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Early Sequential Risk Stratification Assessment to Optimize Fluid Dosing, CRRT Initiation and Discontinuation in Critically Ill Children with Acute Kidney Injury: Taking Focus 2 Process Article

Jean-Philippe Roy, Kelli A. Krallman, Rajit K. Basu, Ranjit S. Chima, Lin Fei, Sarah Wilder, Alexandra Schmerge, Bradley Gerhardt, Kaylee Fox, Cassie Kirby, Stuart L. Goldstein

J Clin Trials. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: J Clin Trials. 2020; 10(6): 435. Published online 2020 Oct 12.

PMCID:: PMC8409431

Article PubReader PDF–137K Cite

Select item 47119562.

Hip Hop Stroke: Study Protocol for a Randomized Controlled Trial to Address Stroke Literacy

Olajide Williams, Ellyn Leighton-Herrmann, Alexandra DeSorbo, Mindy Hecht, Monique Hedmann, Saima Huq, William Gerin, Vernon Chinchilli, Gbenga Ogedegbe, James Noble

J Clin Trials. Author manuscript; available in PMC 2016 Jan 13.

Published in final edited form as: J Clin Trials. 2015 Oct; 5(5): 242. Published online 2015 Oct 23. doi: 10.4172/2167-0870.1000242

PMCID:: PMC4711956

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Select item 46924593.

Assessment of Worldwide Acute Kidney Injury, Renal Angina and Epidemiology in Critically Ill Children (AWARE): A Prospective Study to Improve Diagnostic Precision

Rajit K Basu, Ahmad Kaddourah, Tara Terrell, Theresa Mottes, Patricia Arnold, Judd Jacobs, Jennifer Andringa, Melissa Armor, Lauren Hayden, Stuart L Goldstein

J Clin Trials. Author manuscript; available in PMC 2015 Dec 28.

Published in final edited form as: J Clin Trials. 2015; 5(3): 222. Published online 2015 Apr 17. doi: 10.4172/2167-0870.1000222

PMCID:: PMC4692459

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Select item 45176854.

Evaluation of a Mammography Screening Decision Aid for Women Aged 75 and Older: Protocol for a Cluster-randomized Controlled Trial

Mara A Schonberg, Christine E Kistler, Larissa Nekhlyudov, Angela Fagerlin, Roger B Davis, Christina C Wee, Edward R Marcantonio, Carmen L Lewis, Whitney A Stanley, Trisha M. Crutchfield, Mary Beth Hamel

J Clin Trials. Author manuscript; available in PMC 2015 Jul 28.

Published in final edited form as: J Clin Trials. 2014; 4: 191. Published online 2014 Oct 16. doi: 10.4172/2167-0870.1000191

PMCID:: PMC4517685

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Select item 56502455.

Long-Term Chamomile Therapy of Generalized Anxiety Disorder: A Study Protocol for a Randomized, Double-Blind, Placebo- Controlled Trial

Jun J Mao, Qing S. Li, Irene Soeller, Kenneth Rockwell, Sharon X Xie, Jay D. Amsterdam

J Clin Trials. Author manuscript; available in PMC 2017 Oct 20.

Published in final edited form as: J Clin Trials. 2014 Nov; 4(5): 188. Published online 2014 Oct 9. doi: 10.4172/2167-0870.1000188

PMCID:: PMC5650245

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Select item 44744846.

Chemoprevention Trial Feasibility Using Botanicals in Exceptionally High Risk Populations for Lung Cancer

Nagi B Kumar, Gwendolyn P Quinn, Mark G Alexandrow, Jhanelle Gray, Michael Schell, Steve Sutton, Eric B Haura

J Clin Trials. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: J Clin Trials. 2014 Sep; 4(4): 180. doi: 10.4172/2167-0870.1000180

PMCID:: PMC4474484

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Select item 41363837.

Emerging Tools for Computer-Aided Diagnosis and Prognostication

Scott Ritter, Kenneth B Margulies

J Clin Trials. Author manuscript; available in PMC 2014 Aug 18.

Published in final edited form as: J Clin Trials. 2014 Feb 24; 4(2): e117. Published online 2014 Feb 24. doi: 10.4172/2167-0870.1000e117

PMCID:: PMC4136383

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Select item 40680328.

Atrial fibrillation at discharge in older cardiac surgery patients: A prospective study of prevalence and associated medication utilization

Shoshana J. Herzig, James L. Rudolph, Miguel Haime, Long H. Ngo, Edward R. Marcantonio

J Clin Trials. Author manuscript; available in PMC 2014 Jun 24.

Published in final edited form as: J Clin Trials. 2012 Jan 13; 2(1): 2:106. Published online 2012 Jan 13.

PMCID:: PMC4068032

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Select item 37231419.

Reasons for Staying as a Participant in the Environmental Determinants of Diabetes in the Young (TEDDY) Longitudinal Study

Barbro Lernmark, Kristian Lynch, Lori Ballard, Judith Baxter, Roswith Roth, Tuula Simell, Suzanne Bennett Johnson

J Clin Trials. Author manuscript; available in PMC 2013 Jul 25.

Published in final edited form as: J Clin Trials. 2012; 2(2): 1000114. Published online 2012. doi: 10.4172/2167-0870.1000114

PMCID:: PMC3723141

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Select item 783610110.

Non-Invasive Strategies for Nose-to-Brain Drug Delivery

JT Trevino, RC Quispe, F Khan, V Novak

J Clin Trials. Author manuscript; available in PMC 2021 Jan 26.

Published in final edited form as: J Clin Trials. 2020; 10(7): 439. Published online 2020 Dec 10.

PMCID:: PMC7836101

Article PubReader PDF–733K Cite

Select item 520111211.

Potential of Radiofrequency Ablation in Combination with Immunotherapy in the Treatment of Hepatocellular Carcinoma

Guangfu Li, Kevin F Staveley-O’Carroll, Eric T Kimchi

J Clin Trials. Author manuscript; available in PMC 2016 Dec 30.

Published in final edited form as: J Clin Trials. 2016 Apr; 6(2): 257. Published online 2016 Apr 5. doi: 10.4172/2167-0870.1000257

PMCID:: PMC5201112

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Select item 471191512.

Improving Post-Hospitalization Transition Outcomes through Accessible Health Information Technology and Caregiver Support: Protocol for a Randomized Controlled Trial

John D Piette, Dana Striplin, Nicolle Marinec, Jenny Chen, Lynn A Gregory, Denise L Sumerlin, Angela M DeSantis, Carolyn Gibson, Ingrid Crause, Marylena Rouse, James E Aikens

J Clin Trials. Author manuscript; available in PMC 2016 Jan 13.

Published in final edited form as: J Clin Trials. 2015 Oct; 5(5): 240. Published online 2015 Oct 3. doi: 10.4172/2167-0870.1000240

PMCID:: PMC4711915

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Select item 661402713.

Efficacy of Mobile Phone Short Message Service (SMS) Reminders on Malaria Treatment Adherence and Day 3 Post-Treatment Reviews (SMS-RES-MAL) in Kenya: A Study Protocol

Ambrose O Talisuna, Dejan Zurovac, Sophie Githinji, Amos Oburu, Josephine Malinga, Andrew Nyandigisi, Caroline OH Jones, Robert W Snow

J Clin Trials. Author manuscript; available in PMC 2019 Jul 8.

Published in final edited form as: J Clin Trials. 2019 Jun 25; 5(2): 217. Published online 2015 Mar 23. doi: 10.4172/2167-0870.1000217

PMCID:: PMC6614027

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Select item 638870514.

Rationale and Methods of a Trial to Evaluate a Depression Telemonitoring Program that Includes a Patient-Selected Support Person

John D Piette, Marcia Valenstein, Daniel Eisenberg, Michael D Fetters, Ananda Sen, Daniel Saunders, Daphne Watkins, James E Aikens

J Clin Trials. Author manuscript; available in PMC 2019 Feb 25.

Published in final edited form as: J Clin Trials. 2015; 5(1): 205. Published online 2014 Dec 20. doi: 10.4172/2167-0870.1000205

PMCID:: PMC6388705

Article PubReader PDF–534K Cite

Select item 429766315.

Rhodiola rosea therapy for major depressive disorder: a study protocol for a randomized, double-blind, placebo- controlled trial

Jun J Mao, Qing S. Li, Irene Soeller, Sharon X Xie, Jay D. Amsterdam

J Clin Trials. Author manuscript; available in PMC 2015 Jun 20.

Published in final edited form as: J Clin Trials. 2014 Jun 20; 4: 170. Published online 2014 Jun 20. doi: 10.4172/2167-0870.1000170

PMCID:: PMC4297663

Article PubReader PDF–176K Cite

Select item 426693716.

Gentle Massage Improves Disease- and Treatment-Related Symptoms in Patients with Acute Myelogenous Leukemia

Ann Gill Taylor, Audrey E Snyder, Joel G Anderson, Cynthia J Brown, John J Densmore, Cheryl Bourguignon

J Clin Trials. Author manuscript; available in PMC 2015 Mar 17.

Published in final edited form as: J Clin Trials. 2014; 4: 1000161. Published online 2014 Mar 17. doi: 10.4172/2167-0870.1000161

PMCID:: PMC4266937

Article PubReader PDF–448K Cite

Select item 474509517.

Methods for an International Randomized Clinical Trial to Investigate the Effect of Gsk249320 on Motor Cortex Neurophysiology using Transcranial Magnetic Stimulation in Survivors of Stroke

Matt P. Malcolm, Lori Enney, Steven C Cramer

J Clin Trials. Author manuscript; available in PMC 2016 Feb 8.

Published in final edited form as: J Clin Trials. 2014; 4(6): 1–9. doi: 10.4172/2167-0870.1000199

PMCID:: PMC4745095

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Select item 452454718.

Impaired signaling intrinsic to sinoatrial node pacemaker cells affects heart rate variability during cardiac disease

Yael Yaniv, Alexey E. Lyashkov, Edward G. Lakatta

J Clin Trials. Author manuscript; available in PMC 2015 Aug 4.

Published in final edited form as: J Clin Trials. 2014 Mar; 4(1): 152. Published online 2013 Dec 19. doi: 10.4172/2167-0870.1000152

PMCID:: PMC4524547

Article PubReader PDF–564K Cite

Select item 398213719.

Efficacy of Gastrografin^® Compared with Standard Conservative Treatment in Management of Adhesive Small Bowel Obstruction at Mulago National Referral Hospital

Caspar Haule, Peter A Ongom, Timothy Kimuli

J Clin Trials. Author manuscript; available in PMC 2014 Apr 10.

Published in final edited form as: J Clin Trials. 2013 Dec 1; 3(4): 1000144. Published online 2013 Dec 1. doi: 10.4172/2167-0870.1000144

PMCID:: PMC3982137

Article PubReader PDF–327K Cite

Select item 392055020.

When Standard Therapy Fails in Breast Cancer: Current and Future Options for HER2-Positive Disease

Erin Olson, D’Anna Mullins

J Clin Trials. Author manuscript; available in PMC 2014 Feb 11.

Published in final edited form as: J Clin Trials. 2013 Mar 6; 3: 1000129. Published online 2013 Mar 6. doi: 10.4172/2167-0870.1000129

PMCID:: PMC3920550

Article PubReader PDF–280K Cite

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Figure 2

Association between reduction in LDL‐C levels and reduction in CRP levels among clinical trials comparing statin monotherapy with ezetimibe/statin combination. The following studies were included in the figure: VYVA: Ballantyne, Am Heart J, 2005; VYMET: Robinson, Am J Cardiol, 2009; EXPLORER: Ballantyne, Am J Cardiol, 2007; ENHANCE: Kastelein, NEJM, 2008; SANDS: Fleg, J Am Coll Cardiol, 2008; A: Sager, Atherosclerosis, 2005; B: Goldberg, Mayo Clin Proc, 2004; C: Bays, Clin Ther, 2004; D: Ballantyne, Circulation, 2003; E: Gagne, Am J Cardiol, 2002.

Vascular inflammation and low‐density lipoproteins: is cholesterol the link? A lesson from the clinical trials

Br J Pharmacol. 2017 Nov;174(22):3973-3985.
Figure. Disclosed and Undisclosed Payments Received by Oncologist Authors of Clinical Drug Trials, by Journal

J Clin Onc indicates Journal of Clinical Oncology; JAMA Onc, JAMA Oncology; Lancet: Haem, The Lancet Haemotology; Lancet: Onc, The Lancet Oncology; and NEJM, The New England Journal of Medicine.

Financial Conflicts of Interest Among Oncologist Authors of Reports of Clinical Drug Trials

JAMA Oncol. 2018 Oct;4(10):1426-1428.
Figure 5

Defining PD response at the patient level and PD effect at the dose level. (Adapted with permission from Murgo AJ, Kummar S, Rubinstein L, Gutierrez M, Collins J, Kinders R, et al. Designing phase 0 cancer clinical trials. Clin Cancer Res 2008;14:3675-82)

Phase 0 clinical trials in oncology new drug development

Perspect Clin Res. 2011 Jan-Mar;2(1):13-22.
Figure 2

Mutation in the tumor suppressor gene PTEN leads to hyperactivation of the PI3K/AKT/MTOR pathway, which can potentially be targeted at various sites downstream of PTEN. PIP indicates phosphatidyl phosphate. Adapted with modifications from Rodon J, Dienstmann R, Serra V, Tabernero J. Development of PI3K inhibitors: lessons learned from early clinical trials. Nat Rev Clin Oncol. 2013;10:143–153.

Therapeutic Targeting of Tumor Suppressor Genes

Cancer. ;121(9):1357-1368.