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Am J Pathol. 1971 Jul; 64(1): 145–154.
PMCID: PMC2047551

Experimental Production of Cartilage Necrosis by Cold Injury: Failure to Cause Degenerative Joint Disease

William H. Simon and William T. Green, Jr
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Abstract

A cryoprobe (-20 to -80 C) was applied for 10-60 seconds to cause necrosis of metatarsal head cartilages of 11 rabbits. Segmental loss of nuclear staining was noted at 1 week and depletion of chondroitin sulfate (toluidine blue metachromasia and staining with safranin 0) a few days later. No degenerative joint disease was evident up to 6 months later. The latter finding suggests that, in addition to chondrocyte death, externally imposed stresses are necessary to disrupt the collagenous “skeleton” and initiate the changes of degenerative joint disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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