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Arch Dis Child. 1998 Mar; 78(3): 273–274.
doi: 10.1136/adc.78.3.273
PMCID: PMC1717498
PMID: 9613364

Thrombocytopenic purpura as adverse reaction to recombinant hepatitis B vaccine

F Ronchi, P Cecchi, F Falcioni, A Marsciani, G Minak, G Muratori, P Tazzari, and S Beverini
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Abstract

Three cases of immune thrombocytopenic purpura after the first dose of recombinant hepatitis B vaccine occurred in infants under 6 months of age. Other possible causes of this condition were excluded. Antiplatelet antibodies were present. A defect in platelet production was excluded in two children. Corticosteroid treatment was effective. Subsequent administration of other vaccines (against polio, diphtheria, and tetanus) did not cause relapse of thrombocytopenia.

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Selected References

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