Reduction of neonatal tetanus by mass immunization of non-pregnant women: duration of protection provided by one or two doses of aluminium-adsorbed tetanus toxoid*
Abstract
Immunization of non-pregnant women in rural Bangladesh with two doses of aluminium-adsorbed tetanus-diphtheria toxoids reduced neonatal mortality by one-third during a period of 9-32 months after vaccination. The reduction in mortality rate was attributable almost entirely to a 75% lower mortality rate among 4-14-day-old infants, when tetanus was the predominant cause of death.
In the period up to 20 months following vaccination, the reduction in deaths among 4-14-day-old infants after a single dose of tetanus-diptheria toxoids was about the same as that after two doses. However, beyond 20 months a single dose did not appear to provide protection.
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- Bytchenko B. Geographical distribution of tetanus in the world, 1951-60. A review of the problem. Bull World Health Organ. 1966;34(1):71–104. [PMC free article] [PubMed] [Google Scholar]
- SCHOFIELD FD, TUCKER VM, WESTBROOK GR. Neonatal tetanus in New Guinea. Effect of active immunization in pregnancy. Br Med J. 1961 Sep 23;2(5255):785–789. [PMC free article] [PubMed] [Google Scholar]
- Newell KW, Dueñas Lehmann A, LeBlanc DR, Garces Osorio N. The use of toxoid for the prevention of tetanus neonatorum. Final report of a double-blind controlled field trial. Bull World Health Organ. 1966;35(6):863–871. [PMC free article] [PubMed] [Google Scholar]
- Miller JK. The prevention of neonatal tetanus by maternal immunization. J Trop Pediatr Environ Child Health. 1972 Jun;18(2):159–167. [PubMed] [Google Scholar]
- Stanfield JP, Gall D, Bracken PM. Single-dose antenatal tetanus immunisation. Lancet. 1973 Feb 3;1(7797):215–219. [PubMed] [Google Scholar]
- Matveev KI, Sergeeva TI, Zarubina EK, Minaeva ZL. Single - dose immunization of human subjects against tetanus. J Hyg Epidemiol Microbiol Immunol. 1976;20(1):112–120. [PubMed] [Google Scholar]
- Kielmann AA, Vohra SR. Control of tetanus neonatorum in rural communities--immunization effects of high-dose calcium phosphate-absorbed tetanus toxoid. Indian J Med Res. 1977 Dec;66(6):906–916. [PubMed] [Google Scholar]
- MacLennan R, Schofield FD, Pittman M, Hardegree MC, Barile MF. Immunization against neonatal tetanus in New Guinea. Antitoxin response of pregnant women to adjuvant and plain toxoids. Bull World Health Organ. 1965;32(5):683–697. [PMC free article] [PubMed] [Google Scholar]
- Maclennan R, Levine L, Newell KW, Edsall G. The early primary immune response to absorbed tetanus toxoid in man: A study of the influence of antigen concentration, carrier concentration, and sequence of dosage on the rate, extent, and persistence of the immune response to one and to two doses of toxoid. Bull World Health Organ. 1973;49(6):615–626. [PMC free article] [PubMed] [Google Scholar]
- Cabau N, Levy FM, Relyveld EH, Labusquiere R, Poirier A, Ravisse P, Chambon L. Vaccination antidiphtérique-antitétanique par anatoxines adsorbées sur phosphate de calcium en deux injections à un an d'intervalle. Ann Inst Pasteur (Paris) 1970 Nov;119(5):663–670. [PubMed] [Google Scholar]