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Figure 8

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NOS inhibition blunts AMPK-dependent upregulation of mitochondrial biogenesis markers in myotubes

L6 cells were exposed to l-NAME 1 h prior and during the AICAR treatments of 16 h. Cells were harvested immediately after treatments. Values represent fold change versus untreated (Control) cells (means ±s.e.m., n = 5–7/group). Effect of AICAR treatment alone or in combination with l-NAME in PGC-1α mRNA (A), F1ATP synthase mRNA (B) and citrate synthase mRNA (C). *P < 0.05 in comparison to all other groups.

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