PMC full text:
Published online 2015 Jan 23. doi: 10.1371/journal.pone.0117047
Table 1
Sexually dimorphic gene expression in Fischer 344 rats.
| Gene Description (Gene Symbol) | GenBank Acc ID | 8 weeks | 21 weeks | 78 weeks | |||
|---|---|---|---|---|---|---|---|
| p | FC | p | FC | p | FC | ||
| Oxidative Phosphorylation (85) a | 0.971 | 0.109 | 0.034 b | ||||
| Complex I (NADH—Ubiquinone dehydrogenase) (36) a | 0.990 | 0.105 | 0.039 b | ||||
| NADH dehydrogenase 1 alpha subcomplex, 1 (Ndufa1) | XM_343760 | 0.690 | 1.022 | 0.346 | 0.855 | 0.017 c | 1.144 |
| NADH dehydrogenase 1 alpha subcomplex, 2 (Ndufa2) | XM_214570 | 0.645 | 1.023 | 0.071 | 0.755 | 0.041 c | 1.075 |
| NADH dehydrogenase complex I, assembly factor 1 (Ndufaf1) | XM_215814 | 0.856 | 0.992 | 0.031 c | 0.835 | 0.907 | 1.009 |
| NADH dehydrogenase 1 beta subcomplex, 2 (Ndufb2) | XM_342664 | 0.437 | 1.054 | 0.264 | 0.846 | 0.045 c | 1.126 |
| NADH dehydrogenase Fe-S protein 6 (Ndufs6) | NM_019223 | 0.614 | 1.028 | 0.174 | 0.806 | 0.037 c | 1.119 |
| NADH dehydrogenase flavoprotein 1 (Ndufv1) | NM_001006972 | 0.851 | 1.011 | 0.022 c | 0.831 | 0.527 | 1.109 |
| NADH dehydrogenase flavoprotein 3 (Ndufv3) | NM_022607 | 0.516 | 1.031 | 0.103 | 0.754 | 0.016 c | 1.115 |
| Complex IV (Cytochrome c oxidase) (20) a | 0.910 | 0.104 | 0.009 b | ||||
| cytochrome c oxidase assembly protein 11 (Cox11) | BF567145 | 0.932 | 0.987 | 0.008 c | 2.019 | 0.312 | 1.233 |
| cytochrome c oxidase subunit VIIa polypeptide 2 (Cox7a2) | NM_022503 | 0.421 | 1.059 | 0.365 | 0.885 | 0.036 c | 1.174 |
| cytochrome c oxidase subunit VIIb (Cox7b) | NM_182819 | 0.248 | 1.056 | 0.163 | 0.801 | 0.013 c | 1.213 |
| cytochrome c oxidase subunit VIIIa (Cox8a) | AI102505 | 0.718 | 1.148 | 0.532 | 1.343 | 0.009 c | 1.673 |
| surfeit 1 (Surf1) | NM_172068 | 0.648 | 1.016 | 0.228 | 0.863 | 0.017 c | 1.124 |
| FA Metabolism (53) a | 0.007 b | 0.001 b | 0.950 | ||||
| acetyl-CoA acyltransferase 2 (Acaa2) | NM_130433 | 0.033 c | 1.103 | 0.002 c | 0.739 | 0.580 | 1.061 |
| acyl-CoA dehydrogenase, C-4 to C-12 straight chain (Acadm) | NM_016986 | 0.051 | 1.085 | 0.002 c | 0.899 | 0.479 | 1.065 |
| acyl-CoA dehydrogenase, C-2 to C-3 short chain (Acads) | BM986570 | 0.022 c | 1.286 | 0.110 | 0.744 | 0.937 | 1.011 |
| acetyl-CoA acetyltransferase 1 (Acat1) | NM_017075 | 0.779 | 0.990 | 0.050 c | 0.887 | 0.778 | 1.016 |
| acyl-CoA thioesterase 2 (Acot2) | NM_138907 | 0.152 | 1.137 | 0.011 c | 1.240 | 0.267 | 1.181 |
| acyl-CoA synthetase long-chain family member 3 (Acsl3) | NM_057107 | 0.654 | 0.982 | 0.004 c | 1.335 | 0.443 | 0.944 |
| acyl-CoA synthetase long-chain family member 4 (Acsl4) | NM_053623 | 0.010 c | 0.850 | 0.261 | 1.362 | 0.010 c | 0.795 |
| acyl-CoA synthetase long-chain family member 6 (Acsl6) | NM_130739 | 0.056 | 0.856 | 0.008 c | 0.790 | 0.299 | 1.142 |
| cytochrome P450, family 11, subfamily a, polypeptide 1 (Cyp11a1) | NM_017286 | 0.804 | 1.044 | 0.008 c | 0.575 | 0.575 | 1.143 |
| enoyl CoA hydratase 1, peroxisomal (Ech1) | NM_022594 | 0.017 c | 1.176 | 0.476 | 0.931 | 0.344 | 1.114 |
| hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit (Hadhb) | NM_133618 | 0.036 c | 1.115 | 0.382 | 0.943 | 0.200 | 1.237 |
| 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (Hmgcs2) | AI232320 | 0.023 c | 1.618 | 0.824 | 0.929 | 0.550 | 1.271 |
| malonyl-CoA decarboxylase (Mlycd) | AI232703 | 0.033 c | 1.180 | 0.784 | 0.958 | 0.086 | 1.225 |
| 3-oxoacyl-ACP synthase, mitochondrial (Oxsm) | XM_001068016 | 0.493 | 0.949 | 0.013 c | 0.818 | 0.785 | 1.026 |
| propionyl CoA carboxylase, alpha polypeptide (Pcca) | XM_001075496 | 0.032 c | 1.058 | 0.059 | 0.902 | 0.377 | 1.065 |
| Pyruvate dehydrogenase complex (11) a | 0.175 | 0.002 b | 0.068 | ||||
| dihydrolipoamide S-acetyltransferase (Dlat) | NM_031025 | 0.146 | 0.900 | 0.041 c | 0.898 | 0.438 | 1.051 |
| pyruvate dehydrogenase complex, component X (Pdhx) | XM_230327 | 0.225 | 0.895 | 0.040 c | 0.794 | 0.994 | 0.999 |
| pyruvate dehydrogenase kinase, isozyme 1 (Pdk1) | NM_053826 | 0.085 | 1.150 | 0.009 c | 0.689 | 0.091 | 1.169 |
| pyruvate dehydrogenase kinase, isozyme 4 (Pdk4) | AI031053 | 0.002 c | 1.443 | 0.018 c | 1.762 | 0.355 | 1.248 |
| pyruvate dehyrogenase phosphatase catalytic subunit 1 (Pdp1) | NM_019372 | 0.724 | 1.014 | 0.610 | 0.980 | 0.043 c | 1.267 |
| Apoptosis (65) a | 0.005 b | 0.003 b | 0.008 b | ||||
| apoptosis, caspase activation inhibitor (Aven) | XM_230438 | 0.381 | 1.063 | 0.038 c | 0.858 | 0.570 | 1.072 |
| BCL2-associated agonist of cell death (Bad) | NM_022698 | 0.695 | 0.977 | 0.040 c | 0.736 | 0.943 | 0.993 |
| Bcl2-associated X protein (Bax) | XM_001061020 | 0.020 c | 1.055 | 0.425 | 0.930 | 0.941 | 0.994 |
| BCL2/adenovirus E1B interacting protein 2 (Bnip2) | XM_217191 | 0.254 | 0.935 | 0.012 c | 0.861 | 0.608 | 1.106 |
| BCL2/adenovirus E1B interacting protein 3-like (Bnip3l) | AI175871 | 0.805 | 0.952 | 0.059 | 0.585 | 0.00004 c | 0.471 |
| caspase 1 (Casp1) | NM_012762 | 0.083 | 0.928 | 0.005 c | 0.726 | 0.175 | 0.841 |
| caspase 12 (Casp12) | NM_130422 | 0.140 | 0.891 | 0.002 c | 0.792 | 0.071 | 0.779 |
| caspase 2 (Casp2) | NM_022522 | 0.315 | 0.985 | 0.040 c | 1.294 | 0.651 | 0.987 |
| caspase 3 (Casp3) | AI059604 | 0.329 | 0.865 | 0.004 c | 0.564 | 0.201 | 0.673 |
| caspase 4, apoptosis-related cysteine peptidase (Casp4) | NM_053736 | 0.0004 c | 0.852 | 0.016 c | 0.698 | 0.160 | 0.837 |
| caspase 7 (Casp7) | NM_022260 | 0.068 | 0.961 | 0.597 | 0.954 | 0.010 c | 1.147 |
| death-associated protein (Dap) | NM_022526 | 0.280 | 0.924 | 0.060 | 0.813 | 0.040 c | 0.856 |
| death associated protein kinase 1 (Dapk1) | XM_225138 | 0.894 | 1.005 | 0.442 | 0.906 | 0.032 c | 0.810 |
| death associated protein kinase 2 (Dapk2) | XM_578739 | 0.155 | 0.856 | 0.001 c | 0.682 | 0.328 | 0.862 |
| death associated protein kinase 3 (Dapk3) | NM_022546 | 0.973 | 1.002 | 0.049 c | 0.813 | 0.368 | 0.929 |
| death associated protein-like 1 (Dapl1) | XM_342436 | 0.029 c | 0.529 | 0.848 | 0.906 | 0.938 | 1.031 |
| DNA fragmentation factor, alpha subunit (Dffa) | NM_053679 | 0.072 | 0.882 | 0.009 c | 0.785 | 0.481 | 0.949 |
| DNA fragmentation factor, beta subunit (Dffb) | NM_053362 | 0.921 | 1.025 | 0.038 c | 0.525 | 0.081 | 0.648 |
| dihydroorotate dehydrogenase (quinone) (Dhodh) | NM_001008553 | 0.611 | 0.958 | 0.004 c | 0.788 | 0.501 | 0.953 |
| mitochondrial carrier 2 (Mtch2) | AA892863 | 0.034 c | 1.908 | 0.539 | 1.181 | 0.131 | 0.782 |
| programmed cell death 10 (Pdcd10) | AA964705 | 0.491 | 1.084 | 0.044 c | 0.662 | 0.384 | 0.876 |
| programmed cell death 5 (Pdcd5) | XM_214911 | 0.208 | 1.052 | 0.416 | 0.920 | 0.011 c | 1.161 |
| programmed cell death 6 (Pdcd6) | XM_217732 | 0.837 | 0.993 | 0.018 c | 0.722 | 0.445 | 1.034 |
| programmed cell death 7 (Pdcd7) | XM_343413 | 0.051 | 1.103 | 0.030 c | 1.176 | 0.725 | 1.020 |
| TP53 regulated inhibitor of apoptosis 1 (Triap1) | XM_001077518 | 0.010 c | 1.072 | 0.400 | 0.916 | 0.044 c | 1.100 |
| voltage-dependent anion channel 1 (Vdac1) | AA875489 | 0.410 | 1.085 | 0.025 c | 0.725 | 0.846 | 0.982 |
This table represents a list of sexually dimorphic genes in one or more of the 3 ages (young, adult and old).
a Gene Ontology (GO) term (number of genes evaluated).
b Significant (p< 0.05) sex difference on overall GO term.
c Significant (p< 0.05) sex difference in expression level of each gene.
FC—Fold Change calculated as a ratio of average expression levels in female hearts to male hearts.
p—probability value < 0.05.
