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Select item 114103631.

Impact of the COVID-19 Pandemic on Cancer Clinical Trials: Alliance for Clinical Trials in Oncology Experience (Alliance A152022)

Rebecca A Snyder, Shauna L Hillman, Veronique Marcotte, Electra D Paskett, Suzanne George, Olwen Hahn, Sumithra J Mandrekar

J Clin Trials. Author manuscript; available in PMC 2024 Sep 18.

Published in final edited form as: J Clin Trials. 2024; 14(5): 570. Published online 2024 Jul 25.

PMCID:: PMC11410363

Article PDF–1.2M

Select item 112588792.

Efficacy and Safety of Pharmacokinetically-Driven Dosing of Mycophenolate Mofetil for the Treatment of Pediatric Proliferative Lupus Nephritis–A Double-Blind Placebo Controlled Clinical Trial (The Pediatric Lupus Nephritis Mycophenolate Mofetil Study)

Anna Carmela P Sagcal-Gironella, Angela Merritt, Tomoyuki Mizuno, Vikas R Dharnidharka, Joseph McDonald, Marietta DeGuzman, Dawn Wahezi, Beatrice Goilav, Karen Onel, Susan Kim, Ellen Cody, Eveline Y Wu, Laura Cannon, Kristen Hayward, Daryl M Okamura, Pooja N Patel, Larry A Greenbaum, Kelly A Rouster-Stevens, Jennifer C Cooper, Natasha M Ruth, Stacy Ardoin, Kathryn Cook, R Ezequiel Borgia, Aimee Hersh, Bin Huang, Prasad Devarajan, Hermine Brunner

J Clin Trials. Author manuscript; available in PMC 2024 Jul 19.

Published in final edited form as: J Clin Trials. 2024; 14(4): 563. Published online 2024 May 13.

PMCID:: PMC11258879

Article PDF–475K

Select item 84094313.

Early Sequential Risk Stratification Assessment to Optimize Fluid Dosing, CRRT Initiation and Discontinuation in Critically Ill Children with Acute Kidney Injury: Taking Focus 2 Process Article

Jean-Philippe Roy, Kelli A. Krallman, Rajit K. Basu, Ranjit S. Chima, Lin Fei, Sarah Wilder, Alexandra Schmerge, Bradley Gerhardt, Kaylee Fox, Cassie Kirby, Stuart L. Goldstein

J Clin Trials. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: J Clin Trials. 2020; 10(6): 435. Published online 2020 Oct 12.

PMCID:: PMC8409431

Article PDF–137K

Select item 66140274.

Efficacy of Mobile Phone Short Message Service (SMS) Reminders on Malaria Treatment Adherence and Day 3 Post-Treatment Reviews (SMS-RES-MAL) in Kenya: A Study Protocol

Ambrose O Talisuna, Dejan Zurovac, Sophie Githinji, Amos Oburu, Josephine Malinga, Andrew Nyandigisi, Caroline OH Jones, Robert W Snow

J Clin Trials. Author manuscript; available in PMC 2019 Jul 8.

Published in final edited form as: J Clin Trials. 2019 Jun 25; 5(2): 217. Published online 2015 Mar 23. doi: 10.4172/2167-0870.1000217

PMCID:: PMC6614027

Article PDF–708K

Select item 45176855.

Evaluation of a Mammography Screening Decision Aid for Women Aged 75 and Older: Protocol for a Cluster-randomized Controlled Trial

Mara A Schonberg, Christine E Kistler, Larissa Nekhlyudov, Angela Fagerlin, Roger B Davis, Christina C Wee, Edward R Marcantonio, Carmen L Lewis, Whitney A Stanley, Trisha M. Crutchfield, Mary Beth Hamel

J Clin Trials. Author manuscript; available in PMC 2015 Jul 28.

Published in final edited form as: J Clin Trials. 2014; 4: 191. Published online 2014 Oct 16. doi: 10.4172/2167-0870.1000191

PMCID:: PMC4517685

Article PDF–520K

Select item 56502456.

Long-Term Chamomile Therapy of Generalized Anxiety Disorder: A Study Protocol for a Randomized, Double-Blind, Placebo- Controlled Trial

Jun J Mao, Qing S. Li, Irene Soeller, Kenneth Rockwell, Sharon X Xie, Jay D. Amsterdam

J Clin Trials. Author manuscript; available in PMC 2017 Oct 20.

Published in final edited form as: J Clin Trials. 2014 Nov; 4(5): 188. Published online 2014 Oct 9. doi: 10.4172/2167-0870.1000188

PMCID:: PMC5650245

Article PDF–352K

Select item 47450957.

Methods for an International Randomized Clinical Trial to Investigate the Effect of Gsk249320 on Motor Cortex Neurophysiology using Transcranial Magnetic Stimulation in Survivors of Stroke

Matt P. Malcolm, Lori Enney, Steven C Cramer

J Clin Trials. Author manuscript; available in PMC 2016 Feb 8.

Published in final edited form as: J Clin Trials. 2014; 4(6): 1–9. doi: 10.4172/2167-0870.1000199

PMCID:: PMC4745095

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Select item 45245478.

Impaired signaling intrinsic to sinoatrial node pacemaker cells affects heart rate variability during cardiac disease

Yael Yaniv, Alexey E. Lyashkov, Edward G. Lakatta

J Clin Trials. Author manuscript; available in PMC 2015 Aug 4.

Published in final edited form as: J Clin Trials. 2014 Mar; 4(1): 152. Published online 2013 Dec 19. doi: 10.4172/2167-0870.1000152

PMCID:: PMC4524547

Article PDF–564K

Select item 111925469.

Study Protocol for a Randomized Controlled Trial of Low Intensity Shockwave Therapy for the Treatment of Post-Radical Prostatectomy Erectile Dysfunction: “SHARP-ED TRIAL”

Francis Petrella, Braian R Ledesma, David Velasquez, Manuel Molina, Russell G Saltzman, Sanoj Punnen, Paul H Chung, Ranjith Ramasamy

J Clin Trials. Author manuscript; available in PMC 2024 Jun 21.

Published in final edited form as: J Clin Trials. 2024; 14(3): 559. Published online 2024 Apr 8.

PMCID:: PMC11192546

Article PDF–570K

Select item 783610110.

Non-Invasive Strategies for Nose-to-Brain Drug Delivery

JT Trevino, RC Quispe, F Khan, V Novak

J Clin Trials. Author manuscript; available in PMC 2021 Jan 26.

Published in final edited form as: J Clin Trials. 2020; 10(7): 439. Published online 2020 Dec 10.

PMCID:: PMC7836101

Article PDF–733K

Select item 520111211.

Potential of Radiofrequency Ablation in Combination with Immunotherapy in the Treatment of Hepatocellular Carcinoma

Guangfu Li, Kevin F Staveley-O’Carroll, Eric T Kimchi

J Clin Trials. Author manuscript; available in PMC 2016 Dec 30.

Published in final edited form as: J Clin Trials. 2016 Apr; 6(2): 257. Published online 2016 Apr 5. doi: 10.4172/2167-0870.1000257

PMCID:: PMC5201112

Article PDF–300K

Select item 471195612.

Hip Hop Stroke: Study Protocol for a Randomized Controlled Trial to Address Stroke Literacy

Olajide Williams, Ellyn Leighton-Herrmann, Alexandra DeSorbo, Mindy Hecht, Monique Hedmann, Saima Huq, William Gerin, Vernon Chinchilli, Gbenga Ogedegbe, James Noble

J Clin Trials. Author manuscript; available in PMC 2016 Jan 13.

Published in final edited form as: J Clin Trials. 2015 Oct; 5(5): 242. Published online 2015 Oct 23. doi: 10.4172/2167-0870.1000242

PMCID:: PMC4711956

Article PDF–1.3M

Select item 471191513.

Improving Post-Hospitalization Transition Outcomes through Accessible Health Information Technology and Caregiver Support: Protocol for a Randomized Controlled Trial

John D Piette, Dana Striplin, Nicolle Marinec, Jenny Chen, Lynn A Gregory, Denise L Sumerlin, Angela M DeSantis, Carolyn Gibson, Ingrid Crause, Marylena Rouse, James E Aikens

J Clin Trials. Author manuscript; available in PMC 2016 Jan 13.

Published in final edited form as: J Clin Trials. 2015 Oct; 5(5): 240. Published online 2015 Oct 3. doi: 10.4172/2167-0870.1000240

PMCID:: PMC4711915

Article PDF–311K

Select item 469245914.

Assessment of Worldwide Acute Kidney Injury, Renal Angina and Epidemiology in Critically Ill Children (AWARE): A Prospective Study to Improve Diagnostic Precision

Rajit K Basu, Ahmad Kaddourah, Tara Terrell, Theresa Mottes, Patricia Arnold, Judd Jacobs, Jennifer Andringa, Melissa Armor, Lauren Hayden, Stuart L Goldstein

J Clin Trials. Author manuscript; available in PMC 2015 Dec 28.

Published in final edited form as: J Clin Trials. 2015; 5(3): 222. Published online 2015 Apr 17. doi: 10.4172/2167-0870.1000222

PMCID:: PMC4692459

Article PDF–210K

Select item 638870515.

Rationale and Methods of a Trial to Evaluate a Depression Telemonitoring Program that Includes a Patient-Selected Support Person

John D Piette, Marcia Valenstein, Daniel Eisenberg, Michael D Fetters, Ananda Sen, Daniel Saunders, Daphne Watkins, James E Aikens

J Clin Trials. Author manuscript; available in PMC 2019 Feb 25.

Published in final edited form as: J Clin Trials. 2015; 5(1): 205. Published online 2014 Dec 20. doi: 10.4172/2167-0870.1000205

PMCID:: PMC6388705

Article PDF–534K

Select item 447448416.

Chemoprevention Trial Feasibility Using Botanicals in Exceptionally High Risk Populations for Lung Cancer

Nagi B Kumar, Gwendolyn P Quinn, Mark G Alexandrow, Jhanelle Gray, Michael Schell, Steve Sutton, Eric B Haura

J Clin Trials. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: J Clin Trials. 2014 Sep; 4(4): 180. doi: 10.4172/2167-0870.1000180

PMCID:: PMC4474484

Article PDF–120K

Select item 429766317.

Rhodiola rosea therapy for major depressive disorder: a study protocol for a randomized, double-blind, placebo- controlled trial

Jun J Mao, Qing S. Li, Irene Soeller, Sharon X Xie, Jay D. Amsterdam

J Clin Trials. Author manuscript; available in PMC 2015 Jun 20.

Published in final edited form as: J Clin Trials. 2014 Jun 20; 4: 170. Published online 2014 Jun 20. doi: 10.4172/2167-0870.1000170

PMCID:: PMC4297663

Article PDF–176K

Select item 426693718.

Gentle Massage Improves Disease- and Treatment-Related Symptoms in Patients with Acute Myelogenous Leukemia

Ann Gill Taylor, Audrey E Snyder, Joel G Anderson, Cynthia J Brown, John J Densmore, Cheryl Bourguignon

J Clin Trials. Author manuscript; available in PMC 2015 Mar 17.

Published in final edited form as: J Clin Trials. 2014; 4: 1000161. Published online 2014 Mar 17. doi: 10.4172/2167-0870.1000161

PMCID:: PMC4266937

Article PDF–448K

Select item 413638319.

Emerging Tools for Computer-Aided Diagnosis and Prognostication

Scott Ritter, Kenneth B Margulies

J Clin Trials. Author manuscript; available in PMC 2014 Aug 18.

Published in final edited form as: J Clin Trials. 2014 Feb 24; 4(2): e117. Published online 2014 Feb 24. doi: 10.4172/2167-0870.1000e117

PMCID:: PMC4136383

Article PDF–25K

Select item 398213720.

Efficacy of Gastrografin^® Compared with Standard Conservative Treatment in Management of Adhesive Small Bowel Obstruction at Mulago National Referral Hospital

Caspar Haule, Peter A Ongom, Timothy Kimuli

J Clin Trials. Author manuscript; available in PMC 2014 Apr 10.

Published in final edited form as: J Clin Trials. 2013 Dec 1; 3(4): 1000144. Published online 2013 Dec 1. doi: 10.4172/2167-0870.1000144

PMCID:: PMC3982137

Article PDF–327K

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Figure 2

Association between reduction in LDL‐C levels and reduction in CRP levels among clinical trials comparing statin monotherapy with ezetimibe/statin combination. The following studies were included in the figure: VYVA: Ballantyne, Am Heart J, 2005; VYMET: Robinson, Am J Cardiol, 2009; EXPLORER: Ballantyne, Am J Cardiol, 2007; ENHANCE: Kastelein, NEJM, 2008; SANDS: Fleg, J Am Coll Cardiol, 2008; A: Sager, Atherosclerosis, 2005; B: Goldberg, Mayo Clin Proc, 2004; C: Bays, Clin Ther, 2004; D: Ballantyne, Circulation, 2003; E: Gagne, Am J Cardiol, 2002.

Vascular inflammation and low‐density lipoproteins: is cholesterol the link? A lesson from the clinical trials

Br J Pharmacol. 2017 Nov;174(22):3973-3985.
Figure. Disclosed and Undisclosed Payments Received by Oncologist Authors of Clinical Drug Trials, by Journal

J Clin Onc indicates Journal of Clinical Oncology; JAMA Onc, JAMA Oncology; Lancet: Haem, The Lancet Haemotology; Lancet: Onc, The Lancet Oncology; and NEJM, The New England Journal of Medicine.

Financial Conflicts of Interest Among Oncologist Authors of Reports of Clinical Drug Trials

JAMA Oncol. 2018 Oct;4(10):1426-1428.
Figure 5

Defining PD response at the patient level and PD effect at the dose level. (Adapted with permission from Murgo AJ, Kummar S, Rubinstein L, Gutierrez M, Collins J, Kinders R, et al. Designing phase 0 cancer clinical trials. Clin Cancer Res 2008;14:3675-82)

Phase 0 clinical trials in oncology new drug development

Perspect Clin Res. 2011 Jan-Mar;2(1):13-22.
Figure 2

Mutation in the tumor suppressor gene PTEN leads to hyperactivation of the PI3K/AKT/MTOR pathway, which can potentially be targeted at various sites downstream of PTEN. PIP indicates phosphatidyl phosphate. Adapted with modifications from Rodon J, Dienstmann R, Serra V, Tabernero J. Development of PI3K inhibitors: lessons learned from early clinical trials. Nat Rev Clin Oncol. 2013;10:143–153.

Therapeutic Targeting of Tumor Suppressor Genes

Cancer. ;121(9):1357-1368.