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Select item 99254471.

Integrated comparative metabolite profiling via NMR and GC–MS analyses for tongkat ali (Eurycomalongifolia) fingerprinting and quality control analysis

Ahmed Serag, Ahmed Zayed, Ahmed Mediani, Mohamed A. Farag

Sci Rep. 2023; 13: 2533. Published online 2023 Feb 13. doi: 10.1038/s41598-023-28551-x

PMCID:: PMC9925447

Article PDF–2.9M

Select item 61305422.

Assessing product adulteration of Eurycoma longifolia (Tongkat Ali) herbal medicinal product using DNA barcoding and HPLC analysis

Bashir Mohammed Abubakar, Faezah Mohd Salleh, Mohd Shahir Shamsir Omar, Alina Wagiran

Pharm Biol. 2018; 56(1): 368–377. Published online 2018 Jul 28. doi: 10.1080/13880209.2018.1479869

PMCID:: PMC6130542

Article PDF–1.0M

Select item 92790653.

A Systematic Review on Antimicrobial and Antiparasitic Activity of Eurycoma longifolia Jack (Tongkat Ali)

Mohd Qayyum Ab Latip, Mohd Hezmee Mohd Noor, Hafandi Ahmad, Hasliza Abu Hassim, Annas Salleh, Mohd Hair Bejo, Alif Aiman Zakaria

Biomed Res Int. 2022; 2022: 4999797. Published online 2022 Jul 6. doi: 10.1155/2022/4999797

PMCID:: PMC9279065

Article PDF–494K

Select item 44761694.

Tongkat Ali (Eurycoma longifolia): a possible therapeutic candidate against Blastocystis sp.

Sonal Girish, Suresh Kumar, Norhaniza Aminudin

Parasit Vectors. 2015; 8: 332. Published online 2015 Jun 18. doi: 10.1186/s13071-015-0942-y

PMCID:: PMC4476169

Article PDF–804K

Select item 98507165.

A Multifaceted Review of Eurycoma longifolia Nutraceutical Bioactives: Production, Extraction, and Analysis in Drugs and Biofluids

Mohamed A. Farag, Abiodun O. Ajayi, Mohammed Taleb, Kai Wang, Iriny M. Ayoub

ACS Omega. 2023 Jan 17; 8(2): 1838–1850. Published online 2022 Dec 30. doi: 10.1021/acsomega.2c06340

PMCID:: PMC9850716

Article PDF–5.2M

Select item 86932406.

Safety of Eurycoma longifolia (Tongkat Ali) root extract as a novel food pursuant to Regulation (EU) 2015/2283

EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Rosangela Marchelli, Monika Neuhäeuser‐Berthold, Morten Poulsen, Josef Rudolf Schlatter, Henk van Loveren, Leonard Matijević, Helle Katrine Knutsen

EFSA J. 2021 Dec; 19(12): e06937. Published online 2021 Dec 22. doi: 10.2903/j.efsa.2021.6937

PMCID:: PMC8693240

Article PDF–1.7M

Select item 62742577.

Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology

Shaheed Ur Rehman, Kevin Choe, Hye Hyun Yoo

Molecules. 2016 Mar; 21(3): 331. Published online 2016 Mar 10. doi: 10.3390/molecules21030331

PMCID:: PMC6274257

Article PDF–724K

Select item 36690338.

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects

Shawn M Talbott, Julie A Talbott, Annie George, Mike Pugh

J Int Soc Sports Nutr. 2013; 10: 28. Published online 2013 May 26. doi: 10.1186/1550-2783-10-28

PMCID:: PMC3669033

Article PDF–3.2M

Select item 80353749.

Comparison of apoptotic responses in Blastocystis sp. upon treatment with Tongkat Ali and Metronidazole

Sonal Girish, Suresh Kumar, Norhaniza Aminudin, Najihah Mohd Hashim

Sci Rep. 2021; 11: 7833. Published online 2021 Apr 9. doi: 10.1038/s41598-021-81418-x

PMCID:: PMC8035374

Article PDF–4.1M

Select item 376707710.

Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack)

Ching-Hao Li, Jiunn-Wang Liao, Po-Lin Liao, Wei-Kuang Huang, Ling-Shan Tse, Cheng-Hui Lin, Jaw-Jou Kang, Yu-Wen Cheng

Evid Based Complement Alternat Med. 2013; 2013: 102987. Published online 2013 Aug 25. doi: 10.1155/2013/102987

PMCID:: PMC3767077

Article PDF–554K

Select item 1103212511.

A Rare Case of Tongkat Ali-Induced Liver Injury: A Case Report

Aboud Kaliounji, Grace Shadid, Helena Saba, Sushil Ahlawat

Cureus. 2024 Mar; 16(3): e56639. Published online 2024 Mar 21. doi: 10.7759/cureus.56639

PMCID:: PMC11032125

Article PDF–407K

Select item 760199312.

Eurycoma longifolia—Infused Coffee—An Oral Toxicity Study

Norzahirah Ahmad, Bee Ping Teh, Siti Zaleha Halim, Nor Azlina Zolkifli, Nurulfariza Ramli, Hussin Muhammad

Nutrients. 2020 Oct; 12(10): 3125. Published online 2020 Oct 13. doi: 10.3390/nu12103125

PMCID:: PMC7601993

Article PDF–3.3M

Select item 753351913.

Differentially expressed genes on the growth of mouse Leydig cells treated with standardised Eurycoma longifolia extract

Nor Amira Khurshid Ahmed, Shern Kwok Lim, Ganesh N. Pandian, Hiroshi Sugiyama, Chong Yew Lee, Boon Yin Khoo, Kit Lam Chan

Mol Med Rep. 2020 Nov; 22(5): 3645–3658. Published online 2020 Sep 2. doi: 10.3892/mmr.2020.11485

PMCID:: PMC7533519

Article PDF–831K

Select item 1038134214.

Anti-Inflammatory, Antinociceptive, Antipyretic, and Gastroprotective Effects of Eurycoma longifolia Jack Ethanolic Extract

Subhawat Subhawa, Warangkana Arpornchayanon, Kanjana Jaijoy, Sunee Chansakaow, Noppamas Soonthornchareonnon, Seewaboon Sireeratawong

Life (Basel) 2023 Jul; 13(7): 1465. Published online 2023 Jun 28. doi: 10.3390/life13071465

PMCID:: PMC10381342

Article PDF–4.5M

Select item 1036564515.

Eurycoma longifolia: an overview on the pharmacological properties for the treatment of common cancer

Shankar Jothi, Thaigarajan Parumasivam, Noratiqah Mohtar

J Public Health Afr. 2023 Mar 30; 14(Suppl 1): 2495. Published online 2023 Mar 16. doi: 10.4081/jphia.2023.2495

PMCID:: PMC10365645

Article PDF–12M

Select item 956471716.

How Internet Websites Portray Herbal Vitality Products Containing Eurycoma longifolia Jack: An Evaluation of the Quality and Risks of Online Information

Mohd Shahezwan Abd Wahab, Nurfarah Nadiah Abd Hamid, Ali Omar Yassen, Mohd Javed Naim, Javed Ahamad, Nur Wahida Zulkifli, Farhana Fakhira Ismail, Muhammad Harith Zulkifli, Khang Wen Goh, Long Chiau Ming

Int J Environ Res Public Health. 2022 Oct; 19(19): 11853. Published online 2022 Sep 20. doi: 10.3390/ijerph191911853

PMCID:: PMC9564717

Article PDF–490K

Select item 941550017.

Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials

Kristian Leisegang, Renata Finelli, Suresh C. Sikka, Manesh Kumar Panner Selvam

Medicina (Kaunas) 2022 Aug; 58(8): 1047. Published online 2022 Aug 4. doi: 10.3390/medicina58081047

PMCID:: PMC9415500

Article PDF–1.6M

Select item 791675118.

Herbal-Based Formulation Containing Eurycoma longifolia and Labisia pumila Aqueous Extracts: Safe for Consumption?

Bee Ping Teh, Norzahirah Ahmad, Elda Nurafnie Ibnu Rasid, Nor Azlina Zolkifli, Umi Rubiah Sastu@Zakaria, Norliyana Mohamed Yusoff, Azlina Zulkapli, Norfarahana Japri, June Chelyn Lee, Hussin Muhammad

Pharmaceuticals (Basel) 2021 Feb; 14(2): 142. Published online 2021 Feb 10. doi: 10.3390/ph14020142

PMCID:: PMC7916751

Article PDF–2.5M

Select item 658286319.

Brain Cortical and Hippocampal Dopamine: A New Mechanistic Approach for Eurycoma longifolia Well-Known Aphrodisiac Activity and Its Chemical Characterization

Shahira M. Ezzat, Marwa I. Ezzat, Mona M. Okba, Salah M. Hassan, Amgad I. Alkorashy, Mennatallah M. Karar, Sherif H. Ahmed, Shanaz O. Mohamed

Evid Based Complement Alternat Med. 2019; 2019: 7543460. Published online 2019 Jun 2. doi: 10.1155/2019/7543460

PMCID:: PMC6582863

Article PDF–1.6M

Select item 791018620.

A review on extraction techniques and therapeutic value of polar bioactives from Asian medicinal herbs: Case study on Orthosiphon aristatus, Eurycoma longifolia and Andrographis paniculata

Nur Amanina Abd Aziz, Rosnani Hasham, Mohamad Roji Sarmidi, Siti Hasyimah Suhaimi, Mohamad Khairul Hafiz Idris

Saudi Pharm J. 2021 Feb; 29(2): 143–165. Published online 2021 Jan 7. doi: 10.1016/j.jsps.2020.12.016

PMCID:: PMC7910186

Article PDF–2.1M

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Figure 3

Salivary testosterone. Salivary testosterone levels were significantly higher (+37% compared to placebo, PL) following tongkat ali (TA) supplementation (200 mg/day for 4 weeks). * = p < 0.05 by ANOVA.

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects

J Int Soc Sports Nutr. 2013;10:28-28.
Figure 2

Salivary cortisol. Salivary cortisol levels were significantly lower (−16% compared to placebo, PL) following tongkat ali (TA) supplementation (200 mg/day for 4 weeks). * = p < 0.05 by ANOVA.

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects

J Int Soc Sports Nutr. 2013;10:28-28.
Figure 4

GC–MS total ion chromatograms (TIC) of investigated Eurycoma longifolia (Tongkat Ali) products showing the relative abundances (%) of each identified peaks of; (A) authentic root powder, (B) Nu-prep LELAKI^®, and (C) and Naturelle^® specimens highlighting major aroma component in each specimen.

Integrated comparative metabolite profiling via NMR and GC–MS analyses for tongkat ali (Eurycoma longifolia) fingerprinting and quality control analysis

Sci Rep. 2023;13:2533.
Figure 1

Profile of Mood States (POMS). Daily supplementation (200 mg/day for 4 weeks) with tongkat ali (TA) resulted in significant improvements compared to placebo (PL) for indices of Tension (−11%), Anger (−12%), and Confusion (−15%) in moderately stressed adults (N = 63). * = p < 0.05 by ANOVA.

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects

J Int Soc Sports Nutr. 2013;10:28-28.