Mycophenolate mofetil inhibits the development of Coxsackie B3-virus-induced myocarditis in mice

Elizaveta Padalko; Erik Verbeken; Patrick Matthys; Joeri L Aerts; Erik De Clercq; Johan Neyts

doi:10.1186/1471-2180-3-25

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BMC Microbiol. 2003; 3: 25.

Published online 2003 Dec 21. doi: 10.1186/1471-2180-3-25

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Table 1

Effect of ribavirin and MPA on CBV3 replication in Vero cells and human myocardial fibroblasts (HMF)

	EC₅₀(μg/ml)^a		Yield reduction^b(%)	MTC (μg/ml)^c

	Vero	HMF
MPA	55	80	89	200
Ribavirin	117	250	87	>500

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^aConcentration of compound that reduces viral induced cytopathic effect by 50% ^bReduction of virus yield in Vero cells in the presence of 100 μg/ml of either compound ^cAs determined in Vero cells. Minimal toxic concentration, or correlation required to other normal cell morphology