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Select item 75548031.

The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease

Aleksandra Kicman, Marek Toczek

Int J Mol Sci. 2020 Sep; 21(18): 6740. Published online 2020 Sep 14. doi: 10.3390/ijms21186740

PMCID:: PMC7554803

Abstract Article PDF–2.4M

Select item 108184422.

An Overview of Cannabidiol as a Multifunctional Drug: Pharmacokinetics and Cellular Effects

Nadia Martinez Naya, Jazmin Kelly, Giuliana Corna, Michele Golino, Ariel H. Polizio, Antonio Abbate, Stefano Toldo, Eleonora Mezzaroma

Molecules. 2024 Jan; 29(2): 473. Published online 2024 Jan 18. doi: 10.3390/molecules29020473

PMCID:: PMC10818442

Abstract Article PDF–5.5M

Select item 104587073.

Molecular and Cellular Mechanisms of Action of Cannabidiol

Nadia Martinez Naya, Jazmin Kelly, Giuliana Corna, Michele Golino, Antonio Abbate, Stefano Toldo

Molecules. 2023 Aug; 28(16): 5980. Published online 2023 Aug 9. doi: 10.3390/molecules28165980

PMCID:: PMC10458707

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Geotemporospatial and causal inference epidemiological analysis of US survey and overview of cannabis, cannabidiol and cannabinoid genotoxicity in relation to congenital anomalies 2001–2015

Albert Stuart Reece, Gary Kenneth Hulse

BMC Pediatr. 2022; 22: 47. Published online 2022 Jan 19. doi: 10.1186/s12887-021-02996-3

PMCID:: PMC8767720

Abstract Article PDF–13M

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Opportunities, Challenges and Pitfalls of Using Cannabidiol as an Adjuvant Drug in COVID-19 †

Barbara Malinowska, Marta Baranowska-Kuczko, Aleksandra Kicman, Eberhard Schlicker

Int J Mol Sci. 2021 Feb; 22(4): 1986. Published online 2021 Feb 17. doi: 10.3390/ijms22041986

PMCID:: PMC7922403

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Is the cardiovascular system a therapeutic target for cannabidiol?

Christopher P Stanley, William H Hind, Saoirse E O'Sullivan

Br J Clin Pharmacol. 2013 Feb; 75(2): 313–322. Published online 2012 Jun 1. doi: 10.1111/j.1365-2125.2012.04351.x

PMCID:: PMC3579247

Abstract Article PDF–940K

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Entry of cannabidiol into the fetal, postnatal and adult rat brain

Georgia Fitzpatrick, Yifan Huang, Fiona Qiu, Mark D. Habgood, Robert L. Medcalf, Heidi Ho, Katarzyna M. Dziegielewska, Norman R. Saunders

Cell Tissue Res. 2024; 396(2): 177–195. Published online 2024 Feb 17. doi: 10.1007/s00441-024-03867-w

PMCID:: PMC11055756

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Select item 94093118.

Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance

Eleni P. Papagianni, William G. Warren, Helen J. Cassaday, Carl W. Stevenson

Int J Mol Sci. 2022 Aug; 23(16): 9333. Published online 2022 Aug 19. doi: 10.3390/ijms23169333

PMCID:: PMC9409311

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Select item 76996139.

Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders

María S. García-Gutiérrez, Francisco Navarrete, Ani Gasparyan, Amaya Austrich-Olivares, Francisco Sala, Jorge Manzanares

Biomolecules. 2020 Nov; 10(11): 1575. Published online 2020 Nov 19. doi: 10.3390/biom10111575

PMCID:: PMC7699613

Abstract Article PDF–807K

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The NLRP3 Inflammasome in Stress Response: Another Target for the Promiscuous Cannabidiol

Alice Hartmann, Carla Vila-Verde, Francisco S. Guimarães, Sâmia R. Joca, Sabrina F. Lisboa

Curr Neuropharmacol. 2023 Feb 1; 21(2): 284–308. Published online 2023 Feb 1. doi: 10.2174/1570159X20666220411101217

PMCID:: PMC10190150

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Cannabidiol as a Treatment for Mood Disorders: A Systematic Review: Le cannabidiol comme traitement des troubles de l’humeur: une revue systématique

Jairo Vinícius Pinto, Gayatri Saraf, Christian Frysch, Daniel Vigo, Kamyar Keramatian, Trisha Chakrabarty, Raymond W. Lam, Márcia Kauer-Sant’Anna, Lakshmi N. Yatham

Can J Psychiatry. 2020 Apr; 65(4): 213–227. doi: 10.1177/0706743719895195

PMCID:: PMC7385425

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Research progress in the management of vascular disease with cannabidiol: a review

Yilong Guo, Ren Wei, Jianqing Deng, Wei Guo

J Cardiothorac Surg. 2024; 19: 6. Published online 2024 Jan 3. doi: 10.1186/s13019-023-02476-y

PMCID:: PMC10765825

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Select item 1009675213.

The Polypharmacological Effects of Cannabidiol

Jorge Castillo-Arellano, Ana Canseco-Alba, Stephen J. Cutler, Francisco León

Molecules. 2023 Apr; 28(7): 3271. Published online 2023 Apr 6. doi: 10.3390/molecules28073271

PMCID:: PMC10096752

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Select item 764126714.

Therapeutic Applications of Cannabinoids in Cardiomyopathy and Heart Failure

J. A. Garza-Cervantes, M. Ramos-González, O. Lozano, C. Jerjes-Sánchez, G. García-Rivas

Oxid Med Cell Longev. 2020; 2020: 4587024. Published online 2020 Oct 27. doi: 10.1155/2020/4587024

PMCID:: PMC7641267

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Cannabidiol for the Treatment of Brain Disorders: Therapeutic Potential and Routes of Administration

Grace Tsz Yan Yau, Waiting Tai, Jonathon Carl Arnold, Hak-Kim Chan, Philip Chi Lip Kwok

Pharm Res. 2023; 40(5): 1087–1114. Published online 2023 Jan 12. doi: 10.1007/s11095-023-03469-1

PMCID:: PMC10229467

Abstract Article PDF–850K

Select item 717043416.

Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities

Marta Baranowska-Kuczko, Hanna Kozłowska, Monika Kloza, Olga Sadowska, Mirosław Kozłowski, Magdalena Kusaczuk, Irena Kasacka, Barbara Malinowska

J Hypertens. 2020 May; 38(5): 896–911. Published online 2019 Dec 2. doi: 10.1097/HJH.0000000000002333

PMCID:: PMC7170434

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Cannabidiol in clinical and preclinical anxiety research. A systematic review into concentration–effect relations using the IB-de-risk tool

Caroline MB Kwee, Joop MA van Gerven, Fleur LP Bongaerts, Danielle C Cath, Gabriël Jacobs, Johanna MP Baas, Lucianne Groenink

J Psychopharmacol. 2022 Dec; 36(12): 1299–1314. Published online 2022 Oct 14. doi: 10.1177/02698811221124792

PMCID:: PMC9716490

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Select item 724693618.

Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals?

Vicente Martínez, Amaia Iriondo De-Hond, Francesca Borrelli, Raffaele Capasso, María Dolores del Castillo, Raquel Abalo

Int J Mol Sci. 2020 May; 21(9): 3067. Published online 2020 Apr 26. doi: 10.3390/ijms21093067

PMCID:: PMC7246936

Abstract Article PDF–2.7M

Select item 915724419.

Cannabidiol and substance use disorder: dream or reality

Saeideh Karimi-Haghighi, Yasaman Razavi, Daniela Iezzi, Andrew F. Scheyer, Olivier Manzoni, Abbas Haghparast

Neuropharmacology. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: Neuropharmacology. 2022 Apr 1; 207: 108948. Published online 2022 Jan 13. doi: 10.1016/j.neuropharm.2022.108948

PMCID:: PMC9157244

Abstract Article PDF–528K

Select item 1004885720.

THC and CBD: Villain versus Hero? Insights into Adolescent Exposure

Nicholas Pintori, Francesca Caria, Maria Antonietta De Luca, Cristina Miliano

Int J Mol Sci. 2023 Mar; 24(6): 5251. Published online 2023 Mar 9. doi: 10.3390/ijms24065251

PMCID:: PMC10048857

Abstract Article PDF–2.3M

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PMC Images search for cardiovascular cannabidiol

Figure 5

Effects of cannabidiol (CBD) on the cardiovascular system under physiological and pathological conditions [,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,]. Abbreviations: BP: blood pressure, HR: heart rate; this figure was prepared using a template on the Servier Medical Art website.

The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease

Int J Mol Sci. 2020 Sep;21(18):6740.
Figure 8

Possible mechanisms involved in the cardiovascular effects of cannabidiol (CBD) in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats.

Cannabidiol Affects the Bezold-Jarisch Reflex via TRPV1 and 5-HT3 Receptors and Has Peripheral Sympathomimetic Effects in Spontaneously Hypertensive and Normotensive Rats

Front Pharmacol. 2019;10:500.
Figure 3

Metabolism of cannabidiol [,,,,,,,,]. Abbreviations: 7-COOH-, 7-OH-CBD:7-Carboxy-, 7-hydroxycannabidiol; CBD: Cannabidiol; CYP: Cytochrome P450; p.o.: Per os, orally; s.c.: Subcutaneously; THC: Δ⁹-Tetrahydrocannabinol; UGT: UDP-Glucuronosyltransferase.

The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease

Int J Mol Sci. 2020 Sep;21(18):6740.
Figure 4

Mean arterial pressure (MAP), pulsatile arterial pressure (PAP) and heart rate (HR) individual recordings showing the cardiovascular changes evoked by acute restraint in animals treated with vehicle (control, Tween 80 2%-saline), cannabidiol (CBD) or cannabidiol after WAY100635 (WAY+CBD). The restraint period started at time 0.

5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats

Br J Pharmacol. 2009 Jan;156(1):181-188.