cannabidiol amyotrophic lateral sclerosis - PMC

Vincenzo Pota, Pasquale Sansone, Sara De Sarno, Caterina Aurilio, Francesco Coppolino, Manlio Barbarisi, Francesco Barbato, Marco Fiore, Gianluigi Cosenza, Maria Beatrice Passavanti, Maria Caterina Pace

Behav Neurol. 2024; 2024: 1228194. Published online 2024 Mar 16. doi: 10.1155/2024/1228194

PMCID:: PMC10960655

Abstract Article PDF–868K

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A perspective on therapies for amyotrophic lateral sclerosis: can disease progression be curbed?

Xiaojiao Xu, Dingding Shen, Yining Gao, Qinming Zhou, You Ni, Huanyu Meng, Hongqin Shi, Weidong Le, Shengdi Chen, Sheng Chen

Transl Neurodegener. 2021; 10: 29. Published online 2021 Aug 10. doi: 10.1186/s40035-021-00250-5

PMCID:: PMC8353789

Abstract Article PDF–1.1M

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Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents

Flávia P. Dias Viegas, Vanessa Silva Gontijo, Matheus de Freitas Silva, Cindy Juliet Cristancho Ortiz, Graziella dos Reis Rosa Franco, Januário Tomás Ernesto, Caio Miranda Damasio, Isabela Marie Fernandes Silva, Thâmara Gaspar Campos, Claudio Viegas, Jr.

Curr Neuropharmacol. 2022 Jul 15; 20(7): 1297–1328. Published online 2022 Jul 15. doi: 10.2174/1570159X19666210712152532

PMCID:: PMC9881080

Abstract Article PDF–4.4M

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Changes in Endocannabinoid Receptors and Enzymes in the Spinal Cord of SOD1^G93A Transgenic Mice and Evaluation of a Sativex^®‐like Combination of Phytocannabinoids: Interest for Future Therapies in Amyotrophic Lateral Sclerosis

Miguel Moreno‐Martet, Francisco Espejo‐Porras, Javier Fernández‐Ruiz, Eva de Lago

CNS Neurosci Ther. 2014 Sep; 20(9): 809–815. Published online 2014 Apr 7. doi: 10.1111/cns.12262

PMCID:: PMC6493201

Abstract Article PDF–362K

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Study protocol for a randomised, double-blind, placebo-controlled study evaluating the Efficacy of cannabis-based Medicine Extract in slowing the disease pRogression of Amyotrophic Lateral sclerosis or motor neurone Disease: the EMERALD trial

Berzenn Urbi, Simon Broadley, Richard Bedlack, Ethan Russo, Arman Sabet

BMJ Open. 2019; 9(11): e029449. Published online 2019 Nov 11. doi: 10.1136/bmjopen-2019-029449

PMCID:: PMC6858175

Abstract Article PDF–313K

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Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol

Santa Mammana, Eugenio Cavalli, Agnese Gugliandolo, Serena Silvestro, Federica Pollastro, Placido Bramanti, Emanuela Mazzon

Medicina (Kaunas) 2019 Nov; 55(11): 747. Published online 2019 Nov 18. doi: 10.3390/medicina55110747

PMCID:: PMC6915685

Abstract Article PDF–3.2M

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Oligodendrocyte Dysfunction in Amyotrophic Lateral Sclerosis: Mechanisms and Therapeutic Perspectives

Stefano Raffaele, Marta Boccazzi, Marta Fumagalli

Cells. 2021 Mar; 10(3): 565. Published online 2021 Mar 5. doi: 10.3390/cells10030565

PMCID:: PMC8000560

Abstract Article PDF–2.1M

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Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease

Serena Silvestro, Giovanni Schepici, Placido Bramanti, Emanuela Mazzon

Molecules. 2020 Nov; 25(21): 5186. Published online 2020 Nov 7. doi: 10.3390/molecules25215186

PMCID:: PMC7664437

Abstract Article PDF–911K

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Oxidative Stress as a Therapeutic Target in Amyotrophic Lateral Sclerosis: Opportunities and Limitations

Hee Ra Park, Eun Jin Yang

Diagnostics (Basel) 2021 Sep; 11(9): 1546. Published online 2021 Aug 26. doi: 10.3390/diagnostics11091546

PMCID:: PMC8465946

Abstract Article PDF–301K

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New Insights into Oxidative Stress and Inflammatory Response in Neurodegenerative Diseases

Eveljn Scarian, Camilla Viola, Francesca Dragoni, Rosalinda Di Gerlando, Bartolo Rizzo, Luca Diamanti, Stella Gagliardi, Matteo Bordoni, Orietta Pansarasa

Int J Mol Sci. 2024 Mar; 25(5): 2698. Published online 2024 Feb 26. doi: 10.3390/ijms25052698

PMCID:: PMC10931808

Abstract Article PDF–1.2M

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The Role of Macrophages in Neuroinflammatory and Neurodegenerative Pathways of Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis: Pathogenetic Cellular Effectors and Potential Therapeutic Targets

Santa Mammana, Paolo Fagone, Eugenio Cavalli, Maria Sofia Basile, Maria Cristina Petralia, Ferdinando Nicoletti, Placido Bramanti, Emanuela Mazzon

Int J Mol Sci. 2018 Mar; 19(3): 831. Published online 2018 Mar 13. doi: 10.3390/ijms19030831

PMCID:: PMC5877692

Abstract Article PDF–917K

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Amyotrophic Lateral Sclerosis: Molecular Mechanisms, Biomarkers, and Therapeutic Strategies

Xiaoming Yang, Yanan Ji, Wei Wang, Lilei Zhang, Zehao Chen, Miaomei Yu, Yuntian Shen, Fei Ding, Xiaosong Gu, Hualin Sun

Antioxidants (Basel) 2021 Jul; 10(7): 1012. Published online 2021 Jun 24. doi: 10.3390/antiox10071012

PMCID:: PMC8300638

Abstract Article PDF–600K

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Inactivation of the CB₂ receptor accelerated the neuropathological deterioration in TDP‐43 transgenic mice, a model of amyotrophic lateral sclerosis

Carmen Rodríguez‐Cueto, Marta Gómez‐Almería, Laura García Toscano, Julián Romero, Cecilia J. Hillard, Eva de Lago, Javier Fernández‐Ruiz

Brain Pathol. 2021 Nov; 31(6): e12972. Published online 2021 May 13. doi: 10.1111/bpa.12972

PMCID:: PMC8549023

Abstract Article PDF–1.6M

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Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?

Sabrina Giacoppo, Emanuela Mazzon

Neural Regen Res. 2016 Dec; 11(12): 1896–1899. doi: 10.4103/1673-5374.197125

PMCID:: PMC5270417

Abstract Article PDF–382K

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Real world experience of patients with amyotrophic lateral sclerosis (ALS) in the treatment of spasticity using tetrahydrocannabinol:cannabidiol (THC:CBD)

Thomas Meyer, Andreas Funke, Christoph Münch, Dagmar Kettemann, André Maier, Bertram Walter, Annett Thomas, Susanne Spittel

BMC Neurol. 2019; 19: 222. Published online 2019 Sep 7. doi: 10.1186/s12883-019-1443-y

PMCID:: PMC6732193

Abstract Article PDF–1.7M

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Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson’s Disease

Claudio Giuliano, Miriam Francavilla, Gerardo Ongari, Alessandro Petese, Cristina Ghezzi, Nora Rossini, Fabio Blandini, Silvia Cerri

Int J Mol Sci. 2021 Aug; 22(16): 8920. Published online 2021 Aug 18. doi: 10.3390/ijms22168920

PMCID:: PMC8396349

Abstract Article PDF–4.5M

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Potential Preventive Strategies for Amyotrophic Lateral Sclerosis

B. Kuraszkiewicz, H. Goszczyńska, T. Podsiadły-Marczykowska, M. Piotrkiewicz, P. Andersen, M. Gromicho, J. Grosskreutz, M. Kuźma-Kozakiewicz, S. Petri, B. Stubbendorf, K. Szacka, H. Uysal, M. de Carvalho

Front Neurosci. 2020; 14: 428. Published online 2020 May 26. doi: 10.3389/fnins.2020.00428