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Aspirin (single dose) for perineal pain in the early postpartum period

Sujana Molakatalla, Emily Shepherd, Rosalie M Grivell

Cochrane Database Syst Rev. 2017 Feb; 2017(2): CD012129. Published online 2017 Feb 9. doi: 10.1002/14651858.CD012129.pub2

PMCID:: PMC6464254

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Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events

Alessandro Squizzato, Marta Bellesini, Andrea Takeda, Saskia Middeldorp, Marco Paolo Donadini

Cochrane Database Syst Rev. 2017 Dec; 2017(12): CD005158. Published online 2017 Dec 14. doi: 10.1002/14651858.CD005158.pub4

PMCID:: PMC6486024

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Antiplatelet Drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

John W. Eikelboom, Jack Hirsh, Frederick A. Spencer, Trevor P. Baglin, Jeffrey I. Weitz

Chest. 2012 Feb; 141(2 Suppl): e89S–e119S. Published online 2012 Jan 23. doi: 10.1378/chest.11-2293

Correction in:: Chest. 2015 Dec; 148(6): 1529.

PMCID:: PMC3278069

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Contemporary Reflections on the Safety of Long-Term Aspirin Treatment for the Secondary Prevention of Cardiovascular Disease

Alexander C. Fanaroff, Matthew T. Roe

Drug Saf. Author manuscript; available in PMC 2018 Jan 23.

Published in final edited form as: Drug Saf. 2016 Aug; 39(8): 715–727. doi: 10.1007/s40264-016-0421-1

PMCID:: PMC5778440

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Aspirin and the prevention of venous thromboembolism following total joint arthroplasty: commonly asked questions

I. Azboy, R. Barrack, A. M. Thomas, F. S. Haddad, J. Parvizi

Bone Joint J. 2017 Nov; 99-B(11): 1420–1430. Published online 2017 Nov 1. doi: 10.1302/0301-620X.99B11.BJJ-2017-0337.R2

PMCID:: PMC5742873

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Synergistic effect of nutlin-3 combined with aspirin in hepatocellular carcinoma HepG2 cells through activation of Bcl-2/Bax signaling pathway

Runchen Miao, Xinsen Xu, Zhixin Wang, Sushun Liu, Kai Qu, Wei Chen, Chang Liu

Mol Med Rep. 2018 Mar; 17(3): 3735–3743. Published online 2017 Dec 22. doi: 10.3892/mmr.2017.8346

PMCID:: PMC5802178

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Esomeprazole and aspirin fixed combination for the prevention of cardiovascular events

Katelyn W Sylvester, Judy WM Cheng, Mandeep R Mehra

Vasc Health Risk Manag. 2013; 9: 245–254. Published online 2013 May 16. doi: 10.2147/VHRM.S44265

PMCID:: PMC3658534

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A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome

Michael H. Tatham, Christian Cole, Paul Scullion, Ross Wilkie, Nicholas J. Westwood, Lesley A. Stark, Ronald T. Hay

Mol Cell Proteomics. 2017 Feb; 16(2): 310–326. Published online 2016 Dec 5. doi: 10.1074/mcp.O116.065219

PMCID:: PMC5294217

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Aspirin and colorectal cancer: the promise of precision chemoprevention

David A. Drew, Yin Cao, Andrew T. Chan

Nat Rev Cancer. 2016 Mar; 16(3): 173–186. Published online 2016 Feb 12. doi: 10.1038/nrc.2016.4

PMCID:: PMC6741347

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Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials

Peter M Rothwell, Nancy R Cook, J Michael Gaziano, Jacqueline F Price, Jill F F Belch, Maria Carla Roncaglioni, Takeshi Morimoto, Ziyah Mehta

Lancet. 2018 Aug 4; 392(10145): 387–399. doi: 10.1016/S0140-6736(18)31133-4

PMCID:: PMC6083400

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Aspirin in the Treatment of Cancer: Reductions in Metastatic Spread and in Mortality: A Systematic Review and Meta-Analyses of Published Studies

Peter C. Elwood, Gareth Morgan, Janet E. Pickering, Julieta Galante, Alison L. Weightman, Delyth Morris, Mark Kelson, Sunil Dolwani

PLoS One. 2016; 11(4): e0152402. Published online 2016 Apr 20. doi: 10.1371/journal.pone.0152402

PMCID:: PMC4838306

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Single dose oral aspirin for acute postoperative pain in adults

Sheena Derry, R Andrew Moore

Cochrane Database Syst Rev. 2012 Apr; 2012(4): CD002067. Published online 2012 Apr 18. doi: 10.1002/14651858.CD002067.pub2

PMCID:: PMC6485902

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Aspirin Use in Sturge-Weber Syndrome: Side Effects and Clinical Outcomes

Eboni I. Lance, Aditya K. Sreenivasan, T. Andrew Zabel, Eric H. Kossoff, Anne M. Comi

J Child Neurol. 2013 Feb; 28(2): 213–218. Published online 2012 Oct 30. doi: 10.1177/0883073812463607

PMCID:: PMC4373084

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Aspirin for Prevention of Preeclampsia

A. Atallah, E. Lecarpentier, F. Goffinet, M. Doret-Dion, P. Gaucherand, V. Tsatsaris

Drugs. 2017; 77(17): 1819–1831. Published online 2017 Oct 16. doi: 10.1007/s40265-017-0823-0

PMCID:: PMC5681618

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Effects of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs on the incidence of recurrent colorectal adenomas: a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials

Sajesh K. Veettil, Kean Ghee Lim, Siew Mooi Ching, Surasak Saokaew, Pochamana Phisalprapa, Nathorn Chaiyakunapruk

BMC Cancer. 2017; 17: 763. Published online 2017 Nov 14. doi: 10.1186/s12885-017-3757-8

PMCID:: PMC5686945

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Aspirin Resistance: Current Status and Role of Tailored Therapy

Jonathan Grinstein, Christopher P. Cannon

Clin Cardiol. 2012 Nov; 35(11): 673–680. Published online 2012 Jun 27. doi: 10.1002/clc.22031

PMCID:: PMC6652698

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Systematic Review and Meta-Analysis of Randomised Trials to Ascertain Fatal Gastrointestinal Bleeding Events Attributable to Preventive Low-Dose Aspirin: No Evidence of Increased Risk

Peter C. Elwood, Gareth Morgan, Julieta Galante, John W. K. Chia, Sunil Dolwani, J. Michael Graziano, Mark Kelson, Angel Lanas, Marcus Longley, Ceri J. Phillips, Janet Pickering, Stephen E. Roberts, Swee S. Soon, Will Steward, Delyth Morris, Alison L. Weightman

PLoS One. 2016; 11(11): e0166166. Published online 2016 Nov 15. doi: 10.1371/journal.pone.0166166

PMCID:: PMC5113022

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Aspirin for acute treatment of episodic tension‐type headache in adults

Sheena Derry, Philip J Wiffen, R Andrew Moore

Cochrane Database Syst Rev. 2017 Jan; 2017(1): CD011888. Published online 2017 Jan 13. doi: 10.1002/14651858.CD011888.pub2

PMCID:: PMC6464783

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A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

Nguyen TH Mai, Nicholas Dobbs, Nguyen Hoan Phu, Romain A Colas, Le TP Thao, Nguyen TT Thuong, Ho DT Nghia, Nguyen HH Hanh, Nguyen T Hang, A Dorothee Heemskerk, Jeremy N Day, Lucy Ly, Do DA Thu, Laura Merson, Evelyne Kestelyn, Marcel Wolbers, Ronald Geskus, David Summers, Nguyen VV Chau, Jesmond Dalli, Guy E Thwaites

eLife. 2018; 7: e33478. Published online 2018 Feb 27. doi: 10.7554/eLife.33478

PMCID:: PMC5862527

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Estimates of benefits and harms of prophylactic use of aspirin in the general population

J. Cuzick, M. A. Thorat, C. Bosetti, P. H. Brown, J. Burn, N. R. Cook, L. G. Ford, E. J. Jacobs, J. A. Jankowski, C. La Vecchia, M. Law, F. Meyskens, P. M. Rothwell, H. J. Senn, A. Umar

Ann Oncol. 2015 Jan; 26(1): 47–57. Published online 2014 Aug 5. doi: 10.1093/annonc/mdu225

PMCID:: PMC4269341

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PMC Images search for aspirin side effects

Figure 1

Aspirin side effects: (A) Overall incidence of side effects from aspirin seen in the Sturge-Weber syndrome cohort. (B) Frequency of each reported side effect.

Aspirin Use in Sturge-Weber Syndrome: Side Effects and Clinical Outcomes

J Child Neurol. 2013 Feb;28(2):213-218.
FIGURE 1

Chemical structures of salicylate (a) and aspirin (b) (ACD/ChemSketch 5.0). Both compounds are benzoic acid derivatives. Aspirin is quickly hydrolyzed to salicylate in an aqueous environment. These amphiphilic molecules interact with membranes, potentially leading to serious side effects.

Effect of Salicylate on the Elasticity, Bending Stiffness, and Strength of SOPC Membranes

Biophys J. 2005 Sep;89(3):1789-1801.
Figure 2

Analysis of side effects. (A) Overview of the different categories of drugs. Drugs are grouped by their drug class. The number of shared and unique drugs and side effects is shown for each class. (Some drugs, e.g., aspirin, have more than one anatomical class assigned to them.) (B) Using Fisher's exact test, over-represented side effects were determined for each category. A few over-represented medical concepts might describe indications for the drugs (e.g., ‘cancer') that were not caught by our filtering mechanisms (see Materials and methods). These concepts are marked with an asterisk. (C) Associations between drug classes and anatomical classes of side effects are shown (see ). Positive values indicate an association between a drug and an anatomical class. Negative values represent an under-representation, for example, drugs indicated for disorders of the blood system cause few sensory side effects.

A side effect resource to capture phenotypic effects of drugs

Mol Syst Biol. 2010;6:343-343.
Figure 5

The absolute risk of vascular complications determines the magnitude of benefit from aspirin. Reproduced from: Patrono C, et al. Platelet-active drugs. The relationship among dose effectiveness and side effects. Chest 1998;114:470S–88S9822058, with permission.

Antiplatelet treatment in stable coronary artery disease

Heart. 2003 Oct;89(10):1273-1278.