McConnell in Shock

The ideal approach to hemodynamically unstable patients requires the quick identification of the type of shock and its etiology. This can be a challenge in critically ill patients due to the limited information, the wide number of differential diagnosis and the need for fast intervention. Point-of-care ultrasound (POCUS) is a non-invasive, low-cost, real-time and reliable tool used to rapidly and accurately assess hemodynamically unstable patients at the bedside. It can support diagnosis, tailor therapy and guide further workup, especially in patients deemed too unstable to undergo other imaging studies. The authors describe the case of a patient in obstructive shock due to pulmonary embolism, in which McConnell sign was identified by bedside echocardiography, before lab tests and pulmonary computerized tomography angiogram results were obtained


Introduction
Shock is a life-threatening condition characterized by a severe mismatch between the supply and demand of oxygen. Although this can lead to multiorgan failure, different therapeutic measures are needed depending on the type and etiology of shock.
Recognizing the possible causes of shock in the critically ill patient in the emergency department (ED) is difficult due to limited information and extensive differentials [1]. Point-of-care ultrasound (POCUS) is a low-cost, real-time, noninvasive tool that allows a quick examination. It is useful to evaluate undifferentiated shock, limiting differential diagnosis and tailoring therapy and workup [1].
The authors present the case of an ED patient with obstructive shock identified by POCUS before other exams.

Case Presentation
An 82-year-old male presented to ED with sudden onset of drowsiness and hypotension. Previous medical history was significant for hypertension, dyslipidaemia, obesity, liver steatosis, benign prostatic hyperplasia and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection two months earlier. Current medication included furosemide, clopidogrel, perindopril, indapamide, metformin, silodosin, and iron.
He started fluid-challenge and oxygen therapy, while further workup was ordered.
He was admitted to the coronary intensive care unit.
Twenty-four hours later his systolic blood pressure (SBP) was 105-120 mmHg, HR 75 bpm and lactates 1 mmol/L. Bedside ultrasound showed no right heart overload, tricuspid annular plane systolic excursion 20 mm, good left ventricle systolic function and no inferior vena cava (IVC) distention with inspiratory collapse.
He was discharged 11 days later with hemodynamic stability, with no dyspnea on exertion or hypoxemia.

Discussion
Pulmonary embolism (PE) is a frequently underestimated, underdiagnosed, and undertreated disease [2]. It is a cardiovascular emergency with mortality of 15%-25% if complicated with unstable hemodynamics [2][3]. Quick diagnosis of PE is essential because rapid management can decrease mortality but is frequently confounded by nonspecific clinical presentation [2].
Diagnosis and early treatment of PE can be lifesaving. CTPA is the gold standard for PE diagnosis but often unsuitable for unstable patients; An imaging modality that can be rapidly performed at the immobile and critically ill patient's bedside is needed [3]. Bedside critical care ultrasound is a real-time exam with many advantages, as it is rapidly performed and non-invasive [3].
Echocardiographic findings that support the diagnosis of acute PE can be indirect as enlarged RV in parasternal long-axis view, dilated RV with basal RV/left ventricle ratio>1.0, McConnell sign, flattened intraventricular septum in parasternal short-axis view, distended IVC with diminished inspiratory collapsibility in subcostal view; or direct identification of right heart mobile thrombus. Generally, indirect signs have poor sensitivity (29-56%) except McConnell sign [1,4].
In obstructive shock due to acute PE, echocardiograph images will demonstrate signs of right heart strain or dysfunction and sudden pressure on RV can cause ventricular wall to balloon outward and display the McConnell sign [5]. Thus, McConnell's sign is characterized by hypokinesis of RV mid-free wall with preserved apical contractility seen in apical four-chamber view. It is seen in only 20% of PE with hemodynamic instability cases. In the original study, it was observed a 77% sensitivity and 94% specificity. Over time, other studies have validated the results and came to a similar conclusion. [4,6,7].
According to the 2019 Guidelines of European Society of Cardiology in "hemodynamically compromised patient with suspected PE, unequivocal signs of RV pressure overload, especially with more specific echocardiographic findings (60/60 sign, McConnell sign, or right heart thrombi), justify emergency reperfusion treatment for PE if immediate CT angiography is not feasible in a patient with high clinical probability and no other obvious causes for RV pressure overload" [4].
This case demonstrates the successful application of bedside ultrasound in the diagnosis of massive PE in a patient with hemodynamic instability. Although thrombolytics were given immediately after confirmation of PE by CTPA, the McConnell sign also suggested the diagnosis. PE was diagnosed using bedside echocardiogram, observing the McConnell sign that is rare but specific and confirmed with CTA of the thorax. Further validation and real-time implementation of this low-cost modality could facilitate the decision to implement thrombolytics for unstable patients with massive pulmonary embolism who cannot undergo formal radiographic evaluation.

Additional Information Disclosures
Human subjects: All authors have confirmed that this study did not involve human participants or tissue.

Conflicts of interest:
In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.