Line-field confocal optical coherence tomography imaging findings of scalp psoriasis

LC-OCT: line-field confocal optical coherence tomography SP: scalp psoriasis CLINICAL PRESENTATION A 64-year-old woman presented to the clinic with two pink, scaly plaques with excoriations on the right side of the temple and the left side of the abdomen. The initial clinical suspicion was eczema, and the patient was instructed to apply hydrocortisone 2.5% cream to the area. There was no resolution after 2 months of treatment, and the patient was imaged with line-field confocal optical coherence tomography (LC-OCT), and a shave tangential biopsy was also performed (Fig 1).


LC-OCT APPEARANCE
The lesion showed psoriasiform epidermal hyperplasia along with a papillomatous appearance on both vertical and horizontal sections (Figs 2 and 3).In addition, parakeratosis was present along with clusters of bright small white cells within the stratum corneum, likely correlating to collections of neutrophils.Small round areas filled with amorphous material were present at the spinous layer, which likely correlate to spongiform pustules of Kogoj, which were visible from the vertical view (Fig 3).Video 1, available on https://www.jaad.org.and horizontal 2-dimensional images to create a 3-dimensional image block to provide an image of the target lesion in real time.LC-OCT has a higher resolution than that of optical coherence tomography (5 m vs 20-25 m) and a higher penetration depth than that of reflectance confocal microscopy ([400 m vs [200 m). 1 LC-OCT has been used to evaluate histopathologic features of skin cancer and some inflammatory skin conditions. 2 Scalp psoriasis (SP) is an immune-mediated chronic inflammatory condition of the head and neck characterized by painful and pruritic erythematous thickened plaques. 3,4Although these lesions may closely mimic other inflammatory conditions, such as seborrheic dermatitis and atopic dermatitis, rapid histopathologic visualizations with LC-OCT may help confirm the diagnosis.LC-OCT imaging showed good histopathologic correlation with visualization of parakeratosis, clubbed and elongated rete ridges, and spongiform micropustules.Features such as follicular plugging and lymphocytic exocytosis are more characteristic of seborrheic dermatitis, and were not observed in this patient. 5This case report supports the use of LC-OCT imaging as a diagnostic aid for an earlier recognition of SP to guide clinical decision making and prevent longerterm complications, such as alopecia.

Fig 2 .
Fig 2. Two-dimensional vertical views.A, A psoriasis plaque showing classic psoriasiform hyperplasia (white bracket), with parakeratosis (yellow arrows) and bright small cells, likely neutrophils, clustered (neutrophilic lakes) in the stratum corneum as (red arrows).B, Adjacent lesion-free skin of the scalp.

Fig 3 .
Fig 3. Multiple views of the psoriasis plaque using line-field confocal optical coherence tomography.A, Three-dimensional block view demonstrating epidermal hyperplasia with spongiform pustules of Kogoj (yellow arrows).The red dashed line indicates a transverse cut represented in image (B) showing papillomatosis.C, Collections of neutrophils within the stratum corneum (yellow arrows).The red dash line shows the en face view (D) of clusters of small bright cells within the stratum corneum (yellow dotted circle).

Fig 4 .
Fig 4. Histology shows that regular psoriasiform hyperplasia is present with parakeratosis and focal neutrophilic collections within the stratum corneum (yellow dotted circle).
Histology confirmed the diagnosis of psoriasis, showing regular psoriasiform epidermal hyperplasia, parakeratosis, and numerous collections of neutrophils within the stratum corneum (Fig 4).
From Rao Dermatology, Atlantic Highlands, New Jersey a ; Department of Dermatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey b ; and Department of Dermatology, Weill Cornell Medicine, New York, New York.c Funding sources: None.IRB approval status: Not applicable.Patient consent: Received from the patient.Correspondence to: Gaurav N. Pathak, PharmD, Department of Dermatology, Robert Wood Johnson Medical School, 1 Worlds Ó 2023 by the American Academy of Dermatology, Inc. Published by Elsevier Inc.This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).https://doi.org/10.1016/j.jdcr.2023.06.050