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Select item 103298091.

Discovery of a Phosphonoacetic Acid Derived Natural Product by Pathway Refactoring

Todd S. Freestone, Kou-San Ju, Bin Wang, Huimin Zhao

ACS Synth Biol. Author manuscript; available in PMC 2023 Jul 9.

Published in final edited form as: ACS Synth Biol. 2017 Feb 17; 6(2): 217–223. Published online 2017 Jan 23. doi: 10.1021/acssynbio.6b00299

PMCID:: PMC10329809

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Select item 41336372.

Phosphate-independent utilization of phosphonoacetic acid as sole phosphorus source by a psychrophilic strain of Geomyces pannorum P15

Magdalena Klimek-Ochab

Folia Microbiol (Praha) 2014; 59(5): 375–380. Published online 2014 Feb 26. doi: 10.1007/s12223-014-0309-3

PMCID:: PMC4133637

Article PDF–240K

Select item 60101363.

Conjugation of phosphonoacetic acid to nucleobase promotes a mechanism-based inhibition

Algirdas Mikalkėnas, Bazilė Ravoitytė, Daiva Tauraitė, Elena Servienė, Rolandas Meškys, Saulius Serva

J Enzyme Inhib Med Chem. 2018; 33(1): 384–389. Published online 2018 Jan 26. doi: 10.1080/14756366.2017.1417275

PMCID:: PMC6010136

Article PDF–953K

Select item 53514974.

A Salmonella Regulator Modulates Intestinal Colonization and Use of Phosphonoacetic Acid

Johanna R. Elfenbein, Leigh A. Knodler, Allison R. Schaeffer, Franziska Faber, Andreas J. Bäumler, Helene L. Andrews-Polymenis

Front Cell Infect Microbiol. 2017; 7: 69. Published online 2017 Mar 15. doi: 10.3389/fcimb.2017.00069

PMCID:: PMC5351497

Article PDF–989K

Select item 10430275.

Effect of phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.

Y J Gordon, M Lahav, S Photiou, Y Becker

Br J Ophthalmol. 1977 Aug; 61(8): 506–509. doi: 10.1136/bjo.61.8.506

PMCID:: PMC1043027

Summary Page Browse PDF–649K

Select item 3524606.

Phosphonoacetic Acid in the Treatment of Simian Varicella

A. D. Felsenfeld, C. R. Abee, P. J. Gerone, K. F. Soike, S. R. Williams

Antimicrob Agents Chemother. 1978 Sep; 14(3): 331–335. doi: 10.1128/aac.14.3.331

PMCID:: PMC352460

Summary Page Browse PDF–780K

Select item 3479087.

p105, an Epstein-Barr virus-induced, phosphonoacetic acid-insensitive glycoprotein target of the anti-Epstein-Barr virus immune response.

D Casareale, W Jones, T Sairenji, R E Humphreys

Infect Immun. 1983 Jan; 39(1): 85–90. doi: 10.1128/iai.39.1.85-90.1983

PMCID:: PMC347908

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Select item 3539108.

Cytofluorometry of lymphocytes infected with Epstein-Barr virus: effect of phosphonoacetic acid on nucleic acid.

S M Lemon, L M Hutt, J S Pagano

J Virol. 1978 Jan; 25(1): 138–145. doi: 10.1128/jvi.25.1.138-145.1978

PMCID:: PMC353910

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Select item 2560409.

Isolation and preliminary characterization of a phosphonoacetic acid-resistant and temperature-sensitive mutant of herpes simplex virus type 1.

J I Daksis, M M Priemer, V L Chan

J Virol. 1982 Apr; 42(1): 20–29. doi: 10.1128/jvi.42.1.20-29.1982

PMCID:: PMC256040

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Select item 44465110.

Inhibition of Herpes Simplex Virus Replication by Phosphonoacetic Acid

L. R. Overby, E. E. Robishaw, J. B. Schleicher, A. Rueter, N. L. Shipkowitz, J. C.-H. Mao

Antimicrob Agents Chemother. 1974 Sep; 6(3): 360–365. doi: 10.1128/aac.6.3.360

PMCID:: PMC444651

Summary Page Browse PDF–1003K

Select item 23733711.

Bacteriophage T4 DNA polymerase mutations that confer sensitivity to the PPi analog phosphonoacetic acid.

L J Reha-Krantz, R L Nonay, S Stocki

J Virol. 1993 Jan; 67(1): 60–66. doi: 10.1128/jvi.67.1.60-66.1993

PMCID:: PMC237337

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Select item 25409712.

Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus.

R T D'Aquila, W C Summers

J Virol. 1987 Apr; 61(4): 1291–1295. doi: 10.1128/jvi.61.4.1291-1295.1987

PMCID:: PMC254097

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Select item 35218413.

Alteration of Mortality and Pathogenesis of Three Experimental Herpesvirus hominis Infections of Mice with Adenine Arabinoside 5′-Monophosphate, Adenine Arabinoside, and Phosphonoacetic Acid

Earl R. Kern, James T. Richards, James C. Overall, Jr., Lowell A. Glasgow

Antimicrob Agents Chemother. 1978 Jan; 13(1): 53–60. doi: 10.1128/aac.13.1.53

PMCID:: PMC352184

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Select item 145039614.

Sensitivity to Phosphonoacetic Acid: A New Phenotype to Probe DNA Polymerase δ in Saccharomyces cerevisiae

Lei Li, Kelly M. Murphy, Uliana Kanevets, Linda J. Reha-Krantz

Genetics. 2005 Jun; 170(2): 569–580. doi: 10.1534/genetics.104.040295

PMCID:: PMC1450396

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Select item 438382615.

Method development in quantitative NMR towards metrologically traceable organic certified reference materials used as ³¹P qNMR standards

Michael Weber, Christine Hellriegel, Alexander Rueck, Juerg Wuethrich, Peter Jenks, Markus Obkircher

Anal Bioanal Chem. 2015; 407(11): 3115–3123. Published online 2014 Nov 22. doi: 10.1007/s00216-014-8306-6

PMCID:: PMC4383826

Article PDF–607K

Select item 315337416.

Identification of a New Motif in Family B DNA Polymerases by Mutational Analyses of the Bacteriophage T4 DNA Polymerase

Vincent Li, Matthew Hogg, Linda J. Reha-Krantz

J Mol Biol. Author manuscript; available in PMC 2011 Aug 9.

Published in final edited form as: J Mol Biol. 2010 Jul 16; 400(3): 295–308. Published online 2010 May 21. doi: 10.1016/j.jmb.2010.05.030

PMCID:: PMC3153374

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Select item 28383217.

Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with adenine arabinoside, 5-ethyldeoxyuridine, 5-iododeoxyuridine, and phosphonoacetic acid against herpes simplex virus types 1 and 2.

N K Ayisi, V S Gupta, J B Meldrum, A K Taneja, L A Babiuk

Antimicrob Agents Chemother. 1980 Apr; 17(4): 558–566. doi: 10.1128/aac.17.4.558

PMCID:: PMC283832

Summary Page Browse PDF–983K

Select item 284032218.

Transport and signaling through the phosphate-binding site of the yeast Pho84 phosphate transceptor

Yulia Popova, Palvannan Thayumanavan, Elena Lonati, Margarida Agrochão, Johan M. Thevelein

Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7): 2890–2895. Published online 2010 Feb 1. doi: 10.1073/pnas.0906546107

PMCID:: PMC2840322

Article PDF–391K

Select item 11212319.

Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50/Rta Protein Activates the Entire Viral Lytic Cycle in the HH-B2 Primary Effusion Lymphoma Cell Line

Lyndle Gradoville, Jennifer Gerlach, Elizabeth Grogan, Duane Shedd, Sarah Nikiforow, Craig Metroka, George Miller

J Virol. 2000 Jul; 74(13): 6207–6212. doi: 10.1128/jvi.74.13.6207-6212.2000

PMCID:: PMC112123

Article PDF–852K

Select item 107570220.

Architecture of Replication Compartments Formed during Epstein-Barr Virus Lytic Replication

Tohru Daikoku, Ayumi Kudoh, Masatoshi Fujita, Yutaka Sugaya, Hiroki Isomura, Noriko Shirata, Tatsuya Tsurumi

J Virol. 2005 Mar; 79(6): 3409–3418. doi: 10.1128/JVI.79.6.3409-3418.2005

PMCID:: PMC1075702

Article PDF–786K

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PMC Images search for Phosphonoacetic acid

Figure 1.

Conjugates of nucleotides with phosphonoacetic acid used in this study.

Conjugation of phosphonoacetic acid to nucleobase promotes a mechanism-based inhibition

J Enzyme Inhib Med Chem. 2018;33(1):384-389.
Fig. 1

Growth of G. pannorum P15 in media containing inorganic phosphate or phosphonoacetic acid as P sources and fungal utilization of both substrates. Data are means ± SD of three replication

Phosphate-independent utilization of phosphonoacetic acid as sole phosphorus source by a psychrophilic strain of Geomyces pannorum P15

Folia Microbiol (Praha). 2014;59(5):375-380.
Fig. 2

Growth of Geomyces pannorum P15 in media containing inorganic phosphate and phosphonoacetic acid as P source. The residual concentration of both substrates in the broth supernatants was also evaluated. Data are means ± SD of three replication. a 5 mM PAA + 2 mM Pi. b 5 mM PAA + 0.15 mM Pi

Phosphate-independent utilization of phosphonoacetic acid as sole phosphorus source by a psychrophilic strain of Geomyces pannorum P15

Folia Microbiol (Praha). 2014;59(5):375-380.
Fig 3Phosphonoacetic acid inhibits expression of four BGLF3-independent genes.

A) Western blot analysis of 2089 cell lysates assessing the effect of siBGLF3 and phosphonoacetic acid (PAA), an inhibitor of viral DNA replication, on expression of viral genes. B) The effect of phosphonoacetic acid (PAA) on expression of EBV early (dotted white bars), late (dotted black bars) and BGLF3-independent (diagonally stripped bars) genes in lytic 2089 cells. RT-qPCR was used to assess the level of each transcript. BTRF1, BPLF1, BCRF1 and BSRF1 represent a new subclass of late genes expressed in a manner independent of BGLF3. The value of (n) indicates the number of biological replicates. FR3, BFRF3; Z, ZEBRA, and siBGLF3, siRNA to BGLF3.

The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex

PLoS Pathog. 2016 Nov;12(11):e1006008.

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