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Gut. 1987 Jan; 28(1): 96–107.
doi: 10.1136/gut.28.1.96
PMCID: PMC1432731
PMID: 3546004

Relationship between gastric secretion and infection.

C W Howden and R H Hunt
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Selected References

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  • Giannella RA, Broitman SA, Zamcheck N. Salmonella enteritis. I. Role of reduced gastric secretion in pathogenesis. Am J Dig Dis. 1971 Nov;16(11):1000–1006. [PubMed] [Google Scholar]
  • Giannella RA, Broitman SA, Zamcheck N. Influence of gastric acidity on bacterial and parasitic enteric infections. A perspective. Ann Intern Med. 1973 Feb;78(2):271–276. [PubMed] [Google Scholar]
  • DuPont HL, Hornick RB, Snyder MJ, Libonati JP, Formal SB, Gangarosa EJ. Immunity in shigellosis. I. Response of man to attenuated strains of Shigella. J Infect Dis. 1972 Jan;125(1):5–11. [PubMed] [Google Scholar]
  • Cash RA, Music SI, Libonati JP, Snyder MJ, Wenzel RP, Hornick RB. Response of man to infection with Vibrio cholerae. I. Clinical, serologic, and bacteriologic responses to a known inoculum. J Infect Dis. 1974 Jan;129(1):45–52. [PubMed] [Google Scholar]
  • Nalin DR, Levine RJ, Levine MM, Hoover D, Bergquist E, McLaughlin J, Libonati J, Alam J, Hornick RB. Cholera, non-vibrio cholera, and stomach acid. Lancet. 1978 Oct 21;2(8095):856–859. [PubMed] [Google Scholar]
  • Steffen R. Antacids--a risk factor in travellers brucellosis? Scand J Infect Dis. 1977;9(4):311–312. [PubMed] [Google Scholar]
  • Gurian L, Ward TT, Katon RM. Possible foodborne transmission in a case of pseudomembranous colitis due to Clostridium difficile: influence of gastrointestinal secretions on Clostridium difficile infection. Gastroenterology. 1982 Aug;83(2):465–469. [PubMed] [Google Scholar]
  • KUNZ LJ, WADDELL WR. Association of Salmonella enteritis with operations on the stomach. N Engl J Med. 1956 Sep 20;255(12):555–559. [PubMed] [Google Scholar]
  • Gray JA, Trueman AM. Severe salmonella gastroenteritis associated with hypochlorhydria. Scott Med J. 1971 May;16(5):255–258. [PubMed] [Google Scholar]
  • GROSSMAN MI, KIRSNER JB, GILLESPIE IE. BASAL AND HISTALOG-STIMULATED GASTRIC SECRETION IN CONTROL SUBJECTS AND IN PATIENTS WITH PEPTIC ULCER OR GASTRIC CANCER. Gastroenterology. 1963 Jul;45:14–26. [PubMed] [Google Scholar]
  • Bird T, Hall MR, Schade RO. Gastric histology and its relation to anaemia in the elderly. Gerontology. 1977;23(4):309–321. [PubMed] [Google Scholar]
  • Sack RB, Carpenter CC. Experimental canine cholera. I. Development of the model. J Infect Dis. 1969 Feb;119(2):138–149. [PubMed] [Google Scholar]
  • Nalin DR, Levine MM, Rhead J, Bergquist E, Rennels M, Hughes T, O'Donnel S, Hornick RB. Cannabis, hypochlorhydria, and cholera. Lancet. 1978 Oct 21;2(8095):859–862. [PubMed] [Google Scholar]
  • Giannella RA, Broitman SA, Zamcheck N. Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro. Gut. 1972 Apr;13(4):251–256. [PMC free article] [PubMed] [Google Scholar]
  • Gray JD, Shiner M. Influence of gastric pH on gastric and jejunal flora. Gut. 1967 Dec;8(6):574–581. [PMC free article] [PubMed] [Google Scholar]
  • Drasar BS, Shiner M, McLeod GM. Studies on the intestinal flora. I. The bacterial flora of the gastrointestinal tract in healthy and achlorhydric persons. Gastroenterology. 1969 Jan;56(1):71–79. [PubMed] [Google Scholar]
  • Milton-Thompson GJ, Lightfoot NF, Ahmet Z, Hunt RH, Barnard J, Bavin PM, Brimblecombe RW, Darkin DW, Moore PJ, Viney N. Intragastric acidity, bacteria, nitrite, and N-nitroso compounds before, during, and after cimetidine treatment. Lancet. 1982 May 15;1(8281):1091–1095. [PubMed] [Google Scholar]
  • Ruddell WS, Axon AT, Findlay JM, Bartholomew BA, Hill MJ. Effect of cimetidine on the gastric bacterial flora. Lancet. 1980 Mar 29;1(8170):672–674. [PubMed] [Google Scholar]
  • Sharma BK, Santana IA, Wood EC, Walt RP, Pereira M, Noone P, Smith PL, Walters CL, Pounder RE. Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole. Br Med J (Clin Res Ed) 1984 Sep 22;289(6447):717–719. [PMC free article] [PubMed] [Google Scholar]
  • HIRSCHOWITZ BI, LONDON JA, POLLARD HM, STREETEN DH. A steroid-induced gastric ulcer. Lancet. 1956 Nov 24;271(6952):1081–1083. [PubMed] [Google Scholar]
  • SPIRO HM, SCHWARTZ RD. Superficial gastritis; a cause of temporary achlorhydria and hyperpepsinemia. N Engl J Med. 1958 Oct 2;259(14):682–684. [PubMed] [Google Scholar]
  • Desai HG, Antia FP. Spontaneous achlorhydria with atrophic gastritis in the Zollinger-Ellison syndrome. Gut. 1969 Nov;10(11):935–939. [PMC free article] [PubMed] [Google Scholar]
  • LAWRIE RS, WILLIAMSON AW, HUNT JN. Zollinger-Ellison syndrome treated with poldine methyl methosulphate. Lancet. 1962 May 12;1(7237):1002–1004. [PubMed] [Google Scholar]
  • Waterfall W. Spontaneous decrease in gastric secretory response to humoral stimuli. Br Med J. 1969 Nov 22;4(5681):459–461. [PMC free article] [PubMed] [Google Scholar]
  • Desai HG, Zaveri MP, Antia FP. Spontaneous and persisting decrease in maximal acid output. Br Med J. 1971 May 8;2(5757):313–315. [PMC free article] [PubMed] [Google Scholar]
  • Wiersinga WM, Tytgat GN. Clinical recovery owing to target parietal cell failure in a patient with Zollinger-Ellison syndrome. Gastroenterology. 1977 Dec;73(6):1413–1417. [PubMed] [Google Scholar]
  • Ramsey EJ, Carey KV, Peterson WL, Jackson JJ, Murphy FK, Read NW, Taylor KB, Trier JS, Fordtran JS. Epidemic gastritis with hypochlorhydria. Gastroenterology. 1979 Jun;76(6):1449–1457. [PubMed] [Google Scholar]
  • Gledhill T, Leicester RJ, Addis B, Lightfoot N, Barnard J, Viney N, Darkin D, Hunt RH. Epidemic hypochlorhydria. Br Med J (Clin Res Ed) 1985 May 11;290(6479):1383–1386. [PMC free article] [PubMed] [Google Scholar]
  • Marshall BJ, McGechie DB, Rogers PA, Glancy RJ. Pyloric Campylobacter infection and gastroduodenal disease. Med J Aust. 1985 Apr 15;142(8):439–444. [PubMed] [Google Scholar]
  • Chouraqui JP, Roy CC, Brochu P, Gregoire H, Morin CL, Weber AM. Ménétrier's disease in children: report of a patient and review of sixteen other cases. Gastroenterology. 1981 May;80(5 Pt 1):1042–1047. [PubMed] [Google Scholar]
  • Lachman RS, Martin DJ, Vawter GF. Thick gastric folds in childhood. Am J Roentgenol Radium Ther Nucl Med. 1971 May;112(1):83–92. [PubMed] [Google Scholar]
  • Leonidas JC, Beatty EC, Wenner HA. Ménétrier disease and cytomegalovirus infection in childhood. Am J Dis Child. 1973 Dec;126(6):806–808. [PubMed] [Google Scholar]
  • Floret D, Renaud H, Hage G, Aymard M, Monnet P. Gastrite avec hypoproteinemie chez l'enfant. Rapport avec la maladie de Menetrier et la maladie des inclusions cytomegaliques. Arch Fr Pediatr. 1978 Jan;35(1):82–89. [PubMed] [Google Scholar]
  • Buts JP, Harmant G, de Meyer R. La gastropathie hypertrophique et exsudative de l'enfant. Arch Fr Pediatr. 1978 Oct;35(8):845–853. [PubMed] [Google Scholar]
  • DEGNAN TJ. Idiopathic hypoproteinemia. J Pediatr. 1957 Oct;51(4):448–452. [PubMed] [Google Scholar]
  • Schuster W. Clinical and roentgenological signs of giant hypertrophic gastritis in childhood (Ménétrier's disease). Ann Radiol (Paris) 1967;10(3):221–225. [PubMed] [Google Scholar]
  • Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984 Jun 16;1(8390):1311–1315. [PubMed] [Google Scholar]
  • Shirokova KI, Filimonov RM, Poliakova LV. Primenenie metronidazola v lechenii bol'nykh iazvennoi bolezn'iu. Klin Med (Mosk) 1981 Feb;59(2):48–50. [PubMed] [Google Scholar]
  • McLean AJ, Harrison PM, Ioannides-Demos LL, Byrne AJ, McCarthy P, Dudley FJ. Microbes, peptic ulcer, and relapse rates with different drugs. Lancet. 1984 Sep 1;2(8401):525–526. [PubMed] [Google Scholar]
  • Martin DF, Hollanders D, May SJ, Ravenscroft MM, Tweedle DE, Miller JP. Difference in relapse rates of duodenal ulcer after healing with cimetidine or tripotassium dicitrato bismuthate. Lancet. 1981 Jan 3;1(8210):7–10. [PubMed] [Google Scholar]
  • Vantrappen G, Schuurmans P, Rutgeerts P, Janssens J. A comparative study of colloidal bismuth subcitrate and cimetidine on the healing and recurrence of duodenal ulcer. Scand J Gastroenterol Suppl. 1982;80:23–30. [PubMed] [Google Scholar]
  • Bernier JJ. Du nouveau dans le traitement des ulcères gastro-duodénaux. Presse Med. 1983 May 14;12(21):1355–1358. [PubMed] [Google Scholar]
  • Hamilton I, Worsley BW, O'Connor HJ, Axon AT. Effects of tripotassium dicitrato bismuthate (TDB) tablets or cimetidine in the treatment of duodenal ulcer. Gut. 1983 Dec;24(12):1148–1151. [PMC free article] [PubMed] [Google Scholar]
  • Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ. Attempt to fulfil Koch's postulates for pyloric Campylobacter. Med J Aust. 1985 Apr 15;142(8):436–439. [PubMed] [Google Scholar]
  • Vestergaard BF, Rune SJ. Type-specific herpes-simplex-virus antibodies in patients with recurrent duodenal ulcer. Lancet. 1980 Jun 14;1(8181):1273–1274. [PubMed] [Google Scholar]
  • Calam J. Future treatment of peptic ulcers. Scand J Gastroenterol Suppl. 1985;117:47–53. [PubMed] [Google Scholar]
  • Bhalla S, Vij JC, Anand BS, Varghese A, Chuttani HK. Gastric acid secretion in patients with typhoid fever. Gut. 1985 May;26(5):491–494. [PMC free article] [PubMed] [Google Scholar]
  • Howden CW, Hunt RH. Gastric secretion in patients with typhoid. Gut. 1985 Dec;26(12):1387–1388. [PMC free article] [PubMed] [Google Scholar]
  • MOSBECH J, VIDEBAEK A. Mortality from and risk of gastric carcinoma among patients with pernicious anaemia. Br Med J. 1950 Aug 12;2(4675):390–394. [PMC free article] [PubMed] [Google Scholar]
  • Blackburn EK, Callender ST, Dacie JV, Doll R, Girdwood RH, Mollin DL, Saracci R, Stafford JL, Thompson RB, Varadi S, et al. Possible association between pernicious anaemia and leukaemia: a prospective study of 1,625 patients with a note on the very high incidence of stomach cancer. Int J Cancer. 1968 Jan 15;3(1):163–170. [PubMed] [Google Scholar]
  • Nicholls JC. Stump cancer following gastric surgery. World J Surg. 1979 Nov;3(6):731–736. [PubMed] [Google Scholar]
  • Ruddell WS, Bone ES, Hill MJ, Walters CL. Pathogenesis of gastric cancer in pernicious anaemia. Lancet. 1978 Mar 11;1(8063):521–523. [PubMed] [Google Scholar]
  • Sharma BK, Walt RP, Pounder RE, Gomes MD, Wood EC, Logan LH. Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity. Gut. 1984 Sep;25(9):957–964. [PMC free article] [PubMed] [Google Scholar]
  • Pounder RE. Duodenal ulcers that will not heal. Gut. 1984 Jul;25(7):697–702. [PMC free article] [PubMed] [Google Scholar]
  • Larsson H, Carlsson E, Mattsson H, Lundell L, Sundler F, Sundell G, Wallmark B, Watanabe T, Håkanson R. Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats. Gastroenterology. 1986 Feb;90(2):391–399. [PubMed] [Google Scholar]
  • Wilander E, Sundström C, Grimelius L. Pernicious anaemia in association with argyrophil (Sevier-Munger) gastric carcinoid. Scand J Haematol. 1979 Nov;23(5):415–420. [PubMed] [Google Scholar]
  • Stockbrügger RW, Menon GG, Beilby JO, Mason RR, Cotton PB. Gastroscopic screening in 80 patients with pernicious anaemia. Gut. 1983 Dec;24(12):1141–1147. [PMC free article] [PubMed] [Google Scholar]
  • Bordi C, Cocconi G, Togni R, Vezzadini P, Missale G. Gastric endocrine cell proliferation. Association with Zollinger-Ellison syndrome. Arch Pathol. 1974 Oct;98(4):274–278. [PubMed] [Google Scholar]
  • Harvey RF, Bradshaw MJ, Davidson CM, Wilkinson SP, Davies PS. Multifocal gastric carcinoid tumours, achlorhydria, and hypergastrinaemia. Lancet. 1985 Apr 27;1(8435):951–954. [PubMed] [Google Scholar]
  • Cook RW, Williams JF. Pathology of Taenia taeniaeformis infection in the rat: gastrointestinal changes. J Comp Pathol. 1981 Apr;91(2):205–217. [PubMed] [Google Scholar]
  • Cook RW, Williams JF, Lichtenberger LM. Hyperplastic gastropathy in the rat due to Taenia taeniaeformis infection: parabiotic transfer and hypergastrinemia. Gastroenterology. 1981 Apr;80(4):728–734. [PubMed] [Google Scholar]
  • FELL BF, SMITH KA, CAMPBELL RM. Hypertrophic and hyperplastic changes in the alimentary canal of the lactating rat. J Pathol Bacteriol. 1963 Jan;85:179–188. [PubMed] [Google Scholar]
  • Jervis EL, Levin RJ. Anatomic adaptation of the alimentary tract of the rat to the hyperphagia of chronic alloxan-diabetes. Nature. 1966 Apr 23;210(5034):391–393. [PubMed] [Google Scholar]
  • Dowling RH, Booth CC. Structural and functional changes following small intestinal resection in the rat. Clin Sci. 1967 Feb;32(1):139–149. [PubMed] [Google Scholar]
  • McLEAY LM, Anderson N, Bingley JB, Titchen DA. Effects on abomasal function of Ostertagia circumcincta infections in sheep. Parasitology. 1973 Apr;66(2):241–257. [PubMed] [Google Scholar]
  • Barker IK, Titchen DA. Gastric dysfunction in sheep infected with Trichostrongylus colubriformis, a nematode inhabiting the small intestine. Int J Parasitol. 1982 Aug;12(4):345–356. [PubMed] [Google Scholar]
  • Douglass HO, Jr, Falk GA, LeVeen HH. Infection: a cause of acute peptic ulceration in hypersecreting animals. Surgery. 1970 Nov;68(5):827–830. [PubMed] [Google Scholar]
  • Rasche R, Butterfield WC. The effect of sepsis on acute gastric ulcerations in the rat. Surgery. 1974 Nov;76(5):764–770. [PubMed] [Google Scholar]
  • Wyllie JH, Limbosch JM, Nyhus LM. Inhibition of gastric acid secretion by bacterial lipopolysaccharide. Nature. 1967 Aug 19;215(5103):879–879. [PubMed] [Google Scholar]
  • Mimura T, Muto N, Tanaka J, Oshita H, Onishi N, Aonuma S. Effects of the gastric juice inhibitory substance from Streptomyces bottropensis on gastric secretion and experimental ulcerations in rats. Chem Pharm Bull (Tokyo) 1977 May;25(5):897–903. [PubMed] [Google Scholar]
  • Mimura T, Muto N, Tsujibo H, Onishi N, Aonuma S. Purification and partial characterization of the gastric ulcer inhibitory substance from culture filtrate of Bacillus subtilis H. Chem Pharm Bull (Tokyo) 1977 Oct;25(10):2770–2774. [PubMed] [Google Scholar]
  • Aonuma S, Kohama Y, Enmi K, Aonuma S, Okazaki Y, Miyawaki T, Torii K, Yoneda R, Ohhara H. [Studies on anti-ulcerogenic protein in inflamed rabbit skin tissues. III. Anti-ulcerogenic peptide (Gly-Ser-His-Lys) obtained from tissues infected with vaccinia virus]. Yakugaku Zasshi. 1984 Apr;104(4):362–373. [PubMed] [Google Scholar]
  • Chang HC. GASTRIC SECRETION IN FEVER AND INFECTIOUS DISEASES. J Clin Invest. 1933 Jan;12(1):155–169. [PMC free article] [PubMed] [Google Scholar]
  • Salokannel J. Intrinsic factor in tapeworm anaemia. Acta Med Scand Suppl. 1970;517:1–51. [PubMed] [Google Scholar]
  • Padovan W, Godoy RA, Meneghelli UG, Dantas RO, Oliveira RB, Troncon LE. Acid and pepsin secretion in chronic Chagas' disease patients in response to graded doses of pentagastrin and pentagastrin plus bethanecol. Digestion. 1982;23(1):48–56. [PubMed] [Google Scholar]
  • Padovan W, Meneghelli UG, Alves de Godoy R. Gastric secretory and motility studies in chronic chagasic patients. Am J Dig Dis. 1977 Jul;22(7):618–622. [PubMed] [Google Scholar]
  • Pimparkar BD, Sharma P, Satoskar RS, Raghavan P, Kinare SG. Anaemia and gastro-intestinal function in ancylostomiasis. J Postgrad Med. 1982 Apr;28(2):51–63. [PubMed] [Google Scholar]
  • Meeroff JC, Schreiber DS, Trier JS, Blacklow NR. Abnormal gastric motor function in viral gastroenteritis. Ann Intern Med. 1980 Mar;92(3):370–373. [PubMed] [Google Scholar]
  • Widerlite L, Trier JS, Blacklow NR, Schreiber DS. Structure of the gastric mucosa in acute infectious bacterial gastroenteritis. Gastroenterology. 1975 Mar;68(3):425–430. [PubMed] [Google Scholar]
  • Gledhill T, Howard OM, Buck M, Paul A, Hunt RH. Single nocturnal dose of an H2 receptor antagonist for the treatment of duodenal ulcer. Gut. 1983 Oct;24(10):904–908. [PMC free article] [PubMed] [Google Scholar]
  • Colin-Jones DG, Langman MJ, Lawson DH, Vessey MP. Cimetidine and gastric cancer: preliminary report from post-marketing surveillance study. Br Med J (Clin Res Ed) 1982 Nov 6;285(6351):1311–1313. [PubMed] [Google Scholar]
  • Colin-Jones DG, Langman MJ, Lawson DH, Vessey MP. Postmarketing surveillance of the safety of cimetidine: 12 month mortality report. Br Med J (Clin Res Ed) 1983 May 28;286(6379):1713–1716. [PMC free article] [PubMed] [Google Scholar]
  • Colin Jones DG, Langman MJ, Lawson DH, Vessey MP. Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report. Q J Med. 1985 Mar;54(215):253–268. [PubMed] [Google Scholar]
  • Kumar N, Vij JC, Karol A, Anand BS. Controlled therapeutic trial to determine the optimum dose of antacids in duodenal ulcer. Gut. 1984 Nov;25(11):1199–1202. [PMC free article] [PubMed] [Google Scholar]
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