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J Clin Microbiol. 1995 Sep; 33(9): 2485–2488.
PMCID: PMC228449
PMID: 7494055

Detection of measles virus RNA in urine specimens from vaccine recipients.

P A Rota, A S Khan, E Durigon, T Yuran, Y S Villamarzo, and W J Bellini
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Abstract

Analysis of urine specimens by using reverse transcriptase-PCR was evaluated as a rapid assay to identify individuals infected with measles virus. For the study, daily urine samples were obtained from either 15-month-old children or young adults following measles immunization. Overall, measles virus RNA was detected in 10 of 12 children during the 2-week sampling period. In some cases, measles virus RNA was detected as early as 1 day or as late as 14 days after vaccination. Measles virus RNA was also detected in the urine samples from all four of the young adults between 1 and 13 days after vaccination. This assay will enable continued studies of the shedding and transmission of measles virus and, it is hoped, will provide a rapid means to identify measles infection, especially in mild or asymptomatic cases.

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Selected References

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