D-propranolol and DL-propranolol both decrease conversion of L-thyroxine to L-triiodothyronine.
Abstract
The effects of propranolol (DL-propranolol) and D-propranolol on thyroid hormone metabolism were studied in six euthyroid volunteers receiving L-thyroxine (T4) and six hypothyroid patients receiving T4 replacement. D-propranolol as well as propranolol decreased L-triiodothyronine (T3) concentrations and the ratio of T3 to T4 in the euthyroid subjects, and D-propranolol decreased these variables in the subjects with hypothyroidism (propranolol was not given to this group). It is concluded from this study and from parallel invitro investigations that the effect of propranolol on the conversion of T4 to T3 is unrelated to its beta-adrenergic blocking activity, and that at low therapeutic doses propranolol may exert appreciable "membrane-stabilising" effects in vivo.
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- Lotti G, Delitala G, Devilla L, Alagna S, Masala A. Reduction of plasma triiodothyronine (T3) induced by propranolol. Clin Endocrinol (Oxf) 1977 Jun;6(6):405–410. [PubMed] [Google Scholar]
- Saunders J, Hall SE, Crowther A, Sönksen PH. The effect of propranolol on thyroid hormones and oxygen consumption in thyrotoxicosis. Clin Endocrinol (Oxf) 1978 Jul;9(1):67–72. [PubMed] [Google Scholar]
- Lumholtz IB, Siersbaek-Nielsen K, Faber J, Kirkegaard C, Friis T. Effect of propranolol on extrathyroidal metabolism of thyroxine and 3,3',5-triiodothyronine evaluated by noncompartmental kinetics. J Clin Endocrinol Metab. 1978 Sep;47(3):587–589. [PubMed] [Google Scholar]
- Harrower AD, Fyffe JA, Horn DB, Strong JA. Thyroxine and triiodothyronine levels in hyperthyroid patients during treatment with propranolol. Clin Endocrinol (Oxf) 1977 Jul;7(1):41–44. [PubMed] [Google Scholar]
- Verhoeven RP, Visser TJ, Doctor R, Hennemann G, Schalekamp MA. Plasma thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine during beta-adrenergic blockade in hyperthyroidism. J Clin Endocrinol Metab. 1977 May;44(5):1002–1005. [PubMed] [Google Scholar]
- Heyma P, Larkins RG, Stockigt JR, Campbell DG. The formation of tri-iodothyronine and reverse tri-iodothyronine from thyroxine in isolated rat renal tubules. Clin Sci Mol Med Suppl. 1978 Dec;55(6):567–572. [PubMed] [Google Scholar]
- Shanks RG, Hadden DR, Lowe DC, McDevitt DG, Montgomery DA. Controlled trial of propranolol in thyrotoxicosis. Lancet. 1969 May 17;1(7603):993–994. [PubMed] [Google Scholar]
- Murchison LE, Bewsher PD, Chesters MI, Ferrier WR. Comparison of propranolol and practolol in the management of hyperthyroidism. Br J Clin Pharmacol. 1976 Apr;3(2):273–277. [PMC free article] [PubMed] [Google Scholar]
- Leonard JL, Rosenberg IN. Subcellular distribution of thyroxine 5'-deiodinase in the rat kidney: a plasma membrane location. Endocrinology. 1978 Jul;103(1):274–280. [PubMed] [Google Scholar]
- Maciel RM, Ozawa Y, Chopra IJ. Subcellular localization of thyroxine and reverse triiodothyronine outer ring monodeiodinating activities. Endocrinology. 1979 Feb;104(2):365–371. [PubMed] [Google Scholar]
