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Select item 76996131.

Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders

María S. García-Gutiérrez, Francisco Navarrete, Ani Gasparyan, Amaya Austrich-Olivares, Francisco Sala, Jorge Manzanares

Biomolecules. 2020 Nov; 10(11): 1575. Published online 2020 Nov 19. doi: 10.3390/biom10111575

PMCID:: PMC7699613

Abstract Article PDF–807K

Select item 73854252.

Cannabidiol as a Treatment for Mood Disorders: A Systematic Review: Le cannabidiol comme traitement des troubles de l’humeur: une revue systématique

Jairo Vinícius Pinto, Gayatri Saraf, Christian Frysch, Daniel Vigo, Kamyar Keramatian, Trisha Chakrabarty, Raymond W. Lam, Márcia Kauer-Sant’Anna, Lakshmi N. Yatham

Can J Psychiatry. 2020 Apr; 65(4): 213–227. doi: 10.1177/0706743719895195

PMCID:: PMC7385425

Abstract Article PDF–410K

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Association of cannabis, cannabidiol and synthetic cannabinoid use with mental health in UK adolescents

James Hotham, Rebecca Cannings-John, Laurence Moore, Jemma Hawkins, Chris Bonell, Matthew Hickman, Stanley Zammit, Lindsey A. Hines, Linda Adara, Julia Townson, James White

Br J Psychiatry. 2023 Oct; 223(4): 478–484. doi: 10.1192/bjp.2023.91

PMCID:: PMC10866672

Abstract Article PDF–303K

Select item 101901504.

The NLRP3 Inflammasome in Stress Response: Another Target for the Promiscuous Cannabidiol

Alice Hartmann, Carla Vila-Verde, Francisco S. Guimarães, Sâmia R. Joca, Sabrina F. Lisboa

Curr Neuropharmacol. 2023 Feb 1; 21(2): 284–308. Published online 2023 Feb 1. doi: 10.2174/1570159X20666220411101217

PMCID:: PMC10190150

Abstract Article PDF–4.0M

Select item 89126625.

The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective

Cielo García-Montero, Miguel A. Ortega, Miguel Angel Alvarez-Mon, Oscar Fraile-Martinez, Adoración Romero-Bazán, Guillermo Lahera, José Manuel Montes-Rodríguez, Rosa M. Molina-Ruiz, Fernando Mora, Roberto Rodriguez-Jimenez, Javier Quintero, Melchor Álvarez-Mon

Nutrients. 2022 Mar; 14(5): 1107. Published online 2022 Mar 6. doi: 10.3390/nu14051107

PMCID:: PMC8912662

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Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

Danielle Hen-Shoval, Lital Moshe, Talia Indig-Naimer, Raphael Mechoulam, Gal Shoval, Gil Zalsman, Natalya M. Kogan, Aron Weller

Int J Mol Sci. 2023 Feb; 24(4): 3828. Published online 2023 Feb 14. doi: 10.3390/ijms24043828

PMCID:: PMC9958868

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Cannabidiol prevents lipopolysaccharide-induced sickness behavior and alters cytokine and neurotrophic factor levels in the brain

Pedro Augusto Lopes Tito, Túlio Cézar de Souza Bernardino, Paula Maria Quaglio Bellozi, Maria Carolina Machado da Silva, Aline Silva de Miranda, Érica Leandro Marciano Vieira, Fabrício A. Moreira, András Palotás, Antônio Carlos Pinheiro de Oliveira, Helton José Reis

Pharmacol Rep. 2021; 73(6): 1680–1693. Published online 2021 Jul 3. doi: 10.1007/s43440-021-00301-8

PMCID:: PMC8254454

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Select item 110557568.

Entry of cannabidiol into the fetal, postnatal and adult rat brain

Georgia Fitzpatrick, Yifan Huang, Fiona Qiu, Mark D. Habgood, Robert L. Medcalf, Heidi Ho, Katarzyna M. Dziegielewska, Norman R. Saunders

Cell Tissue Res. 2024; 396(2): 177–195. Published online 2024 Feb 17. doi: 10.1007/s00441-024-03867-w

PMCID:: PMC11055756

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Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

Minlan Yuan, Biao Yang, Gerson Rothschild, J. John Mann, Larry D. Sanford, Xiangdong Tang, Canhua Huang, Chuang Wang, Wei Zhang

Signal Transduct Target Ther. 2023; 8: 309. Published online 2023 Aug 30. doi: 10.1038/s41392-023-01519-z

PMCID:: PMC10465587

Abstract Article PDF–4.4M

Select item 616164410.

Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age

José A. Crippa, Francisco S. Guimarães, Alline C. Campos, Antonio W. Zuardi

Front Immunol. 2018; 9: 2009. Published online 2018 Sep 21. doi: 10.3389/fimmu.2018.02009

PMCID:: PMC6161644

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Cannabidiol and substance use disorder: dream or reality

Saeideh Karimi-Haghighi, Yasaman Razavi, Daniela Iezzi, Andrew F. Scheyer, Olivier Manzoni, Abbas Haghparast

Neuropharmacology. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: Neuropharmacology. 2022 Apr 1; 207: 108948. Published online 2022 Jan 13. doi: 10.1016/j.neuropharm.2022.108948

PMCID:: PMC9157244

Abstract Article PDF–528K

Select item 1009675212.

The Polypharmacological Effects of Cannabidiol

Jorge Castillo-Arellano, Ana Canseco-Alba, Stephen J. Cutler, Francisco León

Molecules. 2023 Apr; 28(7): 3271. Published online 2023 Apr 6. doi: 10.3390/molecules28073271

PMCID:: PMC10096752

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Select item 879952313.

A Scoping Review of the Use of Cannabidiol in Psychiatric Disorders

Anna E. Kirkland, Matthew C. Fadus, Staci A. Gruber, Kevin M. Gray, Timothy E. Wilens, Lindsay M. Squeglia

Psychiatry Res. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: Psychiatry Res. 2022 Feb; 308: 114347. Published online 2021 Dec 20. doi: 10.1016/j.psychres.2021.114347

PMCID:: PMC8799523

Abstract Article PDF–380K

Select item 971649014.

Cannabidiol in clinical and preclinical anxiety research. A systematic review into concentration–effect relations using the IB-de-risk tool

Caroline MB Kwee, Joop MA van Gerven, Fleur LP Bongaerts, Danielle C Cath, Gabriël Jacobs, Johanna MP Baas, Lucianne Groenink

J Psychopharmacol. 2022 Dec; 36(12): 1299–1314. Published online 2022 Oct 14. doi: 10.1177/02698811221124792

PMCID:: PMC9716490

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Select item 1022946715.

Cannabidiol for the Treatment of Brain Disorders: Therapeutic Potential and Routes of Administration

Grace Tsz Yan Yau, Waiting Tai, Jonathon Carl Arnold, Hak-Kim Chan, Philip Chi Lip Kwok

Pharm Res. 2023; 40(5): 1087–1114. Published online 2023 Jan 12. doi: 10.1007/s11095-023-03469-1

PMCID:: PMC10229467

Abstract Article PDF–850K

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Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance

Eleni P. Papagianni, William G. Warren, Helen J. Cassaday, Carl W. Stevenson

Int J Mol Sci. 2022 Aug; 23(16): 9333. Published online 2022 Aug 19. doi: 10.3390/ijms23169333

PMCID:: PMC9409311

Abstract Article PDF–3.1M

Select item 776546317.

Subacute cannabidiol alters genome‐wide DNA methylation in adult mouse hippocampus

Nicole M Wanner, Mathia Colwell, Chelsea Drown, Christopher Faulk

Environ Mol Mutagen. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Environ Mol Mutagen. 2020 Nov; 61(9): 890–900. Published online 2020 Aug 10. doi: 10.1002/em.22396

PMCID:: PMC7765463

Abstract Article PDF–676K

Select item 969086818.

Regulation of DNA Methylation by Cannabidiol and Its Implications for Psychiatry: New Insights from In Vivo and In Silico Models

Luana B. Domingos, Nicole R. Silva, Adriano J. M. Chaves Filho, Amanda J. Sales, Anna Starnawska, Sâmia Joca

Genes (Basel) 2022 Nov; 13(11): 2165. Published online 2022 Nov 20. doi: 10.3390/genes13112165

PMCID:: PMC9690868

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Select item 874470619.

Examining the Use of Antidepressants for Adolescents with Depression/Anxiety Who Regularly Use Cannabis: A Narrative Review

Danielle Hen-Shoval, Aron Weller, Abraham Weizman, Gal Shoval

Int J Environ Res Public Health. 2022 Jan; 19(1): 523. Published online 2022 Jan 4. doi: 10.3390/ijerph19010523

PMCID:: PMC8744706

Abstract Article PDF–955K

Select item 754261020.

Treatment of social anxiety disorder and attenuated psychotic symptoms with cannabidiol

Maximus Berger, Emily Li, Günter Paul Amminger

BMJ Case Rep. 2020; 13(10): e235307. Published online 2020 Oct 7. doi: 10.1136/bcr-2020-235307

PMCID:: PMC7542610

Abstract Article PDF–178K

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PMC Images search for depression cannabidiol

Fig. (4)

Plant-derived terpenes against depression (52) Podoandin (53) Cannabidiol (54) Carvacrol (55) β-Caryophyllene (56) Genipin (57) Hyperforin (58) Salvinorin A (59) Ursolic acid.

Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources

Curr Neuropharmacol. 2021 Nov 15;19(11):2020-2037.
Figure 4

Results of the sucrose preference test for rats submitted to a four-week CUMS treatment with or without cannabidiol administration (mean ± SEM, n = 18). (A.) Sucrose preference measured as % preference for sucrose; (B.) sucrose (mL of 1.0% sucrose solution ingested) and water intake on each testing day. CBD, cannabidiol; * p < 0.05 vs baseline.

Effects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression

Biomolecules. 2020 May;10(5):801.
Figure 3

Results of body weight measurements during a four-week CUMS procedure with or without concomitant cannabidiol (10 mg/kg body weight) treatment. Data are expressed as mean ± 95% confidence interval; * p < 0.05 vs. control.

Effects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression

Biomolecules. 2020 May;10(5):801.
Figure 1

The effects of CBD treatment on behavior in rats exposed to UCMS. (a) FST: UCMS rats treated with a vehicle spent more time immobile than the No UCMS groups and UCMS rats treated with CBD. (b) OFT total distance: No UCMS rats treated with the vehicle covered less distance compared to all groups. (c) OFT time in the center: no differences between groups were observed. FST—forced swim test; OFT—open field test; UCMS: unpredictable chronic mild stress; CBD: cannabidiol. *, p < 0.05, **, p < 0.01, ***, p < 0.001.

Cannabidiol Modulates Alterations in PFC microRNAs in a Rat Model of Depression

Int J Mol Sci. 2023 Feb;24(3):2052.