PMC full text:
Published online 2016 Sep 27. doi: 10.1038/tp.2016.184
Table 2
List of mitochondrial proteins found differentially expressed by nano-LC-MS analysis, and with a fold of change ⩾2, in mitochondria from platelets of the twins discordant for CFS
| ID | Protein | Name | a | CTRL; M±s.d. | CFS; M±s.d. | b | c |
|---|---|---|---|---|---|---|---|
| P24752 | THIL | Acetyl-CoA acetyltransferase | 13 | 0.57±0.005 | 1.46±0.007 | 0.00003 | 2.5 |
| P00505 | AATM | Aspartate aminotransferase | 16 | 3.23±0.05 | 9.82±0.19 | 0.0002 | 3.0 |
| P42765 | THIM | 3-ketoacyl-CoA thiolase | 11 | 1.54±0.03 | 6.46±0.13 | 0.0002 | 4.2 |
| Q16762 | THTR | Thiosulfate sulfurtransferase | 14 | 2.82±0.17 | 6.55±0.19 | 0.0002 | 2.3 |
| Q13011 | ECH1 | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase | 12 | 0.42±0.003 | 0.95±0.01 | 0.0002 | 2.2 |
| P55809 | SCOT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1 | 20 | 1.13±0.03 | 2.41±0.05 | 0.0002 | 2.1 |
| P22830 | HEMH | Ferrochelatase | 4 | 0.84±0.07 | 1.72±0.09 | 0.0003 | 2.1 |
| Q9NUB1 | ACS2L | Acetyl-coenzyme A synthetase 2-like | 10 | 0.90±0.01 | 2.56±0.04 | 0.0004 | 2.8 |
| P06576 | ATPB | ATP synthase subunit beta | 24 | 0.32±0.0059 | 0.71±0.004 | 0.0004 | 2.1 |
| O43837 | IDH3B | Isocitrate dehydrogenase (NAD) subunit beta | 7 | 2.74±0.04 | 6.47±0.09 | 0.001 | 2.4 |
| P30084 | ECHM | Enoyl-CoA hydratase | 13 | 0.93±0.04 | 2.40±0.06 | 0.001 | 2.6 |
| O60488 | ACSL4 | Long-chain fatty-acid—CoA ligase 4 | 4 | 0.14±0.004 | 0.05±0.003 | 0.001 | 0.4 |
| P30038 | AL4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase | 10 | 0.90±0.02 | 2.31±0.04 | 0.001 | 2.6 |
| Q9UIJ7 | KAD3 | GTP:AMP phosphotransferase AK3 | 10 | 3.31±0.009 | 7.42±0.18 | 0.001 | 2.2 |
| P04179 | SODM | Superoxide dismutase (Mn) | 13 | 2.93±0.007 | 6.34±0.16 | 0.001 | 2.2 |
| P13804 | ETFA | Electron transfer flavoprotein subunit alpha | 12 | 0.52±0.02 | 1.06±0.02 | 0.001 | 2.0 |
| Q9Y512 | SAM50 | Sorting and assembly machinery component 50 homolog | 7 | 0.10±0.002 | 0.05±0.0005 | 0.001 | 0.5 |
| Q5JRX3 | PREP | Presequence protease | 12 | 1.82±0.03 | 5.96±0.23 | 0.001 | 3.3 |
| P40926 | MDHM | Malate dehydrogenase | 17 | 0.56±0.018 | 1.30±0.03 | 0.001 | 2.3 |
| Q99798 | ACON | Aconitate hydratase | 35 | 0.92±0.004 | 2.01±0.07 | 0.001 | 2.2 |
| P35914 | HMGCL | Hydroxymethylglutaryl-CoA lyase | 9 | 0.64±0.02 | 1.44±0.02 | 0.001 | 2.3 |
| Q9BX68 | HINT2 | Histidine triad nucleotide-binding protein 2 | 4 | 1.48±0.12 | 3.35±0.19 | 0.001 | 2.3 |
| Q9HAV7 | GRPE1 | GrpE protein homolog 1 | 3 | 0.35±0.02 | 1.08±0.02 | 0.001 | 3.1 |
| P45954 | ACDSB | Short/branched chain-specific acyl-CoA dehydrogenase | 11 | 0.32±0.03 | 0.72±0.05 | 0.002 | 2.2 |
| P30405 | PPIF | Peptidyl-prolyl cis–trans isomerase F | 10 | 0.71±0.009 | 1.47±0.09 | 0.005 | 2.1 |
| P54886 | P5CS | Delta-1-pyrroline-5-carboxylate synthase | 3 | 1.52±0.076 | 4.68±0.3 | 0.002 | 3.1 |
| O95563 | MPC2 | Mitochondrial pyruvate carrier 2 | 3 | 0.38±0.008 | 0.19±0.007 | 0.002 | 0.5 |
| P48735 | IDHP | Isocitrate dehydrogenase (NADP) | 25 | 0.34±0.008 | 0.74±0.04 | 0.002 | 2.2 |
| Q9H2U2 | IPYR2 | Inorganic pyrophosphatase 2 | 5 | 0.16±0.002 | 0.36±0.02 | 0.002 | 2.3 |
| P30042 | ES1 | ES1 protein homolog | 7 | 6.10±0.14 | 14.62±0.71 | 0.003 | 2.4 |
| P31937 | 3HIDH | 3-Hydroxyisobutyrate dehydrogenase | 4 | 0.43±0.02 | 1.14±0.07 | 0.003 | 2.7 |
| P50213 | IDH3A | Isocitrate dehydrogenase (NAD) subunit alpha | 6 | 1.70±0.06 | 3.88±0.26 | 0.003 | 2.3 |
| O95571 | ETHE1 | Persulfide dioxygenase ETHE1 | 4 | 1.31±0.05 | 3.19±0.18 | 0.003 | 2.4 |
| P11310 | ACADM | Medium-chain-specific acyl-CoA dehydrogenase | 12 | 0.49±0.01 | 1.13±0.06 | 0.004 | 2.3 |
| Q02252 | MMSA | Methylmalonate-–emialdehyde dehydrogenase (acylating) | 8 | 0.83±0.03 | 1.75±0.07 | 0.004 | 2.1 |
| Q86Y39 | NDUAB | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11 | 4 | 1.13±0.05 | 0.46±0.03 | 0.004 | 0.4 |
| P39210 | MPV17 | Protein Mpv17 | 2 | 0.18±0.006 | 0.08±0.009 | 0.002 | 0.4 |
| Q9Y2R0 | COA3 | Cytochrome c oxidase assembly protein 3 homolog | 3 | 0.40±0.02 | 0.18±0.002 | 0.005 | 0.4 |
| Q9HA77 | SYCM | Probable cysteine—tRNA ligase | 5 | 1.39±0.07 | 3.24±0.36 | 0.008 | 2.3 |
| P56556 | NDUA6 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6 | 2 | 0.60±0.06 | 0.28±0.003 | 0.011 | 0.5 |
| Q07021 | C1QBP | Complement component 1 Q subcomponent-binding protein | 5 | 0.25±0.02 | 0.56±0.05 | 0.020 | 2.2 |
Abbreviations: a, peptides used for quantitation; b, P-value; c, fold CFS/CTRL; CFS, twin brother affected by chronic fatigue syndrome; CTRL, healthy twin brother; ID, UniProt accession number; M±s.d., mean±s.d. of normalized intensity values; nano-LC-MS, nano-liquid chromatography electrospray ionization mass spectrometry.
