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Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway

Po-Chih Shen, Shih-Hsiang Chou, Cheng-Chang Lu, Hsuan-Ti Huang, Song-Hsiung Chien, Peng-Ju Huang, Zi-Miao Liu, Chia-Lung Shih, Shu-Jem Su, Li-Min Chen, Yin-Chun Tien

Cartilage. 2021 Dec; 13(2 Suppl): 238S–253S. Published online 2021 Jul 8. doi: 10.1177/19476035211012465

PMCID:: PMC8804851

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Comparison of Extracorporeal Shockwave Therapy with Non-Steroid Anti-Inflammatory Drugs and Intra-Articular Hyaluronic Acid Injection for Early Osteoarthritis of the Knees

Shun-Wun Jhan, Ching-Jen Wang, Kuan-Ting Wu, Ka-Kit Siu, Jih-Yang Ko, Wen-Chiung Huang, Wen-Yi Chou, Jai-Hong Cheng

Biomedicines. 2022 Feb; 10(2): 202. Published online 2022 Jan 18. doi: 10.3390/biomedicines10020202

PMCID:: PMC8869751

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Select item 116341963.

Clinical, sonographic, and molecular changes in calcific tendinitis of the shoulder following extracorporeal shockwave therapy: a prospective case–control study

Wen-Yi Chou, Kuan-Ting Wu, Po-Cheng Chen, Shun-Wun Jhan, Chia-Feng Wu, Jai-Hong Cheng

Int J Surg. 2024 Dec; 110(12): 7447–7455. Published online 2024 Sep 6. doi: 10.1097/JS9.0000000000002078

PMCID:: PMC11634196

Article PDF–656K

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Adipose-Derived Mesenchymal Stem Cells-Conditioned Medium Modulates the Expression of Inflammation Induced Bone Morphogenetic Protein-2, -5 and -6 as Well as Compared with Shockwave Therapy on Rat Knee Osteoarthritis

Jai-Hong Cheng, Chieh-Cheng Hsu, Shan-Ling Hsu, Wen-Yi Chou, Yi-No Wu, Chun-En Aurea Kuo, Tsai-Chin Hsu, Li-Yen Shiu, Shun-Wun Jhan

Biomedicines. 2021 Oct; 9(10): 1399. Published online 2021 Oct 5. doi: 10.3390/biomedicines9101399

PMCID:: PMC8533238

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Autologous Adipose-Derived Mesenchymal Stem Cells Combined with Shockwave Therapy Synergistically Ameliorates the Osteoarthritic Pathological Factors in Knee Joint

Jai-Hong Cheng, Ke-Tien Yen, Wen-Yi Chou, Shun-Wun Jhan, Shan-Ling Hsu, Jih-Yang Ko, Ching-Jen Wang, Chun-En Aurea Kuo, Szu-Ying Wu, Tsai-Chin Hsu, Chieh-Cheng Hsu

Pharmaceuticals (Basel) 2021 Apr; 14(4): 318. Published online 2021 Apr 1. doi: 10.3390/ph14040318

PMCID:: PMC8065528

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Experimental study on influence of particle shape on shockwave from collapse of cavitation bubble

Lingtao Zou, Jing Luo, Weilin Xu, Yanwei Zhai, Jie Li, Tong Qu, Guihua Fu

Ultrason Sonochem. 2023 Dec; 101: 106693. Published online 2023 Nov 10. doi: 10.1016/j.ultsonch.2023.106693

PMCID:: PMC10665962

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Low-energy extracorporeal shockwave therapy improves locomotor functions, tissue regeneration, and modulating the inflammation induced FGF1 and FGF2 signaling to protect damaged tissue in spinal cord injury of rat model: an experimental animal study

Chieh-Cheng Hsu, Kay L.H. Wu, Jei-Ming Peng, Yi-No Wu, Hou-Tsung Chen, Meng-Shiou Lee, Jai-Hong Cheng

Int J Surg. 2024 Dec; 110(12): 7563–7572. Published online 2024 Oct 24. doi: 10.1097/JS9.0000000000002128

PMCID:: PMC11634128

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Extracorporeal Shockwave Therapy Modulates the Expressions of Proinflammatory Cytokines IL33 and IL17A, and Their Receptors ST2 and IL17RA, within the Articular Cartilage in Early Avascular Necrosis of the Femoral Head in a Rat Model

Jai-Hong Cheng, Shun-Wun Jhan, Chieh-Cheng Hsu, Hung-Wen Chiu, Shan-Ling Hsu

Mediators Inflamm. 2021; 2021: 9915877. Published online 2021 Jul 9. doi: 10.1155/2021/9915877

PMCID:: PMC8285177

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Extracorporeal Shockwave Therapy Enhances Expression of Pdia-3 Which Is a Key Factor of the 1α,25-Dihydroxyvitamin D 3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis of the Knee

Shan-Ling Hsu, Jai-Hong Cheng, Ching-Jen Wang, Jih-Yang Ko, Chih-Hsiang Hsu

Int J Med Sci. 2017; 14(12): 1220–1230. Published online 2017 Sep 19. doi: 10.7150/ijms.20303

PMCID:: PMC5666555

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Medial tibial subchondral bone is the key target for extracorporeal shockwave therapy in early osteoarthritis of the knee

Ching-Jen Wang, Jai-Hong Cheng, Chien-Yiu Huang, Shan-Ling Hsu, Fan-Yen Lee, Hon-Kan Yip

Am J Transl Res. 2017; 9(4): 1720–1731. Published online 2017 Apr 15.

PMCID:: PMC5411920

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TRPV4 promotes acoustic wave-mediated BBB opening via Ca²⁺/PKC-δ pathway

Wei-Hao Liao, Ming-Yen Hsiao, Yi Kung, Hao-Li Liu, Jean-Christophe Béra, Claude Inserra, Wen-Shiang Chen

J Adv Res. 2020 Nov; 26: 15–28. Published online 2020 Jun 21. doi: 10.1016/j.jare.2020.06.012

PMCID:: PMC7584681

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Does extracorporeal shockwave therapy treat leg length discrepancy? an experimental animal study

Shun-Wun Jhan, Kuan-Ting Wu, Wen-Yi Chou, Jeng-Wei Chen, Ka-Kit Siu, Wen-Chiung Huang, Ching-Jen Wang, Jai-Hong Cheng

Arthritis Res Ther. 2025; 27: 47. Published online 2025 Mar 4. doi: 10.1186/s13075-025-03519-6

PMCID:: PMC11877862

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Experimental study on attenuation effect of liquid viscosity on shockwaves of cavitation bubbles collapse

Jing Luo, Guihua Fu, Weilin Xu, Yanwei Zhai, Lixin Bai, Jie Li, Tong Qu

Ultrason Sonochem. 2024 Dec; 111: 107063. Published online 2024 Sep 10. doi: 10.1016/j.ultsonch.2024.107063

PMCID:: PMC11421259

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Enhancement of hyaline cartilage and subchondral bone regeneration in a rat osteochondral defect model through focused extracorporeal shockwave therapy: modulation of transforming growth factor-beta and bone morphogenetic proteins-2, -3, -4, -5, and -7 expression

Jai-Hong Cheng, Shun-Wun Jhan, Po-Cheng Chen, Shan-Ling Hsu, Ching-Jen Wang, Daniel Moya, Yi-No Wu, Chien-Yiu Huang, Wen-Yi Chou, Kuan-Ting Wu

Bone Joint Res. 2024 Jul; 13(7): 342–352. Published online 2024 Jul 9. doi: 10.1302/2046-3758.137.BJR-2023-0264.R2

PMCID:: PMC11311209

Article PDF–7.8M

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Shockwave Therapy Combined with Autologous Adipose-Derived Mesenchymal Stem Cells Is Better than with Human Umbilical Cord Wharton’s Jelly-Derived Mesenchymal Stem Cells on Knee Osteoarthritis

Chieh-Cheng Hsu, Jai-Hong Cheng, Ching-Jen Wang, Jih-Yang Ko, Shan-Ling Hsu, Tsai-Chin Hsu

Int J Mol Sci. 2020 Feb; 21(4): 1217. Published online 2020 Feb 12. doi: 10.3390/ijms21041217

PMCID:: PMC7072878

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Prognostic factors of extracorporeal shockwave therapy in the treatment of nonunion in long bones: a retrospective study

Kuan-Ting Wu, Jai-Hong Cheng, Shun-Wun Jhan, Po-Cheng Chen, Ching-Jen Wang, Wen-Yi Chou

Int J Surg. 2024 Oct; 110(10): 6426–6431. Published online 2024 Jun 24. doi: 10.1097/JS9.0000000000001848

PMCID:: PMC11486991

Article PDF–337K

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Pathological, Morphometric and Correlation Analysis of the Modified Mankin Score, Tidemark Roughness and Calcified Cartilage Thickness in Rat Knee Osteoarthritis after Extracorporeal Shockwave Therapy

Jai-Hong Cheng, Wen-Yi Chou, Ching-Jen Wang, Ka-Kit Siu, Jei-Ming Peng, Yi-No Wu, Meng-Shiou Lee, Chien-Yiu Huang, Jih-Yang Ko, Shun-Wun Jhan

Int J Med Sci. 2022; 19(2): 242–256. Published online 2022 Jan 1. doi: 10.7150/ijms.67741

PMCID:: PMC8795810

Article PDF–2.7M

Select item 1165082518.

A comparative analysis of platelet-rich plasma alone versus combined with extracorporeal shockwave therapy in athletes with patellar tendinopathy and knee pain: a randomized controlled trial

Shun-Wun Jhan, Kuan-Ting Wu, Wen-Yi Chou, Po-Cheng Chen, Ching-Jen Wang, Wen-Chiung Huang, Jai-Hong Cheng

Knee Surg Relat Res. 2024; 36: 47. Published online 2024 Dec 17. doi: 10.1186/s43019-024-00252-3

PMCID:: PMC11650825

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Modulation of cell fate by shock wave therapy in ischaemic heart disease

Michael Graber, Can Gollmann-Tepeköylü, Victor Schweiger, Jakob Hirsch, Leo Pölzl, Felix Nägele, Daniela Lener, Hubert Hackl, Sieghart Sopper, Elke Kirchmair, Sophia Mair, Jakob Voelkl, Christina Plattner, Felix Eichin, Zlatko Trajanoski, Anne Krogsdam, Jonas Eder, Manuel Fiegl, Dominik Hau, Ivan Tancevski, Michael Grimm, John P Cooke, Johannes Holfeld

Eur Heart J Open. 2025 Mar; 5(2): oeaf011. Published online 2025 Apr 8. doi: 10.1093/ehjopen/oeaf011

PMCID:: PMC11977462

Article PDF–5.8M

Select item 633248720.

Shockwave Targeting on Subchondral Bone Is More Suitable than Articular Cartilage for Knee Osteoarthritis

Wen-Yi Chou, Jai-Hong Cheng, Ching-Jen Wang, Shan-Ling Hsu, Jen-Hung Chen, Chien-Yiu Huang

Int J Med Sci. 2019; 16(1): 156–166. Published online 2019 Jan 1. doi: 10.7150/ijms.26659

PMCID:: PMC6332487

Article PDF–1.9M

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Fig. 5.

Cavitation analysis by PCM and the high-speed camera. (a) PCM-detected cavitation collapse probability after each shockwave pulse. A total of 100 shockwave pulses were analyzed. (b) Camera-detected cavitation probability after each shockwave pulse. A total of 10 shockwave pulses were analyzed. (c) Normalized cavitation collapse probability as a function of time, detected by PCM and averaged from the results of 100 shockwave pulses. (d) Normalized cavitation probability as a function of time, detected by the camera and averaged from the results of 10 shockwave pulses.

Simultaneous Photoacoustic Imaging and Cavitation Mapping in Shockwave Lithotripsy

IEEE Trans Med Imaging. ;39(2):468-477.
Figure 2Inflated balloon shockwave in the popliteal artery segment

The rectangle highlights the shockwave balloon being inflated in a segment of the popliteal artery.

Intravascular Shockwave Lithotripsy for the Treatment of Severe Peripheral Arterial Disease: A Single-Centre Experience

Cureus. 2025 Jan;17(1):e78149.
Figure 1:

A) Shockwave therapy being administered; B) Shockwave therapy machine for treatment group; C) Shockwave therapy machine for control/ placebo group.

Study Protocol for a Randomized Controlled Trial of Low Intensity Shockwave Therapy for the Treatment of Post-Radical Prostatectomy Erectile Dysfunction: “SHARP-ED TRIAL”

J Clin Trials. ;14(3):559.
Fig 8.

In vivo PCM of cavitation events induced by shockwave treatment. (a) Representative PCM image of cavitation signals at 116 μs after shockwave pulse #520. (b) Ensembled PCM images of cavitation events induced by 30 shockwave pulses (#520 – #550). (c) Scatter plot of cavitation centers induced by the 30 shockwave pulses. (d) The overlay image with the cavitation centers superimposed on top of the PAT image of the vascular injury.

Simultaneous Photoacoustic Imaging and Cavitation Mapping in Shockwave Lithotripsy

IEEE Trans Med Imaging. ;39(2):468-477.