Suspected adverse reactions to vaccination in Canadian dogs and cats

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Table 1

Suspected adverse reaction report rates for small animal vaccines in Canada^a

	Number of reactions per 10 000 doses sold

	Dogs		Cats		Rabies

Condition	A/B/O^b	N^c	A/B/O^b	N^c	A/B/O^b	N^c
Allergic conditions other than anaphylaxis	2.663	0.040	0.187	0.000	2.646	0.013
Anaphylaxis, circulatory shock	0.332	0.010	0.029	0.001	0.343	0.001
Dyspnea	0.155	0.017	0.110	0.016	0.170	0.008
Vomiting	2.511	0.195	1.131	0.038	2.710	0.054
Diarrhea	0.791	0.111	0.402	0.023	0.921	0.038
Loss of consciousness, collapse	0.141	0.011	0.008	0.001	0.136	0.000
Pain	0.240	0.013	0.176	0.008	0.278	0.014
Lethargy	1.923	0.103	1.473	0.061	1.969	0.095
Fever	0.132	0.025	0.438	0.018	0.180	0.015
Malaise	0.017	0.005	0.017	0.004	0.022	0.003
Vasculitis	0.013	0.002	0.001	0.001	0.022	0.002
Cough	0.445	0.113	0.016	0.006	0.056	0.041
Other upper respiratory tract disorders	0.346	0.070	0.085	0.010	0.047	0.028
Injection site reaction other than sarcoma	1.144	0.130	0.689	0.057	1.129	0.122
Injection site sarcoma	0.002	0.001	0.148	0.012	0.064	0.002
Death	0.104	0.073	0.161	0.055	0.114	0.036
Suspected lack of efficacy	0.228	0.203	0.039	0.019	0.020	0.011
Neurological disorders	0.459	0.081	0.249	0.035	0.478	0.056
Autoimmune disorders	0.027	0.003	0.008	0.001	0.027	0.002

^aReactions reported to the Canadian Centre for Veterinary Biologics between January 1, 2010 to June 30, 2014.

^bReported reactions assessed as possibly associated with vaccine: A (probable) + B (possible) − O (unknown).

^cReported reactions assessed as not associated with vaccine: N (unlikely).