Robert J Wilkinson[Author] - PMC

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Select item 89963761.

Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer

Annika Fendler, Scott T.C. Shepherd, Lewis Au, Katalin A. Wilkinson, Mary Wu, Andreas M. Schmitt, Zayd Tippu, Sheima Farag, Aljosja Rogiers, Ruth Harvey, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Benjamin Shum, Camille L. Gerard, Daqi Deng, Svend Kjaer, Ok-Ryul Song, Christophe Queval, Caitlin Kavanagh, Emma C. Wall, Edward J. Carr, Sina Namjou, Simon Caidan, Mike Gavrielides, James I. MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O’Flaherty, Robyn L. Shea, Gail Gardner, Darren Murray, Sanjay Popat, Nadia Yousaf, Shaman Jhanji, Nicholas Van As, Kate Young, Andrew J.S. Furness, Lisa Pickering, Rupert Beale, Charles Swanton, Crick COVID19 consortium, Sonia Gandhi, Steve Gamblin, David L.V. Bauer, George Kassiotis, Michael Howell, Emma Nicholson, Susanna Walker, Robert J. Wilkinson, James Larkin, Samra Turajlic, CAPTURE consortium

Cancer Cell. 2022 Apr 11; 40(4): 438. Published online 2022 Apr 11. doi: 10.1016/j.ccell.2022.03.010

Corrects:: Cancer Cell. 2022 Feb 14; 40(2): 114–116.

PMCID:: PMC8996376

Correction PubReader PDF–194K Cite

Select item 89930332.

Author Correction: T cell responses to SARS-CoV-2 spike cross-recognize Omicron

Roanne Keeton, Marius B. Tincho, Amkele Ngomti, Richard Baguma, Ntombi Benede, Akiko Suzuki, Khadija Khan, Sandile Cele, Mallory Bernstein, Farina Karim, Sharon V. Madzorera, Thandeka Moyo-Gwete, Mathilda Mennen, Sango Skelem, Marguerite Adriaanse, Daniel Mutithu, Olukayode Aremu, Cari Stek, Elsa du Bruyn, Mieke A. Van Der Mescht, Zelda de Beer, Talita R. de Villiers, Annie Bodenstein, Gretha van den Berg, Adriano Mendes, Amy Strydom, Marietjie Venter, Jennifer Giandhari, Yeshnee Naidoo, Sureshnee Pillay, Houriiyah Tegally, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Robert J. Wilkinson, Tulio de Oliveira, Linda-Gail Bekker, Glenda Gray, Veronica Ueckermann, Theresa Rossouw, Michael T. Boswell, Jinal N. Bhiman, Penny L. Moore, Alex Sigal, Ntobeko A. B. Ntusi, Wendy A. Burgers, Catherine Riou

Nature. 2022; 604(7907): E25. Published online 2022 Apr 8. doi: 10.1038/s41586-022-04708-y

Corrects:: Nature. 2022; 603(7901): 488–492.

PMCID:: PMC8993033

Correction PubReader PDF–666K Cite

Select item 89527293.

Prevalence and Determinants of Vitamin D Deficiency in 1825 Cape Town Primary Schoolchildren: A Cross-Sectional Study

Keren Middelkoop, Neil Walker, Justine Stewart, Carmen Delport, David A. Jolliffe, James Nuttall, Anna K. Coussens, Celeste E. Naude, Jonathan C. Y. Tang, William D. Fraser, Robert J. Wilkinson, Linda-Gail Bekker, Adrian R. Martineau

Nutrients. 2022 Mar; 14(6): 1263. Published online 2022 Mar 16. doi: 10.3390/nu14061263

PMCID:: PMC8952729

Article PubReader PDF–933K Cite

Select item 89388804.

Serial measurement of M. tuberculosis in blood from critically-ill patients with HIV-associated tuberculosis

David A. Barr, Charlotte Schutz, Avuyonke Balfour, Muki Shey, Mireille Kamariza, Carolyn R. Bertozzi, Timothy J. de Wet, Ryan Dinkele, Amy Ward, Kathryn A. Haigh, Jean-Paul Kanyik, Valerie Mizrahi, Mark P. Nicol, Robert J. Wilkinson, David G. Lalloo, Digby F. Warner, Graeme Meintjes, Gerry Davies

EBioMedicine. 2022 Apr; 78: 103949. Published online 2022 Mar 21. doi: 10.1016/j.ebiom.2022.103949

PMCID:: PMC8938880

Article PubReader PDF–3.0M Cite

Select item 88967645.

Mortality from drug-resistant tuberculosis in high-burden countries comparing routine drug susceptibility testing with whole-genome sequencing: a multicentre cohort study

Kathrin Zürcher, Martina L Reichmuth, Marie Ballif, Chloé Loiseau, Sonia Borrell, Miriam Reinhard, Veronika Skrivankova, Rico Hömke, Peter Sander, Anchalee Avihingsanon, Alash’le G Abimiku, Olivier Marcy, Jimena Collantes, E Jane Carter, Robert J Wilkinson, Helen Cox, Marcel Yotebieng, Robin Huebner, Lukas Fenner, Erik C Böttger, Sebastien Gagneux, Matthias Egger

Lancet Microbe. Author manuscript; available in PMC 2022 Mar 4.

Published in final edited form as: Lancet Microbe. 2021 Jul; 2(7): e320–e330. Published online 2021 Apr 29. doi: 10.1016/S2666-5247(21)00044-6

PMCID:: PMC8896764

Article PubReader PDF–908K Cite

Select item 88820686.

Assessing the clinical severity of the Omicron variant in the Western Cape Province, South Africa, using the diagnostic PCR proxy marker of RdRp target delay to distinguish between Omicron and Delta infections – a survival analysis

Hannah Hussey, Mary-Ann Davies, Alexa Heekes, Carolyn Williamson, Ziyaad Valley-Omar, Diana Hardie, Stephen Korsman, Deelan Doolabh, Wolfgang Preiser, Tongai Maponga, Arash Iranzadeh, Sean Wasserman, Linda Boloko, Greg Symons, Peter Raubenheimer, Arifa Parker, Neshaad Schrueder, Wesley Solomon, Petro Rousseau, Nicole Wolter, Waasila Jassat, Cheryl Cohen, Richard Lessells, Robert J Wilkinson, Andrew Boulle, Nei-yuan Hsiao

Int J Infect Dis. 2022 May; 118: 150–154. Published online 2022 Feb 27. doi: 10.1016/j.ijid.2022.02.051

PMCID:: PMC8882068

Article PubReader PDF–405K Cite

Select item 88473517.

Convalescent plasma in the treatment of moderate to severe COVID-19 pneumonia: a randomized controlled trial (PROTECT-Patient Trial)

Karin van den Berg, Tanya Nadia Glatt, Marion Vermeulen, Francesca Little, Ronel Swanevelder, Claire Barrett, Richard Court, Marise Bremer, Cynthia Nyoni, Avril Swarts, Cordelia Mmenu, Thomas Crede, Gerdien Kritzinger, Jonathan Naude, Patryk Szymanski, James Cowley, Thandeka Moyo-Gwete, Penny L. Moore, John Black, Jaimendra Singh, Jinal N. Bhiman, Prinita Baijnath, Priyesh Mody, Jacques Malherbe, Samantha Potgieter, Cloete van Vuuren, Shaun Maasdorp, Robert J. Wilkinson, Vernon J. Louw, Sean Wasserman

Sci Rep. 2022; 12: 2552. Published online 2022 Feb 15. doi: 10.1038/s41598-022-06221-8

PMCID:: PMC8847351

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Select item 87862258.

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

Darren P Martin, Spyros Lytras, Alexander G Lucaci, Wolfgang Maier, Björn Grüning, Stephen D Shank, Steven Weaver, Oscar A MacLean, Richard J Orton, Philippe Lemey, Maciej F Boni, Houriiyah Tegally, Gordon Harkins, Cathrine Scheepers, Jinal N Bhiman, Josie Everatt, Daniel G Amoako, James Emmanuel San, Jennifer Giandhari, Alex Sigal, NGS-SA, Carolyn Williamson, Nei-yuan Hsiao, Anne von Gottberg, Arne De Klerk, Robert W Shafer, David L Robertson, Robert J Wilkinson, B Trevor Sewell, Richard Lessells, Anton Nekrutenko, Allison J. Greaney, Tyler N. Starr, Jesse D. Bloom, Ben Murrell, Eduan Wilkinson, Ravindra K Gupta, Tulio de Oliveira, Sergei L Kosakovsky Pond

Version 1. bioRxiv. Preprint. 2022 Jan 18. doi: 10.1101/2022.01.14.476382

PMCID:: PMC8786225

Abstract Article PDF–2.0M Cite

Select item 87708669.

Kaposi’s Sarcoma-Associated Herpesvirus, but Not Epstein-Barr Virus, Co-infection Associates With Coronavirus Disease 2019 Severity and Outcome in South African Patients

Melissa J. Blumenthal, Humaira Lambarey, Abeen Chetram, Catherine Riou, Robert J. Wilkinson, Georgia Schäfer

Front Microbiol. 2021; 12: 795555. Published online 2022 Jan 6. doi: 10.3389/fmicb.2021.795555

PMCID:: PMC8770866

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Select item 876473010.

Outcomes of laboratory-confirmed SARS-CoV-2 infection in the Omicron-driven fourth wave compared with previous waves in the Western Cape Province, South Africa

Mary-Ann Davies, Reshma Kassanjee, Petro Rosseau, Erna Morden, Leigh Johnson, Wesley Solomon, Nei-Yuan Hsiao, Hannah Hussey, Graeme Meintjes, Masudah Paleker, Theuns Jacobs, Peter Raubenheimer, Alexa Heekes, Pierre Dane, Jamy-Lee Bam, Mariette Smith, Wolfgang Preiser, David Pienaar, Marc Mendelson, Jonathan Naude, Neshaad Schrueder, Ayanda Mnguni, Sue Le Roux, Katie Murie, Hans Prozesky, Hassan Mahomed, Liezel Rossouw, Sean Wasserman, Deborah Maughan, Linda Boloko, Barry Smith, Jantjie Taljaard, Greg Symons, Ntobeko Ntusi, Arifa Parker, Nicole Wolter, Waasila Jassat, Cheryl Cohen, Richard Lessells, Robert J Wilkinson, Juanita Arendse, Saadiq Kariem, Melvin Moodley, Krish Vallabhjee, Milani Wolmarans, Keith Cloete, Andrew Boulle

Version 1. medRxiv. Preprint. 2022 Jan 12. doi: 10.1101/2022.01.12.22269148

PMCID:: PMC8764730

Abstract Article PDF–973K Cite

Select item 872775911.

The In Vivo Transcriptomic Blueprint of Mycobacterium tuberculosis in the Lung

Mariateresa Coppola, Rachel P-J. Lai, Robert J. Wilkinson, Tom H. M. Ottenhoff

Front Immunol. 2021; 12: 763364. Published online 2021 Dec 22. doi: 10.3389/fimmu.2021.763364

PMCID:: PMC8727759

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Select item 871609012.

Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer

Cancer Cell. 2022 Feb 14; 40(2): 114–116. Published online 2021 Dec 29. doi: 10.1016/j.ccell.2021.12.013

Correction in:: Cancer Cell. 2022 Apr 11; 40(4): 438.

PMCID:: PMC8716090

Article PubReader PDF–329K Cite

Select item 864975713.

Transcriptomic Characterization of Tuberculous Sputum Reveals a Host Warburg Effect and Microbial Cholesterol Catabolism

Rachel P. J. Lai, Teresa Cortes, Suzaan Marais, Neesha Rockwood, Melissa L. Burke, Acely Garza-Garcia, Stuart Horswell, Abdul K. Sesay, Anne O’Garra, Douglas B. Young, Robert J. Wilkinson

mBio. 2021 Nov-Dec; 12(6): e01766-21. Published online 2021 Dec 7. doi: 10.1128/mBio.01766-21

PMCID:: PMC8649757

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Select item 847866314.

Radiological and functional evidence of the bronchial spread of tuberculosis: an observational analysis

Ray Y Chen, Xiang Yu, Bronwyn Smith, Xin Liu, Jingcai Gao, Andreas H Diacon, Rodney Dawson, Michele Tameris, Hong Zhu, Yahong Qu, Ruanqing Zhang, Shouguo Pan, Xiaowei Jin, Lisa C Goldfeder, Ying Cai, Kriti Arora, Jing Wang, Joel Vincent, Stephanus T Malherbe, Friedrich Thienemann, Robert J Wilkinson, Gerhard Walzl, Clifton E Barry, III

Lancet Microbe. 2021 Oct; 2(10): e518–e526. Published online 2021 Oct. doi: 10.1016/S2666-5247(21)00058-6

PMCID:: PMC8478663

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Select item 845273115.

Flow cytometry method for absolute counting and single-cell phenotyping of mycobacteria

David A. Barr, Charles Omollo, Mandy Mason, Anastasia Koch, Robert J. Wilkinson, David G. Lalloo, Graeme Meintjes, Valerie Mizrahi, Digby F. Warner, Gerry Davies

Sci Rep. 2021; 11: 18661. Published online 2021 Sep 20. doi: 10.1038/s41598-021-98176-5

PMCID:: PMC8452731

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Select item 834821516.

Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice

Andrea C. Bohrer, Ehydel Castro, Zhidong Hu, Artur T.L. Queiroz, Claire E. Tocheny, Maike Assmann, Shunsuke Sakai, Christine Nelson, Paul J. Baker, Hui Ma, Lin Wang, Wen Zilu, Elsa du Bruyn, Catherine Riou, Keith D. Kauffman, Tuberculosis Imaging Program, Ian N. Moore, Franca Del Nonno, Linda Petrone, Delia Goletti, Adrian R. Martineau, David M. Lowe, Mark R. Cronan, Robert J. Wilkinson, Clifton E. Barry, III, Laura E. Via, Daniel L. Barber, Amy D. Klion, Bruno B. Andrade, Yanzheng Song, Ka-Wing Wong, Katrin D. Mayer-Barber

J Exp Med. 2021 Oct 4; 218(10): e20210469. Published online 2021 Aug 4. doi: 10.1084/jem.20210469

PMCID:: PMC8348215

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Select item 829465417.

What is the optimum time to start antiretroviral therapy in people with HIV and tuberculosis coinfection? A systematic review and meta‐analysis

Rachael M Burke, Hannah M Rickman, Vindi Singh, Elizabeth L Corbett, Helen Ayles, Andreas Jahn, Mina C Hosseinipour, Robert J Wilkinson, Peter MacPherson

J Int AIDS Soc. 2021 Jul; 24(7): e25772. Published online 2021 Jul 21. doi: 10.1002/jia2.25772

PMCID:: PMC8294654

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Select item 828997618.

Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data

Matthew C. Altman, Darawan Rinchai, Nicole Baldwin, Mohammed Toufiq, Elizabeth Whalen, Mathieu Garand, Basirudeen Syed Ahamed Kabeer, Mohamed Alfaki, Scott R. Presnell, Prasong Khaenam, Aaron Ayllón-Benítez, Fleur Mougin, Patricia Thébault, Laurent Chiche, Noemie Jourde-Chiche, J. Theodore Phillips, Goran Klintmalm, Anne O’Garra, Matthew Berry, Chloe Bloom, Robert J. Wilkinson, Christine M. Graham, Marc Lipman, Ganjana Lertmemongkolchai, Davide Bedognetti, Rodolphe Thiebaut, Farrah Kheradmand, Asuncion Mejias, Octavio Ramilo, Karolina Palucka, Virginia Pascual, Jacques Banchereau, Damien Chaussabel

Nat Commun. 2021; 12: 4385. Published online 2021 Jul 19. doi: 10.1038/s41467-021-24584-w

PMCID:: PMC8289976

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Select item 828355119.

Study protocol for a phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis [LASER-TBM]

Angharad G. Davis, Sean Wasserman, Mpumi Maxebengula, Cari Stek, Marise Bremer, Remy Daroowala, Saalikha Aziz, Rene Goliath, Stephani Stegmann, Sonya Koekemoer, Amanda Jackson, Louise Lai Sai, Yakub Kadernani, Thandi Sihoyiya, C.Jason Liang, Lori Dodd, Paolo Denti, Thomas Crede, Jonathan Naude, Patryk Szymanski, Yakoob Vallie, Ismail Banderker, Shiraz Moosa, Peter Raubenheimer, Rachel P.J. Lai, John Joska, Sam Nightingale, Anna Dreyer, Gerda Wahl, Curtis Offiah, Isak Vorster, Sally Candy, Frances Robertson, Ernesta Meintjes, Gary Maartens, John Black, Graeme Meintjes, Robert J. Wilkinson

Version 1. Wellcome Open Res. 2021; 6: 136. Published online 2021 Jun 1. doi: 10.12688/wellcomeopenres.16783.1

PMCID:: PMC8283551

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Select item 820344620.

Relationship of SARS-CoV-2–specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection

Catherine Riou, Elsa du Bruyn, Cari Stek, Remy Daroowala, Rene T. Goliath, Fatima Abrahams, Qonita Said-Hartley, Brian W. Allwood, Nei-Yuan Hsiao, Katalin A. Wilkinson, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Sean Wasserman, Robert J. Wilkinson, on behalf of the HIATUS consortium

J Clin Invest. 2021 Jun 15; 131(12): e149125. Published online 2021 Jun 15. doi: 10.1172/JCI149125

PMCID:: PMC8203446

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