PMC full text:
TABLE 1
Activity of pleconaril against prototypic enterovirus strainsa
| Enterovirus serotype and strain | IC50 (μM) |
|---|---|
| EV3 Morrisey | 0.31 ± 0.10 |
| EV4 Pesascek | 0.02 ± 0.005 |
| EV5 Noyce | 1.05 ± 0.42 |
| EV6 D’Amori | 0.05 ± 0.01 |
| EV7 Wallace | 0.05 ± 0.03 |
| EV9 Hill | 0.18 ± 0.03 |
| EV11 (Gregory) | 0.01 ± 0.005 |
| EV24 (DeCamp) | 0.01 ± 0.003 |
| EV30 (Bastianni) | 0.01 ± 0.005 |
| CVA9 Bozek | 0.005 ± 0.002 |
| CVB1 Conn-5 | 0.002 ± 0.0005 |
| CVB2 Ohio-1 | 0.003 ± 0.002 |
| CVB3 Nancy | >12.5 |
| CVB3 M | 0.02 ± 0 |
| CVB4 JVB | 0.05 ± 0.03 |
| CVB5 Faulkner | 0.001 ± 0.0003 |
aPrototypic strains of the 15 most commonly isolated enteroviruses (49). The results are the mean ± standard deviation IC50 of at least two independent determinations.
