Logo of plosoneLink to Publisher's site
PMC full text:

Table 1

Sexually dimorphic gene expression in Fischer 344 rats.
Gene Description (Gene Symbol) GenBank Acc ID 8 weeks 21 weeks 78 weeks
p FC p FC p FC
Oxidative Phosphorylation (85) a 0.9710.1090.034 b
Complex I (NADH—Ubiquinone dehydrogenase) (36) a 0.9900.1050.039 b
NADH dehydrogenase 1 alpha subcomplex, 1 (Ndufa1)XM_3437600.6901.0220.3460.8550.017 c 1.144
NADH dehydrogenase 1 alpha subcomplex, 2 (Ndufa2)XM_2145700.6451.0230.0710.7550.041 c 1.075
NADH dehydrogenase complex I, assembly factor 1 (Ndufaf1)XM_2158140.8560.9920.031 c 0.8350.9071.009
NADH dehydrogenase 1 beta subcomplex, 2 (Ndufb2)XM_3426640.4371.0540.2640.8460.045 c 1.126
NADH dehydrogenase Fe-S protein 6 (Ndufs6)NM_0192230.6141.0280.1740.8060.037 c 1.119
NADH dehydrogenase flavoprotein 1 (Ndufv1)NM_0010069720.8511.0110.022 c 0.8310.5271.109
NADH dehydrogenase flavoprotein 3 (Ndufv3)NM_0226070.5161.0310.1030.7540.016 c 1.115
Complex IV (Cytochrome c oxidase) (20) a 0.9100.1040.009 b
cytochrome c oxidase assembly protein 11 (Cox11)BF5671450.9320.9870.008 c 2.0190.3121.233
cytochrome c oxidase subunit VIIa polypeptide 2 (Cox7a2)NM_0225030.4211.0590.3650.8850.036 c 1.174
cytochrome c oxidase subunit VIIb (Cox7b)NM_1828190.2481.0560.1630.8010.013 c 1.213
cytochrome c oxidase subunit VIIIa (Cox8a)AI1025050.7181.1480.5321.3430.009 c 1.673
surfeit 1 (Surf1)NM_1720680.6481.0160.2280.8630.017 c 1.124
FA Metabolism (53) a 0.007 b 0.001 b 0.950
acetyl-CoA acyltransferase 2 (Acaa2)NM_1304330.033 c 1.1030.002 c 0.7390.5801.061
acyl-CoA dehydrogenase, C-4 to C-12 straight chain (Acadm)NM_0169860.0511.0850.002 c 0.8990.4791.065
acyl-CoA dehydrogenase, C-2 to C-3 short chain (Acads)BM9865700.022 c 1.2860.1100.7440.9371.011
acetyl-CoA acetyltransferase 1 (Acat1)NM_0170750.7790.9900.050 c 0.8870.7781.016
acyl-CoA thioesterase 2 (Acot2)NM_1389070.1521.1370.011 c 1.2400.2671.181
acyl-CoA synthetase long-chain family member 3 (Acsl3)NM_0571070.6540.9820.004 c 1.3350.4430.944
acyl-CoA synthetase long-chain family member 4 (Acsl4)NM_0536230.010 c 0.8500.2611.3620.010 c 0.795
acyl-CoA synthetase long-chain family member 6 (Acsl6)NM_1307390.0560.8560.008 c 0.7900.2991.142
cytochrome P450, family 11, subfamily a, polypeptide 1 (Cyp11a1)NM_0172860.8041.0440.008 c 0.5750.5751.143
enoyl CoA hydratase 1, peroxisomal (Ech1)NM_0225940.017 c 1.1760.4760.9310.3441.114
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit (Hadhb)NM_1336180.036 c 1.1150.3820.9430.2001.237
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (Hmgcs2)AI2323200.023 c 1.6180.8240.9290.5501.271
malonyl-CoA decarboxylase (Mlycd)AI2327030.033 c 1.1800.7840.9580.0861.225
3-oxoacyl-ACP synthase, mitochondrial (Oxsm)XM_0010680160.4930.9490.013 c 0.8180.7851.026
propionyl CoA carboxylase, alpha polypeptide (Pcca)XM_0010754960.032 c 1.0580.0590.9020.3771.065
Pyruvate dehydrogenase complex (11) a 0.1750.002 b 0.068
dihydrolipoamide S-acetyltransferase (Dlat)NM_0310250.1460.9000.041 c 0.8980.4381.051
pyruvate dehydrogenase complex, component X (Pdhx)XM_2303270.2250.8950.040 c 0.7940.9940.999
pyruvate dehydrogenase kinase, isozyme 1 (Pdk1)NM_0538260.0851.1500.009 c 0.6890.0911.169
pyruvate dehydrogenase kinase, isozyme 4 (Pdk4)AI0310530.002 c 1.4430.018 c 1.7620.3551.248
pyruvate dehyrogenase phosphatase catalytic subunit 1 (Pdp1)NM_0193720.7241.0140.6100.9800.043 c 1.267
Apoptosis (65) a 0.005 b 0.003 b 0.008 b
apoptosis, caspase activation inhibitor (Aven)XM_2304380.3811.0630.038 c 0.8580.5701.072
BCL2-associated agonist of cell death (Bad)NM_0226980.6950.9770.040 c 0.7360.9430.993
Bcl2-associated X protein (Bax)XM_0010610200.020 c 1.0550.4250.9300.9410.994
BCL2/adenovirus E1B interacting protein 2 (Bnip2)XM_2171910.2540.9350.012 c 0.8610.6081.106
BCL2/adenovirus E1B interacting protein 3-like (Bnip3l)AI1758710.8050.9520.0590.5850.00004 c 0.471
caspase 1 (Casp1)NM_0127620.0830.9280.005 c 0.7260.1750.841
caspase 12 (Casp12)NM_1304220.1400.8910.002 c 0.7920.0710.779
caspase 2 (Casp2)NM_0225220.3150.9850.040 c 1.2940.6510.987
caspase 3 (Casp3)AI0596040.3290.8650.004 c 0.5640.2010.673
caspase 4, apoptosis-related cysteine peptidase (Casp4)NM_0537360.0004 c 0.8520.016 c 0.6980.1600.837
caspase 7 (Casp7)NM_0222600.0680.9610.5970.9540.010 c 1.147
death-associated protein (Dap)NM_0225260.2800.9240.0600.8130.040 c 0.856
death associated protein kinase 1 (Dapk1)XM_2251380.8941.0050.4420.9060.032 c 0.810
death associated protein kinase 2 (Dapk2)XM_5787390.1550.8560.001 c 0.6820.3280.862
death associated protein kinase 3 (Dapk3)NM_0225460.9731.0020.049 c 0.8130.3680.929
death associated protein-like 1 (Dapl1)XM_3424360.029 c 0.5290.8480.9060.9381.031
DNA fragmentation factor, alpha subunit (Dffa)NM_0536790.0720.8820.009 c 0.7850.4810.949
DNA fragmentation factor, beta subunit (Dffb)NM_0533620.9211.0250.038 c 0.5250.0810.648
dihydroorotate dehydrogenase (quinone) (Dhodh)NM_0010085530.6110.9580.004 c 0.7880.5010.953
mitochondrial carrier 2 (Mtch2)AA8928630.034 c 1.9080.5391.1810.1310.782
programmed cell death 10 (Pdcd10)AA9647050.4911.0840.044 c 0.6620.3840.876
programmed cell death 5 (Pdcd5)XM_2149110.2081.0520.4160.9200.011 c 1.161
programmed cell death 6 (Pdcd6)XM_2177320.8370.9930.018 c 0.7220.4451.034
programmed cell death 7 (Pdcd7)XM_3434130.0511.1030.030 c 1.1760.7251.020
TP53 regulated inhibitor of apoptosis 1 (Triap1)XM_0010775180.010 c 1.0720.4000.9160.044 c 1.100
voltage-dependent anion channel 1 (Vdac1)AA8754890.4101.0850.025 c 0.7250.8460.982

This table represents a list of sexually dimorphic genes in one or more of the 3 ages (young, adult and old).

a Gene Ontology (GO) term (number of genes evaluated).

b Significant (p< 0.05) sex difference on overall GO term.

c Significant (p< 0.05) sex difference in expression level of each gene.

FC—Fold Change calculated as a ratio of average expression levels in female hearts to male hearts.

p—probability value < 0.05.