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Environ Health Perspect. 1997 Mar; 105(3): 308–314.
doi: 10.1289/ehp.97105308
PMCID: PMC1470002
PMID: 9171992

Intrauterine growth retardation in Iowa communities with herbicide-contaminated drinking water supplies.

R Munger, P Isacson, S Hu, T Burns, J Hanson, C F Lynch, K Cherryholmes, P Van Dorpe, and W J Hausler, Jr
Author information Copyright and License information PMC Disclaimer

Abstract

In a statewide survey of 856 Iowa municipal drinking water supplies in 1986-1987 the Rathbun rural water system was found to contain elevated levels of triazine herbicides. Rates of low birth weight, prematurity, and intrauterine growth retardation (IUGR) in live singleton births during the period 1984-1990 by women living in 13 communities served by the Rathbun water system were compared to other communities of similar size in the same Iowa counties. The Rathbun communities had a greater risk of IUGR than southern Iowa communities with other surface sources of drinking water (relative risk = 1.8; 95% CI = 1.3, 2.7). Multiple linear regression analyses revealed that levels of the herbicides atrazine, metolachlor, and cyanzinc were each significant predictors of community IUGR rates in southern Iowa after controlling for several potentially confounding factors including maternal smoking and socioeconomic variables. The association with IUGR was strongest for atrazine, but all three herbicides were intercorrelated and the independent contributions of each to IUGR risk could not be determined. We conclude that communities in southern Iowa with drinking water supplies contaminated with herbicides have elevated rates of IUGR compared to neighboring communities with different water supplies. Because of the limitations of the ecologic design of this study, including aggregate rather than individual measures of exposure and limited ability to control for confounding factors related to source of drinking water and risk of IUGR, a strong causal relationship between any specific water contaminant and risk of IUGR cannot yet be inferred. The association between the water supplied to the Rathbun communities and the increased risk of IUGR should be considered a preliminary finding that needs to be verified by more detailed epidemiologic studies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  • SCHLESINGER ER, ALLAWAY NC. The combined effect of birth weight and length of gestation on neonatal mortality among single premature births. Pediatrics. 1955 Jun;15(6):698–704. [PubMed] [Google Scholar]
  • LUBCHENCO LO, HANSMAN C, DRESSLER M, BOYD E. INTRAUTERINE GROWTH AS ESTIMATED FROM LIVEBORN BIRTH-WEIGHT DATA AT 24 TO 42 WEEKS OF GESTATION. Pediatrics. 1963 Nov;32:793–800. [PubMed] [Google Scholar]
  • YERUSHALMY J, VANDENBERG BJ, ERHARDT CL, JACOBZINER H. BIRTH WEIGHT AND GESTATION AS INDICES OF "IMMATURITY". NEONATAL MORTALITY AND CONGENITAL ANOMALIES OF THE "IMMATURE". Am J Dis Child. 1965 Jan;109:43–57. [PubMed] [Google Scholar]
  • Pharoah PO, Morris JN. Postneonatal Mortality. Epidemiol Rev. 1979;1:170–183. [PubMed] [Google Scholar]
  • Heinonen K, Matilainen R, Koski H, Launiala K. Intrauterine growth retardation (IUGR) in pre-term infants. J Perinat Med. 1985;13(4):171–178. [PubMed] [Google Scholar]
  • Pena IC, Teberg AJ, Finello KM. The premature small-for-gestational-age infant during the first year of life: comparison by birth weight and gestational age. J Pediatr. 1988 Dec;113(6):1066–1073. [PubMed] [Google Scholar]
  • Kramer MS, Olivier M, McLean FH, Dougherty GE, Willis DM, Usher RH. Determinants of fetal growth and body proportionality. Pediatrics. 1990 Jul;86(1):18–26. [PubMed] [Google Scholar]
  • Arnold CC, Kramer MS, Hobbs CA, McLean FH, Usher RH. Very low birth weight: a problematic cohort for epidemiologic studies of very small or immature neonates. Am J Epidemiol. 1991 Sep 15;134(6):604–613. [PubMed] [Google Scholar]
  • Witter FR. Perinatal mortality and intrauterine growth retardation. Curr Opin Obstet Gynecol. 1993 Feb;5(1):56–59. [PubMed] [Google Scholar]
  • Chen SJ, Vohr BR, Oh W. Effects of birth order, gender, and intrauterine growth retardation on the outcome of very low birth weight in twins. J Pediatr. 1993 Jul;123(1):132–136. [PubMed] [Google Scholar]
  • Luke B, Williams C, Minogue J, Keith L. The changing pattern of infant mortality in the US: the role of prenatal factors and their obstetrical implications. Int J Gynaecol Obstet. 1993 Mar;40(3):199–212. [PubMed] [Google Scholar]
  • Spinillo A, Capuzzo E, Egbe TO, Fazzi E, Colonna L, Nicola S. Pregnancies complicated by idiopathic intrauterine growth retardation. Severity of growth failure, neonatal morbidity and two-year infant neurodevelopmental outcome. J Reprod Med. 1995 Mar;40(3):209–215. [PubMed] [Google Scholar]
  • Deane M, Swan SH, Harris JA, Epstein DM, Neutra RR. Adverse pregnancy outcomes in relation to water contamination, Santa Clara County, California, 1980-1981. Am J Epidemiol. 1989 May;129(5):894–904. [PubMed] [Google Scholar]
  • Swan SH, Shaw G, Harris JA, Neutra RR. Congenital cardiac anomalies in relation to water contamination, Santa Clara County, California, 1981-1983. Am J Epidemiol. 1989 May;129(5):885–893. [PubMed] [Google Scholar]
  • Kramer MD, Lynch CF, Isacson P, Hanson JW. The association of waterborne chloroform with intrauterine growth retardation. Epidemiology. 1992 Sep;3(5):407–413. [PubMed] [Google Scholar]
  • Williams RL, Creasy RK, Cunningham GC, Hawes WE, Norris FD, Tashiro M. Fetal growth and perinatal viability in California. Obstet Gynecol. 1982 May;59(5):624–632. [PubMed] [Google Scholar]
  • Villar J, Belizan JM. The timing factor in the pathophysiology of the intrauterine growth retardation syndrome. Obstet Gynecol Surv. 1982 Aug;37(8):499–506. [PubMed] [Google Scholar]
  • Khoury MJ, Stewart W, Weinstein A, Panny S, Lindsay P, Eisenberg M. Residential mobility during pregnancy: implications for environmental teratogenesis. J Clin Epidemiol. 1988;41(1):15–20. [PubMed] [Google Scholar]
  • Lynch CF, Woolson RF, O'Gorman T, Cantor KP. Chlorinated drinking water and bladder cancer: effect of misclassification on risk estimates. Arch Environ Health. 1989 Jul-Aug;44(4):252–259. [PubMed] [Google Scholar]
  • Zierler S, Danley RA, Feingold L. Type of disinfectant in drinking water and patterns of mortality in Massachusetts. Environ Health Perspect. 1986 Nov;69:275–279. [PMC free article] [PubMed] [Google Scholar]
  • Wrensch M, Swan S, Murphy PJ, Lipscomb J, Claxton K, Epstein D, Neutra R. Hydrogeologic assessment of exposure to solvent-contaminated drinking water: pregnancy outcomes in relation to exposure. Arch Environ Health. 1990 Jul-Aug;45(4):210–216. [PubMed] [Google Scholar]
  • Deane M, Swan SH, Harris JA, Epstein DM, Neutra RR. Adverse pregnancy outcomes in relation to water consumption: a re-analysis of data from the original Santa Clara County Study, California, 1980-1981. Epidemiology. 1992 Mar;3(2):94–97. [PubMed] [Google Scholar]
  • Swan SH, Neutra RR, Wrensch M, Hertz-Picciotto I, Windham GC, Fenster L, Epstein DM, Deane M. Is drinking water related to spontaneous abortion? Reviewing the evidence from the California Department of Health Services Studies. Epidemiology. 1992 Mar;3(2):83–93. [PubMed] [Google Scholar]
  • Blakley PM, Kim JS, Firneisz GD. Effects of gestational exposure to Tordon 202c on fetal growth and development in CD-1 mice. J Toxicol Environ Health. 1989;28(3):309–316. [PubMed] [Google Scholar]
  • Kniewald J, Peruzović M, Gojmerac T, Milković K, Kniewald Z. Indirect influence of s-triazines on rat gonadotropic mechanism at early postnatal period. J Steroid Biochem. 1987;27(4-6):1095–1100. [PubMed] [Google Scholar]
  • Simić B, Kniewald J, Kniewald Z. Effects of atrazine on reproductive performance in the rat. J Appl Toxicol. 1994 Nov-Dec;14(6):401–404. [PubMed] [Google Scholar]
  • Eldridge JC, Tennant MK, Wetzel LT, Breckenridge CB, Stevens JT. Factors affecting mammary tumor incidence in chlorotriazine-treated female rats: hormonal properties, dosage, and animal strain. Environ Health Perspect. 1994 Dec;102 (Suppl 11):29–36. [PMC free article] [PubMed] [Google Scholar]
  • Brusick DJ. An assessment of the genetic toxicity of atrazine: relevance to human health and environmental effects. Mutat Res. 1994 Apr;317(2):133–144. [PubMed] [Google Scholar]
  • Plewa MJ, Gentile JM. Mutagenicity of atrazine: a maize-microbe bioassay. Mutat Res. 1976 Aug;38(4):287–292. [PubMed] [Google Scholar]
  • Plewa MJ, Wagner ED, Gentile GJ, Gentile JM. An evaluation of the genotoxic properties of herbicides following plant and animal activation. Mutat Res. 1984 Jun;136(3):233–245. [PubMed] [Google Scholar]
  • Zoeteman BC. Drinking water and health hazards in environmental perspective. Sci Total Environ. 1985 Dec;47:487–503. [PubMed] [Google Scholar]
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