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Select item 68515631.

Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials—GPPAD‐02 study design and first results

Christiane Winkler, Florian Haupt, Martin Heigermoser, Jose Zapardiel‐Gonzalo, Jasmin Ohli, Theresa Faure, Evdokia Kalideri, Angela Hommel, Petrina Delivani, Reinhard Berner, Olga Kordonouri, Frank Roloff, Thekla von dem Berge, Karin Lange, Mariusz Oltarzewski, Ryszard Glab, Agnieszka Szypowska, Matthew D. Snape, Manu Vatish, John A. Todd, Helena E. Larsson, Anita Ramelius, Jeanette Å. Kördel, Kristina Casteels, Jasmin Paulus, Anette G. Ziegler, Ezio Bonifacio, the GPPAD Study Group

Pediatr Diabetes. 2019 Sep; 20(6): 720–727. Published online 2019 Jun 13. doi: 10.1111/pedi.12870

PMCID:: PMC6851563

Abstract Article PDF–1.2M

Select item 48119982.

Primary prevention of beta-cell autoimmunity and type 1 diabetes – The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) perspectives

A.G. Ziegler, T. Danne, D.B. Dunger, R. Berner, R. Puff, W. Kiess, G. Agiostratidou, J.A. Todd, E. Bonifacio

Mol Metab. 2016 Apr; 5(4): 255–262. Published online 2016 Feb 22. doi: 10.1016/j.molmet.2016.02.003

PMCID:: PMC4811998

Abstract Article PDF–853K

Select item 95669123.

Elevations in blood glucose before and after the appearance of islet autoantibodies in children

Katharina Warncke, Andreas Weiss, Peter Achenbach, Thekla von dem Berge, Reinhard Berner, Kristina Casteels, Lidia Groele, Konstantinos Hatzikotoulas, Angela Hommel, Olga Kordonouri, Helena Elding Larsson, Markus Lundgren, Benjamin A. Marcus, Matthew D. Snape, Agnieszka Szypowska, John A. Todd, Ezio Bonifacio, Anette-G. Ziegler, for the GPPAD and POInT Study Groups

J Clin Invest. 2022 Oct 17; 132(20): e162123. Published online 2022 Oct 17. doi: 10.1172/JCI162123

PMCID:: PMC9566912

Abstract Article PDF–557K

Select item 66090354.

Oral insulin therapy for primary prevention of type 1 diabetes in infants with high genetic risk: the GPPAD-POInT (global platform for the prevention of autoimmune diabetes primary oral insulin trial) study protocol

Anette-Gabriele Ziegler, Peter Achenbach, Reinhard Berner, Kristina Casteels, Thomas Danne, Melanie Gündert, Joerg Hasford, Verena Sophia Hoffmann, Olga Kordonouri, Karin Lange, Helena Elding Larsson, Markus Lundgren, Matthew D Snape, Agnieszka Szypowska, John A Todd, Ezio Bonifacio

BMJ Open. 2019; 9(6): e028578. Published online 2019 Jun 28. doi: 10.1136/bmjopen-2018-028578

PMCID:: PMC6609035

Abstract Article PDF–613K

Select item 85789875.

Supplementation with Bifidobacterium longum subspecies infantis EVC001 for mitigation of type 1 diabetes autoimmunity: the GPPAD-SINT1A randomised controlled trial protocol

Anette-Gabriele Ziegler, Stefanie Arnolds, Annika Kölln, Peter Achenbach, Reinhard Berner, Ezio Bonifacio, Kristina Casteels, Helena Elding Larsson, Melanie Gündert, Joerg Hasford, Olga Kordonouri, Markus Lundgren, Mariusz Oltarzewski, Marcin L Pekalski, Markus Pfirrmann, Matthew D Snape, Agnieszka Szypowska, John A Todd, GPPAD STUDY GROUP

BMJ Open. 2021; 11(11): e052449. Published online 2021 Nov 9. doi: 10.1136/bmjopen-2021-052449

PMCID:: PMC8578987

Abstract Article PDF–472K

Select item 97631606.

Successful integration of newborn genetic testing into UK routine screening using prospective consent to determine eligibility for clinical trials

Owen Martyn Bendor-Samuel, Tabitha Wishlade, Louise Willis, Parvinder Aley, Edward Choi, Rachel Craik, Yama Mujadidi, Ginny Mounce, Fenella Roseman, Arancha De La Horra Gozalo, James Bland, Nazia Taj, Ian Smith, Anette-Gabriele Ziegler, Ezio Bonifacio, Christiane Winkler, Florian Haupt, John A Todd, Laurent Servais, Matthew D Snape, Manu Vatish, the GPPAD Study Group

Arch Dis Child. 2023 Jan; 108(1): 26–30. Published online 2022 Sep 28. doi: 10.1136/archdischild-2022-324270

PMCID:: PMC9763160

Abstract Article PDF–387K

Select item 108065047.

Vitamin D insufficiency in infants with increased risk of developing type 1 diabetes: a secondary analysis of the POInT Study

An Jacobs, Maarten Warnants, Veronika Vollmuth, Christiane Winkler, Andreas Weiss, Anette-Gabriele Ziegler, Markus Lundgren, Helena Elding Larsson, Olga Kordonouri, Thekla von dem Berge, Marie-Luise Zielmann, Ezio Bonifacio, Angela Hommel, Mariusz Ołtarzewski, Agnieszka Szypowska, Rachel Besser, John A. Todd, Kristina Casteels

BMJ Paediatr Open. 2024; 8(1): e002212. Published online 2024 Jan 12. doi: 10.1136/bmjpo-2023-002212

PMCID:: PMC10806504

Abstract Article PDF–438K

Select item 96649878.

The Willingness to Participate in Pediatric Type 1 Diabetes Studies

Sophie Heinke, Angela Hommel, Anja Loff, Reinhard Berner, Ezio Bonifacio, für das Freder1k- & POInT-Studienteam

Dtsch Arztebl Int. 2022 Jul; 119(27-28): 488–489. Published online 2022 Jul 11. doi: 10.3238/arztebl.m2022.0171

PMCID:: PMC9664987

Article PDF–195K

Select item 102127399.

The countdown to type 1 diabetes: when, how and why does the clock start?

Anette-Gabriele Ziegler

Diabetologia. 2023; 66(7): 1169–1178. Published online 2023 May 26. doi: 10.1007/s00125-023-05927-2

PMCID:: PMC10212739

Abstract Article PDF–909K

Select item 1090450810.

Early-childhood body mass index and its association with the COVID-19 pandemic, containment measures and islet autoimmunity in children with increased risk for type 1 diabetes

Sandra Hummel, Sarah Rosenberger, Thekla von dem Berge, Rachel E. J. Besser, Kristina Casteels, Angela Hommel, Olga Kordonouri, Helena Elding Larsson, Markus Lundgren, Benjamin A. Marcus, Mariusz Oltarzewski, Anne Rochtus, Agnieszka Szypowska, John A. Todd, Andreas Weiss, Christiane Winkler, Ezio Bonifacio, Anette-G. Ziegler, for the GPPAD and POInT Study Group

Diabetologia. 2024; 67(4): 670–678. Published online 2024 Jan 12. doi: 10.1007/s00125-023-06079-z

PMCID:: PMC10904508

Abstract Article PDF–1.1M

Select item 743710011.

Typ-1-Diabetes: Früherkennung und Ansätze zur Prävention: Update 2020

Benjamin A. Marcus, Peter Achenbach, Anette-Gabriele Ziegler

Diabetologe. 2020; 16(7): 654–661. German. Published online 2020 Aug 19. doi: 10.1007/s11428-020-00668-x

PMCID:: PMC7437100

Abstract Article PDF–380K

Select item 1149162812.

Screening and Prevention of Type 1 Diabetes: Where Are We?

Kimber M Simmons, Emily K Sims

J Clin Endocrinol Metab. 2023 Dec; 108(12): 3067–3079. Published online 2023 Jun 8. doi: 10.1210/clinem/dgad328

PMCID:: PMC11491628

Abstract Article

Select item 1022550713.

The importance of biomarker development for monitoring type 1 diabetes progression rate and therapeutic responsiveness

Maxwell J. Fyvie, Kathleen M. Gillespie

Front Immunol. 2023; 14: 1158278. Published online 2023 May 15. doi: 10.3389/fimmu.2023.1158278

PMCID:: PMC10225507

Abstract Article PDF–1.1M

Select item 1052317314.

SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood

Marija Lugar, Anne Eugster, Peter Achenbach, Thekla von dem Berge, Reinhard Berner, Rachel E. J. Besser, Kristina Casteels, Helena Elding Larsson, Gita Gemulla, Olga Kordonouri, Annett Lindner, Markus Lundgren, Denise Müller, Mariusz Oltarzewski, Anne Rochtus, Marlon Scholz, Agnieszka Szypowska, John A. Todd, Anette-Gabriele Ziegler, Ezio Bonifacio

JAMA. 2023 Sep 26; 330(12): 1151–1160. Published online 2023 Sep 8. doi: 10.1001/jama.2023.16348

PMCID:: PMC10523173

Abstract Article

Select item 873036815.

100 Years of Insulin: Lifesaver, immune target, and potential remedy for prevention

Anette-Gabriele Ziegler, Thomas Danne, Carolin Daniel, Ezio Bonifacio

Med (N Y) Author manuscript; available in PMC 2022 Jan 5.

Published in final edited form as: Med (N Y). 2021 Oct 8; 2(10): 1120–1137. Published online 2021 Sep 15. doi: 10.1016/j.medj.2021.08.003

PMCID:: PMC8730368

Abstract Article PDF–1.3M

Select item 756363716.

Prevention of Type 1 Diabetes: Past Experiences and Future Opportunities

Przemysław Beik, Martyna Ciesielska, Maria Kucza, Alicja Kurczewska, Joanna Kuźmińska, Bartosz Maćkowiak, Elżbieta Niechciał

J Clin Med. 2020 Sep; 9(9): 2805. Published online 2020 Aug 30. doi: 10.3390/jcm9092805

PMCID:: PMC7563637

Abstract Article PDF–538K

Select item 759836017.

A Public Health Antibody Screening Indicates a 6-Fold Higher SARS-CoV-2 Exposure Rate than Reported Cases in Children

Markus Hippich, Lisa Holthaus, Robin Assfalg, Jose Zapardiel-Gonzalo, Heidi Kapfelsperger, Martin Heigermoser, Florian Haupt, Dominik A. Ewald, Tiziana C. Welzhofer, Benjamin A. Marcus, Susanne Heck, Annika Koelln, Joanna Stock, Franziska Voss, Massimiliano Secchi, Lorenzo Piemonti, Kathrin de la Rosa, Ulrike Protzer, Merle Boehmer, Peter Achenbach, Vito Lampasona, Ezio Bonifacio, Anette-Gabriele Ziegler

Med (N Y) 2021 Feb 12; 2(2): 149–163.e4. Published online 2020 Oct 29. doi: 10.1016/j.medj.2020.10.003

PMCID:: PMC7598360

Abstract Article PDF–12M

Select item 911471918.

Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective

Emily K. Sims, Rachel E.J. Besser, Colin Dayan, Cristy Geno Rasmussen, Carla Greenbaum, Kurt J. Griffin, William Hagopian, Mikael Knip, Anna E. Long, Frank Martin, Chantal Mathieu, Marian Rewers, Andrea K. Steck, John M. Wentworth, Stephen S. Rich, Olga Kordonouri, Anette-Gabriele Ziegler, Kevan C. Herold, for the NIDDK Type 1 Diabetes TrialNet Study Group

Diabetes. 2022 Apr; 71(4): 610–623. Published online 2022 Mar 21. doi: 10.2337/dbi20-0054

PMCID:: PMC9114719

Abstract Article PDF–6.2M

Select item 960325019.

Utilizing Modular Biobanking Software in Different Types of Biobanking Activities

Laurent Jacotot, Mike Woodward, Axel de Montalier, Philippe Vaglio

Biopreserv Biobank. October 2022; 20(5): 417–422. Published online 2022 Oct 17. doi: 10.1089/bio.2022.0076

PMCID:: PMC9603250

Abstract Article PDF–262K

Select item 1082669220.

Type 1 diabetes mellitus prevention

Lidia Groele, Agnieszka Szypowska

Pediatr Endocrinol Diabetes Metab. 2023 Dec; 29(4): 209–213. Published online 2024 Jan 11. doi: 10.5114/pedm.2023.134130

PMCID:: PMC10826692

Article PDF–527K

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