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Bull World Health Organ. 1989; 67(4): 443–448.
PMCID: PMC2491276
PMID: 2680141

Measles immunization research: a review.

P. Aaby and C. J. Clements
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Abstract

Most global estimates indicate that more than 1 million children a year die from acute measles. The actual number of deaths may, however, be considerably higher than this. In addition, the impact of delayed mortality as a result of measles infection is only now being realized. Many months after they contract measles, children continue to experience higher levels of mortality and morbidity than those who do not. Immunization of children against measles therefore prevents mortality and morbidity not only during the acute phase but also during subsequent months. The impact of measles immunization programmes may therefore have generally been underestimated. The effects of measles infection on children during the early months of life are more damaging than those experienced by older children. Children should therefore be immunized against measles as early in life as possible, given the limitations of existing vaccines.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Walsh JA, Warren KS. Selective primary health care: an interim strategy for disease control in developing countries. N Engl J Med. 1979 Nov 1;301(18):967–974. [PubMed]
  • Aaby P, Bukh J, Lisse IM, Smits AJ, Gomes J, Fernandes MA, Indi F, Soares M. Determinants of measles mortality in a rural area of Guinea-Bissau: crowding, age, and malnutrition. J Trop Pediatr. 1984 Jun;30(3):164–168. [PubMed]
  • Lamb WH. Epidemic measles in a highly immunized rural West African (Gambian) village. Rev Infect Dis. 1988 Mar-Apr;10(2):457–462. [PubMed]
  • Morley DC, Martin WJ, Allen I. Measles in West Africa. West Afr Med J Niger Pract. 1967 Feb;16(1):24–31. [PubMed]
  • Aaby P, Bukh J, Lisse IM, Smits AJ. Overcrowding and intensive exposure as determinants of measles mortality. Am J Epidemiol. 1984 Jul;120(1):49–63. [PubMed]
  • Aaby P, Bukh J, Lisse IM, da Silva MC. Further community studies on the role of overcrowding and intensive exposure on measles mortality. Rev Infect Dis. 1988 Mar-Apr;10(2):474–477. [PubMed]
  • GORDON JE, JANSEN AA, ASCOLI W. MEASLES IN RURAL GUATEMALA. J Pediatr. 1965 Apr;66:779–786. [PubMed]
  • Koster FT, Curlin GC, Aziz KM, Haque A. Synergistic impact of measles and diarrhoea on nutrition and mortality in Bangladesh. Bull World Health Organ. 1981;59(6):901–908. [PMC free article] [PubMed]
  • Reddy V, Bhaskaram P, Raghuramulu N, Milton RC, Rao V, Madhusudan J, Krishna KV. Relationship between measles, malnutrition, and blindness: a prospective study in Indian children. Am J Clin Nutr. 1986 Dec;44(6):924–930. [PubMed]
  • Muller AS, Voorhoeve AM, Mannetje W, Schulpen TW. The impact of measles in a rural area of Kenya. East Afr Med J. 1977 Jul;54(7):364–372. [PubMed]
  • Hull HF, Williams PJ, Oldfield F. Measles mortality and vaccine efficacy in rural West Africa. Lancet. 1983 Apr 30;1(8331):972–975. [PubMed]
  • Williams PJ, Hull HF. Status of measles in The Gambia, 1981. Rev Infect Dis. 1983 May-Jun;5(3):391–394. [PubMed]
  • Hull HF. Increased measles mortality in households with multiple cases in the Gambia, 1981. Rev Infect Dis. 1988 Mar-Apr;10(2):463–467. [PubMed]
  • Bhaskaram P, Reddy V, Raj S, Bhatnagar RC. Effect of measles on the nutritional status of preschool children. J Trop Med Hyg. 1984 Feb;87(1):21–25. [PubMed]
  • Bhaskaram P, Madhusudhan J, Radhakrishna KV, Reddy V. Immune response in malnourished children with measles. J Trop Pediatr. 1986 Jun;32(3):123–126. [PubMed]
  • Aaby P, Bukh J, Hoff G, Leerhøy J, Lisse IM, Mordhorst CH, Pedersen IR. High measles mortality in infancy related to intensity of exposure. J Pediatr. 1986 Jul;109(1):40–44. [PubMed]
  • HARTFIELD J, MORLEY D. Efficacy of measles vaccine. J Hyg (Lond) 1963 Mar;61:143–147. [PMC free article] [PubMed]
  • Chen LC, Chowdhury A, Huffman SL. Anthropometric assessment of energy-protein malnutrition and subsequent risk of mortality among preschool aged children. Am J Clin Nutr. 1980 Aug;33(8):1836–1845. [PubMed]
  • Chen LC, Rahman M, Sarder AM. Epidemiology and causes of death among children in a rural area of Bangladesh. Int J Epidemiol. 1980 Mar;9(1):25–33. [PubMed]
  • Natu M, Chavan H, Pratinidhi A. Measles vaccination. Prevention strategy for malnutrition. Indian Pediatr. 1985 Aug;22(8):597–600. [PubMed]
  • Heymann DL, Mayben GK, Murphy KR, Guyer B, Foster SO. Measles control in Yaounde: justification of a one dose, nine month minimum age vaccination policy in tropical Africa. Lancet. 1983 Dec 24;2(8365-66):1470–1472. [PubMed]
  • Loening WE, Coovadia HM. Age-specific occurrence rates of measles in urban, peri-urban, and rural environments: implications for time of vaccination. Lancet. 1983 Aug 6;2(8345):324–326. [PubMed]
  • Taylor WR, Mambu RK, ma-Disu M, Weinman JM. Measles control efforts in urban Africa complicated by high incidence of measles in the first year of life. Am J Epidemiol. 1988 Apr;127(4):788–794. [PubMed]
  • Aaby P. Malnutrition and overcrowding/intensive exposure in severe measles infection: review of community studies. Rev Infect Dis. 1988 Mar-Apr;10(2):478–491. [PubMed]
  • McLean AR, Anderson RM. Measles in developing countries. Part II. The predicted impact of mass vaccination. Epidemiol Infect. 1988 Jun;100(3):419–442. [PMC free article] [PubMed]
  • Whittle HC, Rowland MG, Mann GF, Lamb WH, Lewis RA. Immunisation of 4-6 month old Gambian infants with Edmonston-Zagreb measles vaccine. Lancet. 1984 Oct 13;2(8407):834–837. [PubMed]
  • Khanum S, Uddin N, Garelick H, Mann G, Tomkins A. Comparison of Edmonston-Zagreb and Schwarz strains of measles vaccine given by aerosol or subcutaneous injection. Lancet. 1987 Jan 17;1(8525):150–153. [PubMed]
  • Aaby P, Jensen TG, Hansen HL, Kristiansen H, Thårup J, Poulsen A, Sodemann M, Jakobsen M, Knudsen K, Clotilde da Silva M, et al. Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau: protective efficacy. Lancet. 1988 Oct 8;2(8615):809–811. [PubMed]
  • Whittle H, Hanlon P, O'Neill K, Hanlon L, Marsh V, Jupp E, Aaby P. Trial of high-dose Edmonston-Zagreb measles vaccine in the Gambia: antibody response and side-effects. Lancet. 1988 Oct 8;2(8615):811–814. [PubMed]
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