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EMBO J. 1994 Apr 15; 13(8): 1899–1910.
PMCID: PMC395031
PMID: 8168488

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

M D Jacobson, J F Burne, and M C Raff
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Abstract

The molecular basis of programmed cell death (PCD) is unknown. An important clue is provided by the Bcl-2 protein, which can protect many cell types from PCD, although it is not known where or how it acts. Nuclear condensation, DNA fragmentation and a requirement for new RNA and protein synthesis are often considered hallmarks of PCD. We show here, however, that anucleate cytoplasts can undergo PCD and that Bcl-2 and extracellular survival signals can protect them, indicating that, in some cases at least, the nucleus is not required for PCD or for Bcl-2 or survival factor protection. We propose that PCD, like the cell cycle, is orchestrated by a cytoplasmic regulator that has multiple intracellular targets.

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Selected References

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