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Select item 103591911.

Intervertebral disc degeneration—Current therapeutic options and challenges

Ankita Samanta, Thomas Lufkin, Petra Kraus

Front Public Health. 2023; 11: 1156749. Published online 2023 Jul 6. doi: 10.3389/fpubh.2023.1156749

PMCID:: PMC10359191

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Select item 100413922.

An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therapeutics

Mauro Alini, Ashish D. Diwan, W. Mark Erwin, Chirstopher B. Little, James Melrose

JOR Spine. 2023 Mar; 6(1): e1230. Published online 2023 Jan 30. doi: 10.1002/jsp2.1230

PMCID:: PMC10041392

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Select item 100413903.

Intervertebral disc degeneration and how it leads to low back pain

Ashish D. Diwan, James Melrose

JOR Spine. 2023 Mar; 6(1): e1231. Published online 2022 Nov 14. doi: 10.1002/jsp2.1231

PMCID:: PMC10041390

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Select item 76811024.

Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions

Amir Kamali, Reihane Ziadlou, Gernot Lang, Judith Pfannkuche, Shangbin Cui, Zhen Li, R. Geoff Richards, Mauro Alini, Sibylle Grad

Theranostics. 2021; 11(1): 27–47. Published online 2021 Jan 1. doi: 10.7150/thno.48987

PMCID:: PMC7681102

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Select item 42694225.

Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration

João W. Silveira, Ana Carolina Issy, Vitor A. Castania, Carlos E. G. Salmon, Marcello H. Nogueira-Barbosa, Francisco S. Guimarães, Helton L. A. Defino, Elaine Del Bel

PLoS One. 2014; 9(12): e113161. Published online 2014 Dec 17. doi: 10.1371/journal.pone.0113161

PMCID:: PMC4269422

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Select item 83574776.

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration

Hai-Wei Chen, Guang-Zhi Zhang, Ming-Qiang Liu, Li-Juan Zhang, Ji-He Kang, Zhao-Heng Wang, Wen-Zhao Liu, Ai-Xin Lin, Xue-Wen Kang

Evid Based Complement Alternat Med. 2021; 2021: 9963677. Published online 2021 Aug 3. doi: 10.1155/2021/9963677

PMCID:: PMC8357477

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Select item 89242887.

Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration

Yuhao Wu, Shiwei Shen, Yifeng Shi, Naifeng Tian, Yifei Zhou, Xiaolei Zhang

Front Bioeng Biotechnol. 2022; 10: 823945. Published online 2022 Mar 2. doi: 10.3389/fbioe.2022.823945

PMCID:: PMC8924288

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Bmi deficiency causes oxidative stress and intervertebral disc degeneration which can be alleviated by antioxidant treatment

Qunhu Zhang, Jie Li, You Li, Hui Che, Ying Chen, Jianghui Dong, Cory J. Xian, Dengshun Miao, Liping Wang, Yongxin Ren

J Cell Mol Med. 2020 Aug; 24(16): 8950–8961. Published online 2020 Jun 24. doi: 10.1111/jcmm.15528

PMCID:: PMC7417700

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Select item 75234189.

Apigenin Mitigates Intervertebral Disc Degeneration through the Amelioration of Tumor Necrosis Factor α (TNF-α) Signaling Pathway

Fan Ding, Xia Li

Med Sci Monit. 2020; 26: e924587-1–e924587-11. Prepublished online 2020 Jul 24. Published online 2020 Sep 19. doi: 10.12659/MSM.924587

PMCID:: PMC7523418

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Select item 463552610.

Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration

Satoshi Suzuki, Nobuyuki Fujita, Naobumi Hosogane, Kota Watanabe, Ken Ishii, Yoshiaki Toyama, Keiyo Takubo, Keisuke Horiuchi, Takeshi Miyamoto, Masaya Nakamura, Morio Matsumoto

Arthritis Res Ther. 2015; 17: 316. Published online 2015 Nov 5. doi: 10.1186/s13075-015-0834-8

PMCID:: PMC4635526

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Select item 766443711.

Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease

Serena Silvestro, Giovanni Schepici, Placido Bramanti, Emanuela Mazzon

Molecules. 2020 Nov; 25(21): 5186. Published online 2020 Nov 7. doi: 10.3390/molecules25215186

PMCID:: PMC7664437

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Select item 1061023012.

Plastrum testudinis Ameliorates Oxidative Stress in Nucleus Pulposus Cells via Downregulating the TNF-α Signaling Pathway

Peng Zhang, Jiahui He, Yanchi Gan, Qi Shang, Honglin Chen, Wenhua Zhao, Gengyang Shen, Xiaobing Jiang, Hui Ren

Pharmaceuticals (Basel) 2023 Oct; 16(10): 1482. Published online 2023 Oct 17. doi: 10.3390/ph16101482

PMCID:: PMC10610230

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Select item 648024013.

Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling

Takuya Kameda, Joel Zvick, Miriam Vuk, Aleksandra Sadowska, Wai Kit Tam, Victor Y. Leung, Kata Bölcskei, Zsuzsanna Helyes, Lee Ann Applegate, Oliver N. Hausmann, Juergen Klasen, Olga Krupkova, Karin Wuertz-Kozak

Int J Mol Sci. 2019 Apr; 20(7): 1767. Published online 2019 Apr 10. doi: 10.3390/ijms20071767

PMCID:: PMC6480240

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Select item 839634914.

Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson’s Disease

Claudio Giuliano, Miriam Francavilla, Gerardo Ongari, Alessandro Petese, Cristina Ghezzi, Nora Rossini, Fabio Blandini, Silvia Cerri

Int J Mol Sci. 2021 Aug; 22(16): 8920. Published online 2021 Aug 18. doi: 10.3390/ijms22168920

PMCID:: PMC8396349

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Select item 688863415.

Cannabidiol Protects Dopaminergic Neuronal Cells from Cadmium

Jacopo Junio Valerio Branca, Gabriele Morucci, Matteo Becatti, Donatello Carrino, Carla Ghelardini, Massimo Gulisano, Lorenzo Di Cesare Mannelli, Alessandra Pacini

Int J Environ Res Public Health. 2019 Nov; 16(22): 4420. Published online 2019 Nov 12. doi: 10.3390/ijerph16224420

PMCID:: PMC6888634

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Select item 810361116.

Toxicology and Pharmacokinetics Study of Intradiscal Injection of Simvastatin in Rabbits

Xiaodong Huang, Wei He, Weiheng Wang, Quanchun Fan, Xiaojian Ye, Zenghui Wu, Chia-Ying Lin

Front Pharmacol. 2021; 12: 582309. Published online 2021 Apr 23. doi: 10.3389/fphar.2021.582309

PMCID:: PMC8103611

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Select item 794038817.

Cannabidiol induces autophagy via ERK1/2 activation in neural cells

Talita A. M. Vrechi, Anderson H. F. F. Leão, Ingrid B. M. Morais, Vanessa C. Abílio, Antonio W. Zuardi, Jaime Eduardo C. Hallak, José Alexandre Crippa, Claudia Bincoletto, Rodrigo P. Ureshino, Soraya S. Smaili, Gustavo J. S. Pereira

Sci Rep. 2021; 11: 5434. Published online 2021 Mar 8. doi: 10.1038/s41598-021-84879-2