Logo of tpLink to Publisher's site
PMC full text:

Table 2

List of mitochondrial proteins found differentially expressed by nano-LC-MS analysis, and with a fold of change ⩾2, in mitochondria from platelets of the twins discordant for CFS
IDProteinNameaCTRL; M±s.d.CFS; M±s.d.bc
P24752THILAcetyl-CoA acetyltransferase130.57±0.0051.46±0.0070.000032.5
P00505AATMAspartate aminotransferase163.23±0.059.82±0.190.00023.0
P42765THIM3-ketoacyl-CoA thiolase111.54±0.036.46±0.130.00024.2
Q16762THTRThiosulfate sulfurtransferase142.82±0.176.55±0.190.00022.3
Q13011ECH1Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase120.42±0.0030.95±0.010.00022.2
P55809SCOT1Succinyl-CoA:3-ketoacid coenzyme A transferase 1201.13±0.032.41±0.050.00022.1
P22830HEMHFerrochelatase40.84±0.071.72±0.090.00032.1
Q9NUB1ACS2LAcetyl-coenzyme A synthetase 2-like100.90±0.012.56±0.040.00042.8
P06576ATPBATP synthase subunit beta240.32±0.00590.71±0.0040.00042.1
O43837IDH3BIsocitrate dehydrogenase (NAD) subunit beta72.74±0.046.47±0.090.0012.4
P30084ECHMEnoyl-CoA hydratase130.93±0.042.40±0.060.0012.6
O60488ACSL4Long-chain fatty-acid—CoA ligase 440.14±0.0040.05±0.0030.0010.4
P30038AL4A1Delta-1-pyrroline-5-carboxylate dehydrogenase100.90±0.022.31±0.040.0012.6
Q9UIJ7KAD3GTP:AMP phosphotransferase AK3103.31±0.0097.42±0.180.0012.2
P04179SODMSuperoxide dismutase (Mn)132.93±0.0076.34±0.160.0012.2
P13804ETFAElectron transfer flavoprotein subunit alpha120.52±0.021.06±0.020.0012.0
Q9Y512SAM50Sorting and assembly machinery component 50 homolog70.10±0.0020.05±0.00050.0010.5
Q5JRX3PREPPresequence protease121.82±0.035.96±0.230.0013.3
P40926MDHMMalate dehydrogenase170.56±0.0181.30±0.030.0012.3
Q99798ACONAconitate hydratase350.92±0.0042.01±0.070.0012.2
P35914HMGCLHydroxymethylglutaryl-CoA lyase90.64±0.021.44±0.020.0012.3
Q9BX68HINT2Histidine triad nucleotide-binding protein 241.48±0.123.35±0.190.0012.3
Q9HAV7GRPE1GrpE protein homolog 130.35±0.021.08±0.020.0013.1
P45954ACDSBShort/branched chain-specific acyl-CoA dehydrogenase110.32±0.030.72±0.050.0022.2
P30405PPIFPeptidyl-prolyl cis–trans isomerase F100.71±0.0091.47±0.090.0052.1
P54886P5CSDelta-1-pyrroline-5-carboxylate synthase31.52±0.0764.68±0.30.0023.1
O95563MPC2Mitochondrial pyruvate carrier 230.38±0.0080.19±0.0070.0020.5
P48735IDHPIsocitrate dehydrogenase (NADP)250.34±0.0080.74±0.040.0022.2
Q9H2U2IPYR2Inorganic pyrophosphatase 250.16±0.0020.36±0.020.0022.3
P30042ES1ES1 protein homolog76.10±0.1414.62±0.710.0032.4
P319373HIDH3-Hydroxyisobutyrate dehydrogenase40.43±0.021.14±0.070.0032.7
P50213IDH3AIsocitrate dehydrogenase (NAD) subunit alpha61.70±0.063.88±0.260.0032.3
O95571ETHE1Persulfide dioxygenase ETHE141.31±0.053.19±0.180.0032.4
P11310ACADMMedium-chain-specific acyl-CoA dehydrogenase120.49±0.011.13±0.060.0042.3
Q02252MMSAMethylmalonate-–emialdehyde dehydrogenase (acylating)80.83±0.031.75±0.070.0042.1
Q86Y39NDUABNADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1141.13±0.050.46±0.030.0040.4
P39210MPV17Protein Mpv1720.18±0.0060.08±0.0090.0020.4
Q9Y2R0COA3Cytochrome c oxidase assembly protein 3 homolog30.40±0.020.18±0.0020.0050.4
Q9HA77SYCMProbable cysteine—tRNA ligase51.39±0.073.24±0.360.0082.3
P56556NDUA6NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 620.60±0.060.28±0.0030.0110.5
Q07021C1QBPComplement component 1 Q subcomponent-binding protein50.25±0.020.56±0.050.0202.2

Abbreviations: a, peptides used for quantitation; b, P-value; c, fold CFS/CTRL; CFS, twin brother affected by chronic fatigue syndrome; CTRL, healthy twin brother; ID, UniProt accession number; M±s.d., mean±s.d. of normalized intensity values; nano-LC-MS, nano-liquid chromatography electrospray ionization mass spectrometry.