| PMC full text: |
|
Table 2
A list of miRNAs targeting SIRT1.
| miRNAs regulating SIRT1 | Tissue/cells/diseases | Regulation/function | Reference |
|---|---|---|---|
| miR-449a | Cancer cell lines | Inhibition of growth, apoptosis | Lizé et al. (2010) |
| miR-449 | Gastric cancer | Apoptosis, senescence | Bou Kheir et al. (2011) |
| miR-22 | Fibroblast and cancer | Inhibition of growth and metastasis, senescence | Xu et al. (2011) |
| miR-200a | Mammary epithelial cell | Epithelial to mesenchymal transition (EMT) | Eades et al. (2011) |
| miR-143/145 | Pancreatic cancer | Growth arrest, apoptosis | Pramanik et al. (2011) |
| miR-217 | Endothelial cells | Senescence | Menghini et al. (2009) |
| miR-195 | Cardiomyocyte | Palmitate induced apoptosis | Zhu et al. (2011) |
| miR-199a | Heart | Ischemia | Rane et al. (2009) |
| miR-132 | Adipocyte | Stress-induced chemokine production | Strum et al. (2009) |
| miR-181c, miR-9 | Alzheimer disease | Down-regulated by amyloid-β (Aβ) | Schonrock et al. (2012) |
| miR-9 | Pancreatic β-cell | Insulin secretion | Ramachandran et al. (2011) |
| miR-93 | Liver | Senescence | Li et al. (2011) |
| miR-181a/b, miR-9, miR-204, miR-199b, miR-135a | Mouse ES cell | Differentiation | Saunders et al. (2010) |
| miR-100, miR-137 | Mouse ES cell | Differentiation | Tarantino et al. (2010) |
miRNAs that regulates SIRT1 expression have diverse functions in different cells and tissues.