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Select item 64755721.

Distinct Prognostic Values of Phospholipase C Beta Family Members for Non-Small Cell Lung Carcinoma

Tengfang Zhang, Xiaowei Song, Xiwen Liao, Xiangkun Wang, Guangzhi Zhu, Chengkun Yang, Xiaoyong Xie

Biomed Res Int. 2019; 2019: 4256524. Published online 2019 Apr 7. doi: 10.1155/2019/4256524

PMCID:: PMC6475572

Abstract Article PDF–2.4M

Select item 64480892.

Diagnostic and prognostic value of mRNA expression of phospholipase C β family genes in hepatitis B virus-associated hepatocellular carcinoma

Xiangkun Wang, Ketuan Huang, Xianmin Zeng, Zhengqian Liu, Xiwen Liao, Chengkun Yang, Tingdong Yu, Chuangye Han, Guangzhi Zhu, Wei Qin, Tao Peng

Oncol Rep. 2019 May; 41(5): 2855–2875. Published online 2019 Mar 14. doi: 10.3892/or.2019.7066

PMCID:: PMC6448089

Abstract Article PDF–4.8M

Select item 56331383.

The binding of activated Gα_q to phospholipase C-β exhibits anomalous affinity

Punya Navaratnarajah, Anne Gershenson, Elliott M. Ross

J Biol Chem. 2017 Oct 6; 292(40): 16787–16801. Published online 2017 Aug 24. doi: 10.1074/jbc.M117.809673

PMCID:: PMC5633138

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Select item 49002834.

Intrinsic Pleckstrin Homology (PH) Domain Motion in Phospholipase C-β Exposes a Gβγ Protein Binding Site

Ganesh Kadamur, Elliott M. Ross

J Biol Chem. 2016 May 20; 291(21): 11394–11406. Published online 2016 Mar 21. doi: 10.1074/jbc.M116.723940

PMCID:: PMC4900283

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Select item 38057655.

Role of Phospholipase C-β in RNA interference

Finly Philip, Shriya Sahu, Giuseppe Caso, Suzanne Scarlata

Adv Biol Regul. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Adv Biol Regul. 2013 Sep; 53(3): 319–330. Published online 2013 Jul 18. doi: 10.1016/j.jbior.2013.07.002

PMCID:: PMC3805765

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An Autoinhibitory Helix in the C-Terminal Region of Phospholipase C-ß Mediates Ga_q Activation

Angeline M. Lyon, Valerie M. Tesmer, Vishan D. Dhamsania, David M. Thal, Joanne Gutierrez, Shoaib Chowdhury, Krishna C. Suddala, John K. Northup, John J. G. Tesmer

Nat Struct Mol Biol. Author manuscript; available in PMC 2012 Mar 1.

Published in final edited form as: Nat Struct Mol Biol. 2011 Sep; 18(9): 999–1005. Published online 2011 Aug 7. doi: 10.1038/nsmb.2095

PMCID:: PMC3168981

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Dissociation of the G protein βγ from the Gq–PLCβ complex partially attenuates PIP2 hydrolysis

Dinesh Kankanamge, Sithurandi Ubeysinghe, Mithila Tennakoon, Priyanka Devi Pantula, Kishalay Mitra, Lopamudra Giri, Ajith Karunarathne

J Biol Chem. 2021 Jan-Jun; 296: 100702. Published online 2021 Apr 24. doi: 10.1016/j.jbc.2021.100702

PMCID:: PMC8138763

Abstract Article PDF–6.7M

Select item 42079728.

Membrane-induced Allosteric Control of Phospholipase C-β Isozymes

Thomas H. Charpentier, Gary L. Waldo, Matthew O. Barrett, Weigang Huang, Qisheng Zhang, T. Kendall Harden, John Sondek

J Biol Chem. 2014 Oct 24; 289(43): 29545–29557. Published online 2014 Sep 5. doi: 10.1074/jbc.M114.586784

PMCID:: PMC4207972

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Rhodopsin 5– and Rhodopsin 6–Mediated Clock Synchronization in Drosophila melanogaster Is Independent of Retinal Phospholipase C-β Signaling

Joanna Szular, Hana Sehadova, Carla Gentile, Gisela Szabo, Wen-Hai Chou, Steven G. Britt, Ralf Stanewsky

J Biol Rhythms. Author manuscript; available in PMC 2015 Apr 21.

Published in final edited form as: J Biol Rhythms. 2012 Feb; 27(1): 25–36. doi: 10.1177/0748730411431673

PMCID:: PMC4405110

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Phospholipase C Beta 1: a Candidate Signature Gene for Proneural Subtype High-Grade Glioma

Guangrong Lu, Jeffrey T. Chang, Zheyu Liu, Yong Chen, Min Li, Jay-Jiguang Zhu

Mol Neurobiol. 2016; 53(9): 6511–6525. Published online 2015 Nov 28. doi: 10.1007/s12035-015-9518-2

PMCID:: PMC5085994

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Implantation failure in mice with a disruption in Phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism

Panayiotis Filis, Peter C. Kind, Norah Spears

Mol Hum Reprod. 2013 May; 19(5): 290–301. Published online 2013 Jan 7. doi: 10.1093/molehr/gas067

PMCID:: PMC3632219

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Distinct Phospholipase C-β Isozymes Mediate Lysophosphatidic Acid Receptor 1 Effects on Intestinal Epithelial Homeostasis and Wound Closure

Sei-Jung Lee, Giovanna Leoni, Philipp-Alexander Neumann, Jerold Chun, Asma Nusrat, C. Chris Yun

Mol Cell Biol. 2013 May; 33(10): 2016–2028. doi: 10.1128/MCB.00038-13

PMCID:: PMC3647975

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Downregulation of miRNA‐26 in chronic periodontitis interferes with innate immune responses and cell migration by targeting phospholipase C beta 1

Juhi R. Uttamani, Afsar R. Naqvi, Araceli Maria Valverde Estepa, Varun Kulkarni, Maria F. Brambila, Gloria Martínez, Gabriela Chapa, Christine D. Wu, Wei Li, Sona Rivas‐Tumanyan, Salvador Nares

J Clin Periodontol. 2023 Jan; 50(1): 102–113. Published online 2022 Aug 25. doi: 10.1111/jcpe.13715

PMCID:: PMC10087579

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Select item 788419814.

Phospholipase C Beta 2 Protein Overexpression Is a Favorable Prognostic Indicator in Newly Diagnosed Normal Karyotype Acute Myeloid Leukemia

Mi Suk Park, Young Eun Lee, Hye Ran Kim, Jong Hee Shin, Hyun Wook Cho, Jun Hyung Lee, Myung Geun Shin

Ann Lab Med. 2021 Jul 1; 41(4): 409–413. Published online 2021 Jul 1. doi: 10.3343/alm.2021.41.4.409

PMCID:: PMC7884198

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PI(3,4,5)P₃ Potentiates Phospholipase C-β Activity

Yong Zhang, Sun Hyung Kwon, Walter K. Vogel, Theresa M. Filtz

J Recept Signal Transduct Res. Author manuscript; available in PMC 2010 Mar 2.

Published in final edited form as: J Recept Signal Transduct Res. 2009; 29(1): 52–62. doi: 10.1080/10799890902729449

PMCID:: PMC2830898

Abstract Article PDF–287K

Select item 789187616.

Activation of phospholipase C β by Gβγ and Gα_q involves C-terminal rearrangement to release auto-inhibition

Isaac Fisher, Meredith L. Jenkins, Gregory G. Tall, John E. Burke, Alan V. Smrcka

Structure. Author manuscript; available in PMC 2021 Jul 7.

Published in final edited form as: Structure. 2020 Jul 7; 28(7): 810–819.e5. Published online 2020 May 12. doi: 10.1016/j.str.2020.04.012

PMCID:: PMC7891876

Abstract Article PDF–2.3M

Select item 378138517.

Structural Insights into Phospholipase C-β Function

Angeline M. Lyon, John J. G. Tesmer

Mol Pharmacol. 2013 Oct; 84(4): 488–500. Published online 2013 Oct. doi: 10.1124/mol.113.087403

PMCID:: PMC3781385

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A PLCB1–PI3K–AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression

Shuhang Liang, Hongrui Guo, Kun Ma, Xianying Li, Dehai Wu, Yiqi Wang, Wei Wang, Shugeng Zhang, Yifeng Cui, Yufeng Liu, Linmao Sun, Bo Zhang, Mengyang Xin, Ning Zhang, Huanran Zhou, Yao Liu, Jiabei Wang, Lianxin Liu

Cancer Res. 2021 Dec 1; 81(23): 5889–5903. Published online 2021 Sep 27. doi: 10.1158/0008-5472.CAN-21-1538

PMCID:: PMC9397629

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Select item 432459519.

Phospholipase C-β in Immune Cells

Toshiaki Kawakami, Wenbin Xiao

Adv Biol Regul. Author manuscript; available in PMC 2015 Feb 11.

Published in final edited form as: Adv Biol Regul. 2013 Sep; 53(3): 249–257. Published online 2013 Aug 14. doi: 10.1016/j.jbior.2013.08.001

PMCID:: PMC4324595

Abstract Article PDF–505K

Select item 416655220.

PLCB3 is a key modulator of IL-8 expression in cystic fibrosis bronchial epithelial cells

Valentino Bezzerri, Pio d’Adamo, Alessandro Rimessi, Carmen Lanzara, Sergio Crovella, Elena Nicolis, Anna Tamanini, Emmanouil Athanasakis, Maela Tebon, Giulia Bisoffi, Mitchell L. Drumm, Michael R. Knowles, Paolo Pinton, Paolo Gasparini, Giorgio Berton, Giulio Cabrini

J Immunol. Author manuscript; available in PMC 2014 Sep 17.

Published in final edited form as: J Immunol. 2011 Apr 15; 186(8): 4946–4958. Published online 2011 Mar 16. doi: 10.4049/jimmunol.1003535

PMCID:: PMC4166552

Abstract Article PDF–4.2M

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Figure 6

Correlation analysis between PLCB family members and gender of NSCLC. Notes: PLCB1, phospholipase C beta 1; PLCB2, phospholipase C beta 2; PLCB3, phospholipase C beta 3; PLCB4, phospholipase C beta 4; HR, hazard ratio; CI, confidence interval.

Distinct Prognostic Values of Phospholipase C Beta Family Members for Non-Small Cell Lung Carcinoma

Biomed Res Int. 2019;2019:4256524.
Figure 2

Correlation analysis between PLCB family members and smoking status. Notes: PLCB1, phospholipase C beta 1; PLCB2, phospholipase C beta 2; PLCB3, phospholipase C beta 3; PLCB4, phospholipase C beta 4; HR, hazard ratio; CI, confidence interval.

Distinct Prognostic Values of Phospholipase C Beta Family Members for Non-Small Cell Lung Carcinoma

Biomed Res Int. 2019;2019:4256524.
Figure 3

Correlation analysis between PLCB family members of clinical stage of NSCLC. Notes: PLCB1, phospholipase C beta 1; PLCB2, phospholipase C beta 2; PLCB3, phospholipase C beta 3; PLCB4, phospholipase C beta 4; HR, hazard ratio; CI, confidence interval.

Distinct Prognostic Values of Phospholipase C Beta Family Members for Non-Small Cell Lung Carcinoma

Biomed Res Int. 2019;2019:4256524.
Figure 4

Correlation analysis between PLCB family members and chemotherapy outcomes of NSCLC. Notes: PLCB1, phospholipase C beta 1; PLCB2, phospholipase C beta 2; PLCB3, phospholipase C beta 3; PLCB4, phospholipase C beta 4; HR, hazard ratio; CI, confidence interval.

Distinct Prognostic Values of Phospholipase C Beta Family Members for Non-Small Cell Lung Carcinoma

Biomed Res Int. 2019;2019:4256524.