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Ann Surg. 1965 Oct; 162(4): 724–737.
PMCID: PMC1476969

Bloodless surgery by means of profound hypothermia and circulatory arrest. Effect on brain and heart.

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Selected References

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  • BIORCK G, JOHANSSON BW, NILSSON IM. Blood coagulation studies in hedgehogs, in a hibernating and a non-hibernating state, and in dogs, hypothermic and normothermic. Acta Physiol Scand. 1962 Nov-Dec;56:334–348. [PubMed]
  • BOND TP, DERRICK JR, GUEST MM. MICROCIRCULATION DURING HYPOTHERMIA; HIGH SPEED CINEMATOGRAPH STUDIES. Arch Surg. 1964 Nov;89:887–890. [PubMed]
  • BREWIN EG. PHYSIOLOGY OF HYPOTHERMIA. Int Anesthesiol Clin. 1964 Aug;2:803–827. [PubMed]
  • CONNAUGHTON PJ, HOLT G, LEWIS FJ. Prolonged hypothermia below 25 degrees C. for periods over 20 hours influence of therapy and technique on survival. Surgery. 1961 Aug;50:372–381. [PubMed]
  • CONNOLLY JE, BOYD RJ, CALVIN JW. The protective effect of hypothermia in cerebral ischemia: experimental and clinical application by selective brain cooling in the human. Surgery. 1962 Jul;52:15–24. [PubMed]
  • CONNOLLY JE, HARRIS EJ, BRUNS DL, SMITH JW, GUERNSEY J, BOYD RJ. An experimental study of the technique and effects of selective brain cooling. Surg Forum. 1960;11:405–407. [PubMed]
  • DELIN NA, KJARTANSSON KB, POLLOCK L, SCHENK WG., Jr REDISTRIBUTION OF REGIONAL BLOOD FLOW IN HYPOTHERMIA. J Thorac Cardiovasc Surg. 1965 Mar;49:511–516. [PubMed]
  • DRAKE CG, BARR HW, COLES JC, GERGELY NF. THE USE OF EXTRACORPOREAL CIRCULATION AND PROFOUND HYPOTHERMIA IN THE TREATMENT OF RUPTURED INTRACRANIAL ANEURYSM. J Neurosurg. 1964 Jul;21:575–581. [PubMed]
  • Egerton N, Egerton WS, Kay JH. Neurologic Changes Following Profound Hypothermia. Ann Surg. 1963 Mar;157(3):366–374. [PMC free article] [PubMed]
  • FISHER B, FEDOR EJ, SMITH JW. Temperature gradients associated with extracorporeal perfusion and profound hypothermia. Surgery. 1961 Nov;50:758–764. [PubMed]
  • GOLLAN F, GRACE JT, SCHELL MW, TYSINGER DS, FEASTER LB. Left heart surgery in dogs during respiratory and cardiac arrest at body temperatures below 10 degrees C. Surgery. 1955 Aug;38(2):363–372. [PubMed]
  • GORDON AS, JONES JC, LUDDINGTON LG, MEYER BW. Deep hypothermia for intracardiac surgery. Experimental and clinical use without an oxygenator. Am J Surg. 1960 Aug;100:332–337. [PubMed]
  • GRAY TC. Reflections on circulatory control. Lancet. 1957 Feb 23;272(6965):383–389. [PubMed]
  • HARDAWAY RM, BURNS JW. Mechanism of action of fibrinolysin in the prevention of irreversible hemorrhagic shock. Ann Surg. 1963 Feb;157:305–309. [PMC free article] [PubMed]
  • HELLSTROM G, BJORK VO. Hemodilution with Rheomacrodex during total body perfusion. J Thorac Cardiovasc Surg. 1963 Mar;45:395–401. [PubMed]
  • KEEN G, GERBODE F. Observations on the microcirculation during profound hypothermia. J Thorac Cardiovasc Surg. 1963 Feb;45:252–260. [PubMed]
  • LESAGE AM, FREESE JW, SEALY WC, YOUNG WG., Jr Study of the effects of complete circulatory arrest in the profoundly hypothermic dog. Surg Forum. 1960;11:188–189. [PubMed]
  • LESAGE MA, SEALY WC, YOUNG WG, Jr, LEE JM. Experimental studies on profound hypothermia induced and reverted with a pump oxygenator. Ann Surg. 1962 Nov;156:831–844. [PMC free article] [PubMed]
  • LESAGE MA, TSUCHIOKA H, YOUNG WG, Jr, SEALY WC. TOLERANCE OF DOGS TO DEEP HYPOTHERMIA. CONTROLLED AND MAINTAINED WITH A PUMP OXYGENATOR. Arch Surg. 1964 Oct;89:677–684. [PubMed]
  • MALMEJAC R, NEVERRE G, DOSNE AM. SUR LES MODIFICATIONS DE LA COAGULATION DU SANG EN HYPOTHERMIE PROFONDE. J Physiol (Paris) 1964 May-Jun;56:401–401. [PubMed]
  • MICHENFELDER JD, KIRKLIN JW, UIHLEIN A, SVIEN HJ, MACCARTY CS. CLINICAL EXPERIENCE WITH A CLOSED-CHEST METHOD OF PRODUCING PROFOUND HYPOTHERMIA AND TOTAL CIRCULATORY ARREST IN NEUROSURGERY. Ann Surg. 1964 Jan;159:125–131. [PMC free article] [PubMed]
  • MILLER DR, HALLABA MA, STEEGMANN AT. EFFECT OF PROFOUND HYPOTHERMIA WITH CIRCULATORY ARREST IN DOGS: SPECIAL REFERENCE TO CHANGES IN CEREBROVASCULAR PERMEABILITY. Ann Surg. 1965 Feb;161:272–285. [PMC free article] [PubMed]
  • NEVILLE WE, WHITE RJ, VERDURA J. RELATIONSHIP OF FLOW RATE, "EXCESS LACTATE," AND BUFFER BASE DURING CLOSED CHEST PROFOUND HYPOTHERMIC PERFUSION WITH A PUMP OXYGENATOR. Surgery. 1964 Feb;55:281–290. [PubMed]
  • NEVILLE WE, KAMEYA S, OZ M, BLOOR B, CLOWES GH., Jr Profound hypothermia and complete circulation interruption. Experimental and clinical physiological observations. Arch Surg. 1961 Jan;82:108–119. [PubMed]
  • NIAZI SA, LEWIS FJ. Profound hypothermia in man; report of a case. Ann Surg. 1958 Feb;147(2):264–266. [PMC free article] [PubMed]
  • PATTERSON RH, Jr, RAY BS. Profound hypothermia for intracranial surgery: laboratory and clinical experiences with extracorporeal circulation by peripheral cannulation. Ann Surg. 1962 Sep;156:377–393. [PMC free article] [PubMed]
  • PHILLIPS LL, MALM JR, DETERLING RA., Jr Coagulation defects following extracorporeal circulation. Ann Surg. 1963 Mar;157:317–326. [PMC free article] [PubMed]
  • REHDER K, KIRKLIN JW, MACCARTY CS, THEYE RA. Physiologic studies following profound hypothermia and circulatory arrest for treatment of intracranial aneurysm. Ann Surg. 1962 Dec;156:882–889. [PMC free article] [PubMed]
  • ROSS J, Jr, GILBERT JW, Jr, SHARP EH, MORROW AG. Elective cardiac arrest during total body perfusion: the relationship of elevated intracardiac pressures during arrest to subsequent myocardial function and pathologic pulmonary changes. J Thorac Surg. 1958 Oct;36(4):534–542. [PubMed]
  • RUSH BF, Jr, WILDER RJ, FISHBEIN R, RAVITCH MM. Effects of total circulatory standstill in profound hypothermia. Surgery. 1961 Jul;50:40–49. [PubMed]
  • SCHENK WG, Jr, DELIN NA, DOMANIG E, HAHNLOSER P, HOYT RK. BLOOD VISCOSITY AS A DETERMINANT OF REGIONAL BLOOD FLOW. Arch Surg. 1964 Nov;89:783–796. [PubMed]
  • WOODHALL B, SEALY WC, HALL KD, FLOYD WL. Craniotomy under conditions of quinidine-protected cardioplegia and profound hypothermia. Ann Surg. 1960 Jul;152:37–44. [PMC free article] [PubMed]

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