Fig. 2.

Metabolomic response of Trypanosoma brucei to eflornithine over a 72 h incubation time-course (Vincent et al. 2012). (A) Heat map shows the relative change in abundance of all putative metabolites following incubation with eflornithine. Putative metabolites are ranked according to fold-change at 72 h. The most significant increases and decreases correspond to metabolites of the polyamine pathway. (B) Metabolite abundance profiles of polyamine pathway metabolites showing accumulation of metabolites upstream of ornithine decarboxylase (ODC), and depletion of downstream metabolites. Y-axes represent peak heights from LC-MS data.