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Select item 92868611.

N,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine

Edward James, Joachim Keppler, Thomas L Robertshaw, Ben Sessa

Hum Psychopharmacol. 2022 May; 37(3): e2835. Published online 2022 Feb 17. doi: 10.1002/hup.2835

Correction in:: Hum Psychopharmacol. 2022 May; 37(3): e2843.

PMCID:: PMC9286861

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Select item 87827052.

Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT

Steven A. Barker

Psychopharmacology (Berl) 2022; 239(6): 1749–1763. Published online 2022 Jan 22. doi: 10.1007/s00213-022-06065-0

Correction in:: Psychopharmacology (Berl). 2022 Feb 11

PMCID:: PMC8782705

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Select item 50484973.

Neuropharmacology of N,N-Dimethyltryptamine

Theresa M. Carbonaro, Michael B. Gatch

Brain Res Bull. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: Brain Res Bull. 2016 Sep; 126(Pt 1): 74–88. Published online 2016 Apr 25. doi: 10.1016/j.brainresbull.2016.04.016

PMCID:: PMC5048497

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Select item 71963404.

Effects of N,N-dimethyltryptamine (DMT) on rat behaviors relevant to anxiety and depression

Lindsay P. Cameron, Charlie J. Benson, Lee E. Dunlap, David E. Olson

ACS Chem Neurosci. Author manuscript; available in PMC 2020 May 3.

Published in final edited form as: ACS Chem Neurosci. 2018 Jul 18; 9(7): 1582–1590. Published online 2018 Apr 24. doi: 10.1021/acschemneuro.8b00134

PMCID:: PMC7196340

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Select item 65977275.

Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain

Jon G. Dean, Tiecheng Liu, Sean Huff, Ben Sheler, Steven A. Barker, Rick J. Strassman, Michael M. Wang, Jimo Borjigin

Sci Rep. 2019; 9: 9333. Published online 2019 Jun 27. doi: 10.1038/s41598-019-45812-w

PMCID:: PMC6597727

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Select item 75222656.

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

Jose A. Morales-Garcia, Javier Calleja-Conde, Jose A. Lopez-Moreno, Sandra Alonso-Gil, Marina Sanz-SanCristobal, Jordi Riba, Ana Perez-Castillo

Transl Psychiatry. 2020; 10: 331. Published online 2020 Sep 28. doi: 10.1038/s41398-020-01011-0

PMCID:: PMC7522265

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Select item 105832507.

Optimized infusion rates for N,N‐dimethyltryptamine to achieve a target psychedelic intensity based on a modeling and simulation framework

Emma Eckernäs, Jeroen Koomen, Christopher Timmermann, Robin Carhart‐Harris, Daniel Röshammar, Michael Ashton

CPT Pharmacometrics Syst Pharmacol. 2023 Oct; 12(10): 1398–1410. Published online 2023 Sep 7. doi: 10.1002/psp4.13037

PMCID:: PMC10583250

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Select item 31557248.

When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor

Tsung-Ping Su, Teruo Hayashi, D. Bruce Vaupel

Sci Signal. Author manuscript; available in PMC 2011 Aug 14.

Published in final edited form as: Sci Signal. 2009 Mar 10; 2(61): pe12. Published online 2009 Mar 10. doi: 10.1126/scisignal.261pe12

PMCID:: PMC3155724

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Select item 66397759.

Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents

Lindsay P. Cameron, Charlie J. Benson, Brian C. DeFelice, Oliver Fiehn, David E. Olson

ACS Chem Neurosci. 2019 Jul 17; 10(7): 3261–3270. Published online 2019 Mar 4. doi: 10.1021/acschemneuro.8b00692

PMCID:: PMC6639775

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Select item 402557210.

Noncompetitive Inhibition of Indolethylamine-N-methyltransferase by N,N-Dimethyltryptamine and N,N-Dimethylaminopropyltryptamine

Uyen B. Chu, Sevahn K. Vorperian, Kenneth Satyshur, Kelsey Eickstaedt, Nicholas V. Cozzi, Timur Mavlyutov, Abdol R. Hajipour, Arnold E. Ruoho

Biochemistry. 2014 May 13; 53(18): 2956–2965. Published online 2014 Apr 14. doi: 10.1021/bi500175p

PMCID:: PMC4025572

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Select item 931480511.

The clinical pharmacology and potential therapeutic applications of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT)

Johannes T. Reckweg, Malin V. Uthaug, Attila Szabo, Alan K. Davis, Rafael Lancelotta, Natasha L. Mason, Johannes G. Ramaekers

J Neurochem. 2022 Jul; 162(1): 128–146. Published online 2022 Mar 8. doi: 10.1111/jnc.15587

PMCID:: PMC9314805

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Select item 428259612.

The Role of 5-HT_2A, 5-HT_2C and mGlu2 Receptors in the Behavioral Effects of Tryptamine Hallucinogens N,N-Dimethyltryptamine and N,N-Diisopropyltryptamine in Rats and Mice

Theresa M. Carbonaro, Amy J. Eshleman, Michael J. Forster, Kejun Cheng, Kenner C. Rice, Michael B. Gatch

Psychopharmacology (Berl) Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: Psychopharmacology (Berl). 2015 Jan; 232(1): 275–284. Published online 2014 Jul 3. doi: 10.1007/s00213-014-3658-3

PMCID:: PMC4282596

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Select item 414958213.

Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells

Attila Szabo, Attila Kovacs, Ede Frecska, Eva Rajnavolgyi

PLoS One. 2014; 9(8): e106533. Published online 2014 Aug 29. doi: 10.1371/journal.pone.0106533

PMCID:: PMC4149582

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Select item 932419914.

Enlightening the “Spirit Molecule”: Photomodulation of the 5‐HT_2A Receptor by a Light‐Controllable N,N‐Dimethyltryptamine Derivative

Hubert Gerwe, Feng He, Eline Pottie, Prof. Dr. Christophe Stove, Prof. Dr. Michael Decker

Angew Chem Int Ed Engl. 2022 Jun 27; 61(26): e202203034. Published online 2022 Apr 29. doi: 10.1002/anie.202203034

PMCID:: PMC9324199

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Select item 634320515.

Ayahuasca: Psychological and Physiologic Effects, Pharmacology and
Potential Uses in Addiction and Mental Illness

Jonathan Hamill, Jaime Hallak, Serdar M. Dursun, Glen Baker

Curr Neuropharmacol. 2019 Feb; 17(2): 108–128. Published online 2019 Feb. doi: 10.2174/1570159X16666180125095902

PMCID:: PMC6343205

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Select item 703607416.

Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment

Malin V Uthaug, Rafael Lancelotta, Attila Szabo, Alan K Davis, Jordi Riba, Johannes G Ramaekers

Psychopharmacology (Berl) 2020; 237(3): 773–785. Published online 2019 Dec 10. doi: 10.1007/s00213-019-05414-w

PMCID:: PMC7036074

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Select item 491890817.

Secondary Metabolites from Three Florida Sponges with Antidepressant Activity

Anna J. Kochanowska, Karumanchi V. Rao, Suzanne Childress, Abir El-Alfy, Rae R. Matsumoto, Michelle Kelly, Gina S. Stewart, Kenneth J. Sufka, Mark T. Hamann

J Nat Prod. Author manuscript; available in PMC 2016 Jun 23.

Published in final edited form as: J Nat Prod. 2008 Feb; 71(2): 186–189. Published online 2008 Jan 25. doi: 10.1021/np070371u

PMCID:: PMC4918908

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Select item 294720518.

The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

Dominique Fontanilla, Molly Johannessen, Abdol R. Hajipour, Nicholas V. Cozzi, Meyer B. Jackson, Arnold E. Ruoho

Science. Author manuscript; available in PMC 2010 Sep 29.

Published in final edited form as: Science. 2009 Feb 13; 323(5916): 934–937. doi: 10.1126/science.1166127

PMCID:: PMC2947205

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Select item 1006875619.

Human brain effects of DMT assessed via EEG-fMRI

Christopher Timmermann, Leor Roseman, Sharad Haridas, Fernando E. Rosas, Lisa Luan, Hannes Kettner, Jonny Martell, David Erritzoe, Enzo Tagliazucchi, Carla Pallavicini, Manesh Girn, Andrea Alamia, Robert Leech, David J. Nutt, Robin L. Carhart-Harris

Proc Natl Acad Sci U S A. 2023 Mar 28; 120(13): e2218949120. Published online 2023 Mar 20. doi: 10.1073/pnas.2218949120

PMCID:: PMC10068756

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Select item 707570420.

Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogs Through Structure-Activity Relationship Studies

Lee E. Dunlap, Arya Azinfar, Calvin Ly, Lindsay P. Cameron, Jayashri Viswanathan, Robert J. Tombari, Douglas Myers-Turnbull, Jack C. Taylor, Ana Cristina Grodzki, Pamela J. Lein, David Kokel, David E. Olson

J Med Chem. Author manuscript; available in PMC 2021 Feb 13.

Published in final edited form as: J Med Chem. 2020 Feb 13; 63(3): 1142–1155. Published online 2020 Jan 24. doi: 10.1021/acs.jmedchem.9b01404

PMCID:: PMC7075704

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FIGURE 3

Chemical structure of N,N‐dimethyltryptamine

N,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine

Hum Psychopharmacol. 2022 May;37(3):e2835.
Fig. 1

Structures of compounds discussed. DMT, N,N-dimethyltryptamine; d, deuterium; 5 h, 5-hydroxy; 5 MeO, 5-methoxy

Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT

Psychopharmacology (Berl). 2022;239(6):1749-1763.
FIGURE 6

A simplified general overview of contemporary understanding of the neurochemistry and psychopharmacology of N,N‐dimethyltryptamine and ayahuasca. Grey boxes = DMT mediated; White boxes = β‐carboline mediated; White/grey boxes = both DMT and β‐carboline mediated

N,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine

Hum Psychopharmacol. 2022 May;37(3):e2835.
Figure 2

Chemical structure of serotonin (5-HT) and the main active alkaloids present in ayahuasca preparation. DMT: N,N-Dimethyltryptamine; THH: Tetrahydroharmine.

Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact

Pharmaceuticals (Basel). 2020 Nov;13(11):334.