long-Term Period After Adult Deceased Donor Liver Transplantation
Jong Man Kim, Jae-Won Joh, Gyu-Seong Choi, Suk-Koo Lee
Drug Des Devel Ther. 2019; 13: 4431–4438. Published online 2019 Dec 31. doi: 10.2147/DDDT.S229114
PMCID:
PMC6948198
Article PubReader PDF–1.9MCite
Dexmedetomidine Promotes Hippocampal Neurogenesis and Improves Spatial Learning and Memory in Neonatal Rats
Yahan Zhang, Qiushi Gao, Ziyi Wu, Hang Xue, Bo Liu, Ping Zhao
Drug Des Devel Ther. 2019; 13: 4439–4449. Published online 2019 Dec 31. doi: 10.2147/DDDT.S228220
PMCID:
PMC6997224
Article PubReader PDF–5.8MCite
Sevoflurane Inhibits Proliferation and Invasion of Human Ovarian Cancer Cells by Regulating JNK and p38 MAPK Signaling Pathway
Kai Kang, Yue Wang
Drug Des Devel Ther. 2019; 13: 4451–4460. Published online 2019 Dec 31. doi: 10.2147/DDDT.S223581
PMCID:
PMC6955638
Article PubReader PDF–4.9MCite
Progestin-Primed Ovarian Stimulation with Dydrogesterone versus Medroxyprogesterone Acetate in Women with Polycystic Ovarian Syndrome for in vitro Fertilization: A Retrospective Cohort Study
Jialyu Huang, Qin Xie, Jiaying Lin, Xuefeng Lu, Jing Zhu, Hongyuan Gao, Renfei Cai, Yanping Kuang
Drug Des Devel Ther. 2019; 13: 4461–4470. Published online 2019 Dec 31. doi: 10.2147/DDDT.S230129
PMCID:
PMC6997218
Article PubReader PDF–383KCite

Clinical Trial Report

Ocular side effects of Levitra® (vardenafil) – results of a double-blind crossover study in healthy male subjects
Gernot Roessler, Michael Vobig, Peter Walter, Babac AE Mazinani
Drug Des Devel Ther. 2019; 13: 37–43. Published online 2018 Dec 18. doi: 10.2147/DDDT.S186633
PMCID:
PMC6305137
Article PubReader PDF–234KCite
Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system
Qing An, Yingxin Zheng, Yirong Zhao, Tao Liu, Huaizu Guo, Dapeng Zhang, Weizhu Qian, Hao Wang, Yajun Guo, Sheng Hou, Jing Li
Drug Des Devel Ther. 2019; 13: 791–805. Published online 2019 Mar 12. doi: 10.2147/DDDT.S170913
PMCID:
PMC6420106
Article PubReader PDF–1.6MCite
Dexmedetomidine for the prevention of emergence delirium and postoperative behavioral changes in pediatric patients with sevoflurane anesthesia: a double-blind, randomized trial
Mengzhu Shi, Shuai Miao, Tianchu Gu, Dongyue Wang, Hui Zhang, Jindong Liu
Drug Des Devel Ther. 2019; 13: 897–905. Published online 2019 Mar 15. doi: 10.2147/DDDT.S196075
PMCID:
PMC6421876
Article PubReader PDF–1.0MCite
Comparison of dexmedetomidine and sufentanil as adjuvants to local anesthetic for epidural labor analgesia: a randomized controlled trial
Tao Zhang, Yulong Yu, Wang Zhang, Jin Zhu
Drug Des Devel Ther. 2019; 13: 1171–1175. Published online 2019 Apr 11. doi: 10.2147/DDDT.S197431
PMCID:
PMC6469486
Article PubReader PDF–325KCite
Use of lidocaine to prevent postoperative coughing after partial laryngectomy: comparison of three delivery methods
Yuezhi Wang, Wei S Lu, Hui Qiao, Jian Zhao, Qing Fan
Drug Des Devel Ther. 2019; 13: 1835–1841. Published online 2019 May 27. doi: 10.2147/DDDT.S201416
PMCID:
PMC6549387
Article PubReader PDF–622KCite
The effect of etomidate or propofol on brainstem function during anesthesia induction: a bispectral index-guided study
Huibao Zheng, Yuexin Zhu, Kaizheng Chen, Xia Shen
Drug Des Devel Ther. 2019; 13: 1941–1946. Published online 2019 Jun 5. doi: 10.2147/DDDT.S211523
PMCID:
PMC6559222
Article PubReader PDF–832KCite
A comparative double-blind randomized study on the effectiveness of Duloxetine and Gabapentin on painful diabetic peripheral polyneuropathy
Nastaran Majdinasab, Hossein Kaveyani, Mojgan Azizi
Drug Des Devel Ther. 2019; 13: 1985–1992. Published online 2019 Jun 17. doi: 10.2147/DDDT.S185995
PMCID:
PMC6588725
Article PubReader PDF–656KCite

Short Report

Antistaphylococcal evaluation of indole–naphthalene hybrid analogs
Kerolos Ashraf, Kaveh Yasrebi, Emmanuel Tola Adeniyi, Tobias Hertlein, Knut Ohlsen, Michael Lalk, Frank Erdmann, Andreas Hilgeroth
Drug Des Devel Ther. 2019; 13: 275–283. Published online 2019 Jan 10. doi: 10.2147/DDDT.S184965
PMCID:
PMC6331074
Article PubReader PDF–300KCite

Case Report

Hyperprogression after anti-programmed cell death ligand-1 therapy in a patient with recurrent metastatic urothelial bladder carcinoma following first-line cisplatin-based chemotherapy: a case report
Shiyu Mao, Junfeng Zhang, Yadong Guo, Ziwei Zhang, Yuan Wu, Wentao Zhang, Longsheng Wang, Jiang Geng, Yang Yan, Xudong Yao
Drug Des Devel Ther. 2019; 13: 291–300. Published online 2019 Jan 11. doi: 10.2147/DDDT.S181122
PMCID:
PMC6333318
Article PubReader PDF–2.3MCite

Letters

Letter regarding the article, “A randomized, double- blind clinical trial of canrenone vs hydrochlorothiazide in addition to angiotensin II receptor blockers in hypertensive type 2 diabetic patients”
Ling-Yue Zhao, Yi-Jun Luo, Jing Zhu
Drug Des Devel Ther. 2019; 13: 385–386. Published online 2019 Jan 21. doi: 10.2147/DDDT.S185297
PMCID:
PMC6345323
Article PubReader PDF–143KCite
Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Letter]
Leticia Orsatti, Josep Fortea, Manuel Quaresma
Drug Des Devel Ther. 2019; 13: 1177–1178. Published online 2019 Apr 12. doi: 10.2147/DDDT.S194065
PMCID:
PMC6469738
Article PubReader PDF–154KCite
Nicorandil prior to primary percutaneous coronary intervention improves clinical outcomes in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials [Letter]
Jun Li, Ling Zhang, Aixia Lu
Drug Des Devel Ther. 2019; 13: 2825–2826. Published online 2019 Aug 13. doi: 10.2147/DDDT.S215061
PMCID:
PMC6698177
Article PubReader PDF–177KCite

Research Letter

A nucleoside-sparing regimen of dolutegravir plus ritonavir-boosted atazanavir in HIV-1-infected patients with virological failure: the DOLATAV study
Vincenzo Spagnuolo, Laura Galli, Andrea Poli, Alba Bigoloni, Luca Fumagalli, Nicola Gianotti, Silvia Nozza, Davide Ferrari, Massimo Locatelli, Adriano Lazzarin, Antonella Castagna
Drug Des Devel Ther. 2019; 13: 477–479. Published online 2019 Jan 24. doi: 10.2147/DDDT.S192124
PMCID:
PMC6352870
Article PubReader PDF–161KCite

Case Series

Low-dose adefovir dipivoxil–induced hypophosphatemia osteomalacia in five chronic hepatitis B virus–infected patients. Is low-dose adefovir dipivoxil–induced nephrotoxicity completely reversible?
Yan-Ying Qian, Zhi-Juan Dai, Lu-Ya Ruan, You-Jin Pan, Jian Jin, Meng-Te Shi, Yao-Xin Zhu, Chao-Ming Wu
Drug Des Devel Ther. 2019; 13: 1127–1133. Published online 2019 Apr 10. doi: 10.2147/DDDT.S192632
PMCID:
PMC6498959
Article PubReader PDF–225KCite
A study of refractory cases of persistent epithelial defects associated with dry eye syndrome and recurrent corneal erosions successfully treated with cyclosporine A 0.05% eye drops
Pietro Emanuele Napoli, Mirco Braghiroli, Claudio Iovino, Giuseppe Demarinis, Maurizio Fossarello
Drug Des Devel Ther. 2019; 13: 2001–2008. Published online 2019 Jun 19. doi: 10.2147/DDDT.S207453
PMCID:
PMC6590396
Article PubReader PDF–838KCite

Response to Letter

Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Response to letter]
Mitsuhiro Abe, Kenji Tsushima, Koichiro Tatsumi
Drug Des Devel Ther. 2019; 13: 1687–1688. Published online 2019 May 14. doi: 10.2147/DDDT.S207537
PMCID:
PMC6526187
Article PubReader PDF–159KCite

Original RESEARCH

Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane
Mashooq Ahmad Bhat, Mohamed A Al-Omar, Azmat Ali Khan, Amer M Alanazi, Ahmed M Naglah
Drug Des Devel Ther. 2019; 13: 2393–2404. Published online 2019 Jul 18. doi: 10.2147/DDDT.S198865
PMCID:
PMC6647008
Article PubReader PDF–1.7MCite

Methodology

Validated UPLC-MS/MS method for quantification of fruquintinib in rat plasma and its application to pharmacokinetic study
Yi-Bin Mei, Shun-Bin Luo, Ling-Yan Ye, Qiang Zhang, Jing Guo, Xiang-Jun Qiu, Sai-Li Xie
Drug Des Devel Ther. 2019; 13: 2865–2871. Published online 2019 Aug 15. doi: 10.2147/DDDT.S199362
PMCID:
PMC6699497
Article PubReader PDF–1.5MCite

Errata

Endostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways [Erratum]
Drug Des Devel Ther. 2019; 13: 499–500. Published online 2019 Jan 31. doi: 10.2147/DDDT.S202671
Corrects:
Drug Des Devel Ther. 2019; 13: 285–290.
PMCID:
PMC6363484
Correction PubReader PDF–270KCite
The Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers [Erratum]
Drug Des Devel Ther. 2019; 13: 3835. Published online 2019 Nov 7. doi: 10.2147/DDDT.S236661
Corrects:
Drug Des Devel Ther. 2019; 13: 3625–3634.
PMCID:
PMC6849329
Correction PubReader PDF–147KCite

Corrigenda

Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Corrigendum]
Drug Des Devel Ther. 2019; 13: 807. Published online 2019 Feb 28. doi: 10.2147/DDDT.S203702
Corrects:
Drug Des Devel Ther. 2018; 12: 3369–3375.
PMCID:
PMC6400115
Correction PubReader PDF–107KCite
Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis [Corrigendum]
Y Kameoka, Kishi F, Koura M
Drug Des Devel Ther. 2019; 13: 1689. Published online 2019 May 22. doi: 10.2147/DDDT.S212028
Corrects:
Drug Des Devel Ther. 2019; 13: 555–568.
PMCID:
PMC6535426
Correction PubReader PDF–149KCite
Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway [Corrigendum]
Mao Mu, Shi Zuo, Rong-Min Wu, Kai-Sheng Deng, Shuang Lu, Juan-Juan Zhu, Gao-Liang Zou, Jing Yang, Ming-Liang Cheng, Xue-Ke Zhao
Drug Des Devel Ther. 2019; 13: 1819. Published online 2019 May 24. doi: 10.2147/DDDT.S215949
Corrects:
Drug Des Devel Ther. 2018; 12: 4107–4115.
PMCID:
PMC6538833
Correction PubReader PDF–466KCite
Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress [Corrigendum]
Drug Des Devel Ther. 2019; 13: 1865. Published online 2019 May 29. doi: 10.2147/DDDT.S215948
Corrects:
Drug Des Devel Ther. 2019; 13: 1461–1472.
PMCID:
PMC6549761
Correction PubReader PDF–147KCite
20(S)-Ginsenoside Rg3 Promotes Senescence And Apoptosis In Gallbladder Cancer Cells Via The P53 Pathway [Corrigendum]
Drug Des Devel Ther. 2019; 13: 3527–3528. Published online 2019 Oct 8. doi: 10.2147/DDDT.S230835
Corrects:
Drug Des Devel Ther. 2015; 9: 3969–3987.
PMCID:
PMC6791250
Correction PubReader PDF–1.9MCite
A Novel Hybrid Compound LLP2A-Alendronate Accelerates Open Fracture Healing in a Rabbit Model [Corrigendum]
Drug Des Devel Ther. 2019; 13: 4159–4160. Published online 2019 Dec 9. doi: 10.2147/DDDT.S239224
Corrects:
Drug Des Devel Ther. 2019; 13: 1077–1086.
PMCID:
PMC6911234
Correction PubReader PDF–157KCite

Retraction

Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models [Retraction]
Drug Des Devel Ther. 2019; 13: 907–908. Published online 2019 Mar 18. doi: 10.2147/DDDT.S207534
Retracts:
Drug Des Devel Ther. 2017; 11: 2605–2619.
PMCID:
PMC6498976
Retraction PubReader PDF–163KCite
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