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Select item 54920831.

Randomized controlled trial of the effects of consumption of ‘Yabukita’ or ‘Benifuuki’ encapsulated tea-powder on low-density lipoprotein cholesterol level and body weight

Yuko Igarashi, Taku Obara, Mami Ishikuro, Hiroko Matsubara, Michiko Shigihara, Hirohito Metoki, Masahiro Kikuya, Yoichi Sameshima, Hirofumi Tachibana, Mari Maeda-Yamamoto, Shinichi Kuriyama

Food Nutr Res. 2017; 61(1): 1334484. Published online 2017 Jun 19. doi: 10.1080/16546628.2017.1334484

PMCID:: PMC5492083

Abstract Article PDF–906K

Select item 58926312.

Effect of Benifuuki Tea on Cytochrome P450-mediated Metabolic Activity in Rats

TAKAHITO HIRAI, YUKI NISHIMURA, NORIMITSU KURATA, HOKUTO NAMBA, MARIKO IWASE, YURIKA GOMI, HIROMICHI TSUCHIYA, TOMOYUKI YAMAKAWA, YUJI KIUCHI

In Vivo. 2018 Jan-Feb; 32(1): 33–40. Published online 2018 Jan 15. doi: 10.21873/invivo.11201

PMCID:: PMC5892631

Abstract Article PDF–326K

Select item 30804763.

Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study

Mari Maeda-Yamamoto, Kaori Ema, Yoshiko Tokuda, Manami Monobe, Hirofumi Tachibana, Yoichi Sameshima, Shinichi Kuriyama

Cytotechnology. 2011 Mar; 63(2): 171–179. Published online 2011 Jan 5. doi: 10.1007/s10616-010-9331-8

PMCID:: PMC3080476

Abstract Article PDF–338K

Select item 60733424.

“Benifuuki” Extract Reduces Serum Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B: A Double-Blind Placebo-Controlled Randomized Trial

Masahiro Miyawaki, Hiroyuki Sano, Hisashi Imbe, Reiko Fujisawa, Keiji Tanimoto, Jungo Terasaki, Mari Maeda-Yamamoto, Hirofumi Tachibana, Toshiaki Hanafusa, Akihisa Imagawa

Nutrients. 2018 Jul; 10(7): 924. Published online 2018 Jul 19. doi: 10.3390/nu10070924

PMCID:: PMC6073342

Abstract Article PDF–958K

Select item 21045505.

In vitro and in vivo anti-allergic effects of ‘benifuuki’ green tea containing O-methylated catechin and ginger extract enhancement

Mari Maeda-Yamamoto, Kaori Ema, Ikuo Shibuichi

Cytotechnology. 2007 Dec; 55(2-3): 135–142. Published online 2007 Nov 25. doi: 10.1007/s10616-007-9112-1

PMCID:: PMC2104550

Abstract Article PDF–374K

Select item 37828876.

Green Tea Extract Containing a Highly Absorbent Catechin Prevents Diet-Induced Lipid Metabolism Disorder

Takashi Suzuki, Motofumi Kumazoe, Yoonhee Kim, Shuya Yamashita, Kanami Nakahara, Shuntaro Tsukamoto, Masako Sasaki, Takatoki Hagihara, Yukari Tsurudome, Yuhui Huang, Mari Maeda-Yamamoto, Yuki Shinoda, Wataru Yamaguchi, Koji Yamada, Hirofumi Tachibana

Sci Rep. 2013; 3: 2749. Published online 2013 Sep 25. doi: 10.1038/srep02749

PMCID:: PMC3782887

Abstract Article PDF–586K

Select item 86301267.

Methylated (−)-epigallocatechin 3-O-gallate potentiates the effect of split vaccine accompanied with upregulation of Toll-like receptor 5

Motofumi Kumazoe, Kanako Takamatsu, Fuyumi Horie, Ren Yoshitomi, Hiroki Hamagami, Hiroshi Tanaka, Yoshinori Fujimura, Hirofumi Tachibana

Sci Rep. 2021; 11: 23101. Published online 2021 Nov 29. doi: 10.1038/s41598-021-02346-4

PMCID:: PMC8630126

Abstract Article PDF–1.9M

Select item 72979688.

Baiyacha, a wild tea plant naturally occurring high contents of theacrine and 3″-methyl-epigallocatechin gallate from Fujian, China

Ji-Qiang Jin, Chen-Kai Jiang, Ming-Zhe Yao, Liang Chen

Sci Rep. 2020; 10: 9715. Published online 2020 Jun 16. doi: 10.1038/s41598-020-66808-x

PMCID:: PMC7297968

Abstract Article PDF–3.3M

Select item 85586349.

Nutraceutical Aid for Allergies – Strategies for Down-Regulating Mast Cell Degranulation

Mark F McCarty, Aaron Lerner, James J DiNicolantonio, Carina Benzvi

J Asthma Allergy. 2021; 14: 1257–1266. Published online 2021 Oct 27. doi: 10.2147/JAA.S332307

PMCID:: PMC8558634

Abstract Article PDF–1.5M

Select item 315445410.

Metabolomics-Driven Nutraceutical Evaluation of Diverse Green Tea Cultivars

Yoshinori Fujimura, Kana Kurihara, Megumi Ida, Reia Kosaka, Daisuke Miura, Hiroyuki Wariishi, Mari Maeda-Yamamoto, Atsushi Nesumi, Takeshi Saito, Tomomasa Kanda, Koji Yamada, Hirofumi Tachibana

PLoS One. 2011; 6(8): e23426. Published online 2011 Aug 10. doi: 10.1371/journal.pone.0023426

PMCID:: PMC3154454

Abstract Article PDF–2.7M

Select item 620766211.

Postprandial glycaemia-lowering effect of a green tea cultivar Sunrouge and cultivar-specific metabolic profiling for determining bioactivity-related ingredients

Masafumi Wasai, Yoshinori Fujimura, Haruna Nonaka, Ryo Kitamura, Motoki Murata, Hirofumi Tachibana

Sci Rep. 2018; 8: 16041. Published online 2018 Oct 30. doi: 10.1038/s41598-018-34316-8

PMCID:: PMC6207662

Abstract Article PDF–2.1M

Select item 1112110612.

LOX-1 in Cardiovascular Disease: A Comprehensive Molecular and Clinical Review

Maria Eugenia Sánchez-León, Karen Julissa Loaeza-Reyes, Carlos Alberto Matias-Cervantes, Gabriel Mayoral-Andrade, Eduardo L. Pérez-Campos, Laura Pérez-Campos-Mayoral, María Teresa Hernández-Huerta, Edgar Zenteno, Yobana Pérez-Cervera, Socorro Pina-Canseco

Int J Mol Sci. 2024 May; 25(10): 5276. Published online 2024 May 12. doi: 10.3390/ijms25105276

PMCID:: PMC11121106

Abstract Article PDF–1.8M

Select item 937030113.

Efficacy and Safety of Oral Green Tea Preparations in Skin Ailments: A Systematic Review of Clinical Studies

Antonella Di Sotto, Marco Gullì, Ester Percaccio, Annabella Vitalone, Gabriela Mazzanti, Silvia Di Giacomo

Nutrients. 2022 Aug; 14(15): 3149. Published online 2022 Jul 30. doi: 10.3390/nu14153149

PMCID:: PMC9370301

Abstract Article PDF–1.7M

Select item 1067032514.

Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies?

Sina Kaag, Axel Lorentz

Cells. 2023 Nov; 12(22): 2602. Published online 2023 Nov 10. doi: 10.3390/cells12222602

PMCID:: PMC10670325

Abstract Article PDF–1.2M

Select item 941608715.

67-kDa Laminin Receptor-Mediated Cellular Sensing System of Green Tea Polyphenol EGCG and Functional Food Pairing

Yoshinori Fujimura, Motofumi Kumazoe, Hirofumi Tachibana

Molecules. 2022 Aug; 27(16): 5130. Published online 2022 Aug 11. doi: 10.3390/molecules27165130

PMCID:: PMC9416087

Abstract Article PDF–3.7M

Select item 571534216.

Effects of O‐methylated (−)‐epigallocatechin gallate (EGCG) on LPS‐induced osteoclastogenesis, bone resorption, and alveolar bone loss in mice

Tsukasa Tominari, Ryota Ichimaru, Shosei Yoshinouchi, Chiho Matsumoto, Kenta Watanabe, Michiko Hirata, Florian M.W. Grundler, Masaki Inada, Chisato Miyaura

FEBS Open Bio. 2017 Dec; 7(12): 1972–1981. Published online 2017 Nov 15. doi: 10.1002/2211-5463.12340

PMCID:: PMC5715342

Abstract Article PDF–855K

Select item 535450217.

Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216

Motofumi Kumazoe, Yuki Nakamura, Mai Yamashita, Takashi Suzuki, Kanako Takamatsu, Yuhui Huang, Jaehoon Bae, Shuya Yamashita, Motoki Murata, Shuhei Yamada, Yuki Shinoda, Wataru Yamaguchi, Yui Toyoda, Hirofumi Tachibana

J Biol Chem. 2017 Mar 10; 292(10): 4077–4088. Published online 2017 Feb 1. doi: 10.1074/jbc.M116.755959

PMCID:: PMC5354502

Abstract Article PDF–2.7M

Select item 722639718.

The Pharmacological Activity of Camellia sinensis (L.) Kuntze on Metabolic and Endocrine Disorders: A Systematic Review

Marta Sánchez, Elena González-Burgos, Irene Iglesias, Rafael Lozano, M. Pilar Gómez-Serranillos

Biomolecules. 2020 Apr; 10(4): 603. Published online 2020 Apr 13. doi: 10.3390/biom10040603

PMCID:: PMC7226397

Abstract Article PDF–976K

Select item 1044244119.

Characterization of two O-methyltransferases involved in the biosynthesis of O-methylated catechins in tea plant

Ji-Qiang Jin, Fu-Rong Qu, Huisi Huang, Qing-Shuai Liu, Meng-Yuan Wei, Yuee Zhou, Ke-Lin Huang, Zhibo Cui, Jie-Dan Chen, Wei-Dong Dai, Li Zhu, Ming-Zhe Yao, Zhi-Min Zhang, Liang Chen

Nat Commun. 2023; 14: 5075. Published online 2023 Aug 21. doi: 10.1038/s41467-023-40868-9

PMCID:: PMC10442441

Abstract Article PDF–4.0M

Select item 661716920.

Effects and Mechanisms of Tea and Its Bioactive Compounds for the Prevention and Treatment of Cardiovascular Diseases: An Updated Review

Shi-Yu Cao, Cai-Ning Zhao, Ren-You Gan, Xiao-Yu Xu, Xin-Lin Wei, Harold Corke, Atanas G. Atanasov, Hua-Bin Li

Antioxidants (Basel) 2019 Jun; 8(6): 166. Published online 2019 Jun 6. doi: 10.3390/antiox8060166

PMCID:: PMC6617169

Abstract Article PDF–1.4M

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Fig. 2

Absorption of catechins versus time profiles after the oral administration of 4 types of Benifuuki green tea in rats i.g. BGP 2.86 μm: Benifuuki green tea powder with a mean particle size of 2.86 μm, BGP 18.6 μm: Benifuuki green tea powder 18.6 μm, BGP 76.1 μm: Benifuuki green tea powder 76.1 μm, BGI: Benifuuki green tea infusion. Absorption was calculated as follows; Absorption = (plasma concentration (μg/L)/1,000 * blood volume (rat weight(g) * 70/1,000))/(intake (mg) * 1,000) * 100). Each point represents the mean of five rats, and the cross-vertical bars represent the SD of the mean. All rats were given Benifuuki green tea within 1 min via gavage. a EGCG3”Me, b EGCG, c ECG, d EGC, e EC

Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study

Cytotechnology. 2011 Mar;63(2):171-179.
Figure 2Serum concentration-time profiles of MDZ after two treatments with Benifuuki tea. Benifuuki tea (10 ml/kg) or water (control) was orally administered to rats twice at 0.5 and 2 h before oral administration of MDZ (20 mg/kg). Each point represents the mean±S.D. of 5 rats.

Effect of Benifuuki Tea on Cytochrome P450-mediated Metabolic Activity in Rats

In Vivo. 2018 Jan-Feb;32(1):33-40.
Fig. 1

Chemical structures of catechins in Benifuuki green tea

Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study

Cytotechnology. 2011 Mar;63(2):171-179.
Figure 3

The changes in LOX-1 ligands containing ApoB (LAB) level from 0 to 12 weeks. The Steel–Dwass test shows significant differences in the Δ value at 12 weeks between group H and group L, and between group H and group C. Data are shown as mean ± SD, * p < 0.05. Black bar: High-dose “Benifuuki” extract ice cream group (group H). Gray bar: Low-dose “Benifuuki” extract ice cream group (group L). White bar: No “Benifuuki” extract ice cream (control) group (group C).

“Benifuuki” Extract Reduces Serum Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B: A Double-Blind Placebo-Controlled Randomized Trial

Nutrients. 2018 Jul;10(7):924.