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TABLE 1

Activity of pleconaril against prototypic enterovirus strainsa

Enterovirus serotype and strain IC50 (μM)
EV3 Morrisey0.31 ± 0.10
EV4 Pesascek0.02 ± 0.005
EV5 Noyce1.05 ± 0.42
EV6 D’Amori0.05 ± 0.01
EV7 Wallace0.05 ± 0.03
EV9 Hill0.18 ± 0.03
EV11 (Gregory)0.01 ± 0.005
EV24 (DeCamp)0.01 ± 0.003
EV30 (Bastianni)0.01 ± 0.005
CVA9 Bozek0.005 ± 0.002
CVB1 Conn-50.002 ± 0.0005
CVB2 Ohio-10.003 ± 0.002
CVB3 Nancy>12.5
CVB3 M0.02 ± 0
CVB4 JVB0.05 ± 0.03
CVB5 Faulkner0.001 ± 0.0003
aPrototypic strains of the 15 most commonly isolated enteroviruses (49). The results are the mean ± standard deviation IC50 of at least two independent determinations.