PMC full text:
Published online 2019 Jul 26. doi: 10.1371/journal.pone.0219531
Table 3
Biochemical pathways disturbed in Gulf War illness.
| No. | Pathway Name | Measured Metabolites in the Pathway (N) | Expected Pathway Proportion (P = N/358) | Expected Hits in Sample of 30 (P * 30) | Observed Hits in the Top 30 Metabolites | Fold Enrichment (Obs/Exp) | Impact (Sum VIP Score) | Fraction of Impact Explained (% of 63.0) | Increased | Decreased |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Ceramide Metabolism* | 31 | 0.09 | 2.6 | 11 | 4.2 | 23.9 | 38% | 11 | 0 |
| 2 | Phospholipid Metabolism* | 56 | 0.16 | 4.7 | 5 | 1.1 | 10.6 | 17% | 4 | 1 |
| 3 | Sphingomyelin Metabolism* | 36 | 0.10 | 3.0 | 4 | 1.3 | 8.0 | 13% | 4 | 0 |
| 4 | Purine Metabolism | 18 | 0.05 | 1.5 | 4 | 2.7 | 7.6 | 12% | 0 | 4 |
| 5 | Pyrimidine Metabolism | 9 | 0.03 | 0.8 | 2 | 2.7 | 4.5 | 7% | 1 | 1 |
| 6 | Endocannabinoid Metabolism* | 4 | 0.01 | 0.3 | 2 | 6.0 | 4.1 | 6% | 0 | 2 |
| 7 | Eicosanoid and Resolvins* | 7 | 0.02 | 0.6 | 1 | 1.7 | 2.3 | 4% | 0 | 1 |
| 8 | Branch Chain Amino Acids | 8 | 0.02 | 0.7 | 1 | 1.5 | 2.0 | 3% | 1 | 0 |
| Subtotal: | 21 | 9 | ||||||||
| Total: | 30 | |||||||||
*Lipid pathways.
