Visceral leishmaniasis in eastern Africa – current status

Visceral leishmaniasis (VL) is among the most neglected of the tropical diseases, afflicting the poorest of the poor. In eastern Africa, VL causes at least 4000 deaths annually, a loss of approximately 385 000 disability-adjusted life years. Due to the chronicity of underlying causes, it is likely that the caseload will increase in the foreseeable future. While efforts should be pursued to develop novel case management and prevention tools, several effective interventions already exist but are rarely deployed. Funds are needed now to procure commodities and strengthen health systems, so that effective VL control can be delivered to populations at risk.

contributing to the rise in VL cases in some populations is the increasing prevalence of HIV (Anema and Ritmeijer, 2005), another common risk factor for VL (Murray et al., 2005). Because mass migration of VL-affected populations due to either armed conflict (e.g. Somalia) or peace (e.g. Sudan) will continue over the coming years, it is likely that the caseload will increase even further. Despite the significant and increasing VL burden in eastern Africa, efforts to control the disease are either non-existent or remain sub-optimal.
Few VL-endemic countries in eastern Africa have functional leishmaniasis control programmes, and these have little or no resources to train health staff on VL case management and methods for prevention and control, let alone to procure commodities to implement activities. Many affected people thus have no access to VL diagnosis, treatment or prevention, and they die, undetected by the health information system, in their community (Collin et al., 2006). Those cases that receive VL treatment often do so only because of temporary health service delivery provided by third party organisations (e.g. Médécins Sans Frontières) or international research projects (e.g. through the Leishmaniasis East African Platform of the Drugs for Neglected Diseases Initiative). Moreover, owing to difficulties in accessing endemic foci (e.g. because of security concerns or lack of infrastructure) up-todate and scientifically credible data on the epidemiology, disease burden and possible risk factors of VL are scarce. The lack of such information adds to the difficulty of identifying and targeting populations at risk, and selecting appropriate tools for prevention and control.
However, several effective tools to diagnose, treat or prevent VL have been developed and tested (Murray et al., 2005), including: highly sensitive and specific rapid immunochromatographic dipsticks; effective and safe generic antimonial drugs; and longlasting insecticidal nets (LLINs) for personal protection. Other tools have yet to be fully developed, evaluated or operationalised, particularly for eastern Africa; these include the use of geographic information systems and remote sensing data to delineate VL risk areas, and the use of drugs other than antimony to reduce treatment duration, cost and toxicity and to delay antimony drug resistance.
Rather than wait for the results from ongoing studies on novel tools, the time has come to deploy the existing ones. We advocate a strategy that combines commodity support (e.g. for dipsticks, drugs and LLINs), health system strengthening, capacity building and operational research. Wherever feasible, interventions should be integrated into multifunctional health service delivery in order to maximise effectiveness and resources. If substantial funds were made available to provide this support, the reduction of the VL burden would be highly costeffective (Laxminarayan et al., 2006). Improved estimates of the number and location of people at risk are essential to determine and target intervention resources required to control or even eliminate VL, and to lobby for the increased financial and political support to do so. Limited support is currently being provided by WHO and, primarily, non-governmental organisations to help establish and support control programmes in Ethiopia, Kenya and Sudan. There remains a need to expand these efforts, ensuring a coordinated regional approach.
Past experience has shown that VL has a devastating morbidity and mortality impact on affected communities. Several tools to effectively prevent infection and manage VL exist; however, there has been a chronic lack of funds to effectively implement them operationally. Making these tools available at a greater scale, both locally and regionally, will lead to significant inroads into the disease's incidence and distribution.

Funding
The authors' work on VL in Uganda is being supported by the Sir Halley Stewart Trust. SB is supported by a Wellcome Trust Career Development Fellowship.