Logo of bullwhoWHO Home PageBulletin Home PageBulletin Home PageAbout Bulletine-mail AlertSubmissions
Bull World Health Organ. 1971; 44(1-2-3): 215–219.
PMCID: PMC2428034

Toxic effects produced in insects by organophosphorus compounds*

Abstract

This paper reviews the toxicity of organophosphorus compounds in relation to cholinesterase inhibition in insects. It covers anticholinesterase effects on different stages of the life cycle and the relationship between cholinesterase inhibition and lethality. Other effects of organophosphorus compounds, which may account for anomalies in insecticidal action, are also considered.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (781K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Burt PE, Gregory GE, Molloy FM. A histochemical and electrophysiological study of the action of diazoxon on cholinesterase activity and nerve conduction in ganglia of the cockroach Periplaneta americana L. Ann Appl Biol. 1966 Dec;58(3):341–354. [PubMed]
  • CASIDA JE. Comparative enzymology of certain insect acetylesterases in relation to poisoning by organophosphorus insecticides. Biochem J. 1955 Jul;60(3):487–496. [PMC free article] [PubMed]
  • COLHOUN EH. Tetraethyl pyrophosphate and acetylcholine in Periplaneta americana. Science. 1958 Jan 3;127(3288):25–25. [PubMed]
  • Eto M. Specificity and mechanism in the action f saligenin cyclic phosphorus esters. Residue Rev. 1969;25:187–200. [PubMed]
  • Flattum RF, Sternburg JG. Release of a synaptically active material by nicotine in the central nervous system of the American cockroach. J Econ Entomol. 1970 Feb;63(1):67–70. [PubMed]
  • Goszczyńska K, Styczyńska B. Badanie hamowania aktywności esterazy cholinowej u much M. domestica L. pod wpływem zwiazkow fosforooganiczych. Rocz Panstw Zakl Hig. 1968;19(4):491–497. [PubMed]
  • MEHROTRA KN, SMALLMAN BN. Ovicidal action of organo-phosphorus insecticides. Nature. 1957 Jul 13;180(4576):97–98. [PubMed]
  • Mengle DC, O'brien RD. The spontaneous and induced recovery of fly-brain cholinesterase after inhibition by organophosphates. Biochem J. 1960 Apr;75(1):201–207. [PMC free article] [PubMed]
  • METCALF D. Pseudoneoplastic nonspecific proliferative lesions on the chorio-allantois of the chick embryo. Br J Cancer. 1955 Mar;9(1):222–228. [PMC free article] [PubMed]
  • Miller T, Metcalf RL. Site of action of pharmacologically actve compounds on the heart of Periplaneta americana L. J Insect Physiol. 1968 Mar;14(3):383–394. [PubMed]
  • O'BRIEN B. Rhinological reconstructive surgery. Ir J Med Sci. 1956 Nov;(371):484–490. [PubMed]
  • SMALLMAN BN, FISHER RW. Effect of anticholinesterases on acetylcholine levels in insects. Can J Biochem Physiol. 1958 Jun;36(6):575–586. [PubMed]
  • Smallman BN, Mansingh A. The cholinergic system in insect development. Annu Rev Entomol. 1969;14:387–408. [PubMed]
  • Smith EH, Salkeld EH. The use and action of ovicides. Annu Rev Entomol. 1966;11:331–368. [PubMed]
  • Smith HG, Jr, Goulding RL. Toxicological aspects of three organophosphorus compounds (Cythioate, Famphur, and Fenthion) in the host-ectoparasite system. J Econ Entomol. 1970 Oct;63(5):1640–1646. [PubMed]
  • STERNBURG J. Autointoxication and some stressphenomena. Annu Rev Entomol. 1963;8:19–38. [PubMed]
  • Wharton RH, Roulston WJ. Resistance of ticks to chemicals. Annu Rev Entomol. 1970;15:381–404. [PubMed]
  • Winteringham FP. Mechanisms of selective insecticidal action. Annu Rev Entomol. 1969;14:409–442. [PubMed]

Articles from Bulletin of the World Health Organization are provided here courtesy of World Health Organization